HRP20240136T1 - Metode liječenja raka jajnika - Google Patents
Metode liječenja raka jajnika Download PDFInfo
- Publication number
- HRP20240136T1 HRP20240136T1 HRP20240136TT HRP20240136T HRP20240136T1 HR P20240136 T1 HRP20240136 T1 HR P20240136T1 HR P20240136T T HRP20240136T T HR P20240136TT HR P20240136 T HRP20240136 T HR P20240136T HR P20240136 T1 HRP20240136 T1 HR P20240136T1
- Authority
- HR
- Croatia
- Prior art keywords
- cancer
- use according
- therapeutic agent
- ovarian cancer
- niraparib
- Prior art date
Links
- 206010033128 Ovarian cancer Diseases 0.000 title claims 7
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims 7
- 239000003814 drug Substances 0.000 claims 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- PCHKPVIQAHNQLW-CQSZACIVSA-N niraparib Chemical group N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCCNC1 PCHKPVIQAHNQLW-CQSZACIVSA-N 0.000 claims 4
- 229950011068 niraparib Drugs 0.000 claims 4
- 229910052697 platinum Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 3
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 3
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 2
- 238000009115 maintenance therapy Methods 0.000 claims 2
- 102000036365 BRCA1 Human genes 0.000 claims 1
- 108700020463 BRCA1 Proteins 0.000 claims 1
- 101150072950 BRCA1 gene Proteins 0.000 claims 1
- 102000052609 BRCA2 Human genes 0.000 claims 1
- 108700020462 BRCA2 Proteins 0.000 claims 1
- 101150008921 Brca2 gene Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101710179684 Poly [ADP-ribose] polymerase Proteins 0.000 claims 1
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims 1
- 206010038111 Recurrent cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 claims 1
- 201000002628 peritoneum cancer Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Claims (9)
1. Terapeutsko sredstvo koje inhibira poli [ADP-riboza] polimerazu ("anti-PARP terapija") za uporabu u liječenju raka kod ljudskog pacijenta, naznačeno time što je sredstvo niraparib, ili njegova farmaceutski prihvatljiva sol,
pri čemu je pacijent naznačen prethodnim liječenjem terapijom na bazi platine i odsutnošću zametne linije ili sporadične mutacije u BRCA1 i/ili BRCA2,
pri čemu se niraparib, ili njegova farmaceutski prihvatljiva sol, primjenjuje kao terapija održavanja nakon potpunog ili djelomičnog odgovora na najmanje jednu terapiju baziranu na platini, i
pri čemu je pacijent nadalje naznačen odsutnošću nedostatka homologne rekombinacije (HRD).
2. Terapeutsko sredstvo za uporabu prema zahtjevu 1, naznačeno time što pacijent ima tumor s negativnim HRD statusom.
3. Terapeutsko sredstvo za uporabu prema zahtjevu 1 ili zahtjevu 2, naznačeno time što se niraparib, ili njegova farmaceutski prihvatljiva sol, primjenjuje kao terapija održavanja nakon djelomičnog odgovora na najmanje jednu terapiju baziranu na platini.
4. Terapeutsko sredstvo za uporabu prema bilo kojem od zahtjeva 1-3, naznačeno time što se niraparib, ili njegova farmaceutski prihvatljiva sol pripremaju u obliku tosilat monohidrata.
5. Terapeutsko sredstvo za uporabu prema bilo kojem od zahtjeva 1-4, naznačeno time što je rak odabran iz grupe koju čine: rak jajnika, rak jajovoda, peritonealni rak, i rak dojke.
6. Terapeutsko sredstvo za uporabu prema zahtjevu 5, naznačeno time što je rak jajnika serozni rak jajnika visokog stupnja ili pretežno serozni histološki rak jajnika visokog stupnja.
7. Terapeutsko sredstvo za uporabu prema bilo kojem od zahtjeva 1-6, naznačeno time što je rak rekurentni rak.
8. Terapeutsko sredstvo za uporabu prema zahtjevu 7, naznačeno time što je rak odabran iz grupe koju čine:
rak jajnika, rak jajovoda ili primarni peritonealni rak.
9. Terapeutsko sredstvo za uporabu prema zahtjevu 8, naznačeno time što je rak jajnika, rak jajovoda ili primarni peritonealni rak osjetljiv na platinu na početku liječenja.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662356461P | 2016-06-29 | 2016-06-29 | |
| US201662402427P | 2016-09-30 | 2016-09-30 | |
| US201762470141P | 2017-03-10 | 2017-03-10 | |
| PCT/US2017/040039 WO2018005818A1 (en) | 2016-06-29 | 2017-06-29 | Methods of treating ovarian cancer |
| EP17821262.7A EP3478286B1 (en) | 2016-06-29 | 2017-06-29 | Methods of treating ovarian cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240136T1 true HRP20240136T1 (hr) | 2024-04-12 |
Family
ID=60787744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240136TT HRP20240136T1 (hr) | 2016-06-29 | 2017-06-29 | Metode liječenja raka jajnika |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20220175751A1 (hr) |
| EP (2) | EP4302835A3 (hr) |
| JP (2) | JP7083760B2 (hr) |
| KR (2) | KR20230042136A (hr) |
| CN (1) | CN109640992A (hr) |
| AU (1) | AU2017290244B2 (hr) |
| BR (1) | BR112018077492A2 (hr) |
| CA (1) | CA3029671C (hr) |
| DK (1) | DK3478286T3 (hr) |
| ES (1) | ES2969816T3 (hr) |
| FI (1) | FI3478286T3 (hr) |
| HR (1) | HRP20240136T1 (hr) |
| HU (1) | HUE064978T2 (hr) |
| IL (1) | IL263925B2 (hr) |
| LT (1) | LT3478286T (hr) |
| MA (1) | MA45563A (hr) |
| MX (1) | MX2018016193A (hr) |
| NZ (1) | NZ749413A (hr) |
| PL (1) | PL3478286T3 (hr) |
| PT (1) | PT3478286T (hr) |
| RS (1) | RS65180B1 (hr) |
| SG (1) | SG11201811564QA (hr) |
| SI (1) | SI3478286T1 (hr) |
| WO (1) | WO2018005818A1 (hr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018085469A2 (en) | 2016-11-01 | 2018-05-11 | Anaptysbio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| US11155624B2 (en) | 2016-11-01 | 2021-10-26 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (PD-1) |
| KR102606252B1 (ko) | 2017-01-09 | 2023-11-23 | 테사로, 인코포레이티드 | 항-pd-1 항체로 암을 치료하는 방법 |
| MX2019008208A (es) | 2017-01-09 | 2019-12-11 | Tesaro Inc | Métodos para tratar el cáncer con anticuerpos anti-tim-3. |
| BR112019020211A2 (pt) * | 2017-03-27 | 2020-04-22 | Tesaro Inc | composições de niraparib |
| TW201906632A (zh) * | 2017-05-09 | 2019-02-16 | 美商提薩羅有限公司 | 治療癌症的組合療法 |
| AU2018270112A1 (en) | 2017-05-18 | 2019-12-12 | Tesaro, Inc. | Combination therapies for treating cancer |
| CA3076907A1 (en) | 2017-09-26 | 2019-04-04 | Tesaro, Inc. | Niraparib formulations |
| WO2019067978A1 (en) | 2017-09-30 | 2019-04-04 | Tesaro, Inc. | POLYTHERAPIES FOR THE TREATMENT OF CANCER |
| CN111182923A (zh) | 2017-10-06 | 2020-05-19 | 特沙诺有限公司 | 组合疗法及其用途 |
| EP3749352A1 (en) * | 2018-02-05 | 2020-12-16 | Tesaro Inc. | Pediatric niraparib formulations and pediatric treatment methods |
| WO2019195443A1 (en) * | 2018-04-04 | 2019-10-10 | The Wistar Institute Of Anatomy And Biology | Methods of treating cancers overexpressing carm1 with ezh2 inhibitors and a parp inhibitor |
| EP3860988A1 (en) | 2018-10-03 | 2021-08-11 | Tesaro, Inc. | Crystalline forms of niraparib freebase |
| ES2967517T3 (es) | 2018-10-03 | 2024-04-30 | Tesaro Inc | Sales de niraparib |
| TW202116316A (zh) * | 2019-07-15 | 2021-05-01 | 美商提薩羅有限公司 | 治療卵巢、輸卵管及腹膜癌之方法 |
| KR20230114557A (ko) | 2022-01-25 | 2023-08-01 | 서울대학교산학협력단 | 상동 재조합 결핍 연관 유전자 도출 장치 및 방법, 상동 재조합 결핍 판단 모델 생성 장치 및 방법과, 상동 재조합 결핍 판단 장치 및 방법 |
| WO2023159066A1 (en) | 2022-02-15 | 2023-08-24 | Tesaro, Inc. | Use of niraparib for the treatment of brain cancer |
| CN115253066A (zh) * | 2022-07-21 | 2022-11-01 | 湖南安泰康成生物科技有限公司 | 卵巢癌治疗系统以及卵巢癌治疗的交变电场发生装置 |
| CN116092631A (zh) * | 2023-01-17 | 2023-05-09 | 湖南安泰康成生物科技有限公司 | 铁死亡诱导剂与电场联用的肿瘤治疗系统 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2805945T1 (sl) | 2007-01-10 | 2019-09-30 | Msd Italia S.R.L. | Amid substituirani indazoli, kot inhibitorji poli(ADP-riboza)polimeraze(PARP) |
| AU2008321382A1 (en) * | 2007-11-12 | 2009-05-22 | Bipar Sciences, Inc. | Treatment of uterine cancer and ovarian cancer with a PARP inhibitor alone or in combination with anti-tumor agents |
| RU2495035C2 (ru) | 2008-01-08 | 2013-10-10 | Мерк Шарп Энд Домэ Лтд | Фармацевтически приемлемые соли 2-{4-[(3s)-пиперидин-3-ил]фенил}-2н-индазол-7-карбоксамида |
| CA2802882C (en) | 2010-06-18 | 2018-10-30 | Jerry Lanchbury | Methods and materials for assessing loss of heterozygosity |
| ES2588979T3 (es) | 2010-08-24 | 2016-11-08 | Dana-Farber Cancer Institute, Inc. | Procedimientos para la predicción de una respuesta contra el cáncer |
| WO2014052550A1 (en) * | 2012-09-27 | 2014-04-03 | Thomas Jefferson University | Use of parp inhibitors to treat breast cancer |
| CN105917007A (zh) * | 2014-01-16 | 2016-08-31 | 克洛维斯肿瘤有限公司 | Parp抑制剂用以治疗显示杂合性丧失的乳腺癌或卵巢癌患者的用途 |
| JP6648040B2 (ja) * | 2014-05-28 | 2020-02-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | がん治療のための併用療法としてのエリブリン及びポリ（ａｄｐリボース）ポリメラーゼ（ｐａｒｐ）阻害剤の使用 |
| US20150344968A1 (en) * | 2014-05-30 | 2015-12-03 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Methods for determining parp inhibitor and platinum resistance in cancer therapy |
| CN105384695B (zh) * | 2014-08-22 | 2019-12-20 | 四川海思科制药有限公司 | 嘧啶衍生物及其制备方法和在医药上的应用 |
-
2017
- 2017-06-29 SI SI201731481T patent/SI3478286T1/sl unknown
- 2017-06-29 NZ NZ749413A patent/NZ749413A/en unknown
- 2017-06-29 CA CA3029671A patent/CA3029671C/en active Active
- 2017-06-29 PT PT178212627T patent/PT3478286T/pt unknown
- 2017-06-29 ES ES17821262T patent/ES2969816T3/es active Active
- 2017-06-29 LT LTEPPCT/US2017/040039T patent/LT3478286T/lt unknown
- 2017-06-29 EP EP23211450.4A patent/EP4302835A3/en active Pending
- 2017-06-29 AU AU2017290244A patent/AU2017290244B2/en active Active
- 2017-06-29 RS RS20240163A patent/RS65180B1/sr unknown
- 2017-06-29 SG SG11201811564QA patent/SG11201811564QA/en unknown
- 2017-06-29 WO PCT/US2017/040039 patent/WO2018005818A1/en active Application Filing
- 2017-06-29 PL PL17821262.7T patent/PL3478286T3/pl unknown
- 2017-06-29 KR KR1020237008762A patent/KR20230042136A/ko not_active Application Discontinuation
- 2017-06-29 MA MA045563A patent/MA45563A/fr unknown
- 2017-06-29 DK DK17821262.7T patent/DK3478286T3/da active
- 2017-06-29 MX MX2018016193A patent/MX2018016193A/es unknown
- 2017-06-29 FI FIEP17821262.7T patent/FI3478286T3/fi active
- 2017-06-29 CN CN201780051916.1A patent/CN109640992A/zh active Pending
- 2017-06-29 KR KR1020197002633A patent/KR102510996B1/ko active IP Right Grant
- 2017-06-29 JP JP2018568951A patent/JP7083760B2/ja active Active
- 2017-06-29 IL IL263925A patent/IL263925B2/en unknown
- 2017-06-29 HR HRP20240136TT patent/HRP20240136T1/hr unknown
- 2017-06-29 BR BR112018077492-8A patent/BR112018077492A2/pt unknown
- 2017-06-29 EP EP17821262.7A patent/EP3478286B1/en active Active
- 2017-06-29 HU HUE17821262A patent/HUE064978T2/hu unknown
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2021
- 2021-12-27 JP JP2021212103A patent/JP2022031478A/ja active Pending
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2022
- 2022-02-24 US US17/652,422 patent/US20220175751A1/en not_active Abandoned
- 2022-02-24 US US17/652,457 patent/US20220395493A1/en not_active Abandoned
- 2022-02-24 US US17/652,443 patent/US20220175752A1/en not_active Abandoned
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2023
- 2023-09-08 US US18/463,851 patent/US20240058319A1/en active Pending
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