RU95103438A - Фторированное производное витамина d3 - Google Patents

Фторированное производное витамина d3

Info

Publication number
RU95103438A
RU95103438A RU95103438/04A RU95103438A RU95103438A RU 95103438 A RU95103438 A RU 95103438A RU 95103438/04 A RU95103438/04 A RU 95103438/04A RU 95103438 A RU95103438 A RU 95103438A RU 95103438 A RU95103438 A RU 95103438A
Authority
RU
Russia
Prior art keywords
vitamin
compound
fluorinated derivative
groups
fluoro
Prior art date
Application number
RU95103438/04A
Other languages
English (en)
Other versions
RU2142803C1 (ru
Inventor
И.Доран Томас
Us]
Шиуей Шиан-Джан
Радое Ускокович Милан
Original Assignee
Ф.Хоффманн-Ля Рош Аг (Ch)
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг (Ch), Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг (Ch)
Publication of RU95103438A publication Critical patent/RU95103438A/ru
Application granted granted Critical
Publication of RU2142803C1 publication Critical patent/RU2142803C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к 1альфа-фтор-25-гидрокси-16-ен-23-инхолекальциферолу формулы, приведенной в описании, и который используется в качестве агента для лечения заболеваний сальной железы, таких, как угревая сыпь или себорейный дерматит. Он может быть получен удалением силильных защитных групп из соответствующего соединения с защищающими гидроксилсилильными группами.

Claims (1)

  1. Изобретение относится к 1альфа-фтор-25-гидрокси-16-ен-23-инхолекальциферолу формулы, приведенной в описании, и который используется в качестве агента для лечения заболеваний сальной железы, таких, как угревая сыпь или себорейный дерматит. Он может быть получен удалением силильных защитных групп из соответствующего соединения с защищающими гидроксилсилильными группами.
RU95103438A 1994-03-11 1995-03-09 Агент для лечения заболеваний сальной железы и фармацевтическая композиция на его основе RU2142803C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08212453 US5384314B1 (en) 1994-03-11 1994-03-11 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
US212.453 1994-03-11

Publications (2)

Publication Number Publication Date
RU95103438A true RU95103438A (ru) 1997-02-10
RU2142803C1 RU2142803C1 (ru) 1999-12-20

Family

ID=22791087

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95103438A RU2142803C1 (ru) 1994-03-11 1995-03-09 Агент для лечения заболеваний сальной железы и фармацевтическая композиция на его основе

Country Status (22)

Country Link
US (1) US5384314B1 (ru)
EP (1) EP0671387B1 (ru)
JP (1) JP2659345B2 (ru)
KR (1) KR100360732B1 (ru)
CN (1) CN1051227C (ru)
AT (1) ATE165595T1 (ru)
AU (1) AU687972B2 (ru)
BR (1) BR9501035A (ru)
CA (1) CA2141652C (ru)
CZ (1) CZ288793B6 (ru)
DE (1) DE69502223T2 (ru)
DK (1) DK0671387T3 (ru)
ES (1) ES2116634T3 (ru)
FI (1) FI112323B (ru)
HU (1) HU219906B (ru)
IL (1) IL112887A0 (ru)
NO (1) NO307782B1 (ru)
NZ (1) NZ270624A (ru)
PH (1) PH31333A (ru)
PL (1) PL179120B1 (ru)
RU (1) RU2142803C1 (ru)
ZA (1) ZA951798B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830885A (en) * 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
US5840718A (en) * 1997-03-06 1998-11-24 Hoffmann-La Roche Inc. 22-epimeric-1,25-dihydroxy-16,22,23-triene-cholecalciferol
US6008209A (en) * 1997-04-28 1999-12-28 Hoffmann-La Roche Inc. Method of using vitamin D3 analogs with bis C-20 side chains
JPH10316652A (ja) * 1997-05-02 1998-12-02 Duphar Internatl Res Bv １６−デヒドロビタミンｄ化合物の製造方法
US5872113A (en) * 1997-05-16 1999-02-16 Syntex (U.S.A.) Inc. Fluorinated vitamin D3 analogs
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
WO2000051554A2 (en) * 1999-03-05 2000-09-08 Johns Hopkins University Regulating skin appearance and composition with a fluorinated vitamin d3 analog compound
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
DE10211555A1 (de) * 2002-03-15 2003-10-02 Imtm Inst Fuer Medizintechnolo Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit sebozytärer Hyperproliferation und veränderten Differenzierungszuständen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188345A (en) * 1978-07-26 1980-02-12 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
JPS6340975A (ja) * 1986-08-05 1988-02-22 Mitsubishi Electric Corp 階調補正方式
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
GB9004544D0 (en) * 1990-03-01 1990-04-25 Leo Pharm Prod Ltd Novel treatment ii
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
ATE141914T1 (de) * 1992-05-20 1996-09-15 Hoffmann La Roche Fluorierte analoge vitamins d3

Also Published As

Publication number Publication date
RU2142803C1 (ru) 1999-12-20
PH31333A (en) 1998-07-06
ATE165595T1 (de) 1998-05-15
ZA951798B (en) 1996-08-14
US5384314B1 (en) 1997-08-05
KR100360732B1 (ko) 2003-03-04
CA2141652A1 (en) 1995-09-12
BR9501035A (pt) 1995-10-31
FI951134A0 (fi) 1995-03-10
ES2116634T3 (es) 1998-07-16
PL179120B1 (pl) 2000-07-31
JPH07258208A (ja) 1995-10-09
NO950920L (no) 1995-09-12
AU687972B2 (en) 1998-03-05
DE69502223D1 (de) 1998-06-04
EP0671387A1 (en) 1995-09-13
CZ288793B6 (cs) 2001-09-12
AU1364495A (en) 1995-09-21
CN1051227C (zh) 2000-04-12
HU9500666D0 (en) 1995-04-28
US5384314A (en) 1995-01-24
DK0671387T3 (da) 1998-10-07
CA2141652C (en) 2006-05-09
JP2659345B2 (ja) 1997-09-30
FI951134A (fi) 1995-09-12
HUT70746A (en) 1995-10-30
CZ63295A3 (en) 1995-11-15
KR950032046A (ko) 1995-12-20
FI112323B (fi) 2003-11-28
IL112887A0 (en) 1995-06-29
NO950920D0 (no) 1995-03-10
EP0671387B1 (en) 1998-04-29
NO307782B1 (no) 2000-05-29
DE69502223T2 (de) 1998-10-29
HU219906B (hu) 2001-09-28
CN1112918A (zh) 1995-12-06
PL307629A1 (en) 1995-09-18
NZ270624A (en) 1996-06-25

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