HRP20210838T1 - Kombinacija protutijela anti-cd19 s inhibitorom bcl-2 te njihove uporabe - Google Patents
Kombinacija protutijela anti-cd19 s inhibitorom bcl-2 te njihove uporabe Download PDFInfo
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- HRP20210838T1 HRP20210838T1 HRP20210838TT HRP20210838T HRP20210838T1 HR P20210838 T1 HRP20210838 T1 HR P20210838T1 HR P20210838T T HRP20210838T T HR P20210838TT HR P20210838 T HRP20210838 T HR P20210838T HR P20210838 T1 HRP20210838 T1 HR P20210838T1
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- Prior art keywords
- lymphoma
- combination according
- hodgkin
- seq
- antibody
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- 239000012664 BCL-2-inhibitor Substances 0.000 title 1
- 229940123711 Bcl2 inhibitor Drugs 0.000 title 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 10
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 7
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 7
- 229960001183 venetoclax Drugs 0.000 claims 7
- LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims 7
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 4
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 2
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 1
- 201000003791 MALT lymphoma Diseases 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003563 lymphoid tissue Anatomy 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (20)
1. Kombinacija, naznačena time, da sadrži protutijelo specifično za CD19 gdje navedeno protutijelo sadrži regiju HCDR1 koja sadrži slijed SYVMH (SEQ ID NO: 1), regiju HCDR2 koja sadrži slijed NPYNDG (SEQ ID NO: 2), regiju HCDR3 koja sadrži slijed GTYYYGTRVFDY (SEQ ID NO: 3), regiju LCDR1 koja sadrži slijed RSSKSLQNVNGNTYLY (SEQ ID NO: 4), regiju LCDR2 koja sadrži slijed RMSNLNS (SEQ ID NO: 5), i regiju LCDR3 koja sadrži slijed MQHLEYPIT (SEQ ID NO: 6) i venetoklaks za uporabu u liječenju non-Hodgkinovog limfoma, kronične limfocitne leukemije i/ili akutne limfoblastične leukemije.
2. Kombinacija u skladu s uporabom iz patentnog zahtjeva 1, naznačena time, da protutijelo ima djelovanje ADCC.
3. Kombinacija u skladu s uporabom iz patentnog zahtjeva 1 ili 2, naznačena time, da protutijelo sadrži varijabilni teški lanac koji sadrži slijed
EVQLVESGGGLVKPGGSLKLSCAASGYTFTSYVMHWVRQAPGKGLEWIGYINPY
NDGTKYNEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYGTRVFDYW
G QGTLVTVSS (SEQ ID NO: 10) i varijabilni laki lanac koji sadrži slijed
DIVMTQSPATLSLSPGERATLSCRSSKSLQNVNGNTYLYWFQQKPGQSPQLLIYR
MSNLNSGVPDRFSGSGSGTEFTLTISSLEPEDFAVYYCMQHLEYPITFGAGTKLEIK
(SEQ ID NO: 11).
4. Kombinacija u skladu s uporabom iz bilo kojeg od prethodnih patentnih zahtjeva, naznačena time, da protutijelo sadrži konstantnu domenu teškog lanca koja sadrži slijed
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQ
SSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPE
LLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKP
REEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKALPAPEEKTISKTKGQPREPQV
YLTPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFL
YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK (SEQ ID NO: 12).
5. Kombinacija u skladu s uporabom iz bilo kojeg od prethodnih patentnih zahtjeva, naznačena time, da protutijelo sadrži konstantnu domenu lakog lanca koja sadrži slijed
RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTE
QDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC (SEQ ID NO: 13).
6. Kombinacija u skladu s uporabom iz bilo kojeg od prethodnih patentnih zahtjeva, naznačena time, da se spomenuto protutijelo koje je specifično za CD19 i venetoklaks formuliraju u različitim farmaceutskim pripravcima.
7. Kombinacija u skladu s uporabom iz bilo kojeg od prethodnih patentnih zahtjeva, naznačena time, da se spomenuto protutijelo koje je specifično za CD19 i venetoklaks primjenjuju odvojeno.
8. Kombinacija u skladu s uporabom iz bilo kojeg od prethodnih patentnih zahtjeva, naznačena time, da:
(a) venetoklaks se primjenjuje prije primjene protutijela koje je specifično za CD19; ili
(b) spomenuto protutijelo koje je specifično za CD19 se primjenjuje prije venetoklaksa.
9. Kombinacija u skladu s uporabom iz bilo kojeg od patentnih zahtjeva 1 do 6, naznačena time, da se spomenuto protutijelo koje je specifično za CD19 i venetoklaks primjenjuju istovremeno.
10. Kombinacija u skladu s uporabom iz bilo kojeg od prethodnih patentnih zahtjeva, naznačena time, da se spomenuto protutijelo koje je specifično za CD19 i venetoklaks primjenjuju u razdoblju kada su oba lijeka aktivna kod pacijenta u isto vrijeme.
11. Kombinacija u skladu s uporabom iz bilo kojeg od prethodnih patentnih zahtjeva, naznačena time, da je za uporabu u liječenju kronične limfocitne leukemije.
12. Kombinacija u skladu s uporabom iz bilo kojeg od patentnih zahtjeva 1 do 10, naznačena time, da je za uporabu u liječenju akutne limfoblastične leukemije.
13. Kombinacija u skladu s uporabom iz bilo kojeg od patentnih zahtjeva 1 do 10, naznačena time, da je za uporabu u liječenju non-Hodgkinovog limfoma, opcionalno gdje se non-Hodgkinov limfom bira iz skupine koja se sastoji od folikularnog limfoma, malog limfocitnog limfoma, limfoma limfnog tkiva vezanog uz sluznicu, limfoma marginalne zone, difuznog velikog limfoma B stanica, Burkittovog limfoma, i limfoma plaštenih stanica.
14. Kombinacija u skladu s uporabom patentnog zahtjeva 13, naznačena time, da non-Hodgkinov limfom jest folikularni limfom.
15. Kombinacija u skladu s uporabom patentnog zahtjeva 13, naznačena time, da non-Hodgkinov limfom jest mali limfocitni limfom.
16. Kombinacija u skladu s uporabom patentnog zahtjeva 13, naznačena time, da non-Hodgkinov limfom jest limfom limfnog tkiva vezanog uz sluznicu.
17. Kombinacija u skladu s uporabom patentnog zahtjeva 13, naznačena time, da non-Hodgkinov limfom jest limfom marginalne zone.
18. Kombinacija u skladu s uporabom patentnog zahtjeva 13, naznačena time, da non-Hodgkinov limfom jest difuzni veliki limfom B stanice.
19. Kombinacija u skladu s uporabom patentnog zahtjeva 13, naznačena time, da non-Hodgkinov limfom jest Burkittov limfom.
20. Kombinacija u skladu s uporabom patentnog zahtjeva 13, naznačena time, da non-Hodgkinov limfom jest limfom plaštenih stanica.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16196184 | 2016-10-28 | ||
| PCT/EP2017/077654 WO2018078123A1 (en) | 2016-10-28 | 2017-10-27 | Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof |
| EP17797564.6A EP3532098B1 (en) | 2016-10-28 | 2017-10-27 | Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20210838T1 true HRP20210838T1 (hr) | 2021-08-06 |
Family
ID=57218739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20210838TT HRP20210838T1 (hr) | 2016-10-28 | 2021-05-25 | Kombinacija protutijela anti-cd19 s inhibitorom bcl-2 te njihove uporabe |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20190241656A1 (hr) |
| EP (2) | EP3532098B1 (hr) |
| JP (2) | JP7094950B2 (hr) |
| KR (2) | KR102500868B1 (hr) |
| CN (2) | CN109890418B (hr) |
| AU (1) | AU2017348624B2 (hr) |
| BR (1) | BR112019008244A2 (hr) |
| CA (1) | CA3037246A1 (hr) |
| CY (1) | CY1124648T1 (hr) |
| DK (1) | DK3532098T3 (hr) |
| ES (1) | ES2871574T3 (hr) |
| HR (1) | HRP20210838T1 (hr) |
| HU (1) | HUE054496T2 (hr) |
| IL (2) | IL266216B2 (hr) |
| LT (1) | LT3532098T (hr) |
| MX (2) | MX2019004942A (hr) |
| PL (1) | PL3532098T3 (hr) |
| PT (1) | PT3532098T (hr) |
| RS (1) | RS62036B1 (hr) |
| RU (1) | RU2756405C2 (hr) |
| SG (1) | SG10202104036QA (hr) |
| SI (1) | SI3532098T1 (hr) |
| WO (1) | WO2018078123A1 (hr) |
| ZA (1) | ZA201903302B (hr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018276384A1 (en) * | 2017-05-31 | 2019-11-07 | Incyte Corporation | Treatment paradigm for an anti-CD19 antibody and venetoclax combination treatment |
| GB201809746D0 (en) * | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
| CN112638392B (zh) * | 2018-08-31 | 2024-09-10 | Adc治疗有限公司 | 组合疗法 |
| CN114786723A (zh) * | 2019-10-31 | 2022-07-22 | 莫佛塞斯公司 | 序贯抗cd19疗法 |
| US20220389104A1 (en) * | 2021-05-28 | 2022-12-08 | Ose Immunotherapeutics | Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US5686072A (en) | 1992-06-17 | 1997-11-11 | Board Of Regents, The University Of Texas | Epitope-specific monoclonal antibodies and immunotoxins and uses thereof |
| WO2002022212A2 (en) | 2000-09-18 | 2002-03-21 | Idec Pharmaceuticals Corporation | Combination therapy for treatment of autoimmune diseases using b cell depleting/immunoregulatory antibody combination |
| US7771951B2 (en) | 2001-12-03 | 2010-08-10 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| CA2534639C (en) | 2003-07-31 | 2013-07-30 | Immunomedics, Inc. | Anti-cd19 antibodies |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| EP1899379B1 (en) | 2005-06-20 | 2018-04-11 | E. R. Squibb & Sons, L.L.C. | Cd19 antibodies and their uses |
| EP2270050B1 (en) | 2005-12-30 | 2013-06-05 | Merck Patent GmbH | Anti-CD19 antibodies with reduced immunogenicity |
| ES2402591T3 (es) | 2006-08-14 | 2013-05-07 | Xencor Inc. | Anticuerpos optimizados que seleccionan como diana CD19 |
| EP2066349B1 (en) | 2006-09-08 | 2012-03-28 | MedImmune, LLC | Humanized anti-cd19 antibodies and their use in treatment of tumors, transplantation and autoimmune diseases |
| EP2708557A1 (en) | 2007-05-30 | 2014-03-19 | Xencor, Inc. | Method and compositions for inhibiting CD32B expressing cells |
| LT2211904T (lt) | 2007-10-19 | 2016-11-25 | Seattle Genetics, Inc. | Cd19 surišantys agentai ir jų panaudojimas |
| US8679492B2 (en) | 2009-02-23 | 2014-03-25 | Glenmark Pharmaceuticals S.A. | Humanized antibodies that bind to CD19 and their uses |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2010151341A1 (en) | 2009-06-24 | 2010-12-29 | The Feinstein Institute For Medical Research | Method for treating chronic lymphocytic leukemia |
| WO2011147834A1 (en) | 2010-05-26 | 2011-12-01 | Roche Glycart Ag | Antibodies against cd19 and uses thereof |
| EP2409712A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
| EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
| EP2524929A1 (en) | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| KR20200058583A (ko) * | 2011-08-16 | 2020-05-27 | 모르포시스 아게 | 항-cd19 항체 및 질소 머스타드를 사용한 조합 요법 |
| HUE058855T2 (hu) * | 2011-08-16 | 2022-09-28 | Morphosys Ag | Kombinációs terápia, CD19 elleni ellenanyag és purinanalóg alkalmazásával |
| EP3476392A1 (en) * | 2014-02-28 | 2019-05-01 | Merck Sharp & Dohme Corp. | Method for treating cancer |
| CA2972827A1 (en) | 2015-02-12 | 2016-08-18 | Seattle Genetics, Inc. | Combination therapy using a cd19-adc and vincristine |
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2017
- 2017-10-27 LT LTEP17797564.6T patent/LT3532098T/lt unknown
- 2017-10-27 JP JP2019522273A patent/JP7094950B2/ja active Active
- 2017-10-27 MX MX2019004942A patent/MX2019004942A/es unknown
- 2017-10-27 ES ES17797564T patent/ES2871574T3/es active Active
- 2017-10-27 DK DK17797564.6T patent/DK3532098T3/da active
- 2017-10-27 HU HUE17797564A patent/HUE054496T2/hu unknown
- 2017-10-27 CN CN201780067047.1A patent/CN109890418B/zh active Active
- 2017-10-27 RS RS20210792A patent/RS62036B1/sr unknown
- 2017-10-27 CA CA3037246A patent/CA3037246A1/en active Pending
- 2017-10-27 EP EP17797564.6A patent/EP3532098B1/en active Active
- 2017-10-27 IL IL266216A patent/IL266216B2/en unknown
- 2017-10-27 SI SI201730811T patent/SI3532098T1/sl unknown
- 2017-10-27 SG SG10202104036QA patent/SG10202104036QA/en unknown
- 2017-10-27 BR BR112019008244A patent/BR112019008244A2/pt unknown
- 2017-10-27 WO PCT/EP2017/077654 patent/WO2018078123A1/en unknown
- 2017-10-27 RU RU2019113370A patent/RU2756405C2/ru active
- 2017-10-27 IL IL301786A patent/IL301786A/en unknown
- 2017-10-27 EP EP21165598.0A patent/EP3903821A1/en active Pending
- 2017-10-27 KR KR1020197012532A patent/KR102500868B1/ko active IP Right Grant
- 2017-10-27 PT PT177975646T patent/PT3532098T/pt unknown
- 2017-10-27 AU AU2017348624A patent/AU2017348624B2/en active Active
- 2017-10-27 KR KR1020237005018A patent/KR20230028571A/ko not_active Application Discontinuation
- 2017-10-27 CN CN202410183851.8A patent/CN118045175A/zh active Pending
- 2017-10-27 US US16/342,645 patent/US20190241656A1/en active Pending
- 2017-10-27 PL PL17797564T patent/PL3532098T3/pl unknown
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2019
- 2019-04-26 MX MX2022016270A patent/MX2022016270A/es unknown
- 2019-05-24 ZA ZA2019/03302A patent/ZA201903302B/en unknown
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2021
- 2021-05-25 HR HRP20210838TT patent/HRP20210838T1/hr unknown
- 2021-06-10 CY CY20211100512T patent/CY1124648T1/el unknown
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2022
- 2022-06-22 JP JP2022100006A patent/JP2022137089A/ja active Pending
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