ES2101044T3 - Taxanos alcoxi substituidos como agentes antitumorales. - Google Patents

Taxanos alcoxi substituidos como agentes antitumorales.

Info

Publication number
ES2101044T3
ES2101044T3 ES92308607T ES92308607T ES2101044T3 ES 2101044 T3 ES2101044 T3 ES 2101044T3 ES 92308607 T ES92308607 T ES 92308607T ES 92308607 T ES92308607 T ES 92308607T ES 2101044 T3 ES2101044 T3 ES 2101044T3
Authority
ES
Spain
Prior art keywords
substituted
alcoxy
taxanes
antitumoral agents
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92308607T
Other languages
English (en)
Inventor
Robert A Holton
Ronald J Biediger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University filed Critical Florida State University
Application granted granted Critical
Publication of ES2101044T3 publication Critical patent/ES2101044T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic System without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

UN DERIVADO DEL TAXANO DE LA FORMULA EN DONDE R1 ES FENILO O FENILO SUSTITUIDO, R3 ES CH30HIDROGENO, UN GRUPO PROTECTOR HIDROXILO O -COT2, T2 ES H, ALKILO C1-C6, ALQUENILO C1-C6, ALKINILO C1-C6 O ARILO MONOCICLICO, AC ES ACETILO Y E1 Y E2 SE SELECCIONAN INDEPENDIENTEMENTE DEL HIDROGENO Y DE GRUPOS FUNCIONALES QUE AUMENTAN LA SOLUBILIDAD EN AGUA DEL DERIVADO DE TAXANO Y SON UTILES COMO AGENTES ANTITUMORES.
ES92308607T 1991-09-23 1992-09-22 Taxanos alcoxi substituidos como agentes antitumorales. Expired - Lifetime ES2101044T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US07/863,198 US5243045A (en) 1991-09-23 1992-04-03 Certain alkoxy substituted taxanes and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES2101044T3 true ES2101044T3 (es) 1997-07-01

Family

ID=27117341

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92308607T Expired - Lifetime ES2101044T3 (es) 1991-09-23 1992-09-22 Taxanos alcoxi substituidos como agentes antitumorales.

Country Status (15)

Country Link
US (1) US5243045A (es)
EP (1) EP0534707B1 (es)
JP (1) JP3217155B2 (es)
AT (1) ATE146464T1 (es)
AU (1) AU653247B2 (es)
CA (1) CA2077598C (es)
DE (1) DE69216028T2 (es)
DK (1) DK0534707T3 (es)
ES (1) ES2101044T3 (es)
FI (1) FI112478B (es)
GR (1) GR3022853T3 (es)
HU (1) HU218283B (es)
MX (1) MX9205310A (es)
NO (1) NO303633B1 (es)
NZ (1) NZ244456A (es)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
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US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
ZA926828B (en) * 1991-09-23 1993-03-15 Univ Florida State Novel alkoxy substituted taxanes and pharmaceutical compositions containing them.
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
DK1001036T3 (da) * 1992-01-15 2004-11-29 Squibb & Sons Inc Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fremstillingen af taxaner
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5445809A (en) * 1992-03-03 1995-08-29 Research And Development Institute At Montana State University Production of taxol from the yew tree
US5451392A (en) * 1992-03-03 1995-09-19 The Research And Development Institute At Montana State University Production of taxol
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
FR2696461B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent.
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
AU682173B2 (en) * 1993-01-15 1997-09-25 Florida State University Process for the preparation of 10-desacetoxybaccatin III
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State History of C-10 Texan and pharmaceuticals containing them
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
ATE232854T1 (de) * 1993-03-05 2003-03-15 Univ Florida State Verfahren zur herstellung von 9-desoxotaxanen
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
PT1227093E (pt) * 1993-03-22 2005-09-30 Univ Florida State Beta-cactamas uteis para a preparacao de taxanos possuindo cadeia lateral substituida com furilo ou tienilo
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
EP0927175A4 (en) 1996-05-06 2002-05-22 Univ Florida State 1-DEOXYBACCATIN III, 1-DEOXYTAXOL AND 1-DEOXYTAXOL ANALOG AND METHOD FOR THE PRODUCTION THEREOF
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
JPH1192468A (ja) * 1997-09-17 1999-04-06 Yakult Honsha Co Ltd 新規なタキサン誘導体
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6136988A (en) 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
KR100603877B1 (ko) 1999-05-28 2006-07-25 브리스톨-마이어즈 스퀴브 컴페니 디알킬디클로로실란을 사용한 파클리탁셀의 반합성
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
KR20010111580A (ko) * 2000-02-02 2001-12-19 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 개선된 용해도를 갖는 탁산 제형물
BR0104351A (pt) 2000-02-02 2002-01-02 Univ Florida State Res Found Taxanos substituìdos com carbonato c7 como agentes antitumor
CZ20013430A3 (cs) * 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxany substituované v poloze C10 esterovou skupinou
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
KR20010112393A (ko) * 2000-02-02 2001-12-20 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서 ｃ７ 헤테로치환된 아세테이트 탁산
JP2003521545A (ja) * 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 改良された溶解性を有するタキサン製剤
EP1165551B1 (en) * 2000-02-02 2008-07-16 Florida State University Research Foundation, Inc. C10 carbamoyloxy substituted taxanes as antitumor agents
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
JP2003522171A (ja) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン
HUP0200752A3 (en) 2000-02-02 2005-02-28 Univ Florida State Res Found C7 carbamoyloxy substituted taxanes as antitumor agents
DE60131927D1 (de) * 2000-02-02 2008-01-31 Univ Florida State Res Found Heterosubstituierte taxan-c10-acetate als antitumormittel
US6638742B1 (en) 2000-07-07 2003-10-28 University Of Portland Methods for obtaining taxanes
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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
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US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NZ244456A (en) 1995-04-27
JPH05239044A (ja) 1993-09-17
ATE146464T1 (de) 1997-01-15
EP0534707B1 (en) 1996-12-18
AU653247B2 (en) 1994-09-22
NO923678L (no) 1993-03-24
DK0534707T3 (da) 1997-06-09
CA2077598A1 (en) 1993-03-24
CA2077598C (en) 1997-11-25
AU2212392A (en) 1993-03-25
NO923678D0 (no) 1992-09-22
DE69216028T2 (de) 1997-07-03
GR3022853T3 (en) 1997-06-30
FI924227A0 (fi) 1992-09-21
HU218283B (en) 2000-07-28
HUT62873A (en) 1993-06-28
FI924227A (fi) 1993-03-24
DE69216028D1 (de) 1997-01-30
HU9203016D0 (en) 1992-12-28
MX9205310A (es) 1993-07-01
NO303633B1 (no) 1998-08-10
US5243045A (en) 1993-09-07
FI112478B (fi) 2003-12-15
EP0534707A1 (en) 1993-03-31
JP3217155B2 (ja) 2001-10-09

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