ES2182770T3 - "n-(pieridin-4-il)-4h-3,1 benzo(tia/oxa)zinas-2-aminas substituidas, su preparacion y su aplicacion en terapeutica. - Google Patents

"n-(pieridin-4-il)-4h-3,1 benzo(tia/oxa)zinas-2-aminas substituidas, su preparacion y su aplicacion en terapeutica.

Info

Publication number
ES2182770T3
ES2182770T3 ES00900639T ES00900639T ES2182770T3 ES 2182770 T3 ES2182770 T3 ES 2182770T3 ES 00900639 T ES00900639 T ES 00900639T ES 00900639 T ES00900639 T ES 00900639T ES 2182770 T3 ES2182770 T3 ES 2182770T3
Authority
ES
Spain
Prior art keywords
carbon atoms
branched
oxa
benzo
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00900639T
Other languages
English (en)
Inventor
Jean-Pierre Rieu
Jean-Francois Patoiseau
Gareth John
Bruno Legrand
Yvan Verscheure
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Application granted granted Critical
Publication of ES2182770T3 publication Critical patent/ES2182770T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

N - alcoil - N - [1 - {w - (arilalcoiloxi)alcoil)piperidin - 4 - il] - 4H - 3, 1 - benzo(tia/oxa)cínas - 2 aminas sustituidas de fórmula I: **(Ver fórmula I)** en la cual: - X representa un átomo de oxígeno o de azufre - Y representa o bien: un radical alcoileno, ramificado o que contiene de 2 a 6 átomos de carbono, un radical -CH2-CH(OH)-CH2- - R representa; un hidrógeno, un radical alcoilo saturado o no, ramificado o no que comporta de 1 a 7 átomos de carbono, - R1 a R6 iguales o diferentes representan: un hidrógeno, un alcoilo ramificado o no, saturado o no que contiene de 1 a 5 átomos de carbono, un alcoiloxi ramificado o no, saturado o no que contiene de 1 a 5 átomos de carbono, un grupo halógeno, un grupo nitro, un grupo hidroxi, un grupo acilo o aciloxi que comprende de 2 a 3 átomos de carbono, un grupo dialcoilamino que contiene de 1 a 5 átomos de carbono, un grupo trifluorometilo o trifluorometóxilo. - n es un número entero que puede variar de 1 a 6 ambos inclusive, así como sus enantiómeros puros y sus mezclas, y las sales minerales u orgánicas terapéuticamente aceptables de los compuestos de fórmula I y sus eventuales hidratos.
ES00900639T 1999-01-22 2000-01-21 "n-(pieridin-4-il)-4h-3,1 benzo(tia/oxa)zinas-2-aminas substituidas, su preparacion y su aplicacion en terapeutica. Expired - Lifetime ES2182770T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9900706A FR2788775B1 (fr) 1999-01-22 1999-01-22 Nouvelles n-alcoyl-n-[1-(omega-(arylalcoyloxy)alcoyl] piperidin-4-yl]-4h-3,1-benzo(thia/oxa)zines-2-amines substituees, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES2182770T3 true ES2182770T3 (es) 2003-03-16

Family

ID=9541133

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00900639T Expired - Lifetime ES2182770T3 (es) 1999-01-22 2000-01-21 "n-(pieridin-4-il)-4h-3,1 benzo(tia/oxa)zinas-2-aminas substituidas, su preparacion y su aplicacion en terapeutica.

Country Status (15)

Country Link
US (1) US6531469B1 (es)
EP (1) EP1144408B1 (es)
JP (1) JP2002535329A (es)
CN (1) CN1129599C (es)
AT (1) ATE224892T1 (es)
AU (1) AU767132B2 (es)
BR (1) BR0007674A (es)
CA (1) CA2359103A1 (es)
DE (1) DE60000500T2 (es)
DK (1) DK1144408T3 (es)
ES (1) ES2182770T3 (es)
FR (1) FR2788775B1 (es)
PT (1) PT1144408E (es)
WO (1) WO2000043391A1 (es)
ZA (1) ZA200105921B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0436585A4 (en) * 1988-09-29 1992-01-02 Meheco Proprietary Limited Meat preservation
EP0982300A3 (en) * 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
FR2821356A1 (fr) 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
FR3001151B1 (fr) 2013-01-21 2016-04-08 Pf Medicament Association d'un bloqueur de courant sodique lent et d'un inhibiteur du courant if sinusal et les compositions pharmarceutiques la contenant
MY186048A (en) 2013-03-14 2021-06-17 Cytokinetics Inc Heterocyclic compounds and their uses
CN114349745B (zh) * 2022-01-14 2023-12-08 黑龙江中医药大学 一种用于治疗心肌缺血的药物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2737207B1 (fr) * 1995-07-26 1997-10-17 Pf Medicament Nouvelles n-heterocyclyl-1-aryloxyalcoyl-4-piperidinamines substituees, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
EP1144408B1 (fr) 2002-09-25
JP2002535329A (ja) 2002-10-22
CN1129599C (zh) 2003-12-03
CN1344267A (zh) 2002-04-10
DK1144408T3 (da) 2003-02-03
CA2359103A1 (fr) 2000-07-27
FR2788775A1 (fr) 2000-07-28
WO2000043391A1 (fr) 2000-07-27
AU3058100A (en) 2000-08-07
DE60000500D1 (de) 2002-10-31
ATE224892T1 (de) 2002-10-15
BR0007674A (pt) 2001-11-20
ZA200105921B (en) 2002-05-08
DE60000500T2 (de) 2003-07-31
EP1144408A1 (fr) 2001-10-17
FR2788775B1 (fr) 2001-04-13
US6531469B1 (en) 2003-03-11
AU767132B2 (en) 2003-10-30
PT1144408E (pt) 2003-02-28

Similar Documents

Publication Publication Date Title
DE60015927D1 (en) Phenylharnstoff und phenylthioharnstoffderivate
PT870768E (pt) Derivados azaindole-etilamina como agentes de ligacao nicotinicos aos receptores de acetilcolina
MXPA05003193A (es) Compuesto de adenina novedoso y uso del mismo.
PE20010126A1 (es) Pirrolotriazinas como inhibidores de cinasas
NO941210L (no) Benzo- og pyrido-pyridazinonforbindelser og -pyridazintionforbindelser
HRP20000445B1 (en) Aryl fused azapolycyclic compounds
YU48855B (sh) Heterociklična jedinjenja i njihovi derivati koji su modifikatori dejstva 5-hidroksi-triptamina i postupak njihovog dobijanja
PT1161428E (pt) Compostos de pirimidina
PE20001601A1 (es) Derivados de pirimidina como inhibidores de la sorbitol deshidrogenasa
MXPA00006605A (es) Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
BR9509629A (pt) Derivados de aminotetrazol úteis como inibidores de óxido nítrico sintase
ES2182770T3 (es) "n-(pieridin-4-il)-4h-3,1 benzo(tia/oxa)zinas-2-aminas substituidas, su preparacion y su aplicacion en terapeutica.
IL110831A0 (en) Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
IL66835A0 (en) Triazoloquinazolone derivatives and their salts,their preparation,their use as medicaments and the compositions containing them
FR2788771B1 (fr) Nouvelles 1,2-alcoyl-1-[1-[aryl (alcoyl) oxyalcoyl] piperidin-4-yl]-3-aryl isothiourees substituees, leur preparation et leur application en therapeutique
SE9701912D0 (sv) Pharmaceutical composition and use thereof
MX9601163A (es) Nuevos compuestos derivados de cromeno.
DE69124017D1 (de) Heterocyclische Derivate
DE60004669D1 (de) Indolocarbazolalkaloide aus einer marinen actinomycete
ATE120188T1 (de) 15-deoxyprostaglandinderivat.
DE69107851T2 (de) Phenolische thioetheramide als 5-lipoxygenase-inhibitoren.
AR029004A1 (es) Compuesto del acido 7-acilamino-3-heteroariltio-3-cefem carboxilico y su uso para la preparacion de una composicion antibacteriana
TW353071B (en) Chromene compounds with neutroleptic activity, their preparation and pharmaceutical compositions
SE7607515L (sv) Kinolinkarbonsyraderivat och sett att framstella desamma
ECSP972346A (es) Cefalosporinas de vinil - pirrolidinonas con sustituyentes basicos