ES2667729T3 - Fusiones de anticuerpos con doble especificidad - Google Patents
Fusiones de anticuerpos con doble especificidad Download PDFInfo
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- ES2667729T3 ES2667729T3 ES12183573.0T ES12183573T ES2667729T3 ES 2667729 T3 ES2667729 T3 ES 2667729T3 ES 12183573 T ES12183573 T ES 12183573T ES 2667729 T3 ES2667729 T3 ES 2667729T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
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Landscapes
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| GB0718832 | 2007-09-26 | ||
| GB0718832A GB0718832D0 (en) | 2007-09-26 | 2007-09-26 | Antibody fusions |
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| ES2667729T3 true ES2667729T3 (es) | 2018-05-14 |
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| ES08806478.7T Active ES2622460T3 (es) | 2007-09-26 | 2008-09-26 | Fusiones de anticuerpos con doble especificidad |
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| WO2009040562A1 (en) * | 2007-09-26 | 2009-04-02 | Ucb Pharma S.A. | Dual specificity antibody fusions |
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| JP5901517B2 (ja) * | 2009-05-28 | 2016-04-13 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 抗原結合性タンパク質 |
| TW201106971A (en) * | 2009-05-28 | 2011-03-01 | Glaxo Group Ltd | Antigen-binding proteins |
| US20120134984A1 (en) * | 2009-06-01 | 2012-05-31 | Olga Lubman | Molecules with extended half-lives and uses thereof |
| WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
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| US20130115215A1 (en) * | 2010-07-14 | 2013-05-09 | Hongxing Zhou | Domain insertion immunoglobulin |
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| JP2014501515A (ja) | 2010-12-01 | 2014-01-23 | グラクソ グループ リミテッド | 改良された抗血清アルブミン結合単一可変ドメイン |
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| US10208349B2 (en) | 2011-01-07 | 2019-02-19 | Ucb Biopharma Sprl | Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy |
| KR101950306B1 (ko) | 2011-01-14 | 2019-02-20 | 유씨비 바이오파마 에스피알엘 | Ｉｌ-17ａ 및 ｉｌ-17ｆ에 결합하는 항체 분자 |
| CN107903325B (zh) | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
| EP2723380B1 (en) * | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
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| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
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| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| CN110981964B (zh) | 2013-01-14 | 2023-09-15 | Xencor股份有限公司 | 新型异二聚体蛋白 |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
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| AU2014207549B2 (en) | 2013-01-15 | 2018-12-06 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| EP2961773B1 (en) * | 2013-02-26 | 2019-03-20 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
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| US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
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| CN105555310B (zh) | 2013-07-08 | 2019-07-23 | 南京传奇生物科技有限公司 | 一种提高蛋白血清半衰期的组合物和方法 |
| DK3039038T3 (da) * | 2013-08-30 | 2021-02-08 | Aprilbio Co Ltd | Fusionskonstruktion med antiserumalbumin-fab-effektordel, og fremstillingsmetode dertil |
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| TR201802728T4 (tr) | 2013-10-25 | 2018-03-21 | Psioxus Therapeutics Ltd | Heterolog genlerle donatılmış onkolitik adenovirüsler. |
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| WO2015127288A1 (en) | 2014-02-20 | 2015-08-27 | Alder Biopharmaceuticals, Inc. | Anti-acth antibodies and use thereof |
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| US9884921B2 (en) | 2014-07-01 | 2018-02-06 | Pfizer Inc. | Bispecific heterodimeric diabodies and uses thereof |
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| ES2738705T3 (es) * | 2014-09-19 | 2020-01-24 | Hope City | Linfocitos T de receptor de antígeno quimérico coestimulante que se dirigen a IL13R 2 |
| PE20171103A1 (es) | 2014-11-26 | 2017-08-07 | Xencor Inc | Anticuerpos heterodimericos que se unen a cd3 y cd38 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
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| WO2009040562A1 (en) | 2009-04-02 |
| CN104004088B (zh) | 2017-11-07 |
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