ES2347491T3 - Piridin carboxamidas como inhibidores de 11-beta-hsd1. - Google Patents
Piridin carboxamidas como inhibidores de 11-beta-hsd1. Download PDFInfo
- Publication number
- ES2347491T3 ES2347491T3 ES07824375T ES07824375T ES2347491T3 ES 2347491 T3 ES2347491 T3 ES 2347491T3 ES 07824375 T ES07824375 T ES 07824375T ES 07824375 T ES07824375 T ES 07824375T ES 2347491 T3 ES2347491 T3 ES 2347491T3
- Authority
- ES
- Spain
- Prior art keywords
- pyridin
- acid
- propylsulfanyl
- piperidyl
- cyclohexylcarbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003112 inhibitor Substances 0.000 title description 20
- -1 trifluoromoxy Chemical group 0.000 claims abstract description 224
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 192
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract description 158
- 150000001875 compounds Chemical class 0.000 claims abstract description 131
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 127
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 114
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 112
- 125000005843 halogen group Chemical group 0.000 claims abstract description 106
- 239000001257 hydrogen Substances 0.000 claims abstract description 95
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 95
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 93
- 125000001424 substituent group Chemical group 0.000 claims abstract description 90
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 82
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 70
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 63
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 60
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 60
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 59
- 229910052717 sulfur Chemical group 0.000 claims abstract description 59
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 57
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 57
- 239000001301 oxygen Chemical group 0.000 claims abstract description 57
- 239000011593 sulfur Chemical group 0.000 claims abstract description 57
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 51
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 44
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 41
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 39
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 39
- 150000003839 salts Chemical class 0.000 claims abstract description 37
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 35
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract description 35
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract description 34
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 33
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 32
- 150000002431 hydrogen Chemical group 0.000 claims abstract description 32
- 150000002148 esters Chemical class 0.000 claims abstract description 30
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims abstract description 28
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract description 27
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 22
- 125000005592 polycycloalkyl group Polymers 0.000 claims abstract description 21
- 125000004429 atom Chemical group 0.000 claims abstract description 20
- 125000002950 monocyclic group Chemical group 0.000 claims abstract description 19
- 238000001727 in vivo Methods 0.000 claims abstract description 18
- 125000002619 bicyclic group Chemical group 0.000 claims abstract description 13
- 125000006413 ring segment Chemical group 0.000 claims abstract description 12
- 125000003003 spiro group Chemical group 0.000 claims abstract description 11
- 125000001589 carboacyl group Chemical group 0.000 claims abstract description 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract description 7
- 125000002757 morpholinyl group Chemical group 0.000 claims abstract description 7
- 125000004193 piperazinyl group Chemical group 0.000 claims abstract description 7
- 125000003386 piperidinyl group Chemical group 0.000 claims abstract description 7
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims abstract description 6
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims abstract description 5
- FLIPCDXQSSQHMS-SCUMNGBJSA-N 2-[(3s)-1-[5-(1-adamantylcarbamoyl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C1=CC=C(C(=O)NC23CC4CC(CC(C4)C2)C3)C=N1 FLIPCDXQSSQHMS-SCUMNGBJSA-N 0.000 claims abstract description 4
- ZRWLIWLEJVTMNH-KRWDZBQOSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-piperazin-1-ylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C(N=C1N2CCNCC2)=CC=C1C(=O)NC1CCCCC1 ZRWLIWLEJVTMNH-KRWDZBQOSA-N 0.000 claims abstract description 4
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims abstract description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 8
- 239000002253 acid Substances 0.000 claims description 301
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 118
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 94
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 71
- 238000000034 method Methods 0.000 claims description 70
- 238000006243 chemical reaction Methods 0.000 claims description 63
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 53
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims description 44
- 102000004190 Enzymes Human genes 0.000 claims description 40
- 108090000790 Enzymes Proteins 0.000 claims description 40
- 101100451537 Caenorhabditis elegans hsd-1 gene Proteins 0.000 claims description 38
- 238000011282 treatment Methods 0.000 claims description 30
- 241000282414 Homo sapiens Species 0.000 claims description 17
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 15
- 125000000304 alkynyl group Chemical group 0.000 claims description 13
- 230000002401 inhibitory effect Effects 0.000 claims description 13
- 125000006239 protecting group Chemical group 0.000 claims description 13
- JAEIBKXSIXOLOL-UHFFFAOYSA-N pyrrolidin-1-ium-3-carboxylate Chemical compound OC(=O)C1CCNC1 JAEIBKXSIXOLOL-UHFFFAOYSA-N 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 11
- 241001465754 Metazoa Species 0.000 claims description 10
- 125000003342 alkenyl group Chemical group 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 208000011580 syndromic disease Diseases 0.000 claims description 9
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 8
- 241000282693 Cercopithecidae Species 0.000 claims description 6
- 208000008589 Obesity Diseases 0.000 claims description 6
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims description 6
- 230000002503 metabolic effect Effects 0.000 claims description 6
- 235000020824 obesity Nutrition 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 5
- OTVUUOKTGJTVOI-NXEDIBJZSA-N (3r,5s)-4-[[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]amino]adamantane-1-carboxylic acid Chemical compound C1([C@]2([H])CC3C[C@]1(CC(C3)(C2)C(O)=O)[H])NC(N=C1SCCC)=CC=C1C(=O)NC1CCCCC1 OTVUUOKTGJTVOI-NXEDIBJZSA-N 0.000 claims description 4
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims description 4
- SRJOCJYGOFTFLH-UHFFFAOYSA-N isonipecotic acid Chemical compound OC(=O)C1CCNCC1 SRJOCJYGOFTFLH-UHFFFAOYSA-N 0.000 claims description 4
- KXRYVJZOORPUHV-BWVQPMQLSA-N (3r)-1-[5-(2-adamantylcarbamoyl)-6-ethylsulfanylpyridin-2-yl]pyrrolidine-3-carboxylic acid Chemical compound C=1C=C(C(=O)NC2C3CC4CC(C3)CC2C4)C(SCC)=NC=1N1CC[C@@H](C(O)=O)C1 KXRYVJZOORPUHV-BWVQPMQLSA-N 0.000 claims description 3
- NCDZABJPWMBMIQ-MRXNPFEDSA-N 2-[(3r)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@@H](CC(O)=O)CCC2)=CC=C1C(=O)NC1CCCCC1 NCDZABJPWMBMIQ-MRXNPFEDSA-N 0.000 claims description 3
- MAGWXJSYWCUXBU-BALBBAFXSA-N 2-[(3s)-1-[5-(1-adamantylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C=1C=C(C(=O)NC23CC4CC(CC(C4)C2)C3)C(SCCC)=NC=1N1CCC[C@@H](CC(O)=O)C1 MAGWXJSYWCUXBU-BALBBAFXSA-N 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 3
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- GBOKRRIOJRPDOE-BYICEURKSA-N (1r,5s)-3-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid Chemical compound CCCSC1=NC(N2C[C@@H]3[C@@H](C3C(O)=O)C2)=CC=C1C(=O)NC1CCCCC1 GBOKRRIOJRPDOE-BYICEURKSA-N 0.000 claims description 2
- WUYAHJJXCBDIKJ-NPWKZODJSA-N (1s,5r)-3-[5-(2-adamantylcarbamoyl)-6-ethylsulfanylpyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid Chemical compound C1C(CC2C3)CC3CC1C2NC(=O)C1=CC=C(N2C[C@@H]3[C@@H](C3C(O)=O)C2)N=C1SCC WUYAHJJXCBDIKJ-NPWKZODJSA-N 0.000 claims description 2
- UQXYTOYECTZNET-ASODICMLSA-N (1s,5r)-3-[5-(2-adamantylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid Chemical compound C1C(CC2C3)CC3CC1C2NC(=O)C1=CC=C(N2C[C@@H]3[C@@H](C3C(O)=O)C2)N=C1SCCC UQXYTOYECTZNET-ASODICMLSA-N 0.000 claims description 2
- HEAOWUYQOYGPJY-XDIGRCDVSA-N (1s,5r)-3-[6-cyclohexylsulfanyl-5-(3-pyridin-3-ylpyrrolidine-1-carbonyl)pyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid Chemical compound C([C@@H]1C([C@@H]1C1)C(=O)O)N1C(N=C1SC2CCCCC2)=CC=C1C(=O)N(C1)CCC1C1=CC=CN=C1 HEAOWUYQOYGPJY-XDIGRCDVSA-N 0.000 claims description 2
- KKIUUXNWTSIXPO-INIZCTEOSA-N (2s)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]pyrrolidine-2-carboxylic acid Chemical compound CCCSC1=NC(N2[C@@H](CCC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 KKIUUXNWTSIXPO-INIZCTEOSA-N 0.000 claims description 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 claims description 2
- LPURRRBKLBZUPO-WFBUYENLSA-N (3r)-1-[5-(2-adamantylcarbamoyl)-6-methylsulfanylpyridin-2-yl]pyrrolidine-3-carboxylic acid Chemical compound C=1C=C(C(=O)NC2C3CC4CC(C3)CC2C4)C(SC)=NC=1N1CC[C@@H](C(O)=O)C1 LPURRRBKLBZUPO-WFBUYENLSA-N 0.000 claims description 2
- LLTNOCNNDPGMCN-KTRILSHOSA-N (3r)-1-[5-(2-adamantylcarbamoyl)-6-propylsulfanylpyridin-2-yl]pyrrolidine-3-carboxylic acid Chemical compound C=1C=C(C(=O)NC2C3CC4CC(C3)CC2C4)C(SCCC)=NC=1N1CC[C@@H](C(O)=O)C1 LLTNOCNNDPGMCN-KTRILSHOSA-N 0.000 claims description 2
- LLTNOCNNDPGMCN-ZAKJRURMSA-N (3s)-1-[5-(2-adamantylcarbamoyl)-6-propylsulfanylpyridin-2-yl]pyrrolidine-3-carboxylic acid Chemical compound C=1C=C(C(=O)NC2C3CC4CC(C3)CC2C4)C(SCCC)=NC=1N1CC[C@H](C(O)=O)C1 LLTNOCNNDPGMCN-ZAKJRURMSA-N 0.000 claims description 2
- NVKADYQHGSKWAU-UHFFFAOYSA-N 1-[1-[5-(cyclohexylcarbamoyl)-6-cyclopentylsulfanylpyridin-2-yl]piperidin-3-yl]cyclopropane-1-carboxylic acid Chemical compound C1CCN(C=2N=C(SC3CCCC3)C(C(=O)NC3CCCCC3)=CC=2)CC1C1(C(=O)O)CC1 NVKADYQHGSKWAU-UHFFFAOYSA-N 0.000 claims description 2
- SEPOOLQHIXKDEF-UHFFFAOYSA-N 1-[1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]cyclobutane-1-carboxylic acid Chemical compound CCCSC1=NC(N2CC(CCC2)C2(CCC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 SEPOOLQHIXKDEF-UHFFFAOYSA-N 0.000 claims description 2
- OBIBTFMGDXQHMI-UHFFFAOYSA-N 1-[1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]cyclopropane-1-carboxylic acid Chemical compound CCCSC1=NC(N2CC(CCC2)C2(CC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 OBIBTFMGDXQHMI-UHFFFAOYSA-N 0.000 claims description 2
- TUQXAEMHWYQEKQ-UHFFFAOYSA-N 1-[1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-4-yl]cyclobutane-1-carboxylic acid Chemical compound CCCSC1=NC(N2CCC(CC2)C2(CCC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 TUQXAEMHWYQEKQ-UHFFFAOYSA-N 0.000 claims description 2
- XJAXAWKEAXKJJB-UHFFFAOYSA-N 1-[1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-4-yl]cyclopropane-1-carboxylic acid Chemical compound CCCSC1=NC(N2CCC(CC2)C2(CC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 XJAXAWKEAXKJJB-UHFFFAOYSA-N 0.000 claims description 2
- JVJMSDLTRHBRJB-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-methylpiperidine-3-carboxylic acid Chemical compound CCCSC1=NC(N2CC(C)(CCC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 JVJMSDLTRHBRJB-UHFFFAOYSA-N 0.000 claims description 2
- BLTSAQQQTCVULJ-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-methylpiperidine-4-carboxylic acid Chemical compound CCCSC1=NC(N2CC(C)C(CC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 BLTSAQQQTCVULJ-UHFFFAOYSA-N 0.000 claims description 2
- NLMGUVBLHWMZKH-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-4-methylpiperidine-4-carboxylic acid Chemical compound CCCSC1=NC(N2CCC(C)(CC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 NLMGUVBLHWMZKH-UHFFFAOYSA-N 0.000 claims description 2
- NELACKFJPMHQOT-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-4-propan-2-ylpiperidine-4-carboxylic acid Chemical compound CCCSC1=NC(N2CCC(CC2)(C(C)C)C(O)=O)=CC=C1C(=O)NC1CCCCC1 NELACKFJPMHQOT-UHFFFAOYSA-N 0.000 claims description 2
- OYJYRXPSEFHPIA-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]azepane-4-carboxylic acid Chemical compound CCCSC1=NC(N2CCC(CCC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 OYJYRXPSEFHPIA-UHFFFAOYSA-N 0.000 claims description 2
- OUWJQKDZRGZBGA-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidine-2-carboxylic acid Chemical compound CCCSC1=NC(N2C(CCCC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 OUWJQKDZRGZBGA-UHFFFAOYSA-N 0.000 claims description 2
- MFQPYWLVPWCPPR-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidine-3-carboxylic acid Chemical compound CCCSC1=NC(N2CC(CCC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 MFQPYWLVPWCPPR-UHFFFAOYSA-N 0.000 claims description 2
- ZLGMJDQCLXIRIW-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidine-4-carboxylic acid Chemical compound CCCSC1=NC(N2CCC(CC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 ZLGMJDQCLXIRIW-UHFFFAOYSA-N 0.000 claims description 2
- IPWNSFXRBGOKPT-UHFFFAOYSA-N 1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]pyrrolidine-3-carboxylic acid Chemical compound CCCSC1=NC(N2CC(CC2)C(O)=O)=CC=C1C(=O)NC1CCCCC1 IPWNSFXRBGOKPT-UHFFFAOYSA-N 0.000 claims description 2
- WIWMHUGRFDJESS-OAQYLSRUSA-N 2-[(3r)-1-[5-(cyclohexylcarbamoyl)-6-(2-phenylethylsulfanyl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@@H](CC(=O)O)CCCN1C(N=C1SCCC=2C=CC=CC=2)=CC=C1C(=O)NC1CCCCC1 WIWMHUGRFDJESS-OAQYLSRUSA-N 0.000 claims description 2
- QQWHNWGBOUKEIN-QGZVFWFLSA-N 2-[(3r)-1-[5-(cyclohexylcarbamoyl)-6-cyclopentylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@@H](CC(=O)O)CCCN1C(N=C1SC2CCCC2)=CC=C1C(=O)NC1CCCCC1 QQWHNWGBOUKEIN-QGZVFWFLSA-N 0.000 claims description 2
- OQGIUZADBRQLNO-HNNXBMFYSA-N 2-[(3s)-1-[5-(4,4-difluoropiperidine-1-carbonyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N1CCC(F)(F)CC1 OQGIUZADBRQLNO-HNNXBMFYSA-N 0.000 claims description 2
- AGRNYJCBLOMLGJ-HNNXBMFYSA-N 2-[(3s)-1-[5-(4-carbamoylpiperidine-1-carbonyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N1CCC(C(N)=O)CC1 AGRNYJCBLOMLGJ-HNNXBMFYSA-N 0.000 claims description 2
- WIWMHUGRFDJESS-NRFANRHFSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-(2-phenylethylsulfanyl)pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound C1[C@H](CC(=O)O)CCCN1C(N=C1SCCC=2C=CC=CC=2)=CC=C1C(=O)NC1CCCCC1 WIWMHUGRFDJESS-NRFANRHFSA-N 0.000 claims description 2
- GJSCCAPNPKHPKQ-QFIPXVFZSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-[methyl(2-phenylethyl)amino]pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound N=1C(N2C[C@H](CC(O)=O)CCC2)=CC=C(C(=O)NC2CCCCC2)C=1N(C)CCC1=CC=CC=C1 GJSCCAPNPKHPKQ-QFIPXVFZSA-N 0.000 claims description 2
- DBVAIWWZAHIRPF-KRWDZBQOSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-[methyl(propyl)amino]pyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCN(C)C1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)NC1CCCCC1 DBVAIWWZAHIRPF-KRWDZBQOSA-N 0.000 claims description 2
- NCDZABJPWMBMIQ-INIZCTEOSA-N 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)NC1CCCCC1 NCDZABJPWMBMIQ-INIZCTEOSA-N 0.000 claims description 2
- NJMKZNRIZPAUCN-INIZCTEOSA-N 2-[(3s)-1-[5-(piperidine-1-carbonyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N1CCCCC1 NJMKZNRIZPAUCN-INIZCTEOSA-N 0.000 claims description 2
- QYVSMIVRWCSXAZ-SFHVURJKSA-N 2-[(3s)-1-[5-[cyclohexyl(cyclopropyl)carbamoyl]-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid Chemical compound CCCSC1=NC(N2C[C@H](CC(O)=O)CCC2)=CC=C1C(=O)N(C1CCCCC1)C1CC1 QYVSMIVRWCSXAZ-SFHVURJKSA-N 0.000 claims description 2
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/04—Anorexiants; Antiobesity agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86430306P | 2006-11-03 | 2006-11-03 | |
| US86424706P | 2006-11-03 | 2006-11-03 | |
| US864303P | 2006-11-03 | ||
| US864247P | 2006-11-03 |
Publications (1)
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| TW200836719A (en) * | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| CN103288738B (zh) | 2007-05-18 | 2016-03-16 | 盐野义制药株式会社 | 具有11β-羟基类固醇脱氢酶I型抑制活性的含氮杂环衍生物 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2009051112A1 (ja) | 2007-10-15 | 2009-04-23 | Takeda Pharmaceutical Company Limited | アミド化合物およびその用途 |
| WO2009056881A1 (en) * | 2007-10-29 | 2009-05-07 | Astrazeneca Ab | Chemical compounds 313 |
| EP2244705A1 (en) * | 2008-02-04 | 2010-11-03 | AstraZeneca AB | Novel crystalline forms of 4- [4- (2-adamantylcarbam0yl) -5-tert-butyl-pyrazol-1-yl]benzoic acid |
| KR20110002475A (ko) * | 2008-04-22 | 2011-01-07 | 아스트라제네카 아베 | 치환 피리미딘-5-카르복시아미드 281 |
| US8507493B2 (en) | 2009-04-20 | 2013-08-13 | Abbvie Inc. | Amide and amidine derivatives and uses thereof |
| JP2012529535A (ja) | 2009-06-12 | 2012-11-22 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼモジュレーターとして有用なニコチンアミド化合物 |
| AR078673A1 (es) * | 2009-10-20 | 2011-11-23 | Astrazeneca Ab | Pirimidinas sustituidas con adamantiliminocarbonilo como inhibidores de 11-b-hsd1 826 |
| MX2012006028A (es) * | 2009-11-24 | 2012-06-19 | Allergan Inc | Compuestos novedosos como moduladores de receptor con utilidad terapeutica. |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| KR20110123657A (ko) * | 2010-05-07 | 2011-11-15 | 에스케이케미칼주식회사 | 피콜린아마이드 및 피리미딘-4-카복사미드 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
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