MXPA03010960A - Proceso para la produccion de fexofenadina derivado de piperidina. - Google Patents
Proceso para la produccion de fexofenadina derivado de piperidina.Info
- Publication number
- MXPA03010960A MXPA03010960A MXPA03010960A MXPA03010960A MXPA03010960A MX PA03010960 A MXPA03010960 A MX PA03010960A MX PA03010960 A MXPA03010960 A MX PA03010960A MX PA03010960 A MXPA03010960 A MX PA03010960A MX PA03010960 A MXPA03010960 A MX PA03010960A
- Authority
- MX
- Mexico
- Prior art keywords
- fexofenadine
- production
- piperidine derivative
- processes
- relates
- Prior art date
Links
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003592 fexofenadine Drugs 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940008201 allegra Drugs 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29839701P | 2001-06-15 | 2001-06-15 | |
| PCT/EP2002/006424 WO2002102776A1 (en) | 2001-06-15 | 2002-06-12 | Process for the production of the piperidine derivative fexofenadine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03010960A true MXPA03010960A (es) | 2004-02-27 |
Family
ID=23150325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03010960A MXPA03010960A (es) | 2001-06-15 | 2002-06-12 | Proceso para la produccion de fexofenadina derivado de piperidina. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6743941B2 (OSRAM) |
| EP (1) | EP1401816B1 (OSRAM) |
| JP (1) | JP4344230B2 (OSRAM) |
| KR (1) | KR100903285B1 (OSRAM) |
| CN (1) | CN1229347C (OSRAM) |
| AR (1) | AR037005A1 (OSRAM) |
| AT (1) | ATE386021T1 (OSRAM) |
| AU (1) | AU2002320847B2 (OSRAM) |
| BR (1) | BR0210410A (OSRAM) |
| CA (1) | CA2450313C (OSRAM) |
| DE (1) | DE60225008T2 (OSRAM) |
| DK (1) | DK1401816T3 (OSRAM) |
| ES (1) | ES2298384T3 (OSRAM) |
| HU (1) | HUP0401125A2 (OSRAM) |
| IL (2) | IL159304A0 (OSRAM) |
| MX (1) | MXPA03010960A (OSRAM) |
| NO (1) | NO20035572L (OSRAM) |
| NZ (1) | NZ530153A (OSRAM) |
| PL (1) | PL364369A1 (OSRAM) |
| PT (1) | PT1401816E (OSRAM) |
| WO (1) | WO2002102776A1 (OSRAM) |
| ZA (1) | ZA200308697B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7498443B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
| US7498345B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| CN100453522C (zh) * | 2005-01-26 | 2009-01-21 | 中国科学技术大学 | 4-[4-(1-乙氧基酰基-1-甲基乙基苯)]-4-氧代丁酸的制备方法 |
| WO2007135693A2 (en) * | 2006-05-18 | 2007-11-29 | Ind-Swift Laboratories Limited | Intermediates useful for the preparation of antihistaminic piperidine derivative |
| ITMI20061491A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| CN102070570A (zh) * | 2009-11-21 | 2011-05-25 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-甲基-2(4-(2-氧代四氢呋喃-3-羰基)苯基)丙氰及其盐的制备方法 |
| CN102070490B (zh) * | 2009-11-21 | 2014-07-30 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法 |
| DK3307727T3 (da) | 2015-06-15 | 2024-01-08 | Asana Biosciences Llc | Heterocykliske inhibitorer af erk1 og erk2 og deres anvendelse i behandlingen af kræft |
| CN104876853B (zh) * | 2015-06-17 | 2017-06-16 | 苏州卫生职业技术学院 | 盐酸非索非那定的合成方法 |
| EP3365327B1 (en) | 2015-10-22 | 2019-11-20 | Sanofi-Aventis Deutschland GmbH | Process for the preparation of fexofenadine and of intermediates used therein |
| WO2018183762A1 (en) | 2017-03-29 | 2018-10-04 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating cancer |
| JP7738550B2 (ja) | 2019-10-28 | 2025-09-12 | アサナ バイオサイエンシズ，リミティド ライアビリティ カンパニー | Ｅｒｋ１およびｅｒｋ２の複素環式阻害剤の使用のための改善された方法、キット、組成物、ならびに投与レジメン |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2946809A1 (de) * | 1979-11-20 | 1981-06-11 | A. Nattermann & Cie GmbH, 5000 Köln | 4-phenyl-4-oxo-buttersaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| IT1200123B (it) | 1985-09-27 | 1989-01-05 | Ind Chimica Srl | Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo |
| EP0347123A3 (en) | 1988-06-17 | 1991-07-03 | Fisons Corporation | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties |
| IT1249684B (it) | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
| ES2176201T3 (es) * | 1992-04-10 | 2002-12-01 | Merrell Pharma Inc | Derivados de 4-difenilmetil piperidina y procedimiento de preparacion. |
| HU226559B1 (en) | 1993-06-24 | 2009-03-30 | Amr Technology | Process for the production of piperidine derivatives |
-
2002
- 2002-06-11 US US10/166,893 patent/US6743941B2/en not_active Expired - Lifetime
- 2002-06-12 DE DE60225008T patent/DE60225008T2/de not_active Expired - Lifetime
- 2002-06-12 AU AU2002320847A patent/AU2002320847B2/en not_active Ceased
- 2002-06-12 PT PT02754657T patent/PT1401816E/pt unknown
- 2002-06-12 WO PCT/EP2002/006424 patent/WO2002102776A1/en not_active Ceased
- 2002-06-12 KR KR1020037016429A patent/KR100903285B1/ko not_active Expired - Fee Related
- 2002-06-12 CA CA2450313A patent/CA2450313C/en not_active Expired - Fee Related
- 2002-06-12 NZ NZ530153A patent/NZ530153A/en not_active IP Right Cessation
- 2002-06-12 CN CNB028119312A patent/CN1229347C/zh not_active Expired - Fee Related
- 2002-06-12 EP EP02754657A patent/EP1401816B1/en not_active Expired - Lifetime
- 2002-06-12 ES ES02754657T patent/ES2298384T3/es not_active Expired - Lifetime
- 2002-06-12 MX MXPA03010960A patent/MXPA03010960A/es active IP Right Grant
- 2002-06-12 AT AT02754657T patent/ATE386021T1/de active
- 2002-06-12 JP JP2003505319A patent/JP4344230B2/ja not_active Expired - Fee Related
- 2002-06-12 HU HU0401125A patent/HUP0401125A2/hu unknown
- 2002-06-12 BR BR0210410-5A patent/BR0210410A/pt not_active IP Right Cessation
- 2002-06-12 DK DK02754657T patent/DK1401816T3/da active
- 2002-06-12 PL PL02364369A patent/PL364369A1/xx not_active Application Discontinuation
- 2002-06-12 IL IL15930402A patent/IL159304A0/xx unknown
- 2002-06-14 AR ARP020102261A patent/AR037005A1/es unknown
-
2003
- 2003-11-07 ZA ZA200308697A patent/ZA200308697B/en unknown
- 2003-12-10 IL IL159304A patent/IL159304A/en not_active IP Right Cessation
- 2003-12-12 NO NO20035572A patent/NO20035572L/no unknown
-
2004
- 2004-04-22 US US10/829,803 patent/US7235665B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2450313C (en) | 2010-08-10 |
| DE60225008T2 (de) | 2009-01-29 |
| CA2450313A1 (en) | 2002-12-27 |
| CN1516689A (zh) | 2004-07-28 |
| NO20035572D0 (no) | 2003-12-12 |
| AU2002320847B2 (en) | 2007-09-20 |
| HK1063795A1 (en) | 2005-01-14 |
| NO20035572L (no) | 2004-02-16 |
| IL159304A (en) | 2010-02-17 |
| HUP0401125A2 (hu) | 2004-09-28 |
| EP1401816B1 (en) | 2008-02-13 |
| US20030105329A1 (en) | 2003-06-05 |
| AR037005A1 (es) | 2004-10-20 |
| ZA200308697B (en) | 2004-09-03 |
| PT1401816E (pt) | 2008-04-08 |
| JP4344230B2 (ja) | 2009-10-14 |
| US20040198983A1 (en) | 2004-10-07 |
| US7235665B2 (en) | 2007-06-26 |
| US6743941B2 (en) | 2004-06-01 |
| JP2005502603A (ja) | 2005-01-27 |
| BR0210410A (pt) | 2004-08-17 |
| WO2002102776A1 (en) | 2002-12-27 |
| IL159304A0 (en) | 2004-06-01 |
| DE60225008D1 (de) | 2008-03-27 |
| CN1229347C (zh) | 2005-11-30 |
| NZ530153A (en) | 2005-07-29 |
| PL364369A1 (en) | 2004-12-13 |
| KR20040010720A (ko) | 2004-01-31 |
| ATE386021T1 (de) | 2008-03-15 |
| DK1401816T3 (da) | 2008-06-09 |
| EP1401816A1 (en) | 2004-03-31 |
| KR100903285B1 (ko) | 2009-06-17 |
| ES2298384T3 (es) | 2008-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| HC | Change of company name or juridical status |