BR0306143A - Grânulos ou pó para a produção de agentes de revestimento e aglutinantes para formas farmacêuticas - Google Patents

Grânulos ou pó para a produção de agentes de revestimento e aglutinantes para formas farmacêuticas

Info

Publication number
BR0306143A
BR0306143A BR0306143-4A BR0306143A BR0306143A BR 0306143 A BR0306143 A BR 0306143A BR 0306143 A BR0306143 A BR 0306143A BR 0306143 A BR0306143 A BR 0306143A
Authority
BR
Brazil
Prior art keywords
powders
granules
binders
production
coating agents
Prior art date
Application number
BR0306143-4A
Other languages
English (en)
Other versions
BRPI0306143B8 (pt
BRPI0306143B1 (pt
Inventor
Hans-Ulrich Petereit
Christian Meier
Erna Roth
Andreas Gryczke
Original Assignee
Roehm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm Gmbh filed Critical Roehm Gmbh
Publication of BR0306143A publication Critical patent/BR0306143A/pt
Publication of BRPI0306143B1 publication Critical patent/BRPI0306143B1/pt
Publication of BRPI0306143B8 publication Critical patent/BRPI0306143B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"GRâNULOS OU Pó PARA A PRODUçãO DE AGENTES DE REVESTIMENTO E AGLUTINANTES PARA FORMAS FARMACêUTICAS". A invenção refere-se a um processo para a produção de grânulos ou pós, adequados como agentes de revestimento e aglutinantes para formas farmacêuticas orais ou dérmicas, para cosméticos ou suplementos alimentares, consistindo essencialmente em (a) um copolímero, consistindo em C~ 1~-C~ 4~ ésteres de ácido acrílico ou metacrílico polimerizados por radicais livres e ainda monómeros de (met)acrilato que contêm grupos funcionais amino terciário, (b) 3 a 25% em peso, com base em (a), de um emulsificante tendo um HLB de pelo menos 14, (c) 5 a 50% em peso, com base em (a), de um ácido C~ 12~-C~ 18~ monocarboxílico ou de um composto C~ 12~-C~ 18~ hidroxila, onde os componentes (a), (b) e (c) são simultânea ou sucessivamente misturados entre si, opcionalmente com adição de um composto ativo farmacêutico e/ou outros aditivos usuais, fundidos em um misturador aquecível, misturados, e a massa fundida é esfriada e cominuída para dar grânulos ou pós.
BRPI0306143A 2002-08-27 2003-07-08 processo para produção de grânulos ou pós, adequados como agentes de revestimento e aglutinantes para formas farmacêuticas, orais ou dérmicas, para cosméticos ou suplementos alimentares BRPI0306143B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10239999A DE10239999A1 (de) 2002-08-27 2002-08-27 Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen
PCT/EP2003/007319 WO2004019918A1 (de) 2002-08-27 2003-07-08 Granulat oder pulver zur herstellung von überzugs- und bindemitteln für arzneiformen

Publications (3)

Publication Number Publication Date
BR0306143A true BR0306143A (pt) 2004-10-19
BRPI0306143B1 BRPI0306143B1 (pt) 2016-03-08
BRPI0306143B8 BRPI0306143B8 (pt) 2021-05-25

Family

ID=31197526

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0306143A BRPI0306143B8 (pt) 2002-08-27 2003-07-08 processo para produção de grânulos ou pós, adequados como agentes de revestimento e aglutinantes para formas farmacêuticas, orais ou dérmicas, para cosméticos ou suplementos alimentares

Country Status (16)

Country Link
US (1) US7175857B2 (pt)
EP (1) EP1432409B1 (pt)
JP (1) JP4571861B2 (pt)
KR (1) KR100942667B1 (pt)
AT (1) ATE408401T1 (pt)
AU (1) AU2003266232A1 (pt)
BR (1) BRPI0306143B8 (pt)
CA (1) CA2464502C (pt)
DE (2) DE10239999A1 (pt)
ES (1) ES2314275T3 (pt)
IL (2) IL161145A0 (pt)
IN (1) IN2004CH00875A (pt)
MX (1) MX250472B (pt)
PL (1) PL206233B1 (pt)
SI (1) SI1432409T1 (pt)
WO (1) WO2004019918A1 (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10208344A1 (de) 2002-02-27 2003-09-04 Roehm Gmbh Schmelzextrusion von Wirkstoffsalzen
DE10260920A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zur Herstellung von Arnzeiformen oder Nahrungsergänzungsmitteln mit pigmentierten Polymerüberzügen
DE10260919A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zur Herstellung von überzogenen Arzneiformen und Nahrungsergänzungsmitteln mit Konzentrationsgradienten im Überzug
DE10260921A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln
DE10304403A1 (de) * 2003-01-28 2004-08-05 Röhm GmbH & Co. KG Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
DE102004029573A1 (de) * 2004-06-18 2005-12-29 Gambro Lundia Ab MIF-Adsorbent
JP4895819B2 (ja) * 2004-10-29 2012-03-14 大鵬薬品工業株式会社 プロピベリン含有経口粉粒状製剤及びその製造法
EP1681049A1 (fr) * 2005-01-12 2006-07-19 Physica Pharma Composition pharmaceutique et forme galénique correspondante à délitement rapide en bouche, et procédé de fabrication de cette composition
CA2606740A1 (en) * 2005-05-03 2006-11-09 Mutual Pharmaceutical Company, Inc. Quinine-containing controlled-release formulations
DE102005042039A1 (de) * 2005-09-02 2007-03-08 Basf Ag Wässrige Polyvinylacetatdispersionen mit hoher Scherstabilität
CA2659523C (en) * 2006-08-04 2014-01-28 Ethypharm Multilayer orally disintegrating tablet
EP2176301B1 (de) 2007-08-02 2013-05-15 Basf Se Wässrige polymerdispersion auf basis von n, n-diethylaminoethylmethacrylat, deren herstellung und verwendung
WO2010030735A2 (en) * 2008-09-11 2010-03-18 Aethos Pharmaceuticals, Inc. Stabilized coating for pharmaceutical formulations
WO2011051155A2 (en) 2009-10-28 2011-05-05 Basf Se Stable protective coatings for pharmaceutical dosage forms
US20110150986A1 (en) * 2009-12-18 2011-06-23 Kristin Arnold Quinine formulations, method of making, and metho of use thereof
EP2544723A2 (en) * 2010-03-10 2013-01-16 Giuliani International Limited Compositions for colon lavage and methods of making and using same
CN102985074B (zh) * 2010-05-10 2015-09-02 赢创罗姆有限公司 包含一种或多种抗逆转录病毒活性成分的药物剂型
JP2013536821A (ja) 2010-09-07 2013-09-26 ビーエーエスエフ ソシエタス・ヨーロピア 活性化合物含有顆粒及び投与剤形の調製における、アミノ含有ポリマーに基づくコポリマーのマトリックス結合剤としての使用
WO2012041788A1 (de) 2010-09-27 2012-04-05 Basf Se Protektive überzüge für saure wirkstoffe
US9795576B2 (en) * 2010-09-27 2017-10-24 Basf Se Protective coatings for acidic active ingredients
US8865250B2 (en) 2011-02-28 2014-10-21 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
US8962064B2 (en) 2011-02-28 2015-02-24 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
WO2012116941A1 (de) 2011-02-28 2012-09-07 Basf Se Herstellung von pulverförmigen überzugsmitteln für stabile protektive überzüge für pharmazeutische dosierungsformen
CN103347931B (zh) 2011-02-28 2016-02-17 巴斯夫欧洲公司 制备用于药物剂型的稳定保护性衣层的粉末包衣剂
US9044734B2 (en) 2011-09-23 2015-06-02 Basf Se Diesel oxidation catalyst with layered structure containing ceria composition as palladium support material for enhanced HC and CO gas conversion
US20130236505A1 (en) 2012-03-09 2013-09-12 Basf Se Production Of Pharmaceutical Protective Coatings With Good Resistance In A Neutral Environment
EP2636403A1 (de) * 2012-03-09 2013-09-11 Basf Se Herstellung von pharmazeutischen protektiven Überzügen mit guter Resistenz im neutralen Milieu
JP6189429B2 (ja) 2012-06-22 2017-08-30 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ジエチルアミノエチルメタクリレートコポリマーをベースにした活性成分含有固体分散体
US10668156B2 (en) 2012-06-22 2020-06-02 Basf Se Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers
CN105121536A (zh) * 2012-11-22 2015-12-02 赢创罗姆有限公司 由粉末组合物制备颗粒状产品的方法
FR3027802B1 (fr) * 2014-10-31 2018-03-02 Ethypharm Granules de principe actif a double masquage de gout, leur procede de preparation et comprimes orodispersibles les contenant
GR1008992B (el) * 2015-12-17 2017-03-23 Verisfield (Uk) Ltd, Υποκαταστημα Ελλαδας, Εμπορια Φαρμακων Φαρμακευτικη συνθεση σε μορφη κοκκιων για χορηγηση απο το στομα που περιεχει μετρονιδαζολη ή παραγωγα αυτης και εναν παραγοντα καλυψης της γευσης
EP3569225A1 (en) * 2018-05-18 2019-11-20 Pharmaceutical Oriented Services Ltd Solid dispersion containing ritonavir
TWI829841B (zh) * 2018-12-27 2024-01-21 日商興和股份有限公司 醫藥品
CN117500923A (zh) 2021-04-07 2024-02-02 巴特尔纪念研究院 用于鉴定和使用非病毒载体的快速设计、构建、测试和学习技术

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EP0164669B1 (de) * 1984-06-13 1991-01-23 Röhm Gmbh Verfahren zum Überziehen von Arzneiformen
DE3920082A1 (de) * 1989-06-20 1991-03-07 Roehm Gmbh Filmbildendes waessriges ueberzugsmittel fuer feste arzneimittel, verfahren zu seiner herstellung und verwendung
DE29502547U1 (de) * 1995-02-16 1995-03-30 Röhm GmbH, 64293 Darmstadt Thermoplastisches Überzugs- und Bindemittel für Arzneiformen
DE19918435A1 (de) * 1998-07-23 2000-01-27 Roehm Gmbh Überzugs- und Bindemittel für orale oder dermale Arzneiformen
DE19958007A1 (de) * 1999-12-02 2001-06-07 Roehm Gmbh Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen
JP4663957B2 (ja) * 2000-07-14 2011-04-06 ベリデックス・リミテッド・ライアビリティ・カンパニー 磁性ナノ粒子の制御された凝集による増大した分離効率
ES2248291T3 (es) * 2001-02-27 2006-03-16 ROHM GMBH & CO. KG Agente de recubrimiento y aglutinante para formulaciones de medicamento con estabilidad al almcenamiento mejorada.
DE10208344A1 (de) * 2002-02-27 2003-09-04 Roehm Gmbh Schmelzextrusion von Wirkstoffsalzen

Also Published As

Publication number Publication date
MXPA04003970A (es) 2004-06-22
CA2464502A1 (en) 2004-03-11
DE10239999A1 (de) 2004-03-04
EP1432409B1 (de) 2008-09-17
MX250472B (es) 2007-10-17
BRPI0306143B8 (pt) 2021-05-25
US20050197434A9 (en) 2005-09-08
ES2314275T3 (es) 2009-03-16
US20040249035A1 (en) 2004-12-09
KR100942667B1 (ko) 2010-02-17
AU2003266232A1 (en) 2004-03-19
JP4571861B2 (ja) 2010-10-27
US7175857B2 (en) 2007-02-13
IL161145A0 (en) 2004-08-31
WO2004019918A1 (de) 2004-03-11
DE50310506D1 (de) 2008-10-30
IN2004CH00875A (pt) 2006-01-13
SI1432409T1 (sl) 2009-02-28
ATE408401T1 (de) 2008-10-15
PL368186A1 (en) 2005-03-21
CA2464502C (en) 2010-11-23
KR20050034620A (ko) 2005-04-14
IL161145A (en) 2010-11-30
JP2005536555A (ja) 2005-12-02
EP1432409A1 (de) 2004-06-30
PL206233B1 (pl) 2010-07-30
BRPI0306143B1 (pt) 2016-03-08

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: ROEHM GMBH (DE)

Free format text: NOME ALTERADO DE: ROEEHM GMBH AND CO. KG

B25D Requested change of name of applicant approved

Owner name: EVONIK ROEHM GMBH (DE)

Free format text: NOME ALTERADO DE: ROEHM GMBH

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/03/2016, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/07/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25D Requested change of name of applicant approved
B25G Requested change of headquarter approved
B25A Requested transfer of rights approved
B25D Requested change of name of applicant approved