KR970065495A - 1, 25-디하이드록시-16, 22, 23-트리스데하이드로-콜레칼시페롤 유도체 - Google Patents

1, 25-디하이드록시-16, 22, 23-트리스데하이드로-콜레칼시페롤 유도체 Download PDF

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KR970065495A
KR970065495A KR1019970009478A KR19970009478A KR970065495A KR 970065495 A KR970065495 A KR 970065495A KR 1019970009478 A KR1019970009478 A KR 1019970009478A KR 19970009478 A KR19970009478 A KR 19970009478A KR 970065495 A KR970065495 A KR 970065495A
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South Korea
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dihydroxy
formula
cholecalciferol
compound
diseases
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KR1019970009478A
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KR100240541B1 (ko
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버나드 마이클 헤네시
제롬 안토니 야코벨리
밀란 라도예 유스코코빅
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클라우스너 프리돌린, 보러 롤란드
에프 호프만-라 롯슈 아크티엔게젤샤프트
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Publication of KR970065495A publication Critical patent/KR970065495A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Liquid Crystal Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 하기 화학식(1)의 화합물에 관한 것이다:
상기 식에서, R은 하이드록시이고 R1은 H2또는 CH2이거나, 또는 R은 수소 또는 플루오르이고 R1은 CH2이다.
화학식(1)의 화합물은 과증식성 피부 질환(예:건선), 종양성 질환(예:백혈병), 및 피지선 질환(예:여드름 및 지루성 피부염)의 치료제로서 유용하다.

Description

1.25-디하이드록시-16.22.23-트리스데하이드로-콜레칼시페롤 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 화학식(1)의 화합물:
    상기식에서, R은 하이드록시이고 R1은 H2또는 CH2이거나, 또는 R은 수소 또는 플루오르이고 R1은 CH2이다.
  2. 제1항에 있어서, 1.25-디하이드록시-16,22S,23-트리엔-콜레칼시페롤 또는 1,25-디하이드록시-16,22R,23-트리엔-콜레칼시페롤인 화합물.
  3. 제1항 또는 제2항에 따른 유효량의 화학식(1)의 화합물 및 불활성 담체를 포함하는, 특히 피부 과증식증 및 종양 세포를 억제하기 위한, 구체적으로 과증식성 피부 질환(예;건선),종양성 질환(예:백혈병),및 피지선 질환(예:여드름 및 지루성 피부염)을 치료하기 위한 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970009478A 1996-03-21 1997-03-20 1,25-디하이드록시-16,22,23-트리스데하이드로-콜레칼시페롤 유도체 KR100240541B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1380996P 1996-03-21 1996-03-21
US60/013,809 1996-03-21

Publications (2)

Publication Number Publication Date
KR970065495A true KR970065495A (ko) 1997-10-13
KR100240541B1 KR100240541B1 (ko) 2000-01-15

Family

ID=21761865

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970009478A KR100240541B1 (ko) 1996-03-21 1997-03-20 1,25-디하이드록시-16,22,23-트리스데하이드로-콜레칼시페롤 유도체

Country Status (30)

Country Link
EP (1) EP0796843B1 (ko)
JP (1) JP2801587B2 (ko)
KR (1) KR100240541B1 (ko)
CN (1) CN1110477C (ko)
AR (1) AR006315A1 (ko)
AT (1) ATE240941T1 (ko)
AU (1) AU708679B2 (ko)
BR (1) BR9701404A (ko)
CA (1) CA2199893C (ko)
CO (1) CO4820396A1 (ko)
CZ (1) CZ85897A3 (ko)
DE (1) DE69722064T2 (ko)
DK (1) DK0796843T3 (ko)
ES (1) ES2198512T3 (ko)
HR (1) HRP970162A2 (ko)
HU (1) HUP9700609A3 (ko)
ID (1) ID16285A (ko)
IL (1) IL120469A0 (ko)
MA (1) MA26423A1 (ko)
MX (1) MX9702139A (ko)
NO (1) NO971217L (ko)
NZ (1) NZ314424A (ko)
PE (1) PE42998A1 (ko)
PL (1) PL319070A1 (ko)
PT (1) PT796843E (ko)
SG (1) SG70589A1 (ko)
TR (1) TR199700219A3 (ko)
TW (1) TW444001B (ko)
YU (1) YU10397A (ko)
ZA (1) ZA972302B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101285720B1 (ko) * 2012-03-02 2013-07-19 주식회사 유니크메디케어 여드름 개선용 조성물

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
KR102493627B1 (ko) 2015-11-26 2023-01-31 코웨이 주식회사 호르데닌을 유효성분으로 함유하는 피부암 예방 또는 치료용 약학 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
DE69005897D1 (de) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferolderivate.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101285720B1 (ko) * 2012-03-02 2013-07-19 주식회사 유니크메디케어 여드름 개선용 조성물

Also Published As

Publication number Publication date
CO4820396A1 (es) 1999-07-28
PL319070A1 (en) 1997-09-29
ZA972302B (en) 1997-09-22
JP2801587B2 (ja) 1998-09-21
IL120469A0 (en) 1997-07-13
HUP9700609A3 (en) 1999-03-01
HUP9700609A2 (hu) 1998-07-28
NO971217D0 (no) 1997-03-17
AU708679B2 (en) 1999-08-12
EP0796843A3 (en) 1999-04-14
DK0796843T3 (da) 2003-09-15
CN1110477C (zh) 2003-06-04
TR199700219A2 (xx) 1997-10-21
NZ314424A (en) 1998-07-28
HRP970162A2 (en) 1998-04-30
PT796843E (pt) 2003-09-30
ATE240941T1 (de) 2003-06-15
ID16285A (id) 1997-09-18
CA2199893A1 (en) 1997-09-21
KR100240541B1 (ko) 2000-01-15
YU10397A (sh) 1999-07-28
AU1513597A (en) 1997-09-25
MA26423A1 (fr) 2004-12-20
PE42998A1 (es) 1998-08-11
DE69722064D1 (de) 2003-06-26
ES2198512T3 (es) 2004-02-01
CZ85897A3 (cs) 1998-04-15
TR199700219A3 (tr) 1997-10-21
CA2199893C (en) 2008-02-05
HU9700609D0 (en) 1997-05-28
TW444001B (en) 2001-07-01
EP0796843A2 (en) 1997-09-24
MX9702139A (es) 1998-04-30
NO971217L (no) 1997-09-22
DE69722064T2 (de) 2004-04-08
BR9701404A (pt) 1998-11-03
EP0796843B1 (en) 2003-05-21
JPH107651A (ja) 1998-01-13
SG70589A1 (en) 2000-02-22
AR006315A1 (es) 1999-08-25
CN1172793A (zh) 1998-02-11

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