ZA971537B - Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes and their use in tumor therapy and interventional radiology. - Google Patents

Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes and their use in tumor therapy and interventional radiology.

Info

Publication number
ZA971537B
ZA971537B ZA9701537A ZA971537A ZA971537B ZA 971537 B ZA971537 B ZA 971537B ZA 9701537 A ZA9701537 A ZA 9701537A ZA 971537 A ZA971537 A ZA 971537A ZA 971537 B ZA971537 B ZA 971537B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical agents
metal complexes
interventional radiology
containing metal
tumor therapy
Prior art date
Application number
ZA9701537A
Inventor
Johannes Platzek
Bernd Raduechel
Hanns-Joachim Weinmann
Ulrich Niedballa
Wolfgang Schlecker
Thomas Frenzel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA971537B publication Critical patent/ZA971537B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to pharmaceutical agents containing perfluoroalkylated metal complexes of the general formula (I) RF-L-A and the use thereof in tumour therapy and interventional radiology, in which formula RF is a perfluorinated, straight-chain or branched carbon chain with the formula -CnF2nX, in which X is a terminal fluorine, chlorine, bromine, iodine or hydrogen atom and n represents the numbers 4-30, L is a binding group, and A is a metal complex or the salts thereof of organic and/or inorganic bases or amino acids or amino acid amides. L and A are defined in detail in the description.
ZA9701537A 1996-02-23 1997-02-21 Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes and their use in tumor therapy and interventional radiology. ZA971537B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19608278A DE19608278A1 (en) 1996-02-23 1996-02-23 Pharmaceutical compositions containing perfluoroalkyl-containing metal complexes, and their use in tumor therapy and interventional radiology

Publications (1)

Publication Number Publication Date
ZA971537B true ZA971537B (en) 1997-10-30

Family

ID=7787153

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9701537A ZA971537B (en) 1996-02-23 1997-02-21 Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes and their use in tumor therapy and interventional radiology.

Country Status (14)

Country Link
EP (1) EP0882010B1 (en)
JP (1) JP2000504736A (en)
AT (1) ATE200894T1 (en)
AU (1) AU1769297A (en)
CA (1) CA2247253A1 (en)
DE (2) DE19608278A1 (en)
DK (1) DK0882010T3 (en)
ES (1) ES2158493T3 (en)
GR (1) GR3036306T3 (en)
NO (1) NO323547B1 (en)
PT (1) PT882010E (en)
TW (1) TW477699B (en)
WO (1) WO1997030969A1 (en)
ZA (1) ZA971537B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919433A (en) * 1996-12-04 1999-07-06 Schering Aktiengesellschaft Macrocyclic metal complex carboxylic acids, their use as well as process for their production
DE19729013A1 (en) * 1997-07-03 1999-02-04 Schering Ag Oligomeric, perfluoroalkyl-containing compounds, processes for their preparation and their use in NMR diagnostics
DE19731591C2 (en) * 1997-07-17 1999-09-16 Schering Ag Pharmaceutical compositions containing triiodoaromatics containing perfluoroalkyl groups and their use in tumor therapy and interventional radiology
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
US6461587B1 (en) 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
DE19914101C1 (en) * 1999-03-22 2000-10-12 Schering Ag Perfluoroalkylamides, their preparation and their use in diagnostics
US6676928B2 (en) 2000-08-11 2004-01-13 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
DE10040858C2 (en) * 2000-08-11 2003-12-18 Schering Ag Perfluoroalkyl-containing complexes with polar residues, process for their preparation and their use
ATE320795T1 (en) 2001-08-03 2006-04-15 Glaxo Group Ltd SURFACE-ACTIVE COMPOUNDS AND THEIR APPLICATIONS
WO2004006934A2 (en) * 2002-07-10 2004-01-22 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecanes as modulators of the guanine-binding protein for treating tumours
DE102005008309A1 (en) * 2005-02-17 2006-08-24 Schering Ag Pharmaceutical agents containing fluoroalkyl-containing metal complexes and epothilones
ITMI20131225A1 (en) * 2013-07-22 2015-01-23 Miteni Spa NEW FLUORURED ORGANIC COMPOUNDS, PROCEDURE FOR THEIR PREPARATION AND THEIR USE AS INTERMEDIATE SUMMARY
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN110035996B (en) 2016-11-28 2022-08-09 拜耳医药股份公司 Novel highly relaxant gadolinium chelates for magnetic resonance imaging
KR20210095168A (en) 2018-11-23 2021-07-30 바이엘 악티엔게젤샤프트 Formulation of Contrast Media and Method for Preparing Same
JP2024020674A (en) * 2021-01-06 2024-02-15 Ａｇｃ株式会社 peptide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803869C2 (en) * 1978-01-30 1983-12-29 Ethicon, Inc., 08876 Somerville, N.J. Injectable embolization and occlusion solution
JPS59130812A (en) * 1983-01-14 1984-07-27 Green Cross Corp:The Adminiculum for chemotherapy of cancer
JPS59130813A (en) * 1983-01-14 1984-07-27 Green Cross Corp:The Adminiculum for chemotherapy of cancer
JP2657393B2 (en) * 1988-05-18 1997-09-24 日本化薬株式会社 Chemoembolization agent
FR2682110B1 (en) * 1991-10-02 1995-05-24 Atta PERFLUOROALKYL AMPHIPHILIC LIGANDS, THEIR METAL COMPLEXES AND THEIR USES IN PREPARATIONS FOR THERAPEUTIC USE.
WO1993018795A1 (en) * 1992-03-19 1993-09-30 Daikin Industries, Ltd. Mri contrast medium and diagnostic method
US5401493A (en) * 1993-03-26 1995-03-28 Molecular Biosystems, Inc. Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same

Also Published As

Publication number Publication date
WO1997030969A1 (en) 1997-08-28
TW477699B (en) 2002-03-01
ES2158493T3 (en) 2001-09-01
NO323547B1 (en) 2007-06-11
EP0882010A1 (en) 1998-12-09
NO983875D0 (en) 1998-08-21
PT882010E (en) 2001-10-30
DE19608278A1 (en) 1997-08-28
AU1769297A (en) 1997-09-10
DE59703468D1 (en) 2001-06-07
EP0882010B1 (en) 2001-05-02
JP2000504736A (en) 2000-04-18
CA2247253A1 (en) 1997-08-28
GR3036306T3 (en) 2001-10-31
DK0882010T3 (en) 2001-08-20
ATE200894T1 (en) 2001-05-15
NO983875L (en) 1998-10-22

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