KR950032046A - 불소화된 비타민 d₃유도체 - Google Patents

불소화된 비타민 d₃유도체 Download PDF

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Publication number
KR950032046A
KR950032046A KR1019950004861A KR19950004861A KR950032046A KR 950032046 A KR950032046 A KR 950032046A KR 1019950004861 A KR1019950004861 A KR 1019950004861A KR 19950004861 A KR19950004861 A KR 19950004861A KR 950032046 A KR950032046 A KR 950032046A
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KR
South Korea
Prior art keywords
derivatives
hydroxy
ene
fluoro
fluorinated vitamin
Prior art date
Application number
KR1019950004861A
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English (en)
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KR100360732B1 (ko
Inventor
아이. 도란 토마스
슈에이 시안-쟝
라도예 우스코코빅 밀란
Original Assignee
프리돌린 클라우스너, 롤란드 보러
에프. 호프만-라 롯슈 아크티엔게젤샤프트
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Application filed by 프리돌린 클라우스너, 롤란드 보러, 에프. 호프만-라 롯슈 아크티엔게젤샤프트 filed Critical 프리돌린 클라우스너, 롤란드 보러
Publication of KR950032046A publication Critical patent/KR950032046A/ko
Application granted granted Critical
Publication of KR100360732B1 publication Critical patent/KR100360732B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 하기 일반식을 특징으로 할 수 있고, 여드름 또는 지루성 피부염과 같은 피지선 질환 치료용 제제로서 유용한 la-플푸오로-25-하이드록시-16-엔-23-인-콜레칼시페롤 화합물에 관한 것이다. 이는 실릴 보호된 하이드록시 그룹에 의해 상응하는 화합물로부터 실릴 보호 그룹을 제거하므로써 제조할 수 있다.

Description

불소화된 비타민 D3유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

1a-플루오로-25-하이드록시-16-엔-23-인-콜레갈시페롤의 화합물.
효과량의 1a-플루오로-25-하이드록시-16-엔-23-인-콜레칼시페롤의 및 담체 물질을 포함하는, 특히 여드름 또는 지루성 피부염과 같은 피지선 질환을 치료하기 위한 약한 조성물.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950004861A 1994-03-11 1995-03-10 불소화된비타민d3유도체 KR100360732B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/212,453 1994-03-11
US08212453 US5384314B1 (en) 1994-03-11 1994-03-11 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol

Publications (2)

Publication Number Publication Date
KR950032046A true KR950032046A (ko) 1995-12-20
KR100360732B1 KR100360732B1 (ko) 2003-03-04

Family

ID=22791087

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950004861A KR100360732B1 (ko) 1994-03-11 1995-03-10 불소화된비타민d3유도체

Country Status (22)

Country Link
US (1) US5384314B1 (ko)
EP (1) EP0671387B1 (ko)
JP (1) JP2659345B2 (ko)
KR (1) KR100360732B1 (ko)
CN (1) CN1051227C (ko)
AT (1) ATE165595T1 (ko)
AU (1) AU687972B2 (ko)
BR (1) BR9501035A (ko)
CA (1) CA2141652C (ko)
CZ (1) CZ288793B6 (ko)
DE (1) DE69502223T2 (ko)
DK (1) DK0671387T3 (ko)
ES (1) ES2116634T3 (ko)
FI (1) FI112323B (ko)
HU (1) HU219906B (ko)
IL (1) IL112887A0 (ko)
NO (1) NO307782B1 (ko)
NZ (1) NZ270624A (ko)
PH (1) PH31333A (ko)
PL (1) PL179120B1 (ko)
RU (1) RU2142803C1 (ko)
ZA (1) ZA951798B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830885A (en) * 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
US5840718A (en) * 1997-03-06 1998-11-24 Hoffmann-La Roche Inc. 22-epimeric-1,25-dihydroxy-16,22,23-triene-cholecalciferol
US6008209A (en) * 1997-04-28 1999-12-28 Hoffmann-La Roche Inc. Method of using vitamin D3 analogs with bis C-20 side chains
JPH10316652A (ja) * 1997-05-02 1998-12-02 Duphar Internatl Res Bv １６−デヒドロビタミンｄ化合物の製造方法
US5872113A (en) * 1997-05-16 1999-02-16 Syntex (U.S.A.) Inc. Fluorinated vitamin D3 analogs
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
AU3390400A (en) * 1999-03-05 2000-09-21 Johns Hopkins University, The Regulating skin appearance and composition with a fluorinated vitamin d3 analog compound
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
DE10211555A1 (de) * 2002-03-15 2003-10-02 Imtm Inst Fuer Medizintechnolo Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit sebozytärer Hyperproliferation und veränderten Differenzierungszuständen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188345A (en) * 1978-07-26 1980-02-12 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
JPS6340975A (ja) * 1986-08-05 1988-02-22 Mitsubishi Electric Corp 階調補正方式
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
GB9004544D0 (en) * 1990-03-01 1990-04-25 Leo Pharm Prod Ltd Novel treatment ii
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
ES2091515T3 (es) * 1992-05-20 1996-11-01 Hoffmann La Roche Analogos fluorados de la vitamina d3.

Also Published As

Publication number Publication date
CA2141652A1 (en) 1995-09-12
CA2141652C (en) 2006-05-09
FI951134A (fi) 1995-09-12
IL112887A0 (en) 1995-06-29
NO950920D0 (no) 1995-03-10
RU95103438A (ru) 1997-02-10
CN1051227C (zh) 2000-04-12
DE69502223D1 (de) 1998-06-04
HUT70746A (en) 1995-10-30
HU9500666D0 (en) 1995-04-28
US5384314A (en) 1995-01-24
CZ288793B6 (cs) 2001-09-12
FI951134A0 (fi) 1995-03-10
JPH07258208A (ja) 1995-10-09
EP0671387A1 (en) 1995-09-13
HU219906B (hu) 2001-09-28
NZ270624A (en) 1996-06-25
BR9501035A (pt) 1995-10-31
ATE165595T1 (de) 1998-05-15
KR100360732B1 (ko) 2003-03-04
US5384314B1 (en) 1997-08-05
ES2116634T3 (es) 1998-07-16
AU687972B2 (en) 1998-03-05
NO950920L (no) 1995-09-12
PL179120B1 (pl) 2000-07-31
CZ63295A3 (en) 1995-11-15
ZA951798B (en) 1996-08-14
PH31333A (en) 1998-07-06
EP0671387B1 (en) 1998-04-29
FI112323B (fi) 2003-11-28
PL307629A1 (en) 1995-09-18
AU1364495A (en) 1995-09-21
JP2659345B2 (ja) 1997-09-30
DK0671387T3 (da) 1998-10-07
NO307782B1 (no) 2000-05-29
RU2142803C1 (ru) 1999-12-20
DE69502223T2 (de) 1998-10-29
CN1112918A (zh) 1995-12-06

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