ES2214706T5 - Composiciones y métodos para reducir la hipertensión ocular. - Google Patents
Composiciones y métodos para reducir la hipertensión ocular. Download PDFInfo
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- ES2214706T5 ES2214706T5 ES98916948T ES98916948T ES2214706T5 ES 2214706 T5 ES2214706 T5 ES 2214706T5 ES 98916948 T ES98916948 T ES 98916948T ES 98916948 T ES98916948 T ES 98916948T ES 2214706 T5 ES2214706 T5 ES 2214706T5
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- 239000000203 mixture Substances 0.000 title claims abstract description 175
- 238000000034 method Methods 0.000 title description 24
- 206010020772 Hypertension Diseases 0.000 title 1
- 239000003755 preservative agent Substances 0.000 claims abstract description 123
- 239000013543 active substance Substances 0.000 claims abstract description 51
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 44
- 150000003180 prostaglandins Chemical class 0.000 claims abstract description 41
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 27
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 47
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical class [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 46
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 45
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 41
- -1 isopropyl ester Chemical class 0.000 claims description 32
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- 206010030043 Ocular hypertension Diseases 0.000 claims description 6
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
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- WBIQQQGBSDOWNP-UHFFFAOYSA-N 2-dodecylbenzenesulfonic acid Chemical class CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O WBIQQQGBSDOWNP-UHFFFAOYSA-N 0.000 claims description 2
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- VPWNQTHUCYMVMZ-UHFFFAOYSA-N 4,4'-sulfonyldiphenol Chemical class C1=CC(O)=CC=C1S(=O)(=O)C1=CC=C(O)C=C1 VPWNQTHUCYMVMZ-UHFFFAOYSA-N 0.000 claims description 2
- LZUKCYHMVDGDBK-UHFFFAOYSA-N 4-chloro-2-cyclopentylphenol Chemical compound OC1=CC=C(Cl)C=C1C1CCCC1 LZUKCYHMVDGDBK-UHFFFAOYSA-N 0.000 claims description 2
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 claims description 2
- WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 claims description 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims description 2
- QHPQWRBYOIRBIT-UHFFFAOYSA-N 4-tert-butylphenol Chemical compound CC(C)(C)C1=CC=C(O)C=C1 QHPQWRBYOIRBIT-UHFFFAOYSA-N 0.000 claims description 2
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- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical class [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 2
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- A61P27/00—Drugs for disorders of the senses
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Landscapes
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- Animal Behavior & Ethology (AREA)
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
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| US6011062A (en) * | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| AR002194A1 (es) * | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
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| EP0458587B1 (en) * | 1990-05-22 | 1993-07-14 | R-Tech Ueno Ltd. | Synergistic combination for ophthalmic use |
| IE920397A1 (en) * | 1991-02-07 | 1992-08-12 | Allergan Inc | 2-decarboxyl-2-hydroxyalkyl-5-trans prostaglandin f¹derivatives |
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| JP2742333B2 (ja) * | 1994-05-06 | 1998-04-22 | アルコン ラボラトリーズ，インコーポレイテッド | 眼科用組成物におけるビタミンｅトコフェリル誘導体の使用 |
| US5631287A (en) † | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US5558876A (en) * | 1995-03-29 | 1996-09-24 | Alcon Laboratories, Inc. | Topical ophthalmic acidic drug formulations |
| AR002194A1 (es) * | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
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1996
- 1996-06-03 AR ARP960102868A patent/AR002194A1/es unknown
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1998
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- 1998-03-13 BR BRPI9816218A patent/BRPI9816218B1/pt not_active IP Right Cessation
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- 1998-03-13 ES ES98916948T patent/ES2214706T5/es not_active Expired - Lifetime
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- 1998-03-13 DK DK98916948.7T patent/DK0969846T4/da active
- 1998-03-13 UA UA99095110A patent/UA63938C2/uk unknown
- 1998-03-13 DE DE69820997T patent/DE69820997T3/de not_active Expired - Lifetime
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- 1998-03-13 AT AT98916948T patent/ATE257385T1/de active
- 1998-03-13 JP JP54012698A patent/JP4920124B2/ja not_active Expired - Lifetime
- 1998-03-13 PT PT98916948T patent/PT969846E/pt unknown
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- 1998-03-13 CA CA002280089A patent/CA2280089C/en not_active Expired - Fee Related
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