DE602004009943D1 - 9,10-alpha,alpha-oh-taxananaloga und verfahren zu deren herstellung - Google Patents
9,10-alpha,alpha-oh-taxananaloga und verfahren zu deren herstellungInfo
- Publication number
- DE602004009943D1 DE602004009943D1 DE602004009943T DE602004009943T DE602004009943D1 DE 602004009943 D1 DE602004009943 D1 DE 602004009943D1 DE 602004009943 T DE602004009943 T DE 602004009943T DE 602004009943 T DE602004009943 T DE 602004009943T DE 602004009943 D1 DE602004009943 D1 DE 602004009943D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- hydroxyl
- alpha
- present
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50668003P | 2003-09-25 | 2003-09-25 | |
| US506680P | 2003-09-25 | ||
| PCT/US2004/031816 WO2005030150A2 (en) | 2003-09-25 | 2004-09-27 | 9,10-α,α-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004009943D1 true DE602004009943D1 (de) | 2007-12-20 |
| DE602004009943T2 DE602004009943T2 (de) | 2008-08-28 |
Family
ID=34393186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004009943T Expired - Fee Related DE602004009943T2 (de) | 2003-09-25 | 2004-09-27 | 9,10-alpha,alpha-oh-taxananaloga und verfahren zu deren herstellung |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US7745650B2 (de) |
| EP (2) | EP1664033B1 (de) |
| JP (5) | JP4874102B2 (de) |
| CN (1) | CN1886400A (de) |
| AT (1) | ATE377593T1 (de) |
| AU (1) | AU2004275881A1 (de) |
| CA (1) | CA2539975C (de) |
| DE (1) | DE602004009943T2 (de) |
| DK (1) | DK1664033T3 (de) |
| ES (1) | ES2295937T3 (de) |
| HR (1) | HRP20080057T3 (de) |
| PL (1) | PL1664033T3 (de) |
| PT (1) | PT1664033E (de) |
| WO (1) | WO2005030150A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1664033B1 (de) | 2003-09-25 | 2007-11-07 | Tapestry Pharmaceuticals, Inc. | 9,10-alpha,alpha-oh-taxananaloga und verfahren zu deren herstellung |
| CN101535492A (zh) | 2005-02-11 | 2009-09-16 | 南加州大学 | 表达含有二硫键的蛋白质的方法 |
| AU2006331674A1 (en) * | 2005-12-21 | 2007-07-05 | Tapestry Pharmaceuticals, Inc. | Processes for taxane derivatives and intermediates useful therein |
| WO2007073383A1 (en) * | 2005-12-21 | 2007-06-28 | Tapestry Pharmaceuticals, Inc. | Novel compounds and methods for forming taxanes and using the same |
| US20070225510A1 (en) * | 2006-03-27 | 2007-09-27 | Henri John T | Convergent Process for the Synthesis of Taxane Derivatives |
| WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
| WO2007143839A1 (en) * | 2006-06-12 | 2007-12-21 | 6570763 Canada Inc. | Semi-synthetic route for the preparation of paclitaxel, docetaxel and 10-deacetylbaccatin iii from 9-dihydro-13-acetylbaccatin iii |
| US7847111B2 (en) | 2006-06-19 | 2010-12-07 | Canada Inc. | Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008121476A1 (en) * | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20080207743A1 (en) * | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
| WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| US9227983B2 (en) | 2011-04-07 | 2016-01-05 | Arbor Therapeutics, LLC | Taxane and abeo-taxane analogs |
| AU2012364858A1 (en) * | 2011-04-07 | 2013-11-21 | Arbor Therapeutics, LLC | Taxane and abeo-taxane analogs |
| JP5621071B2 (ja) * | 2011-06-06 | 2014-11-05 | アーバー・セラピューティクス・リミテッド・ライアビリティ・カンパニーＡｒｂｏｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，ＬＬＣ | 癌化学療法薬の酸に不安定で親油性のプロドラッグ |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| US6794523B2 (en) | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
| WO1993021173A1 (en) * | 1992-04-17 | 1993-10-28 | Abbott Laboratories | Taxol derivatives |
| FR2697019B1 (fr) | 1992-10-15 | 1994-11-25 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| DK0668762T3 (da) * | 1992-11-13 | 2004-01-05 | Univ Florida State | Isobytenyl-substituerede taxaner og farmaceutiske præparater deraf |
| EP0688212B1 (de) * | 1993-03-05 | 2002-06-12 | Florida State University | C9 taxanderivate und diese enthaltende pharmazeutische zusammensetzungen |
| US6710191B2 (en) * | 1993-03-05 | 2004-03-23 | Florida State University | 9β-hydroxytetracyclic taxanes |
| JP3892481B2 (ja) | 1993-03-05 | 2007-03-14 | フロリダ・ステート・ユニバーシティー | ９−デスオキソタキサンの製法 |
| DE69434373T2 (de) | 1993-03-22 | 2006-03-09 | Florida State University, Tallahassee | Beta-laktame zur Herstellung von Taxanen mit Furyl oder Thienyl substituierter Seitenkette |
| FR2707293A1 (fr) | 1993-07-08 | 1995-01-13 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2715846A1 (fr) * | 1994-02-07 | 1995-08-11 | Rhone Poulenc Rorer Sa | Nouvelle composition pharmceutique à base de taxoïdes. |
| IT1275936B1 (it) | 1995-03-17 | 1997-10-24 | Indena Spa | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
| US5635531A (en) * | 1996-07-08 | 1997-06-03 | Bristol-Myers Squibb Company | 3'-aminocarbonyloxy paclitaxels |
| US5739359A (en) | 1997-01-24 | 1998-04-14 | Virginia Tech Intellectual Properties, Inc. | Methods for preparing 1-deoxy paclitaxels |
| US6048990A (en) * | 1998-05-01 | 2000-04-11 | Napro Biotherapeutics, Inc. | Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position |
| AR030188A1 (es) * | 2000-02-02 | 2003-08-13 | Univ Florida State Res Found | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
| HUP0200750A3 (en) * | 2000-02-02 | 2005-02-28 | Univ Florida State Res Found | C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use |
| JP2004528309A (ja) | 2001-03-23 | 2004-09-16 | ナプロ バイオセラピューティクス，インコーポレイテッド | 癌治療用分子複合体 |
| CA2354471A1 (en) | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 ester substituted taxanes |
| RS52904A (en) | 2001-12-20 | 2006-12-15 | Bristol-Myers Squib Company | Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability |
| US6898834B1 (en) * | 2003-03-03 | 2005-05-31 | Westbridge Pty Ltd | Barrel stave reclaim |
| EP1894921A3 (de) | 2003-09-25 | 2008-03-12 | Tapestry Pharmaceuticals, Inc. | 9, 10-Alpha, Alpha-OH-Taxan-Analoga und Herstellungsverfahren dafür |
| EP1664033B1 (de) * | 2003-09-25 | 2007-11-07 | Tapestry Pharmaceuticals, Inc. | 9,10-alpha,alpha-oh-taxananaloga und verfahren zu deren herstellung |
| WO2006124737A2 (en) | 2005-05-12 | 2006-11-23 | Tapestry Pharmaceuticals, Inc. | Molecular constructs suitable for targeted conjugates |
| WO2007073383A1 (en) | 2005-12-21 | 2007-06-28 | Tapestry Pharmaceuticals, Inc. | Novel compounds and methods for forming taxanes and using the same |
| AU2006331674A1 (en) | 2005-12-21 | 2007-07-05 | Tapestry Pharmaceuticals, Inc. | Processes for taxane derivatives and intermediates useful therein |
| US20070225510A1 (en) | 2006-03-27 | 2007-09-27 | Henri John T | Convergent Process for the Synthesis of Taxane Derivatives |
| WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20080207743A1 (en) | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
-
2004
- 2004-09-27 EP EP04789167A patent/EP1664033B1/de active Active
- 2004-09-27 CN CNA2004800346381A patent/CN1886400A/zh active Pending
- 2004-09-27 JP JP2006528316A patent/JP4874102B2/ja active Active
- 2004-09-27 PT PT04789167T patent/PT1664033E/pt unknown
- 2004-09-27 ES ES04789167T patent/ES2295937T3/es active Active
- 2004-09-27 CA CA2539975A patent/CA2539975C/en active Active
- 2004-09-27 US US10/951,555 patent/US7745650B2/en active Active
- 2004-09-27 EP EP06026009A patent/EP1785416A3/de not_active Withdrawn
- 2004-09-27 PL PL04789167T patent/PL1664033T3/pl unknown
- 2004-09-27 AU AU2004275881A patent/AU2004275881A1/en not_active Abandoned
- 2004-09-27 AT AT04789167T patent/ATE377593T1/de not_active IP Right Cessation
- 2004-09-27 DE DE602004009943T patent/DE602004009943T2/de not_active Expired - Fee Related
- 2004-09-27 WO PCT/US2004/031816 patent/WO2005030150A2/en active IP Right Grant
- 2004-09-27 DK DK04789167T patent/DK1664033T3/da active
-
2008
- 2008-02-05 HR HR20080057T patent/HRP20080057T3/xx unknown
-
2010
- 2010-06-02 US US12/792,427 patent/US7879904B2/en active Active
- 2010-09-07 JP JP2010200399A patent/JP5525394B2/ja active Active
- 2010-11-24 US US12/954,253 patent/US8962870B2/en active Active
-
2011
- 2011-04-08 JP JP2011086840A patent/JP5629632B2/ja active Active
-
2014
- 2014-07-10 JP JP2014141964A patent/JP6106634B2/ja active Active
-
2015
- 2015-01-23 US US14/604,147 patent/US9402824B2/en active Active
-
2016
- 2016-07-12 JP JP2016137271A patent/JP6216417B2/ja active Active
- 2016-07-27 US US15/220,975 patent/US9820962B2/en active Active
-
2017
- 2017-10-09 US US15/728,049 patent/US10238621B2/en active Active
-
2019
- 2019-01-14 US US16/247,425 patent/US10639293B2/en active Active
-
2020
- 2020-04-15 US US16/849,879 patent/US20200237708A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |