ES2162351T3 - Metodos para la preparacion de derivados de benzofenona. - Google Patents

Metodos para la preparacion de derivados de benzofenona.

Info

Publication number
ES2162351T3
ES2162351T3 ES98100582T ES98100582T ES2162351T3 ES 2162351 T3 ES2162351 T3 ES 2162351T3 ES 98100582 T ES98100582 T ES 98100582T ES 98100582 T ES98100582 T ES 98100582T ES 2162351 T3 ES2162351 T3 ES 2162351T3
Authority
ES
Spain
Prior art keywords
derivatives
benzofenone
preparation
methods
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98100582T
Other languages
English (en)
Inventor
Juerg Bruhin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2162351T3 publication Critical patent/ES2162351T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/16—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/784—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with all keto groups bound to a non-condensed ring
    • C07C49/786—Benzophenone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA LA FABRICACION DE DERIVADOS DE ENZOFENONA Y CONSISTE EN LA SEPARACION DE COMPUESTOS DE FORMULA (I), A PARTIR DE LOS CORRESPONDIENTES COMPUESTOS ISOMERICOS DE FORMULA (II), MEDIANTE CRISTALIZACION SELECTIVA DE LAS SALES CORRESPONDIENTES DE LOS COMPUESTOS DE FORMULA (I).
ES98100582T 1997-01-22 1998-01-15 Metodos para la preparacion de derivados de benzofenona. Expired - Lifetime ES2162351T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97100930 1997-01-22

Publications (1)

Publication Number Publication Date
ES2162351T3 true ES2162351T3 (es) 2001-12-16

Family

ID=8226392

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98100582T Expired - Lifetime ES2162351T3 (es) 1997-01-22 1998-01-15 Metodos para la preparacion de derivados de benzofenona.

Country Status (17)

Country Link
US (1) US5877353A (es)
EP (1) EP0855379B1 (es)
JP (1) JP2888814B2 (es)
KR (1) KR100268545B1 (es)
CN (1) CN1092178C (es)
AR (1) AR011542A1 (es)
AT (1) ATE205177T1 (es)
AU (1) AU733422B2 (es)
BR (1) BR9800426B1 (es)
CA (1) CA2227131C (es)
DE (1) DE69801532T2 (es)
DK (1) DK0855379T3 (es)
ES (1) ES2162351T3 (es)
ID (1) ID19540A (es)
PT (1) PT855379E (es)
TR (1) TR199800068A2 (es)
ZA (1) ZA98347B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE340168T1 (de) 2000-02-01 2006-10-15 Kyorin Seiyaku Kk Alkalimetallsalz von thiazolidin-2,4-dion- derivaten
KR20040026964A (ko) * 2002-09-27 2004-04-01 금호석유화학 주식회사 1,3-부타디엔과 아크릴산으로부터 시클로헥실 페닐 케톤의제조방법
EP1630600A3 (en) * 2004-07-29 2006-03-22 Rohm and Haas Electronic Materials, L.L.C. Hot melt composition and method involving forming a masking pattern
CN112601513B (zh) * 2018-04-05 2023-12-22 普莱克斯医药公司 治疗眼部疾病的药物
CN108586224B (zh) * 2018-06-27 2021-05-25 天津大学 一种二苯甲酮纯化分离的方法
CN116963727A (zh) * 2020-11-13 2023-10-27 普莱克斯医药公司 用于治疗眼部病症的药剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236952A (en) * 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
DK175069B1 (da) * 1986-03-11 2004-05-24 Hoffmann La Roche Pyrocatecholderivater
DE3643403A1 (de) * 1986-12-19 1988-06-30 Shell Agrar Gmbh & Co Kg Benzophenone und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
TR199800068A3 (tr) 1998-08-21
BR9800426B1 (pt) 2010-05-18
AU5210298A (en) 1998-07-30
KR100268545B1 (ko) 2000-10-16
CA2227131A1 (en) 1998-07-22
EP0855379A1 (en) 1998-07-29
BR9800426A (pt) 1999-09-08
CN1188755A (zh) 1998-07-29
AU733422B2 (en) 2001-05-17
ID19540A (id) 1998-07-23
ATE205177T1 (de) 2001-09-15
ZA98347B (en) 1998-07-22
DE69801532T2 (de) 2002-05-23
MX9800608A (es) 1998-10-31
JPH10204021A (ja) 1998-08-04
DE69801532D1 (de) 2001-10-11
TR199800068A2 (xx) 1998-08-21
PT855379E (pt) 2002-01-30
DK0855379T3 (da) 2001-12-17
JP2888814B2 (ja) 1999-05-10
CN1092178C (zh) 2002-10-09
KR19980070613A (ko) 1998-10-26
CA2227131C (en) 2008-10-07
EP0855379B1 (en) 2001-09-05
AR011542A1 (es) 2000-08-30
US5877353A (en) 1999-03-02

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