ES2158493T3 - Agentes farmaceuticos que contienen complejos metalicos con un contenido de perfluoroalquilo y su utilizacion en la terapia de tumores y en la radiologia intervencional. - Google Patents

Agentes farmaceuticos que contienen complejos metalicos con un contenido de perfluoroalquilo y su utilizacion en la terapia de tumores y en la radiologia intervencional.

Info

Publication number
ES2158493T3
ES2158493T3 ES97903278T ES97903278T ES2158493T3 ES 2158493 T3 ES2158493 T3 ES 2158493T3 ES 97903278 T ES97903278 T ES 97903278T ES 97903278 T ES97903278 T ES 97903278T ES 2158493 T3 ES2158493 T3 ES 2158493T3
Authority
ES
Spain
Prior art keywords
pharmaceutical agents
agents containing
perfluoroalquilo
interventional radiology
content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97903278T
Other languages
English (en)
Inventor
Johannes Platzek
Ulrich Niedballa
Bernd Raduchel
Wolfgang Schlecker
Hanns-Joachim Weinmann
Thomas Frenzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2158493T3 publication Critical patent/ES2158493T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA INVENCION TRATA DE UNOS PRODUCTOS FARMACEUTICOS QUE CONTIENEN UNOS COMPLEJOS METALICOS PERFLUORALQUILIZADOS DE FORMULA GENERAL (I), DEL RF-L-A Y DE SU EMPLEO EN LA TERAPIA DE TUMORES Y LA RADIOLOGIA INTERVENCIONAL, SIENDO RF UNA CADENA DE CARBONO PERFLUORADA RECTA O ARBORESCENTE CON LA FORMULA CNF2NX, EN DONDE X ES UN ATOMO TERMINAL DE FLUOR, CLORO, BROMO, YODO O HIDROGENO Y N UN NUMERO DEL 4 AL 30; L ES UN GRUPO LIGANTE Y A UN COMPLEJO METALICO O LAS SALES ORGANICAS Y/O INORGANICAS DE BASES O AMINOACIDOS O AMIDAS AMINOACIDAS DE ESTE. L Y A ESTAN DEFINIDAS CON MAS DETALLE EN LA DESCRIPCION.
ES97903278T 1996-02-23 1997-02-14 Agentes farmaceuticos que contienen complejos metalicos con un contenido de perfluoroalquilo y su utilizacion en la terapia de tumores y en la radiologia intervencional. Expired - Lifetime ES2158493T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19608278A DE19608278A1 (de) 1996-02-23 1996-02-23 Pharmazeutische Mittel enthaltend perfluoralkylhaltige Metallkomplexe, und ihre Verwendung in der Tumortherapie und interventioniellen Radiologie

Publications (1)

Publication Number Publication Date
ES2158493T3 true ES2158493T3 (es) 2001-09-01

Family

ID=7787153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97903278T Expired - Lifetime ES2158493T3 (es) 1996-02-23 1997-02-14 Agentes farmaceuticos que contienen complejos metalicos con un contenido de perfluoroalquilo y su utilizacion en la terapia de tumores y en la radiologia intervencional.

Country Status (14)

Country Link
EP (1) EP0882010B1 (es)
JP (1) JP2000504736A (es)
AT (1) ATE200894T1 (es)
AU (1) AU1769297A (es)
CA (1) CA2247253A1 (es)
DE (2) DE19608278A1 (es)
DK (1) DK0882010T3 (es)
ES (1) ES2158493T3 (es)
GR (1) GR3036306T3 (es)
NO (1) NO323547B1 (es)
PT (1) PT882010E (es)
TW (1) TW477699B (es)
WO (1) WO1997030969A1 (es)
ZA (1) ZA971537B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919433A (en) * 1996-12-04 1999-07-06 Schering Aktiengesellschaft Macrocyclic metal complex carboxylic acids, their use as well as process for their production
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
US6461587B1 (en) 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
US6676928B2 (en) 2000-08-11 2004-01-13 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
ATE320795T1 (de) 2001-08-03 2006-04-15 Glaxo Group Ltd Oberflächenaktive verbindungen und ihre anwendungen
WO2004006934A2 (de) * 2002-07-10 2004-01-22 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecane als modulatoren des guanin-nukleotid bindenden roteins zur behandlung von tumoren
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
ITMI20131225A1 (it) * 2013-07-22 2015-01-23 Miteni Spa Nuovi composti organici fluorurati, procedimento per la loro preparazione e loro uso come intermedi di sintesi
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN110035996B (zh) 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
KR20210095168A (ko) 2018-11-23 2021-07-30 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법
JP2024020674A (ja) * 2021-01-06 2024-02-15 Ａｇｃ株式会社 ペプチド

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803869C2 (de) * 1978-01-30 1983-12-29 Ethicon, Inc., 08876 Somerville, N.J. Injizierbare Embolisations- und Okklusionslösung
JPS59130812A (ja) * 1983-01-14 1984-07-27 Green Cross Corp:The 癌化学療法補助剤
JPS59130813A (ja) * 1983-01-14 1984-07-27 Green Cross Corp:The 癌化学療法補助剤
JP2657393B2 (ja) * 1988-05-18 1997-09-24 日本化薬株式会社 化学塞栓療法剤
FR2682110B1 (fr) * 1991-10-02 1995-05-24 Atta Ligands amphiphiles perfluoroalkyles leurs complexes metalliques et leurs utilisations dans des preparations a usage therapeutique.
WO1993018795A1 (en) * 1992-03-19 1993-09-30 Daikin Industries, Ltd. Mri contrast medium and diagnostic method
US5401493A (en) * 1993-03-26 1995-03-28 Molecular Biosystems, Inc. Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same

Also Published As

Publication number Publication date
WO1997030969A1 (de) 1997-08-28
TW477699B (en) 2002-03-01
ZA971537B (en) 1997-10-30
NO323547B1 (no) 2007-06-11
EP0882010A1 (de) 1998-12-09
NO983875D0 (no) 1998-08-21
PT882010E (pt) 2001-10-30
DE19608278A1 (de) 1997-08-28
AU1769297A (en) 1997-09-10
DE59703468D1 (de) 2001-06-07
EP0882010B1 (de) 2001-05-02
JP2000504736A (ja) 2000-04-18
CA2247253A1 (en) 1997-08-28
GR3036306T3 (en) 2001-10-31
DK0882010T3 (da) 2001-08-20
ATE200894T1 (de) 2001-05-15
NO983875L (no) 1998-10-22

Similar Documents

Publication Publication Date Title
ES2158493T3 (es) Agentes farmaceuticos que contienen complejos metalicos con un contenido de perfluoroalquilo y su utilizacion en la terapia de tumores y en la radiologia intervencional.
NO166267C (no) Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet.
FI100998B (fi) Erkaumakarkaistava martensiittinen, ruostumaton teräs
IL127352A0 (en) Pyridyl alkene- and pyridyl alkine-acid amides as cytostatics and immunosupressives
PT623134E (pt) Complexos metalicos de texafirinas soluveis em agua
NO954440D0 (no) 2 pyridylmetylenpolyazamakrocyklo-fosfonsyrer, komplekser og derivater derav, for anvendelse som kontrastmidler
ES2181006T3 (es) Uso de amidas de acidos de piridil alcanos, piridil alquenos y/o piridil alquinos en el tratamiento de tumores o en inmunosupresion.
EP0738142A4 (en) Perfluorocarbons as an anti-inflammatory agent
DE69527980D1 (de) Chalcone und ihre ester mit antiproliferativer aktivität in gebärmutter, ovar- und brusttumoren
ATE173274T1 (de) Basen-tumorzellen behandlungsverfahren
ES2117223T3 (es) Procedimiento para la preparacion de acidos taurocolanicos.
BR9814048A (pt) "misturas de enantiÈmetros de aminociclohexil amidas para produzir de modo simultâneo analgesia com anestesia local ou antiarritmia "
DK0922219T3 (da) Farveblanding omfattende en pyrogallolforbindelse, et jern(II)salt og en organisk syre
ES2072550T3 (es) Procedimiento para la preparacion de sales de complejos de hierro, de acidos aminocarboxilicos e hidroxicarboxilicos.
ES2056953T3 (es) Complejo de hierro-citrato, procedimiento para su fabricacion y su aplicacion farmaceutica.
KR950702507A (ko) 염화 제이철의 제조방법(process for the preparation of ferric chloride)
EP0486045A3 (en) S(+)-phenyl-alkanoic acids and alpha-amino acid containing complexes
FR2275199A1 (fr) (chloro-4 phenoxy) isobutyrate de dimethylbiguanide, son procede de preparation et medicaments contenant ce produit comme principe actif
JPS5396941A (en) Corrosion inhibitor for metal
KR970065495A (ko) 1, 25-디하이드록시-16, 22, 23-트리스데하이드로-콜레칼시페롤 유도체
GR860079B (en) Azolyl - aroxymethyl - dimethylpentinole
Brothers et al. Protein-protein orientation in electron-transfer reactions of the cytochrome c/plastocyanin complex with free cytochrome c and with free plastocyanin
RU97116256A (ru) Катализатор для гидрохлорирования ненасыщенных соединений
Neef Austenitic Manganese-Alloyed Stainless Steel: the AISI 200 Series. III
RU98121242A (ru) Раствор для одновременного травления и фосфатирования углеродистых сталей

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 882010

Country of ref document: ES