BRPI0306143B8 - processo para produção de grânulos ou pós, adequados como agentes de revestimento e aglutinantes para formas farmacêuticas, orais ou dérmicas, para cosméticos ou suplementos alimentares - Google Patents

processo para produção de grânulos ou pós, adequados como agentes de revestimento e aglutinantes para formas farmacêuticas, orais ou dérmicas, para cosméticos ou suplementos alimentares

Info

Publication number
BRPI0306143B8
BRPI0306143B8 BRPI0306143A BR0306143A BRPI0306143B8 BR PI0306143 B8 BRPI0306143 B8 BR PI0306143B8 BR PI0306143 A BRPI0306143 A BR PI0306143A BR 0306143 A BR0306143 A BR 0306143A BR PI0306143 B8 BRPI0306143 B8 BR PI0306143B8
Authority
BR
Brazil
Prior art keywords
granules
binders
powders
production
coating agents
Prior art date
Application number
BRPI0306143A
Other languages
English (en)
Other versions
BRPI0306143B1 (pt
BR0306143A (pt
Inventor
Gryczke Andreas
Meier Christian
Roth Erna
Petereit Hans-Ulrich
Original Assignee
Evonik Roehm Gmbh
Roehm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm Gmbh, Roehm Gmbh filed Critical Evonik Roehm Gmbh
Publication of BR0306143A publication Critical patent/BR0306143A/pt
Publication of BRPI0306143B1 publication Critical patent/BRPI0306143B1/pt
Publication of BRPI0306143B8 publication Critical patent/BRPI0306143B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"grânulos ou pó para a produção de agentes de revestimento e aglutinantes para formas farmacêuticas". a invenção refere-se a um processo para a produção de grânulos ou pós, adequados como agentes de revestimento e aglutinantes para formas farmacêuticas orais ou dérmicas, para cosméticos ou suplementos alimentares, consistindo essencialmente em (a) um copolímero, consistindo em c~ 1~-c~ 4~ ésteres de ácido acrílico ou metacrílico polimerizados por radicais livres e ainda monômeros de (met)acrilato que contêm grupos funcionais amino terciário, (b) 3 a 25% em peso, com base em (a), de um emulsificante tendo um hlb de pelo menos 14, (c) 5 a 50% em peso, com base em (a), de um ácido c~ 12~-c~ 18~ monocarboxílico ou de um composto c~ 12~-c~ 18~ hidroxila, onde os componentes (a), (b) e (c) são simultânea ou sucessivamente misturados entre si, opcionalmente com adição de um composto ativo farmacêutico e/ou outros aditivos usuais, fundidos em um misturador aquecível, misturados, e a massa fundida é esfriada e cominuída para dar grânulos ou pós.
BRPI0306143A 2002-08-27 2003-07-08 processo para produção de grânulos ou pós, adequados como agentes de revestimento e aglutinantes para formas farmacêuticas, orais ou dérmicas, para cosméticos ou suplementos alimentares BRPI0306143B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10239999A DE10239999A1 (de) 2002-08-27 2002-08-27 Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen
PCT/EP2003/007319 WO2004019918A1 (de) 2002-08-27 2003-07-08 Granulat oder pulver zur herstellung von überzugs- und bindemitteln für arzneiformen

Publications (3)

Publication Number Publication Date
BR0306143A BR0306143A (pt) 2004-10-19
BRPI0306143B1 BRPI0306143B1 (pt) 2016-03-08
BRPI0306143B8 true BRPI0306143B8 (pt) 2021-05-25

Family

ID=31197526

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0306143A BRPI0306143B8 (pt) 2002-08-27 2003-07-08 processo para produção de grânulos ou pós, adequados como agentes de revestimento e aglutinantes para formas farmacêuticas, orais ou dérmicas, para cosméticos ou suplementos alimentares

Country Status (16)

Country Link
US (1) US7175857B2 (pt)
EP (1) EP1432409B1 (pt)
JP (1) JP4571861B2 (pt)
KR (1) KR100942667B1 (pt)
AT (1) ATE408401T1 (pt)
AU (1) AU2003266232A1 (pt)
BR (1) BRPI0306143B8 (pt)
CA (1) CA2464502C (pt)
DE (2) DE10239999A1 (pt)
ES (1) ES2314275T3 (pt)
IL (2) IL161145A0 (pt)
IN (1) IN2004CH00875A (pt)
MX (1) MX250472B (pt)
PL (1) PL206233B1 (pt)
SI (1) SI1432409T1 (pt)
WO (1) WO2004019918A1 (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10208344A1 (de) 2002-02-27 2003-09-04 Roehm Gmbh Schmelzextrusion von Wirkstoffsalzen
DE10260919A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zur Herstellung von überzogenen Arzneiformen und Nahrungsergänzungsmitteln mit Konzentrationsgradienten im Überzug
DE10260921A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln
DE10260920A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zur Herstellung von Arnzeiformen oder Nahrungsergänzungsmitteln mit pigmentierten Polymerüberzügen
DE10304403A1 (de) * 2003-01-28 2004-08-05 Röhm GmbH & Co. KG Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
DE102004029573A1 (de) * 2004-06-18 2005-12-29 Gambro Lundia Ab MIF-Adsorbent
JP4895819B2 (ja) * 2004-10-29 2012-03-14 大鵬薬品工業株式会社 プロピベリン含有経口粉粒状製剤及びその製造法
EP1681049A1 (fr) * 2005-01-12 2006-07-19 Physica Pharma Composition pharmaceutique et forme galénique correspondante à délitement rapide en bouche, et procédé de fabrication de cette composition
WO2006119389A2 (en) * 2005-05-03 2006-11-09 Mutual Pharmaceutical Company, Inc. Quinine-containing controlled-release formulations
DE102005042039A1 (de) * 2005-09-02 2007-03-08 Basf Ag Wässrige Polyvinylacetatdispersionen mit hoher Scherstabilität
PT2046300E (pt) * 2006-08-04 2010-07-01 Ethypharm Sa Comprimido multicamadas de desintegraã†o oral
EP2176301B1 (de) 2007-08-02 2013-05-15 Basf Se Wässrige polymerdispersion auf basis von n, n-diethylaminoethylmethacrylat, deren herstellung und verwendung
US20100062062A1 (en) * 2008-09-11 2010-03-11 Aethos Pharmaceuticals, Inc. Stabilized Coating for Pharmaceutical Formulations
JP5693594B2 (ja) 2009-10-28 2015-04-01 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 医薬剤形用の安定な保護コーティング
US20110150986A1 (en) * 2009-12-18 2011-06-23 Kristin Arnold Quinine formulations, method of making, and metho of use thereof
AU2011226324B2 (en) * 2010-03-10 2015-09-24 Nogra Pharma Limited Compositions for colon lavage and methods of making and using same
CA2799110A1 (en) * 2010-05-10 2011-11-17 Evonik Roehm Gmbh Pharmaceutical dosage form comprising one or more antiretroviral active ingredients
EP2613770A1 (de) 2010-09-07 2013-07-17 Basf Se Verwendung von copolymeren auf basis von aminogruppenhaltigen polymeren als matrixbindemittel für die herstellung von wirkstoffhaltigen granulaten und darreichungsformen
CN103221038B (zh) 2010-09-27 2019-05-07 巴斯夫欧洲公司 酸性活性成分的保护涂层
US9795576B2 (en) * 2010-09-27 2017-10-24 Basf Se Protective coatings for acidic active ingredients
CN103347931B (zh) 2011-02-28 2016-02-17 巴斯夫欧洲公司 制备用于药物剂型的稳定保护性衣层的粉末包衣剂
US8865250B2 (en) 2011-02-28 2014-10-21 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
BR112013021510B1 (pt) 2011-02-28 2020-09-24 Basf Se Processo para a produção de composições de revestimento em pó, e, uso de um pó de polímero
US8962064B2 (en) 2011-02-28 2015-02-24 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
US9044734B2 (en) 2011-09-23 2015-06-02 Basf Se Diesel oxidation catalyst with layered structure containing ceria composition as palladium support material for enhanced HC and CO gas conversion
EP2636403A1 (de) * 2012-03-09 2013-09-11 Basf Se Herstellung von pharmazeutischen protektiven Überzügen mit guter Resistenz im neutralen Milieu
US20130236505A1 (en) 2012-03-09 2013-09-12 Basf Se Production Of Pharmaceutical Protective Coatings With Good Resistance In A Neutral Environment
EP2863953A1 (de) 2012-06-22 2015-04-29 Basf Se Wirkstoffhaltige festen dispersionen auf basis von diethylaminoethylmethacrylat-copolymeren
US10668156B2 (en) 2012-06-22 2020-06-02 Basf Se Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers
CN105121536A (zh) * 2012-11-22 2015-12-02 赢创罗姆有限公司 由粉末组合物制备颗粒状产品的方法
FR3027802B1 (fr) * 2014-10-31 2018-03-02 Ethypharm Granules de principe actif a double masquage de gout, leur procede de preparation et comprimes orodispersibles les contenant
GR1008992B (el) * 2015-12-17 2017-03-23 Verisfield (Uk) Ltd, Υποκαταστημα Ελλαδας, Εμπορια Φαρμακων Φαρμακευτικη συνθεση σε μορφη κοκκιων για χορηγηση απο το στομα που περιεχει μετρονιδαζολη ή παραγωγα αυτης και εναν παραγοντα καλυψης της γευσης
EP3569225A1 (en) * 2018-05-18 2019-11-20 Pharmaceutical Oriented Services Ltd Solid dispersion containing ritonavir
JP7058763B2 (ja) * 2018-12-27 2022-04-22 興和株式会社 医薬品

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0164669B1 (de) 1984-06-13 1991-01-23 Röhm Gmbh Verfahren zum Überziehen von Arzneiformen
DE3920082A1 (de) 1989-06-20 1991-03-07 Roehm Gmbh Filmbildendes waessriges ueberzugsmittel fuer feste arzneimittel, verfahren zu seiner herstellung und verwendung
DE29502547U1 (de) 1995-02-16 1995-03-30 Roehm Gmbh Thermoplastisches Überzugs- und Bindemittel für Arzneiformen
DE19918435A1 (de) * 1998-07-23 2000-01-27 Roehm Gmbh Überzugs- und Bindemittel für orale oder dermale Arzneiformen
DE19958007A1 (de) 1999-12-02 2001-06-07 Roehm Gmbh Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen
EP1311820B1 (en) * 2000-07-14 2015-02-11 Janssen Diagnostics, LLC Increased separation efficiency via controlled aggregation of magnetic nanoparticles
CA2403831C (en) * 2001-02-27 2009-11-24 Rohm Gmbh & Co. Kg Coating and binding agent for pharmaceutical formulations having improved storage stability
DE10208344A1 (de) 2002-02-27 2003-09-04 Roehm Gmbh Schmelzextrusion von Wirkstoffsalzen

Also Published As

Publication number Publication date
BRPI0306143B1 (pt) 2016-03-08
BR0306143A (pt) 2004-10-19
AU2003266232A1 (en) 2004-03-19
JP4571861B2 (ja) 2010-10-27
MX250472B (es) 2007-10-17
WO2004019918A1 (de) 2004-03-11
US20050197434A9 (en) 2005-09-08
KR20050034620A (ko) 2005-04-14
IL161145A0 (en) 2004-08-31
ATE408401T1 (de) 2008-10-15
PL368186A1 (en) 2005-03-21
EP1432409A1 (de) 2004-06-30
EP1432409B1 (de) 2008-09-17
DE50310506D1 (de) 2008-10-30
IN2004CH00875A (pt) 2006-01-13
KR100942667B1 (ko) 2010-02-17
PL206233B1 (pl) 2010-07-30
US7175857B2 (en) 2007-02-13
JP2005536555A (ja) 2005-12-02
SI1432409T1 (sl) 2009-02-28
ES2314275T3 (es) 2009-03-16
CA2464502C (en) 2010-11-23
DE10239999A1 (de) 2004-03-04
IL161145A (en) 2010-11-30
MXPA04003970A (es) 2004-06-22
CA2464502A1 (en) 2004-03-11
US20040249035A1 (en) 2004-12-09

Similar Documents

Publication Publication Date Title
BRPI0306143B8 (pt) processo para produção de grânulos ou pós, adequados como agentes de revestimento e aglutinantes para formas farmacêuticas, orais ou dérmicas, para cosméticos ou suplementos alimentares
BRPI0110321B8 (pt) revestimento e agente de ligacão para formas farmacêuticas, processo para sua producão, uso dos mesmos e forma farmacêutica
BRPI0318049B8 (pt) processo para produção de uma forma farmacêutica oral com imediata desintegração e liberação de ingrediente ativo, pó contendo ingrediente ativo e seu uso
BR0316310A (pt) Composições farmacêuticas tendo um veìculo modificado
DE69612373D1 (de) Arzneimittelhaltiges tierfutter
DE59903917D1 (de) Überzugs- und bindemittel für orale oder dermale arzneiformen
EA200100024A1 (ru) Состав таблетки с делавирдином
BRPI0512644A (pt) composições de branqueamento fluorescente encapsulado para melhorar o aspecto superficial
BR9807915A (pt) Processo aperfeiçoado para a produção de partìculas substancialmente esféricas de um copolìmero e partìcula substancialmente esférica de uma composição de revestimento
WO2003028757A1 (fr) Nouvelle methode pour induire des lymphocytes t specifiques d'antigenes
BR112012008132A8 (pt) Composição em pó ou granulada, seu processo de preparação e seu uso
SI1525188T1 (sl) Novi derivati 4,4-ditiobis-(3-aminobutan-1-sulfonatov) in sestavki, ki jih vsebujejo
BR9807398A (pt) Massa de revestimento pulverizada colorida
AU2001297963A1 (en) Alpha olefin monomer partitioning agents for drag reducing agents and methods of forming drag reducing agents using alpha olefin monomer partitioning agents
YU38103A (sh) Nova jedinjenja askorbinske kiseline, postupci sinteze i način njihove primene
CN106137890A (zh) 一种燕麦杏仁牛奶面膜及其制备方法
KR960700701A (ko) 파라세타몰 및 l-시스테인 또는 이것의 전구물질을 함유하는 약제조성물(pharmaceutical compositions comprising paracetamol and l-cysteine or a precursor thereof)
DE59502178D1 (de) Giessbare, aushärtbare masse, zur herstellung von kunststofformteilen
DE69816808D1 (de) Somatostatin agoniste zur reduzierung von körpergewicht
GB2376021A (en) Powder coating compositions
BRPI0411638A (pt) produto alimentìcio e métodos de preparação de uma formulação
TN2020000099A1 (fr) Composition d'appetinat
ATE471978T1 (de) Methoden und zusammenstellungen für die in-vitro synthese von proteinen in einem zellfreien system angereichert mit atp-sulfurylase
ATE359284T1 (de) Neue verbindungen, bei denen es sich um modulatoren von rezeptoren vom ppar-typ handelt, und deren verwendung in kosmetischen oder pharmazeutischen zusammensetzungen
BR0209023A (pt) Antagonista de lfa-1, antagonista de tnf-(alfa) e metotrexato, uso de um antagonista de lfa-1, um antagonista de tnf-(alfa) e metotrexato na preparação de um medicamento, composição e kit contendo os mesmos

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: ROEHM GMBH (DE)

Free format text: NOME ALTERADO DE: ROEEHM GMBH AND CO. KG

B25D Requested change of name of applicant approved

Owner name: EVONIK ROEHM GMBH (DE)

Free format text: NOME ALTERADO DE: ROEHM GMBH

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/03/2016, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/07/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25D Requested change of name of applicant approved
B25G Requested change of headquarter approved
B25A Requested transfer of rights approved
B25D Requested change of name of applicant approved