ES2298384T3 - Procedimiento para la produccion del derivado de piperidina fexofenadina. - Google Patents

Procedimiento para la produccion del derivado de piperidina fexofenadina. Download PDF

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Publication number
ES2298384T3
ES2298384T3 ES02754657T ES02754657T ES2298384T3 ES 2298384 T3 ES2298384 T3 ES 2298384T3 ES 02754657 T ES02754657 T ES 02754657T ES 02754657 T ES02754657 T ES 02754657T ES 2298384 T3 ES2298384 T3 ES 2298384T3
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ES
Spain
Prior art keywords
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compound
alkyl
formula
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02754657T
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English (en)
Spanish (es)
Inventor
Collin Schroeder
Ryan Huddleston
Richard Charles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Application granted granted Critical
Publication of ES2298384T3 publication Critical patent/ES2298384T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES02754657T 2001-06-15 2002-06-12 Procedimiento para la produccion del derivado de piperidina fexofenadina. Expired - Lifetime ES2298384T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29839701P 2001-06-15 2001-06-15
US298397P 2001-06-15

Publications (1)

Publication Number Publication Date
ES2298384T3 true ES2298384T3 (es) 2008-05-16

Family

ID=23150325

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02754657T Expired - Lifetime ES2298384T3 (es) 2001-06-15 2002-06-12 Procedimiento para la produccion del derivado de piperidina fexofenadina.

Country Status (22)

Country Link
US (2) US6743941B2 (OSRAM)
EP (1) EP1401816B1 (OSRAM)
JP (1) JP4344230B2 (OSRAM)
KR (1) KR100903285B1 (OSRAM)
CN (1) CN1229347C (OSRAM)
AR (1) AR037005A1 (OSRAM)
AT (1) ATE386021T1 (OSRAM)
AU (1) AU2002320847B2 (OSRAM)
BR (1) BR0210410A (OSRAM)
CA (1) CA2450313C (OSRAM)
DE (1) DE60225008T2 (OSRAM)
DK (1) DK1401816T3 (OSRAM)
ES (1) ES2298384T3 (OSRAM)
HU (1) HUP0401125A2 (OSRAM)
IL (2) IL159304A0 (OSRAM)
MX (1) MXPA03010960A (OSRAM)
NO (1) NO20035572L (OSRAM)
NZ (1) NZ530153A (OSRAM)
PL (1) PL364369A1 (OSRAM)
PT (1) PT1401816E (OSRAM)
WO (1) WO2002102776A1 (OSRAM)
ZA (1) ZA200308697B (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
CN100453522C (zh) * 2005-01-26 2009-01-21 中国科学技术大学 4-[4-(1-乙氧基酰基-1-甲基乙基苯)]-4-氧代丁酸的制备方法
WO2007135693A2 (en) * 2006-05-18 2007-11-29 Ind-Swift Laboratories Limited Intermediates useful for the preparation of antihistaminic piperidine derivative
ITMI20061491A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
CN102070570A (zh) * 2009-11-21 2011-05-25 浙江华海药业股份有限公司 一种非索非那定中间体2-甲基-2(4-(2-氧代四氢呋喃-3-羰基)苯基)丙氰及其盐的制备方法
CN102070490B (zh) * 2009-11-21 2014-07-30 浙江华海药业股份有限公司 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法
FI3307727T3 (fi) 2015-06-15 2024-01-08 Asana Biosciences Llc Erk1:n ja erk2:n heterosyklisiä estäjiä ja niiden käyttö syövän hoidossa
CN104876853B (zh) * 2015-06-17 2017-06-16 苏州卫生职业技术学院 盐酸非索非那定的合成方法
HUE047669T2 (hu) 2015-10-22 2020-05-28 Sanofi Aventis Deutschland Eljárás fexofenadin és az eljárásban használt köztitermékek elõállítására
US11285154B2 (en) 2017-03-29 2022-03-29 United States Government As Represented By The Department Of Veterans Affairs Methods and compositions for treating cancer
JP7738550B2 (ja) 2019-10-28 2025-09-12 アサナ バイオサイエンシズ，リミティド ライアビリティ カンパニー Ｅｒｋ１およびｅｒｋ２の複素環式阻害剤の使用のための改善された方法、キット、組成物、ならびに投与レジメン

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2946809A1 (de) * 1979-11-20 1981-06-11 A. Nattermann & Cie GmbH, 5000 Köln 4-phenyl-4-oxo-buttersaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel
IT1200123B (it) 1985-09-27 1989-01-05 Ind Chimica Srl Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo
EP0347123A3 (en) 1988-06-17 1991-07-03 Fisons Corporation Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties
IT1249684B (it) 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
HU226561B1 (en) * 1992-04-10 2009-04-28 Merrell Dow Pharma Process for preparation 4-diphenylmethyl piperidine derivatives and the novel intermediates thereof
AU670004B2 (en) 1993-06-24 1996-06-27 Albany Molecular Research, Inc. Piperidine derivatives and process for their production

Also Published As

Publication number Publication date
JP4344230B2 (ja) 2009-10-14
JP2005502603A (ja) 2005-01-27
CN1229347C (zh) 2005-11-30
DE60225008T2 (de) 2009-01-29
ATE386021T1 (de) 2008-03-15
KR20040010720A (ko) 2004-01-31
NO20035572L (no) 2004-02-16
NO20035572D0 (no) 2003-12-12
ZA200308697B (en) 2004-09-03
WO2002102776A1 (en) 2002-12-27
IL159304A0 (en) 2004-06-01
PT1401816E (pt) 2008-04-08
US20030105329A1 (en) 2003-06-05
US7235665B2 (en) 2007-06-26
DE60225008D1 (de) 2008-03-27
DK1401816T3 (da) 2008-06-09
AR037005A1 (es) 2004-10-20
CN1516689A (zh) 2004-07-28
EP1401816B1 (en) 2008-02-13
HUP0401125A2 (hu) 2004-09-28
NZ530153A (en) 2005-07-29
CA2450313A1 (en) 2002-12-27
CA2450313C (en) 2010-08-10
KR100903285B1 (ko) 2009-06-17
PL364369A1 (en) 2004-12-13
MXPA03010960A (es) 2004-02-27
HK1063795A1 (en) 2005-01-14
IL159304A (en) 2010-02-17
US6743941B2 (en) 2004-06-01
BR0210410A (pt) 2004-08-17
US20040198983A1 (en) 2004-10-07
EP1401816A1 (en) 2004-03-31
AU2002320847B2 (en) 2007-09-20

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