PE20061090A1 - Preparaciones de taxanos sustituidos con esteres de ciclopropilo en c10 - Google Patents

Preparaciones de taxanos sustituidos con esteres de ciclopropilo en c10

Info

Publication number
PE20061090A1
PE20061090A1 PE2006000162A PE2006000162A PE20061090A1 PE 20061090 A1 PE20061090 A1 PE 20061090A1 PE 2006000162 A PE2006000162 A PE 2006000162A PE 2006000162 A PE2006000162 A PE 2006000162A PE 20061090 A1 PE20061090 A1 PE 20061090A1
Authority
PE
Peru
Prior art keywords
taxans
preparations
substituted
cyclopropyl
refers
Prior art date
Application number
PE2006000162A
Other languages
English (en)
Inventor
Robert A Holton
Ross E Longley
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of PE20061090A1 publication Critical patent/PE20061090A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE REFIERE A UN COMPUESTO DERIVADO DE TAXANO DE FORMULA (I) (3102), EL CUAL PRESENTA LOS SUSTITUYENTES: CICLOPROPILO EN C10, CETO EN C9, HIDROXILO EN C7, 2-FURANIL EN C3', Y ISOBUTOXICARBAMATO EN C3'. ESTE COMPUESTO ES UN AGENTE QUIMIOTERAPEUTICO QUE PRESENTA MENOR TOXICIDAD Y MAYOR EFICACIA CON RESPECTO A LOS TUMORES RESISTENTES Y NO RESISTENTES AL TAXOL (PACLITAXEL) Y/O DOCETAXEL. TAMBIEN SE REFIERE A UN PROCESO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA, DE ADMINISTRACION ORAL O PARENTERAL
PE2006000162A 2005-02-14 2006-02-13 Preparaciones de taxanos sustituidos con esteres de ciclopropilo en c10 PE20061090A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65283405P 2005-02-14 2005-02-14

Publications (1)

Publication Number Publication Date
PE20061090A1 true PE20061090A1 (es) 2006-10-12

Family

ID=36916949

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000162A PE20061090A1 (es) 2005-02-14 2006-02-13 Preparaciones de taxanos sustituidos con esteres de ciclopropilo en c10

Country Status (14)

Country Link
US (1) US20060189679A1 (es)
EP (1) EP1848423A4 (es)
JP (1) JP2008530122A (es)
AR (1) AR053543A1 (es)
AU (1) AU2006214498A1 (es)
CA (1) CA2597682A1 (es)
GT (1) GT200600066A (es)
IL (1) IL185227A0 (es)
MX (1) MX2007009748A (es)
PE (1) PE20061090A1 (es)
SV (1) SV2007002412A (es)
TW (1) TW200640447A (es)
WO (1) WO2006088767A2 (es)
ZA (1) ZA200706712B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SV2006002010A (es) 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
KR20100023862A (ko) * 2007-06-22 2010-03-04 싸이도우스 엘엘씨. 트윈 80을 함유하지 않은 도세탁셀의 용해 제제
US9180088B2 (en) 2008-03-07 2015-11-10 Scidose, Llc Fulvestrant formulations
US8242166B2 (en) 2008-03-31 2012-08-14 Florida State University Research Foundation, Inc. C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes
US7772274B1 (en) 2009-10-19 2010-08-10 Scidose, Llc Docetaxel formulations with lipoic acid
US20110092579A1 (en) * 2009-10-19 2011-04-21 Scidose Llc Solubilized formulation of docetaxel
US8912228B2 (en) 2009-10-19 2014-12-16 Scidose Llc Docetaxel formulations with lipoic acid
US8541465B2 (en) * 2009-10-19 2013-09-24 Scidose, Llc Docetaxel formulations with lipoic acid and/or dihydrolipoic acid
US11179468B2 (en) 2012-04-09 2021-11-23 Eagle Pharmaceuticals, Inc. Fulvestrant formulations
US9775881B2 (en) * 2013-05-23 2017-10-03 Five Prime Therapeutics, Inc. Methods of treating mesothelioma by administration of compounds comprising FGFR1 ECD

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5714512A (en) * 1991-07-08 1998-02-03 Rhone-Poulenc Rorer, S.A. Compositions containing taxane derivatives
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) * 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5350866A (en) * 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5274124A (en) * 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US6521660B2 (en) * 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
DE69333675T2 (de) * 1992-01-15 2006-02-02 E.R. Squibb & Sons, Inc. Enzymatische Verfahren zur Trennung von Enantiomerengemischen von Verbindungen, die als Zwischenprodukte zur Herstellung von Taxanen nützlich sind
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
ATE249448T1 (de) * 1993-06-11 2003-09-15 Upjohn Co Delta 6,7-taxol derivate antineoplastische verbindungen und diese enthaltende pharmazeutische zusammenstellungen
TW397866B (en) * 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
ES2126919T3 (es) * 1994-07-26 1999-04-01 Indena Spa Taxanos semisinteticos con actividad antitumoral.
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
FR2732342B1 (fr) * 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732968B1 (fr) * 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5780653A (en) * 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
US5767297A (en) * 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
EP0930309A4 (en) * 1996-07-15 2001-09-26 Yakult Honsha Kk TAXANE DERIVATIVES AND MEDICINES CONTAINING THEM
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
JPH1192468A (ja) * 1997-09-17 1999-04-06 Yakult Honsha Co Ltd 新規なタキサン誘導体
WO1999032473A1 (fr) * 1997-12-19 1999-07-01 Kabushiki Kaisha Yakult Honsha Derives de taxane
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
RU2265019C2 (ru) * 2000-02-02 2005-11-27 Флорида Стейт Юниверсити Рисерч Фаундейшн, Инк. Таксаны, фармацевтические композиции, способы ингибирования
EP1165553B1 (en) * 2000-02-02 2009-06-03 Florida State University Research Foundation, Inc. C10 ester substituted taxanes as antitumor agents
JP2003522171A (ja) * 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes

Also Published As

Publication number Publication date
AU2006214498A1 (en) 2006-08-24
ZA200706712B (en) 2008-06-25
JP2008530122A (ja) 2008-08-07
EP1848423A2 (en) 2007-10-31
WO2006088767A3 (en) 2007-11-29
EP1848423A4 (en) 2008-12-31
MX2007009748A (es) 2007-09-26
TW200640447A (en) 2006-12-01
GT200600066A (es) 2006-12-26
CA2597682A1 (en) 2006-08-24
WO2006088767A2 (en) 2006-08-24
US20060189679A1 (en) 2006-08-24
SV2007002412A (es) 2007-11-06
AR053543A1 (es) 2007-05-09
IL185227A0 (en) 2008-06-05

Similar Documents

Publication Publication Date Title
PE20061090A1 (es) Preparaciones de taxanos sustituidos con esteres de ciclopropilo en c10
WO2007069272A3 (en) Pharmaceutical composition comprising at least one anticancer drug and at least one polymer
CL2023000767A1 (es) Métodos para reducir el riesgo de eventos cardiovasculares en un sujeto.
AR053162A1 (es) Compuesto 5 - oxo - pirrolidin sustituido, composicion farmaceutica que lo comprende y su uso para preparar un medicamento para el tratamiento del glaucoma.
CY1116688T1 (el) Τροποποιητες φαρμακοκινητικων ιδιοτητων θεραπευτικων ειδων
WO2007117706A3 (en) Solid oral dosage form containing an enhancer
PE20070945A1 (es) Una formulacion farmaceutica de taxano, una composicion solida de taxano, un procedimiento para la preparacion de dicha composicion solida de taxano, una composicion solubilizante de dicha composicion solida de taxano, y un conjunto de elementos (kit
JP2013503174A5 (es)
WO2005115470A3 (fr) COMPOSITIONS PHARMACEUTIQUES CONTENANT DES DERIVES DE β-­CARBOLINE, ET LEUR UTILISATION POUR LE TRAITEMENT DES CANCERS
DK1819227T3 (da) Farmaceutisk formulering af decitabin
CU20080010A7 (es) Inhibidores macrocíclicos de la replicación del virus de la hepatitis c
WO2008105852A3 (en) Mucoadhesive nanoparticles for cancer treatment
AR074632A1 (es) Compuesto de amidofenoxiindazol, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util en el tratamiento de cancer
NZ588913A (en) Liver cancer drug
CL2008003002A1 (es) Composición farmacéutica inyectable intravenosa en forma de emulsión aceite en agua que comprende al toxoide larotaxel (xrp9881) o cabazitaxel (xrp6258) disuelto en lecitina, y al tensioactivo aniónico fosfatidilglicerol o acido fosfatidico; proeceidimiento para su preparacion, útil como antineoplástico.
CO6400138A2 (es) Compuesto anticancerígeno y composición farmacéutica que lo contiene
WO2008067039A3 (en) Colchicine neoglycosides and methods for their synthesis and use
RU2010140611A (ru) Комбинированное применение производных холестанола
ATE241376T1 (de) Zusammensetzungen, die dolastatin-15-analoge in kombination mit taxane und dessen derivaten enthalten
DE602005023437D1 (de) Als inhibitor von retroviraler protease geeignete ritonavir-analoge verbindung, herstellung der ritonavir-analogen verbindung und pharmazeutische zusammenetzung für die ritonavir-analoge verbindung
UY27220A1 (es) Combinación de un taxano con una quinasa ciclina-dependiente
WO2011151786A3 (en) Injectable formulation of a reverse transcriptase inhibitor for the treatment cancer
WO2010138010A8 (en) Solvates of docetaxel
Lee et al. Anti-tumor activity of paclitaxel prodrug conjugated with polyethylene glycol
GT200100184A (es) Amidas de acido fenilciclohexanocarboxilico sustituido y su uso.

Legal Events

Date Code Title Description
FC Refusal