AR029004A1 - Compuesto del acido 7-acilamino-3-heteroariltio-3-cefem carboxilico y su uso para la preparacion de una composicion antibacteriana - Google Patents
Compuesto del acido 7-acilamino-3-heteroariltio-3-cefem carboxilico y su uso para la preparacion de una composicion antibacterianaInfo
- Publication number
- AR029004A1 AR029004A1 ARP000104904A ARP000104904A AR029004A1 AR 029004 A1 AR029004 A1 AR 029004A1 AR P000104904 A ARP000104904 A AR P000104904A AR P000104904 A ARP000104904 A AR P000104904A AR 029004 A1 AR029004 A1 AR 029004A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- antibacterial composition
- group
- heteroariltio
- ceboem
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229960003085 meticillin Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto del ácido 7-acilamino-3-heteroariltio-3-cefem carboxílico que posee la formula química: 1 o una sal farmacéuticamente aceptable del mismo, en donde: R'1 se selecciona del grupo que consiste de hidrogeno y ûC (O) CH (NH2) CH3; R'2 es hidrogeno o un grupo acilo que es dividido por una enzima encontrada en los mamíferos, B o L es nitrogeno y el otro es carbono; y, Q es seleccionado del grupo que consiste de nitrogeno y ûCX, en donde X se selecciona del grupo que consiste de hidrogeno y cloro. Uso de un compuesto del ácido 7-acilamino-3-heteroariltio-3-cefem carboxílico o sal del mismo para la preparacion de una composicion antibacteriana para tratar un mamífero que padece una infeccion bacteriana causada por Staphylococco resistente a la meticilina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15549699P | 1999-09-22 | 1999-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029004A1 true AR029004A1 (es) | 2003-06-04 |
Family
ID=22555673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000104904A AR029004A1 (es) | 1999-09-22 | 2000-09-19 | Compuesto del acido 7-acilamino-3-heteroariltio-3-cefem carboxilico y su uso para la preparacion de una composicion antibacteriana |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1222194B1 (es) |
| JP (1) | JP2003509512A (es) |
| KR (1) | KR20020068508A (es) |
| CN (1) | CN1206231C (es) |
| AR (1) | AR029004A1 (es) |
| AT (1) | ATE297934T1 (es) |
| AU (1) | AU784077B2 (es) |
| BR (1) | BR0014230A (es) |
| CA (1) | CA2385479A1 (es) |
| CZ (1) | CZ2002993A3 (es) |
| DE (1) | DE60020862D1 (es) |
| HK (1) | HK1048121B (es) |
| HU (1) | HUP0202663A3 (es) |
| IL (2) | IL148669A0 (es) |
| MX (1) | MXPA02003024A (es) |
| MY (1) | MY136038A (es) |
| NO (1) | NO20021416L (es) |
| NZ (1) | NZ517761A (es) |
| PL (1) | PL354919A1 (es) |
| RU (1) | RU2225868C2 (es) |
| SK (1) | SK4122002A3 (es) |
| TW (1) | TWI283682B (es) |
| WO (1) | WO2001021623A1 (es) |
| ZA (1) | ZA200202065B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6534656B2 (en) | 2001-05-31 | 2003-03-18 | North Carolina State University | Short synthesis of pyridine-based pharmaceutical intermediates |
| ATE449775T1 (de) * | 2003-04-30 | 2009-12-15 | Trine Pharmaceuticals Inc | Carbacephem beta-lactam-antibiotika |
| CN111187281B (zh) * | 2020-02-11 | 2023-03-14 | 广西科技大学 | 含胍基的头孢菌素衍生物及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA18891A1 (fr) * | 1979-07-05 | 1981-04-01 | Ciba Geigy Ag | Composes d'amino-thiadiazolyle,procede pour leur preparation |
| EP0025017A1 (de) * | 1979-08-28 | 1981-03-11 | Ciba-Geigy Ag | Polyazathiaverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend solche Verbindungen und Verwendung von letzteren |
| WO1992005156A1 (en) * | 1990-09-13 | 1992-04-02 | Smithkline Beecham Corporation | Pyridylthio or pyridyloxy alkanoic acids |
| NZ284212A (en) * | 1994-04-01 | 1997-11-24 | Microcide Pharmaceuticals Inc | Cephalosporin antibiotics; antibacterial medicament |
| US5498777A (en) * | 1994-07-20 | 1996-03-12 | Merck & Co., Inc. | 3-thioheteroaryl cephalosporin compounds, compositions and methods of use |
| WO1996038450A1 (en) * | 1995-05-31 | 1996-12-05 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
| MY127641A (en) * | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
| JP4174093B2 (ja) * | 1998-01-09 | 2008-10-29 | 富士フイルムファインケミカルズ株式会社 | トリアゾール誘導体ハロゲン化合物の製造方法 |
| WO1999058535A1 (en) * | 1998-05-13 | 1999-11-18 | Lg Chemical Ltd. | Novel cephalosporin compounds, processes for preparation thereof and antimicrobial compositions containing the same |
-
2000
- 2000-09-19 AR ARP000104904A patent/AR029004A1/es not_active Application Discontinuation
- 2000-09-21 AU AU77095/00A patent/AU784077B2/en not_active Ceased
- 2000-09-21 CZ CZ2002993A patent/CZ2002993A3/cs unknown
- 2000-09-21 MX MXPA02003024A patent/MXPA02003024A/es active IP Right Grant
- 2000-09-21 CA CA002385479A patent/CA2385479A1/en not_active Abandoned
- 2000-09-21 CN CNB008157464A patent/CN1206231C/zh not_active Expired - Fee Related
- 2000-09-21 AT AT00966807T patent/ATE297934T1/de not_active IP Right Cessation
- 2000-09-21 IL IL14866900A patent/IL148669A0/xx active IP Right Grant
- 2000-09-21 PL PL00354919A patent/PL354919A1/xx not_active Application Discontinuation
- 2000-09-21 RU RU2002110444/04A patent/RU2225868C2/ru not_active IP Right Cessation
- 2000-09-21 WO PCT/US2000/026069 patent/WO2001021623A1/en active IP Right Grant
- 2000-09-21 MY MYPI20004413A patent/MY136038A/en unknown
- 2000-09-21 EP EP00966807A patent/EP1222194B1/en not_active Expired - Lifetime
- 2000-09-21 BR BR0014230-1A patent/BR0014230A/pt not_active IP Right Cessation
- 2000-09-21 HU HU0202663A patent/HUP0202663A3/hu unknown
- 2000-09-21 NZ NZ517761A patent/NZ517761A/en unknown
- 2000-09-21 KR KR1020027003755A patent/KR20020068508A/ko not_active Application Discontinuation
- 2000-09-21 JP JP2001524998A patent/JP2003509512A/ja active Pending
- 2000-09-21 DE DE60020862T patent/DE60020862D1/de not_active Expired - Lifetime
- 2000-09-21 SK SK412-2002A patent/SK4122002A3/sk unknown
-
2001
- 2001-03-19 TW TW089119608A patent/TWI283682B/zh not_active IP Right Cessation
-
2002
- 2002-03-13 ZA ZA200202065A patent/ZA200202065B/en unknown
- 2002-03-13 IL IL148669A patent/IL148669A/en not_active IP Right Cessation
- 2002-03-21 NO NO20021416A patent/NO20021416L/no not_active Application Discontinuation
-
2003
- 2003-01-14 HK HK03100320.8A patent/HK1048121B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20021416D0 (no) | 2002-03-21 |
| TWI283682B (en) | 2007-07-11 |
| PL354919A1 (en) | 2004-03-22 |
| EP1222194A1 (en) | 2002-07-17 |
| ATE297934T1 (de) | 2005-07-15 |
| HK1048121B (zh) | 2005-11-04 |
| ZA200202065B (en) | 2007-11-28 |
| HUP0202663A3 (en) | 2003-10-28 |
| MXPA02003024A (es) | 2003-09-25 |
| IL148669A (en) | 2006-04-10 |
| IL148669A0 (en) | 2002-09-12 |
| EP1222194B1 (en) | 2005-06-15 |
| JP2003509512A (ja) | 2003-03-11 |
| RU2225868C2 (ru) | 2004-03-20 |
| CZ2002993A3 (cs) | 2002-07-17 |
| CN1451011A (zh) | 2003-10-22 |
| WO2001021623A1 (en) | 2001-03-29 |
| NZ517761A (en) | 2003-10-31 |
| BR0014230A (pt) | 2002-05-21 |
| HUP0202663A2 (hu) | 2002-12-28 |
| CA2385479A1 (en) | 2001-03-29 |
| MY136038A (en) | 2008-08-29 |
| AU784077B2 (en) | 2006-02-02 |
| NO20021416L (no) | 2002-05-22 |
| HK1048121A1 (en) | 2003-03-21 |
| CN1206231C (zh) | 2005-06-15 |
| AU7709500A (en) | 2001-04-24 |
| KR20020068508A (ko) | 2002-08-27 |
| DE60020862D1 (de) | 2005-07-21 |
| SK4122002A3 (en) | 2003-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |