CO4820396A1 - Derivados de 1,25-dihidroxi-16,22,23-trisdehidro-colecalci- ferol - Google Patents
Derivados de 1,25-dihidroxi-16,22,23-trisdehidro-colecalci- ferolInfo
- Publication number
- CO4820396A1 CO4820396A1 CO97015089A CO97015089A CO4820396A1 CO 4820396 A1 CO4820396 A1 CO 4820396A1 CO 97015089 A CO97015089 A CO 97015089A CO 97015089 A CO97015089 A CO 97015089A CO 4820396 A1 CO4820396 A1 CO 4820396A1
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- lower alkyl
- trisdehidro
- colecalci
- dihidroxi
- Prior art date
Links
- 239000011647 vitamin D3 Substances 0.000 title 1
- 229940021056 vitamin d3 Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 150000002221 fluorine Chemical class 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Liquid Crystal Substances (AREA)
Abstract
Un compuesto de fórmulaen donde R es hidroxilo y R1 es H2 ó CH2 , ó R es hidrógeno ó flúor y R1 es CH2 . Un procedimiento para la preparación de un compuesto de fórmula I, como se ha descrito en la reivindicación 1, el cual comprende la eliminación de los grupos protectores sililo de un diol o triol correspondientemente sililados, de fórmula I, siendo de preferencia los grupos sililados protectores Si (R4 , R5 R6 ), en donde R4 y R6 son alquilo inferior y R5 es alquilo inferior, arilo o aril-alquilo inferior, y la eliminación del grupo sililo protector se efectúa convenientemente mediante la reacción con una sal de flúor en un disolvente orgánico polar.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1380996P | 1996-03-21 | 1996-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4820396A1 true CO4820396A1 (es) | 1999-07-28 |
Family
ID=21761865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97015089A CO4820396A1 (es) | 1996-03-21 | 1997-03-20 | Derivados de 1,25-dihidroxi-16,22,23-trisdehidro-colecalci- ferol |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP0796843B1 (es) |
| JP (1) | JP2801587B2 (es) |
| KR (1) | KR100240541B1 (es) |
| CN (1) | CN1110477C (es) |
| AR (1) | AR006315A1 (es) |
| AT (1) | ATE240941T1 (es) |
| AU (1) | AU708679B2 (es) |
| BR (1) | BR9701404A (es) |
| CA (1) | CA2199893C (es) |
| CO (1) | CO4820396A1 (es) |
| CZ (1) | CZ85897A3 (es) |
| DE (1) | DE69722064T2 (es) |
| DK (1) | DK0796843T3 (es) |
| ES (1) | ES2198512T3 (es) |
| HR (1) | HRP970162A2 (es) |
| HU (1) | HUP9700609A3 (es) |
| ID (1) | ID16285A (es) |
| IL (1) | IL120469A0 (es) |
| MA (1) | MA26423A1 (es) |
| MX (1) | MX9702139A (es) |
| NO (1) | NO971217L (es) |
| NZ (1) | NZ314424A (es) |
| PE (1) | PE42998A1 (es) |
| PL (1) | PL319070A1 (es) |
| PT (1) | PT796843E (es) |
| SG (1) | SG70589A1 (es) |
| TR (1) | TR199700219A2 (es) |
| TW (1) | TW444001B (es) |
| YU (1) | YU10397A (es) |
| ZA (1) | ZA972302B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9625271D0 (en) * | 1996-12-04 | 1997-01-22 | Leo Pharm Prod Ltd | Chemical compounds |
| US6331642B1 (en) * | 1999-07-12 | 2001-12-18 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| KR101285720B1 (ko) * | 2012-03-02 | 2013-07-19 | 주식회사 유니크메디케어 | 여드름 개선용 조성물 |
| KR102493627B1 (ko) | 2015-11-26 | 2023-01-31 | 코웨이 주식회사 | 호르데닌을 유효성분으로 함유하는 피부암 예방 또는 치료용 약학 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA8923B (en) * | 1988-01-20 | 1989-09-27 | Hoffmann La Roche | 16-dehydro-vitamin d3-derivatives |
| DE69005897D1 (de) * | 1989-05-18 | 1994-02-24 | Hoffmann La Roche | Dehydrocholecalciferolderivate. |
-
1997
- 1997-03-06 AU AU15135/97A patent/AU708679B2/en not_active Ceased
- 1997-03-11 SG SG1997000771A patent/SG70589A1/en unknown
- 1997-03-12 PE PE1997000190A patent/PE42998A1/es not_active Application Discontinuation
- 1997-03-13 CA CA002199893A patent/CA2199893C/en not_active Expired - Fee Related
- 1997-03-13 TW TW086103109A patent/TW444001B/zh active
- 1997-03-14 DK DK97104387T patent/DK0796843T3/da active
- 1997-03-14 AT AT97104387T patent/ATE240941T1/de not_active IP Right Cessation
- 1997-03-14 DE DE69722064T patent/DE69722064T2/de not_active Expired - Fee Related
- 1997-03-14 EP EP97104387A patent/EP0796843B1/en not_active Expired - Lifetime
- 1997-03-14 ES ES97104387T patent/ES2198512T3/es not_active Expired - Lifetime
- 1997-03-14 PT PT97104387T patent/PT796843E/pt unknown
- 1997-03-17 ZA ZA9702302A patent/ZA972302B/xx unknown
- 1997-03-17 IL IL12046997A patent/IL120469A0/xx unknown
- 1997-03-17 NZ NZ314424A patent/NZ314424A/en unknown
- 1997-03-17 NO NO971217A patent/NO971217L/no not_active Application Discontinuation
- 1997-03-18 JP JP9064030A patent/JP2801587B2/ja not_active Expired - Fee Related
- 1997-03-19 HR HR60/013,809A patent/HRP970162A2/xx not_active Application Discontinuation
- 1997-03-19 YU YU10397A patent/YU10397A/sh unknown
- 1997-03-19 HU HU9700609A patent/HUP9700609A3/hu unknown
- 1997-03-19 ID IDP970894A patent/ID16285A/id unknown
- 1997-03-19 AR ARP970101091A patent/AR006315A1/es not_active Application Discontinuation
- 1997-03-20 CZ CZ97858A patent/CZ85897A3/cs unknown
- 1997-03-20 PL PL97319070A patent/PL319070A1/xx unknown
- 1997-03-20 TR TR97/00219A patent/TR199700219A2/xx unknown
- 1997-03-20 KR KR1019970009478A patent/KR100240541B1/ko not_active IP Right Cessation
- 1997-03-20 BR BR9701404A patent/BR9701404A/pt not_active IP Right Cessation
- 1997-03-20 CO CO97015089A patent/CO4820396A1/es unknown
- 1997-03-20 MX MX9702139A patent/MX9702139A/es not_active IP Right Cessation
- 1997-03-20 CN CN97103358A patent/CN1110477C/zh not_active Expired - Fee Related
- 1997-03-21 MA MA24528A patent/MA26423A1/fr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR910007525A (ko) | 양모제 | |
| KR930703317A (ko) | 이미다조[4,5-c]퀴놀린-4-아민을 제조하는 방법 | |
| ES2191005T3 (es) | Taxanos sustituidos como agentes antitumorales. | |
| ES2083438T3 (es) | Procedimiento para la preparacion de taxol utilizando una oxazinona. | |
| ES8307763A1 (es) | Un procedimiento para la preparacion de nuevas n-aril-piperazin alcanamidas. | |
| CO4700455A1 (es) | Derivados tetraciclicos y proceso para su preparacion | |
| CA2420996A1 (en) | Substituted heterocyclic compounds for treating multidrug resistance | |
| ES2051693T3 (es) | Procedimiento para preparar compuestos biciclos de sulfonamida. | |
| ES2221440T3 (es) | Derivados de acido aminofenoxiacetico como neuroprotectores. | |
| ES2101044T3 (es) | Taxanos alcoxi substituidos como agentes antitumorales. | |
| AR247415A1 (es) | Composiciones organopolisiloxanicas curables con catalizadores de estano (iv) | |
| DE69100428D1 (de) | Reduzierendes kosmetikum fuer die dauerwelle, das ein derivat der n-mercapto-alkyl-succinamsaeure oder eines n-mercapto-alkyl-succinimids enthaelt sowie dessen verwendung in einem haardauerwellverfahren. | |
| AR012032A1 (es) | Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion | |
| ATE234304T1 (de) | Zwischenprodukte zur herstellung von duocarmycin sa und dessen derivaten sowie ein verfahren zur herstellung der zwischenprodukte | |
| ATE180258T1 (de) | Verfahren zur herstellung von taxanderivaten | |
| KR950702976A (ko) | 벤조피란 및 벤족사진 유도체[benzopyran and benzoxazine derivatives] | |
| DE602004009943D1 (de) | 9,10-alpha,alpha-oh-taxananaloga und verfahren zu deren herstellung | |
| CO4820396A1 (es) | Derivados de 1,25-dihidroxi-16,22,23-trisdehidro-colecalci- ferol | |
| KR950014125A (ko) | 2,2-디플루오로케텐 실릴 아세탈 및 α,α-디플루오로-β-실릴옥시-1,3-디옥솔란-4-프로판산 에스테르의 제조방법 | |
| CA2161297A1 (fr) | Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant | |
| ES8304177A1 (es) | Un procedimiento, para la reticulacion de composiciones plastomeras, elastomeras naturales o sinteticas y resinas termo-endurecibles. | |
| HUP9802455A2 (hu) | Piperidinvegyületek alkalmazása polipropilén előállítására | |
| KR840006233A (ko) | 티오펜 유도체의 제조방법 | |
| ATE256108T1 (de) | Verfahren zur herstellung von cholecalciferol- derivaten und zwischenverbindungen | |
| ES2195815T3 (es) | Procedimiento para purificar isocianatos organicos. |