ES2295175T3 - Ensamblaje de particulas similares al virus (vlp) de la gripe de tipo salvaje y quimericas. - Google Patents
Ensamblaje de particulas similares al virus (vlp) de la gripe de tipo salvaje y quimericas. Download PDFInfo
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- ES2295175T3 ES2295175T3 ES01946643T ES01946643T ES2295175T3 ES 2295175 T3 ES2295175 T3 ES 2295175T3 ES 01946643 T ES01946643 T ES 01946643T ES 01946643 T ES01946643 T ES 01946643T ES 2295175 T3 ES2295175 T3 ES 2295175T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Zoology (AREA)
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- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
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- Biophysics (AREA)
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- Immunology (AREA)
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- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
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| US21365600P | 2000-06-23 | 2000-06-23 | |
| US213656P | 2000-06-23 | ||
| US28441101P | 2001-04-17 | 2001-04-17 | |
| US284411P | 2001-04-17 |
Publications (1)
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| ES2295175T3 true ES2295175T3 (es) | 2008-04-16 |
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| ES01946643T Expired - Lifetime ES2295175T3 (es) | 2000-06-23 | 2001-06-21 | Ensamblaje de particulas similares al virus (vlp) de la gripe de tipo salvaje y quimericas. |
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| EP (1) | EP1294892B1 (OSRAM) |
| JP (1) | JP5008244B2 (OSRAM) |
| KR (1) | KR100877019B1 (OSRAM) |
| CN (1) | CN1196788C (OSRAM) |
| AT (1) | ATE376059T1 (OSRAM) |
| AU (2) | AU2001268662A1 (OSRAM) |
| BR (1) | BRPI0111830B8 (OSRAM) |
| CA (1) | CA2410297C (OSRAM) |
| CY (1) | CY1107835T1 (OSRAM) |
| DE (1) | DE60130987T2 (OSRAM) |
| DK (1) | DK1294892T3 (OSRAM) |
| ES (1) | ES2295175T3 (OSRAM) |
| IL (1) | IL153290A0 (OSRAM) |
| MX (1) | MXPA02012254A (OSRAM) |
| PT (1) | PT1294892E (OSRAM) |
| WO (1) | WO2002000885A2 (OSRAM) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH0250488A (ja) * | 1988-08-11 | 1990-02-20 | Nec Corp | 超伝導配線 |
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| US9045727B2 (en) * | 2002-05-17 | 2015-06-02 | Emory University | Virus-like particles, methods of preparation, and immunogenic compositions |
| US20060088909A1 (en) * | 2002-05-17 | 2006-04-27 | Compans Richard W | Virus-like particles, methods of preparation, and immunogenic compositions |
| US20060121468A1 (en) * | 2002-06-26 | 2006-06-08 | Allnutt F C T | Viruses and virus-like particles for multiple antigen and target display |
| ES2217967B1 (es) * | 2003-03-31 | 2006-01-01 | Consejo Sup. Investig. Cientificas | Procedimiento de produccion de particulas virales vacias (vlps) del virus inductor de la bursitis infecciosa (ibdv), composiciones necesarias para su puesta a punto y su uso en la elaboracion de vacunas frente al ibdv. |
| ES2427641T3 (es) | 2003-05-22 | 2013-10-31 | Ibio, Inc. | Molécula vehículo recombinante para la expresión, el suministro y la purificación de polipéptidos diana |
| AU2011218606B2 (en) * | 2003-07-11 | 2012-01-12 | Novavax, Inc | Functional influenza virus-like particles (VLPS) |
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| ES2307345B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias quimericas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
| ES2307346B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias (vlps(-vp4)) del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
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| CN114617959A (zh) | 2015-09-03 | 2022-06-14 | 诺瓦瓦克斯股份有限公司 | 具有改进的稳定性和免疫原性的疫苗组合物 |
| EP3347044B1 (en) * | 2015-09-10 | 2023-04-19 | Academia Sinica | Bird flu vaccine combination comprising virus-like particles and novel adjuvants |
| JP7237344B2 (ja) | 2016-06-15 | 2023-03-13 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルス血球凝集素タンパク質及びその使用 |
| CA3046778A1 (en) * | 2016-10-31 | 2018-05-03 | Georgia State University Research Foundation, Inc. | A virus like particle of hepatitis b virus pre-s protein |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3606555A4 (en) | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| WO2019246363A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| CN111315407B (zh) | 2018-09-11 | 2023-05-02 | 上海市公共卫生临床中心 | 一种广谱抗流感疫苗免疫原及其应用 |
| MX2023012554A (es) | 2018-12-12 | 2023-11-08 | Cambridge Tech Llc | Vacuna universal contra la gripe. |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP3956349A1 (en) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| CN116670154A (zh) | 2020-07-24 | 2023-08-29 | 总医院公司 | 增强的病毒样颗粒及使用其递送至细胞的方法 |
| CN116063409A (zh) * | 2022-09-09 | 2023-05-05 | 中山大学·深圳 | 一种乙型流感Mosaic重组蛋白、重组质粒及其构建方法和应用 |
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|---|---|---|---|---|
| US4009258A (en) * | 1972-09-25 | 1977-02-22 | The Mount Sinai School Of Medicine Of The City University Of New York | Influenza vaccine containing a recombinant, antigenically hybridized virus and method of using the same |
| US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| US6001634A (en) * | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
| US5298244A (en) * | 1990-10-25 | 1994-03-29 | University Of Saskatchewan | Assembled viral particles and their use in a vaccine to rotaviral disease |
| US5830877A (en) * | 1993-08-26 | 1998-11-03 | The Regents Of The University Of California | Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| CA2323929C (en) | 1998-04-03 | 2004-03-09 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| MXPA01003228A (es) | 1998-09-30 | 2003-06-24 | American Cyanamid Co | Holotoxina de colera mutante como un coadyuvante. |
| EP2910629B1 (en) * | 1999-04-06 | 2018-09-19 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses for vaccines and gene therapy |
| CN1196788C (zh) * | 2000-06-23 | 2005-04-13 | 惠氏控股有限公司 | 野生型和嵌合流感病毒样颗粒(vlp)的装配 |
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2001
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- 2001-06-21 CA CA2410297A patent/CA2410297C/en not_active Expired - Lifetime
- 2001-06-21 ES ES01946643T patent/ES2295175T3/es not_active Expired - Lifetime
- 2001-06-21 IL IL15329001A patent/IL153290A0/xx unknown
- 2001-06-21 MX MXPA02012254A patent/MXPA02012254A/es active IP Right Grant
- 2001-06-21 KR KR1020027017581A patent/KR100877019B1/ko not_active Expired - Lifetime
- 2001-06-21 EP EP01946643A patent/EP1294892B1/en not_active Expired - Lifetime
- 2001-06-21 WO PCT/US2001/019890 patent/WO2002000885A2/en not_active Ceased
- 2001-06-21 BR BRPI0111830A patent/BRPI0111830B8/pt not_active IP Right Cessation
- 2001-06-21 AT AT01946643T patent/ATE376059T1/de active
- 2001-06-21 DK DK01946643T patent/DK1294892T3/da active
- 2001-06-21 AU AU2001268662A patent/AU2001268662A1/en not_active Abandoned
- 2001-06-21 PT PT01946643T patent/PT1294892E/pt unknown
- 2001-06-21 DE DE60130987T patent/DE60130987T2/de not_active Expired - Lifetime
- 2001-06-21 JP JP2002506200A patent/JP5008244B2/ja not_active Expired - Lifetime
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2005
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| US7556940B2 (en) | 2009-07-07 |
| US20050186621A1 (en) | 2005-08-25 |
| AU2007201727B2 (en) | 2009-06-04 |
| WO2002000885A3 (en) | 2002-08-08 |
| CN1437655A (zh) | 2003-08-20 |
| WO2002000885A9 (en) | 2002-05-10 |
| EP1294892B1 (en) | 2007-10-17 |
| IL153290A0 (en) | 2003-07-06 |
| KR20030013463A (ko) | 2003-02-14 |
| JP2004501647A (ja) | 2004-01-22 |
| EP1294892A2 (en) | 2003-03-26 |
| BR0111830A (pt) | 2003-03-25 |
| CA2410297C (en) | 2011-03-15 |
| ATE376059T1 (de) | 2007-11-15 |
| KR100877019B1 (ko) | 2009-01-07 |
| AU2001268662A1 (en) | 2002-01-08 |
| WO2002000885A2 (en) | 2002-01-03 |
| JP5008244B2 (ja) | 2012-08-22 |
| AU2007201727A1 (en) | 2007-05-10 |
| BRPI0111830B8 (pt) | 2021-05-25 |
| CA2410297A1 (en) | 2002-01-03 |
| BR0111830B1 (pt) | 2014-12-02 |
| MXPA02012254A (es) | 2003-04-25 |
| DK1294892T3 (da) | 2008-01-28 |
| CY1107835T1 (el) | 2013-06-19 |
| DE60130987D1 (de) | 2007-11-29 |
| PT1294892E (pt) | 2008-01-16 |
| US20090239261A1 (en) | 2009-09-24 |
| CN1196788C (zh) | 2005-04-13 |
| DE60130987T2 (de) | 2008-07-24 |
| US8859231B2 (en) | 2014-10-14 |
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