ES2314275T3 - Granulado o polvo para la produccion de agentes de revestimiento y ligantes para formas de medicamentos. - Google Patents
Granulado o polvo para la produccion de agentes de revestimiento y ligantes para formas de medicamentos. Download PDFInfo
- Publication number
- ES2314275T3 ES2314275T3 ES03790791T ES03790791T ES2314275T3 ES 2314275 T3 ES2314275 T3 ES 2314275T3 ES 03790791 T ES03790791 T ES 03790791T ES 03790791 T ES03790791 T ES 03790791T ES 2314275 T3 ES2314275 T3 ES 2314275T3
- Authority
- ES
- Spain
- Prior art keywords
- powder
- granulate
- weight
- acid
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008187 granular material Substances 0.000 title claims abstract description 50
- 239000011248 coating agent Substances 0.000 title claims abstract description 31
- 239000003814 drug Substances 0.000 title claims abstract description 25
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- 239000011230 binding agent Substances 0.000 title claims abstract description 23
- 229940079593 drug Drugs 0.000 title claims abstract description 21
- 238000000576 coating method Methods 0.000 title abstract description 23
- 239000000843 powder Substances 0.000 claims abstract description 47
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 21
- 229920001577 copolymer Polymers 0.000 claims abstract description 20
- 239000000654 additive Substances 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 16
- 230000008569 process Effects 0.000 claims abstract description 15
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- 150000002148 esters Chemical class 0.000 claims abstract description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 7
- 239000000178 monomer Substances 0.000 claims abstract description 7
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 6
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- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims description 4
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- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 8
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
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- 230000035699 permeability Effects 0.000 description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 6
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- 230000009466 transformation Effects 0.000 description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 5
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 5
- 235000021355 Stearic acid Nutrition 0.000 description 5
- 229940088710 antibiotic agent Drugs 0.000 description 5
- 238000002955 isolation Methods 0.000 description 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 5
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- 235000019640 taste Nutrition 0.000 description 5
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical class O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 5
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 4
- 229920003149 Eudragit® E 100 Polymers 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 230000003356 anti-rheumatic effect Effects 0.000 description 4
- 239000003435 antirheumatic agent Substances 0.000 description 4
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000004051 gastric juice Anatomy 0.000 description 4
- 238000010348 incorporation Methods 0.000 description 4
- 235000012738 indigotine Nutrition 0.000 description 4
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 4
- 229960000991 ketoprofen Drugs 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
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- 239000007787 solid Substances 0.000 description 4
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- 235000012751 sunset yellow FCF Nutrition 0.000 description 4
- 239000004173 sunset yellow FCF Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 235000012756 tartrazine Nutrition 0.000 description 4
- 239000004149 tartrazine Substances 0.000 description 4
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Chemical class OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 description 3
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 3
- 229930182837 (R)-adrenaline Natural products 0.000 description 3
- GJHKWLSRHNWTAN-UHFFFAOYSA-N 1-ethoxy-4-(4-pentylcyclohexyl)benzene Chemical compound C1CC(CCCCC)CCC1C1=CC=C(OCC)C=C1 GJHKWLSRHNWTAN-UHFFFAOYSA-N 0.000 description 3
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 3
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 3
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 3
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 3
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 3
- 235000012735 amaranth Nutrition 0.000 description 3
- WLDHEUZGFKACJH-UHFFFAOYSA-K amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1N=NC1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-UHFFFAOYSA-K 0.000 description 3
- 229940035676 analgesics Drugs 0.000 description 3
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- YSVBPNGJESBVRM-UHFFFAOYSA-L disodium;4-[(1-oxido-4-sulfonaphthalen-2-yl)diazenyl]naphthalene-1-sulfonate Chemical compound [Na+].[Na+].C1=CC=C2C(N=NC3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)O)=CC=C(S([O-])(=O)=O)C2=C1 YSVBPNGJESBVRM-UHFFFAOYSA-L 0.000 description 3
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10239999 | 2002-08-27 | ||
| DE10239999A DE10239999A1 (de) | 2002-08-27 | 2002-08-27 | Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2314275T3 true ES2314275T3 (es) | 2009-03-16 |
Family
ID=31197526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03790791T Expired - Lifetime ES2314275T3 (es) | 2002-08-27 | 2003-07-08 | Granulado o polvo para la produccion de agentes de revestimiento y ligantes para formas de medicamentos. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7175857B2 (enExample) |
| EP (1) | EP1432409B1 (enExample) |
| JP (1) | JP4571861B2 (enExample) |
| KR (1) | KR100942667B1 (enExample) |
| AT (1) | ATE408401T1 (enExample) |
| AU (1) | AU2003266232A1 (enExample) |
| BR (1) | BRPI0306143B8 (enExample) |
| CA (1) | CA2464502C (enExample) |
| DE (2) | DE10239999A1 (enExample) |
| ES (1) | ES2314275T3 (enExample) |
| IL (2) | IL161145A0 (enExample) |
| IN (1) | IN2004CH00875A (enExample) |
| MX (1) | MX250472B (enExample) |
| PL (1) | PL206233B1 (enExample) |
| SI (1) | SI1432409T1 (enExample) |
| WO (1) | WO2004019918A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10208344A1 (de) | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Schmelzextrusion von Wirkstoffsalzen |
| DE10260920A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von Arnzeiformen oder Nahrungsergänzungsmitteln mit pigmentierten Polymerüberzügen |
| DE10260919A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von überzogenen Arzneiformen und Nahrungsergänzungsmitteln mit Konzentrationsgradienten im Überzug |
| DE10260921A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln |
| DE10304403A1 (de) * | 2003-01-28 | 2004-08-05 | Röhm GmbH & Co. KG | Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung |
| DE102004029573A1 (de) * | 2004-06-18 | 2005-12-29 | Gambro Lundia Ab | MIF-Adsorbent |
| JP4895819B2 (ja) * | 2004-10-29 | 2012-03-14 | 大鵬薬品工業株式会社 | プロピベリン含有経口粉粒状製剤及びその製造法 |
| EP1681049A1 (fr) * | 2005-01-12 | 2006-07-19 | Physica Pharma | Composition pharmaceutique et forme galénique correspondante à délitement rapide en bouche, et procédé de fabrication de cette composition |
| JP2008540437A (ja) * | 2005-05-03 | 2008-11-20 | ミユーチユアル・フアーマシユーチカルズ・カンパニー・インコーポレーテツド | キニーネを含有する制御放出調合剤 |
| DE102005042039A1 (de) * | 2005-09-02 | 2007-03-08 | Basf Ag | Wässrige Polyvinylacetatdispersionen mit hoher Scherstabilität |
| DK2046300T3 (da) * | 2006-08-04 | 2010-07-26 | Ethypharm Sa | Oralt desintegrerende multilagstablet |
| WO2009016258A1 (de) | 2007-08-02 | 2009-02-05 | Basf Se | Wässrige polymerdispersion auf basis von n, n-diethylaminoethylmethacrylat, deren herstellung und verwendung |
| WO2010030735A2 (en) * | 2008-09-11 | 2010-03-18 | Aethos Pharmaceuticals, Inc. | Stabilized coating for pharmaceutical formulations |
| WO2011051155A2 (en) | 2009-10-28 | 2011-05-05 | Basf Se | Stable protective coatings for pharmaceutical dosage forms |
| US20110150986A1 (en) * | 2009-12-18 | 2011-06-23 | Kristin Arnold | Quinine formulations, method of making, and metho of use thereof |
| WO2011110347A2 (en) * | 2010-03-10 | 2011-09-15 | Giuliani International Limited | Compositions for colon lavage and methods of making and using same |
| CA2799110A1 (en) * | 2010-05-10 | 2011-11-17 | Evonik Roehm Gmbh | Pharmaceutical dosage form comprising one or more antiretroviral active ingredients |
| CN103189052A (zh) | 2010-09-07 | 2013-07-03 | 巴斯夫欧洲公司 | 基于含氨基聚合物的共聚物作为基质粘合剂在制备含活性成分的颗粒和给药形式中的用途 |
| JP6012604B2 (ja) | 2010-09-27 | 2016-10-25 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 酸性有効成分のための保護コーティング |
| US9795576B2 (en) | 2010-09-27 | 2017-10-24 | Basf Se | Protective coatings for acidic active ingredients |
| CN103347931B (zh) | 2011-02-28 | 2016-02-17 | 巴斯夫欧洲公司 | 制备用于药物剂型的稳定保护性衣层的粉末包衣剂 |
| US8962064B2 (en) | 2011-02-28 | 2015-02-24 | Basf Se | Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms |
| JP5937113B2 (ja) | 2011-02-28 | 2016-06-22 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 医薬剤形用の安定した保護被覆のための粉末被覆剤の製造 |
| US8865250B2 (en) | 2011-02-28 | 2014-10-21 | Basf Se | Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms |
| US9044734B2 (en) | 2011-09-23 | 2015-06-02 | Basf Se | Diesel oxidation catalyst with layered structure containing ceria composition as palladium support material for enhanced HC and CO gas conversion |
| US20130236505A1 (en) | 2012-03-09 | 2013-09-12 | Basf Se | Production Of Pharmaceutical Protective Coatings With Good Resistance In A Neutral Environment |
| EP2636403A1 (de) * | 2012-03-09 | 2013-09-11 | Basf Se | Herstellung von pharmazeutischen protektiven Überzügen mit guter Resistenz im neutralen Milieu |
| US10668156B2 (en) | 2012-06-22 | 2020-06-02 | Basf Se | Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers |
| EP2863953A1 (de) | 2012-06-22 | 2015-04-29 | Basf Se | Wirkstoffhaltige festen dispersionen auf basis von diethylaminoethylmethacrylat-copolymeren |
| US20150290136A1 (en) * | 2012-11-22 | 2015-10-15 | Evonik Roehm Gmbh | Process for preparing a granulated product from a powder composition |
| FR3027802B1 (fr) * | 2014-10-31 | 2018-03-02 | Ethypharm | Granules de principe actif a double masquage de gout, leur procede de preparation et comprimes orodispersibles les contenant |
| GR1008992B (el) * | 2015-12-17 | 2017-03-23 | Verisfield (Uk) Ltd, Υποκαταστημα Ελλαδας, Εμπορια Φαρμακων | Φαρμακευτικη συνθεση σε μορφη κοκκιων για χορηγηση απο το στομα που περιεχει μετρονιδαζολη ή παραγωγα αυτης και εναν παραγοντα καλυψης της γευσης |
| EP3569225A1 (en) * | 2018-05-18 | 2019-11-20 | Pharmaceutical Oriented Services Ltd | Solid dispersion containing ritonavir |
| JP7058763B2 (ja) * | 2018-12-27 | 2022-04-22 | 興和株式会社 | 医薬品 |
| EP4255495A4 (en) | 2020-12-03 | 2025-10-08 | Battelle Memorial Institute | COMPOSITIONS OF POLYMERIC NANOPARTICLES AND DNA NANOSTRUCTURES AND METHODS FOR NON-VIRAL DELIVERY |
| WO2022216977A1 (en) | 2021-04-07 | 2022-10-13 | Batelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| US12441996B2 (en) | 2023-12-08 | 2025-10-14 | Battelle Memorial Institute | Use of DNA origami nanostructures for molecular information based data storage systems |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3581428D1 (de) * | 1984-06-13 | 1991-02-28 | Roehm Gmbh | Verfahren zum ueberziehen von arzneiformen. |
| DE3920082A1 (de) * | 1989-06-20 | 1991-03-07 | Roehm Gmbh | Filmbildendes waessriges ueberzugsmittel fuer feste arzneimittel, verfahren zu seiner herstellung und verwendung |
| DE29502547U1 (de) * | 1995-02-16 | 1995-03-30 | Röhm GmbH, 64293 Darmstadt | Thermoplastisches Überzugs- und Bindemittel für Arzneiformen |
| DE19918435A1 (de) * | 1998-07-23 | 2000-01-27 | Roehm Gmbh | Überzugs- und Bindemittel für orale oder dermale Arzneiformen |
| DE19958007A1 (de) * | 1999-12-02 | 2001-06-07 | Roehm Gmbh | Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen |
| AU6345600A (en) * | 2000-07-14 | 2002-01-30 | Immunivest Corp | Increased separation efficiency via controlled aggregation of magnetic nanoparticles |
| CA2403831C (en) * | 2001-02-27 | 2009-11-24 | Rohm Gmbh & Co. Kg | Coating and binding agent for pharmaceutical formulations having improved storage stability |
| DE10208344A1 (de) * | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Schmelzextrusion von Wirkstoffsalzen |
-
2002
- 2002-08-27 DE DE10239999A patent/DE10239999A1/de not_active Withdrawn
-
2003
- 2003-07-08 EP EP03790791A patent/EP1432409B1/de not_active Expired - Lifetime
- 2003-07-08 ES ES03790791T patent/ES2314275T3/es not_active Expired - Lifetime
- 2003-07-08 MX MXPA04003970 patent/MX250472B/es active IP Right Grant
- 2003-07-08 AU AU2003266232A patent/AU2003266232A1/en not_active Abandoned
- 2003-07-08 JP JP2004531794A patent/JP4571861B2/ja not_active Expired - Lifetime
- 2003-07-08 DE DE50310506T patent/DE50310506D1/de not_active Expired - Lifetime
- 2003-07-08 IL IL16114503A patent/IL161145A0/xx unknown
- 2003-07-08 BR BRPI0306143A patent/BRPI0306143B8/pt active IP Right Grant
- 2003-07-08 CA CA2464502A patent/CA2464502C/en not_active Expired - Lifetime
- 2003-07-08 WO PCT/EP2003/007319 patent/WO2004019918A1/de not_active Ceased
- 2003-07-08 SI SI200331454T patent/SI1432409T1/sl unknown
- 2003-07-08 PL PL368186A patent/PL206233B1/pl unknown
- 2003-07-08 US US10/489,856 patent/US7175857B2/en not_active Expired - Lifetime
- 2003-07-08 AT AT03790791T patent/ATE408401T1/de active
-
2004
- 2004-03-29 IL IL161145A patent/IL161145A/en active IP Right Grant
- 2004-04-26 IN IN875CH2004 patent/IN2004CH00875A/en unknown
- 2004-04-27 KR KR20047006270A patent/KR100942667B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL161145A (en) | 2010-11-30 |
| EP1432409B1 (de) | 2008-09-17 |
| WO2004019918A1 (de) | 2004-03-11 |
| MXPA04003970A (es) | 2004-06-22 |
| KR20050034620A (ko) | 2005-04-14 |
| BRPI0306143B8 (pt) | 2021-05-25 |
| US20040249035A1 (en) | 2004-12-09 |
| IL161145A0 (en) | 2004-08-31 |
| JP4571861B2 (ja) | 2010-10-27 |
| CA2464502A1 (en) | 2004-03-11 |
| KR100942667B1 (ko) | 2010-02-17 |
| IN2004CH00875A (enExample) | 2006-01-13 |
| CA2464502C (en) | 2010-11-23 |
| MX250472B (es) | 2007-10-17 |
| ATE408401T1 (de) | 2008-10-15 |
| PL368186A1 (en) | 2005-03-21 |
| JP2005536555A (ja) | 2005-12-02 |
| US20050197434A9 (en) | 2005-09-08 |
| AU2003266232A1 (en) | 2004-03-19 |
| DE10239999A1 (de) | 2004-03-04 |
| SI1432409T1 (sl) | 2009-02-28 |
| BR0306143A (pt) | 2004-10-19 |
| US7175857B2 (en) | 2007-02-13 |
| PL206233B1 (pl) | 2010-07-30 |
| BRPI0306143B1 (pt) | 2016-03-08 |
| EP1432409A1 (de) | 2004-06-30 |
| DE50310506D1 (de) | 2008-10-30 |
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