ES2710211T3 - Combinación de un antagonista de PD-1 y un inhibidor de VEGFR para tratar el cáncer - Google Patents

Combinación de un antagonista de PD-1 y un inhibidor de VEGFR para tratar el cáncer Download PDF

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Publication number
ES2710211T3
ES2710211T3 ES15703439T ES15703439T ES2710211T3 ES 2710211 T3 ES2710211 T3 ES 2710211T3 ES 15703439 T ES15703439 T ES 15703439T ES 15703439 T ES15703439 T ES 15703439T ES 2710211 T3 ES2710211 T3 ES 2710211T3
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Prior art keywords
cancer
antagonist
medicament
dose
axitinib
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Spanish (es)
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Jean-Francois Andre Martini
Jamal Christo Tarazi
Rodolfo Fleury Perini
David J Mauro
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Pfizer Corp Belgium
Organon Pharma UK Ltd
Pfizer Corp SRL
Merck Sharp and Dohme LLC
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Pfizer Corp Belgium
Merck Sharp and Dohme Ltd
Pfizer Corp SRL
Merck Sharp and Dohme LLC
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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ES15703439T 2014-02-04 2015-02-03 Combinación de un antagonista de PD-1 y un inhibidor de VEGFR para tratar el cáncer Active ES2710211T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461935809P 2014-02-04 2014-02-04
PCT/US2015/014212 WO2015119930A1 (en) 2014-02-04 2015-02-03 Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer

Publications (1)

Publication Number Publication Date
ES2710211T3 true ES2710211T3 (es) 2019-04-23

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ID=52463238

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ES15703439T Active ES2710211T3 (es) 2014-02-04 2015-02-03 Combinación de un antagonista de PD-1 y un inhibidor de VEGFR para tratar el cáncer
ES18205542T Active ES2899457T3 (es) 2014-02-04 2015-02-03 Combinación de un antagonista de PD-1 y un inhibidor de VEGFR para tratar el cáncer

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ES18205542T Active ES2899457T3 (es) 2014-02-04 2015-02-03 Combinación de un antagonista de PD-1 y un inhibidor de VEGFR para tratar el cáncer

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US (3) US10570202B2 (enExample)
EP (3) EP3498734B1 (enExample)
JP (3) JP6591428B2 (enExample)
KR (3) KR20160108566A (enExample)
CN (2) CN118286440A (enExample)
AU (1) AU2015214390B2 (enExample)
BR (1) BR112016017256A2 (enExample)
CA (2) CA3210360A1 (enExample)
CY (2) CY1121374T1 (enExample)
DK (1) DK3102605T3 (enExample)
EA (1) EA201691376A1 (enExample)
ES (2) ES2710211T3 (enExample)
HU (2) HUE041469T2 (enExample)
IL (2) IL311399A (enExample)
MX (1) MX386604B (enExample)
PL (2) PL3102605T3 (enExample)
PT (2) PT3498734T (enExample)
SG (2) SG11201605824XA (enExample)
SI (2) SI3102605T1 (enExample)
TR (1) TR201901507T4 (enExample)
TW (1) TWI663983B (enExample)
WO (1) WO2015119930A1 (enExample)

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