ES2165115T3 - Un procedimiento para la purificacion de fosfatidinilserina. - Google Patents
Un procedimiento para la purificacion de fosfatidinilserina.Info
- Publication number
- ES2165115T3 ES2165115T3 ES98111111T ES98111111T ES2165115T3 ES 2165115 T3 ES2165115 T3 ES 2165115T3 ES 98111111 T ES98111111 T ES 98111111T ES 98111111 T ES98111111 T ES 98111111T ES 2165115 T3 ES2165115 T3 ES 2165115T3
- Authority
- ES
- Spain
- Prior art keywords
- purification
- phosfatidinilserine
- procedure
- phosfatidilserines
- diffusive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/103—Extraction or purification by physical or chemical treatment of natural phosphatides; Preparation of compositions containing phosphatides of unknown structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCESO PARA LA PURIFICACION DE FOSFATIDILSERINAS (PS) POR EXTRACCION SELECTIVA DE MEZCLAS DE FOSFOLIPIDOS QUE CONTIENE UN PS EN SISTEMAS DIFASICOS DE DISOLVENTES ORGANICOS Y, EVENTUALMENTE, POR CRISTALIZACION ADICIONAL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/570,000 US5700668A (en) | 1995-12-08 | 1995-12-08 | Process for the industrial preparation of phosphatidylserine |
US570000 | 1995-12-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2165115T3 true ES2165115T3 (es) | 2002-03-01 |
ES2165115T5 ES2165115T5 (es) | 2010-03-25 |
Family
ID=24277783
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96119350.5T Expired - Lifetime ES2105999T5 (es) | 1995-12-08 | 1996-12-03 | Un procedimiento de preparación industrial de fosfatidilserina |
ES98111111T Expired - Lifetime ES2165115T5 (es) | 1995-12-08 | 1996-12-03 | Un procedimiento para la purificacion de fosfatidinilserina. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96119350.5T Expired - Lifetime ES2105999T5 (es) | 1995-12-08 | 1996-12-03 | Un procedimiento de preparación industrial de fosfatidilserina |
Country Status (9)
Country | Link |
---|---|
US (1) | US5700668A (es) |
EP (2) | EP0776976B2 (es) |
JP (1) | JPH09173092A (es) |
KR (1) | KR100446399B1 (es) |
AT (2) | ATE208399T1 (es) |
CA (1) | CA2192257A1 (es) |
DE (3) | DE69613801T3 (es) |
ES (2) | ES2105999T5 (es) |
IT (1) | IT1316435B1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3791951B2 (ja) * | 1995-11-08 | 2006-06-28 | 株式会社ヤクルト本社 | 多価不飽和脂肪酸含有ホスファチジルセリンを含む油脂組成物の製造方法 |
DE69940426D1 (de) * | 1998-03-31 | 2009-04-02 | Takara Bio Inc | Verfahren zur herstellung von lysosphingolipiden |
AU6408299A (en) * | 1998-10-01 | 2000-04-17 | Albany Molecular Research, Inc. | Transphosphatidylation catalized by phospholipase d in anhydrous organic solvents in the presence of ion-exchange resin |
DE19917249C2 (de) * | 1999-02-26 | 2001-09-27 | Meyer Lucas Gmbh & Co | Verfahren zur Herstellung von Phosphatidylserin-Produkten |
IT1311929B1 (it) * | 1999-04-28 | 2002-03-20 | Chemi Spa | Procedimento per la preparazione di fosfatidilserine. |
IL139224A (en) * | 2000-10-23 | 2009-09-01 | David Rutenberg | Anti depressant, stress suppressor and mood improver |
IT1319679B1 (it) | 2000-12-05 | 2003-10-23 | Chemi Spa | Processo di purificazione di fosfatidilserina. |
JP3697189B2 (ja) * | 2001-01-11 | 2005-09-21 | 日清オイリオグループ株式会社 | リン脂質の塩基交換方法 |
ITPD20010031A1 (it) * | 2001-02-09 | 2002-08-09 | Fidia Farmaceutici | Procedimento per la preparazione di fosfatidi puri e loro impiego in campo cosmetico, farmaceutico ed alimentare. |
US6635456B2 (en) | 2001-02-09 | 2003-10-21 | Fidia Farmaceutici S.P.A. | Procedure for the preparation of pure phosphatides with phospholipase D |
KR100442538B1 (ko) * | 2001-05-07 | 2004-07-30 | 주식회사 두산 | 유기용매에서 포스파티딜세린 및 리조포스파티딜세린의제조방법 |
KR20030086128A (ko) * | 2002-05-03 | 2003-11-07 | 주식회사 두산 | 효소 및 세린의 재사용을 포함하는 포스파티딜세린 및리소포스파티딜세린의 제조방법 |
KR20040069438A (ko) * | 2003-01-29 | 2004-08-06 | 주식회사 두산 | 유기용매 혼합물을 이용한 변형 레시틴의 제조방법 |
US6878532B1 (en) * | 2003-04-28 | 2005-04-12 | Sioux Biochemical, Inc. | Method of producing phosphatidylserine |
IL158139A0 (en) * | 2003-09-25 | 2004-09-27 | Enzymotec Ltd | Stabilized formulations of phosphatidyl serine |
JP4891522B2 (ja) * | 2003-10-03 | 2012-03-07 | 株式会社ファンケル | 血清got、gpt改善剤 |
US8052992B2 (en) * | 2003-10-22 | 2011-11-08 | Enzymotec Ltd. | Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions |
US20050130937A1 (en) * | 2003-10-22 | 2005-06-16 | Enzymotec Ltd. | Lipids containing omega-3 and omega-6 fatty acids |
US7935365B2 (en) * | 2003-10-22 | 2011-05-03 | Enzymotec, Ltd. | Glycerophospholipids for the improvement of cognitive functions |
DE102004002053A1 (de) * | 2004-01-15 | 2005-08-04 | Bioghurt Biogarde Gmbh & Co. Kg | Verfahren zur Herstellung von Phosphatidylserin und dessen Reinigung durch Extraktion |
JP2005318827A (ja) * | 2004-05-07 | 2005-11-17 | Nisshin Oillio Group Ltd | セリンの回収方法 |
CN1308334C (zh) * | 2004-06-01 | 2007-04-04 | 山东师范大学 | 一种从动物脑提取磷脂酰丝氨酸的方法 |
DE102004038443A1 (de) * | 2004-08-07 | 2006-03-16 | Bioghurt Biogarde Gmbh & Co. Kg | Verfahren zur enzymatischen Herstellung und/oder Modifikation von Phospholipiden |
CN1305882C (zh) * | 2005-04-30 | 2007-03-21 | 海城后英生物工程有限公司 | 大豆卵磷脂的加工工艺 |
ITPD20050164A1 (it) | 2005-05-30 | 2006-11-30 | Fidia Farmaceutici | Processo per la preparazione e l'isolamento di fosfatidi |
RU2482186C2 (ru) * | 2008-05-15 | 2013-05-20 | Лодерс Кроклан Б.В. | Способ получения фосфатидилсерина |
US8846338B2 (en) * | 2008-08-07 | 2014-09-30 | Lipogen Ltd. | Processes for the preparation of phosphatides |
JP2012087203A (ja) * | 2010-10-19 | 2012-05-10 | Honda Denki Kk | セラミドの製造方法及びそれに用いる金属除去装置 |
ITPD20120021A1 (it) | 2012-01-26 | 2013-07-27 | Fidia Farmaceutici | "nuove composizioni farmaceutiche contenenti fosfatidilserina e curcumina". |
CN103351403A (zh) * | 2013-07-24 | 2013-10-16 | 华东师范大学 | 一种磷脂酰丝氨酸的合成方法 |
BR112017001483B8 (pt) | 2014-07-25 | 2023-02-28 | Enzymotec Ltd | Composições nutricionais contendo pó de fosfatidilserina |
WO2017125816A1 (en) * | 2016-01-21 | 2017-07-27 | Enzymotec Ltd. | Methods using phosphatidylserine powder |
CN116173045A (zh) * | 2022-09-21 | 2023-05-30 | 中国医学科学院基础医学研究所 | 甘油磷脂类化合物在预防和治疗高血脂、动脉粥样硬化、非酒精性脂肪肝和肥胖中的用途 |
CN116391876A (zh) * | 2023-05-22 | 2023-07-07 | 陕西中科通大生命科学技术有限公司 | 一种改性磷脂酰丝氨酸口服制剂的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2651646A (en) † | 1950-03-04 | 1953-09-08 | Colgate Palmolive Peet Co | Liquid-liquid extraction process |
US3436413A (en) † | 1965-12-21 | 1969-04-01 | Canada Packers Ltd | Process for the isolation of phosphatidyl serine |
JPS5743781A (en) | 1980-08-29 | 1982-03-11 | Janome Sewing Machine Co Ltd | Elongator device for electronic sewing machine |
GR74979B (es) † | 1980-10-02 | 1984-07-12 | Unilever Nv | |
US5084215A (en) * | 1984-02-13 | 1992-01-28 | The Liposome Company, Inc. | Process for purification of phospholipids |
JPS6336791A (ja) | 1986-08-01 | 1988-02-17 | Nippon Oil & Fats Co Ltd | 酵素によるリン脂質の製造方法 |
JPH0716426B2 (ja) † | 1986-08-01 | 1995-03-01 | 日本油脂株式会社 | 酵素によるリン脂質の製造方法 |
DE3627079C1 (de) † | 1986-08-09 | 1987-10-08 | Heidenhain Gmbh Dr Johannes | Laengenmesseinrichtung |
JPH0761276B2 (ja) | 1986-11-14 | 1995-07-05 | 名糖産業株式会社 | 酵素法リン脂質−d−セリン誘導体の製造法 |
JPH0279990A (ja) * | 1988-09-16 | 1990-03-20 | Nippon Oil & Fats Co Ltd | ホスファチジルセリンの製造方法 |
JPH05336983A (ja) | 1992-06-04 | 1993-12-21 | Kanegafuchi Chem Ind Co Ltd | リン脂質の生産方法 |
-
1995
- 1995-12-08 US US08/570,000 patent/US5700668A/en not_active Expired - Lifetime
-
1996
- 1996-08-02 IT IT1996MI001686A patent/IT1316435B1/it active
- 1996-12-03 EP EP96119350.5A patent/EP0776976B2/en not_active Expired - Lifetime
- 1996-12-03 DE DE69613801.8T patent/DE69613801T3/de not_active Expired - Lifetime
- 1996-12-03 EP EP98111111A patent/EP0922707B2/en not_active Expired - Lifetime
- 1996-12-03 AT AT98111111T patent/ATE208399T1/de not_active IP Right Cessation
- 1996-12-03 ES ES96119350.5T patent/ES2105999T5/es not_active Expired - Lifetime
- 1996-12-03 DE DE0776976T patent/DE776976T1/de active Pending
- 1996-12-03 AT AT96119350T patent/ATE203057T1/de not_active IP Right Cessation
- 1996-12-03 ES ES98111111T patent/ES2165115T5/es not_active Expired - Lifetime
- 1996-12-03 DE DE69616834T patent/DE69616834T3/de not_active Expired - Lifetime
- 1996-12-06 JP JP8326787A patent/JPH09173092A/ja active Pending
- 1996-12-06 CA CA002192257A patent/CA2192257A1/en not_active Abandoned
- 1996-12-07 KR KR1019960062864A patent/KR100446399B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0776976B2 (en) | 2014-07-30 |
ITMI961686A0 (es) | 1996-08-02 |
JPH09173092A (ja) | 1997-07-08 |
DE69613801T3 (de) | 2014-12-18 |
EP0922707A1 (en) | 1999-06-16 |
DE69616834T3 (de) | 2010-07-01 |
EP0922707B2 (en) | 2009-11-18 |
ITMI961686A1 (it) | 1998-02-02 |
EP0776976B1 (en) | 2001-07-11 |
DE69613801T2 (de) | 2001-11-22 |
ES2105999T5 (es) | 2014-12-01 |
KR970043060A (ko) | 1997-07-26 |
CA2192257A1 (en) | 1997-06-09 |
KR100446399B1 (ko) | 2004-11-12 |
EP0776976A2 (en) | 1997-06-04 |
DE69616834T2 (de) | 2002-06-06 |
US5700668A (en) | 1997-12-23 |
ATE208399T1 (de) | 2001-11-15 |
DE69616834D1 (de) | 2001-12-13 |
ATE203057T1 (de) | 2001-07-15 |
IT1316435B1 (it) | 2003-04-22 |
EP0922707B1 (en) | 2001-11-07 |
DE69613801D1 (de) | 2001-08-16 |
ES2105999T3 (es) | 2001-09-16 |
ES2105999T1 (es) | 1997-11-01 |
EP0776976A3 (en) | 1997-09-10 |
DE776976T1 (de) | 1998-02-19 |
ES2165115T5 (es) | 2010-03-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2165115T3 (es) | Un procedimiento para la purificacion de fosfatidinilserina. | |
ES2164842T3 (es) | Procedimiento para la preparacion de composiciones de microcapsulas. | |
DK0828717T3 (da) | Fremgangsmåde til fremstilling af 3-haloalkyl-1H-pyrazol | |
ES2098127T3 (es) | Procedimiento para la purificacion de taxoides. | |
AR240990A1 (es) | Procedimiento para la separacion de moleculas de interes biologico,de una mezcla que las contiene." | |
ES2184888T3 (es) | Empleo de catalizadores de estaño, asi como mezclas reticulables que contienen estos catalizadores. | |
TW357104B (en) | Perfluorocompound separation and purification method and system | |
BR0011033A (pt) | Métodos de purificação de dna e dna purificado | |
PT879228E (pt) | Processo para a preparacao de d-treo-(r,r)-metilfenidato e reciclagem de enantiomeros indesejaveis por epimerizacao | |
BR0116074B1 (pt) | processo para a separação de microesferas de vidro ocas de lamas que contêm as mesmas. | |
ES2118851T3 (es) | Un procedimiento para la preparacion de glicerofosfolipidos. | |
BR0209512A (pt) | Processo integrado para a preparação de compostos aromáticos substituìdos com alquila e alquenila | |
DK0785986T3 (da) | Fremgangsmåde til fremstilling af hydrofobe produkter og dertil egnet indretning | |
SE8902919L (sv) | Anvaendning av zeoliter som adsorbenter av detergenter i biokemiska/biotekniska system och processer | |
BR9603115A (pt) | Processo para a separação de trioxano de uma mistura aquosa | |
ES2177942T3 (es) | Formulacion farmaceutica de liberacion prolongada conteniendo mizolastina. | |
MY126792A (en) | Process for purifying caprolactam | |
PT1252327E (pt) | Processo para a separacao enzimatica de racematos de derivados de aminometilaril-ciclo-hexanol | |
ES2162351T3 (es) | Metodos para la preparacion de derivados de benzofenona. | |
ES2139365T3 (es) | Procedimiento de evacuacion de residuos de las aplicaciones transdermales de principios activos. | |
ES2185350T3 (es) | Sintesis de morfina-6-glucuronido. | |
ES2155157T3 (es) | Acido para-hidroxifenilacetico para la reduccion de la repelencia de insecticidas. | |
PT937094E (pt) | Processo para a preparacao de ivermectina | |
AU2002213590A1 (en) | Method of applying foam reagents for radioactive decontamination | |
ES2130755T3 (es) | Procedimiento para la eliminacion de alcoxidos de titanio o de vanadio de mezclas liquidas de hidrocarburos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 922707 Country of ref document: ES |