DK1664033T3 - 9,10-a,a-OH-taxan-analoger samt fremgangsmåder til fremstilling deraf. - Google Patents
9,10-a,a-OH-taxan-analoger samt fremgangsmåder til fremstilling deraf.Info
- Publication number
- DK1664033T3 DK1664033T3 DK04789167T DK04789167T DK1664033T3 DK 1664033 T3 DK1664033 T3 DK 1664033T3 DK 04789167 T DK04789167 T DK 04789167T DK 04789167 T DK04789167 T DK 04789167T DK 1664033 T3 DK1664033 T3 DK 1664033T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- hydroxyl
- methods
- present
- taxane
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50668003P | 2003-09-25 | 2003-09-25 | |
| PCT/US2004/031816 WO2005030150A2 (en) | 2003-09-25 | 2004-09-27 | 9,10-α,α-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1664033T3 true DK1664033T3 (da) | 2008-03-25 |
Family
ID=34393186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04789167T DK1664033T3 (da) | 2003-09-25 | 2004-09-27 | 9,10-a,a-OH-taxan-analoger samt fremgangsmåder til fremstilling deraf. |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US7745650B2 (da) |
| EP (2) | EP1664033B1 (da) |
| JP (5) | JP4874102B2 (da) |
| CN (1) | CN1886400A (da) |
| AT (1) | ATE377593T1 (da) |
| AU (1) | AU2004275881A1 (da) |
| CA (1) | CA2539975C (da) |
| DE (1) | DE602004009943T2 (da) |
| DK (1) | DK1664033T3 (da) |
| ES (1) | ES2295937T3 (da) |
| HR (1) | HRP20080057T3 (da) |
| PL (1) | PL1664033T3 (da) |
| PT (1) | PT1664033E (da) |
| WO (1) | WO2005030150A2 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20080057T3 (en) * | 2003-09-25 | 2008-02-29 | Tapestry Pharmaceuticals | 9,10-alpha,alpha-oh-taxane analogs and methods for production thereof |
| WO2007086879A2 (en) | 2005-02-11 | 2007-08-02 | University Of Southern California | Method of expressing proteins with disulfide bridges |
| MX2008008119A (es) * | 2005-12-21 | 2008-09-24 | Tapestry Pharmaceuticals Inc | Procesos para derivados de taxano y compuestos intermedios utiles en los mismos. |
| JP2009521435A (ja) * | 2005-12-21 | 2009-06-04 | タペストリー ファーマシューティカルズ インコーポレーテッド | タキサンを形成するための新規化合物および方法ならびにその使用 |
| AU2007245085A1 (en) * | 2006-03-27 | 2007-11-08 | Tapestry Pharmaceuticals, Inc. | A convergent process for the synthesis of taxane derivatives |
| WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
| EP2029563A4 (en) * | 2006-06-12 | 2009-12-02 | Canada Inc 6570763 | HALF-SYNTHETIC ROUTE FOR THE PREPARATION OF PACLITAXEL, DOCETAXEL AND 10-DEACETYLBACCATIN III FROM 9-DIHYDRO-13-ACETYLBACCATIN III |
| US7847111B2 (en) | 2006-06-19 | 2010-12-07 | Canada Inc. | Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III |
| WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20080207743A1 (en) * | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
| WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| US9227983B2 (en) | 2011-04-07 | 2016-01-05 | Arbor Therapeutics, LLC | Taxane and abeo-taxane analogs |
| CN103764138A (zh) * | 2011-04-07 | 2014-04-30 | 阿伯疗法责任有限公司 | 紫杉烷和Abeo-紫杉烷类似物 |
| US8440714B2 (en) * | 2011-06-06 | 2013-05-14 | Arbor Therapeutics, LLC | Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents |
| US12403024B2 (en) | 2020-03-04 | 2025-09-02 | Aquedeon Medical, Inc. | Vascular and aortic grafts with telescoping sheath and deployment methods thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| US6794523B2 (en) * | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
| DE69325454T2 (de) * | 1992-04-17 | 2000-01-20 | Abbott Laboratories, Abbott Park | Taxol-derivate |
| FR2697019B1 (fr) * | 1992-10-15 | 1994-11-25 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| ES2206465T3 (es) | 1992-11-13 | 2004-05-16 | Florida State University | Taxanos sustituidos con butenilo y composiciones farmaceuticas. |
| US6710191B2 (en) * | 1993-03-05 | 2004-03-23 | Florida State University | 9β-hydroxytetracyclic taxanes |
| EP0687260B1 (en) * | 1993-03-05 | 2003-02-19 | Florida State University | Process for the preparation of 9-desoxotaxanes |
| ATE218858T1 (de) | 1993-03-05 | 2002-06-15 | Univ Florida State | C9 taxanderivate und diese enthaltende pharmazeutische zusammensetzungen |
| JPH08508469A (ja) | 1993-03-22 | 1996-09-10 | フロリダ・ステート・ユニバーシティー | アルコキシ、アルケンオキシまたはアリールオキシ置換側鎖を有するタキサンおよびそれを含有する薬剤組成物 |
| FR2707293A1 (fr) | 1993-07-08 | 1995-01-13 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2715846A1 (fr) | 1994-02-07 | 1995-08-11 | Rhone Poulenc Rorer Sa | Nouvelle composition pharmceutique à base de taxoïdes. |
| IT1275936B1 (it) | 1995-03-17 | 1997-10-24 | Indena Spa | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
| US5635531A (en) * | 1996-07-08 | 1997-06-03 | Bristol-Myers Squibb Company | 3'-aminocarbonyloxy paclitaxels |
| US5739359A (en) | 1997-01-24 | 1998-04-14 | Virginia Tech Intellectual Properties, Inc. | Methods for preparing 1-deoxy paclitaxels |
| US6048990A (en) * | 1998-05-01 | 2000-04-11 | Napro Biotherapeutics, Inc. | Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position |
| CN1362876A (zh) | 2000-02-02 | 2002-08-07 | 佛罗里达州立大学研究基金有限公司 | C10杂取代的乙酸基紫衫烷抗肿瘤剂 |
| AR030188A1 (es) * | 2000-02-02 | 2003-08-13 | Univ Florida State Res Found | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
| AU2002254400B2 (en) | 2001-03-23 | 2007-08-09 | Napro Biotherapeutics, Inc. | Molecular conjugates for use in treatment of cancer |
| CA2354471A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 ester substituted taxanes |
| HRP20040545A2 (en) | 2001-12-20 | 2005-08-31 | Bristol-Myers Squibb Company A Delaware (Usa) Corp | Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability |
| US6898834B1 (en) * | 2003-03-03 | 2005-05-31 | Westbridge Pty Ltd | Barrel stave reclaim |
| EP1810968A3 (en) | 2003-09-25 | 2007-08-08 | Tapestry Pharmaceuticals, Inc. | 9, 10-a, a-OH-taxane analogs and methods for production thereof |
| HRP20080057T3 (en) | 2003-09-25 | 2008-02-29 | Tapestry Pharmaceuticals | 9,10-alpha,alpha-oh-taxane analogs and methods for production thereof |
| KR20080030564A (ko) | 2005-05-12 | 2008-04-04 | 태피스트리 파마슈티컬스 인코퍼레이티드 | 표적 컨쥬게이트에 적합한 분자 구조물 |
| JP2009521435A (ja) | 2005-12-21 | 2009-06-04 | タペストリー ファーマシューティカルズ インコーポレーテッド | タキサンを形成するための新規化合物および方法ならびにその使用 |
| MX2008008119A (es) | 2005-12-21 | 2008-09-24 | Tapestry Pharmaceuticals Inc | Procesos para derivados de taxano y compuestos intermedios utiles en los mismos. |
| AU2007245085A1 (en) | 2006-03-27 | 2007-11-08 | Tapestry Pharmaceuticals, Inc. | A convergent process for the synthesis of taxane derivatives |
| WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20080207743A1 (en) | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
-
2004
- 2004-09-27 HR HR20080057T patent/HRP20080057T3/xx unknown
- 2004-09-27 US US10/951,555 patent/US7745650B2/en not_active Expired - Lifetime
- 2004-09-27 EP EP04789167A patent/EP1664033B1/en not_active Expired - Lifetime
- 2004-09-27 EP EP06026009A patent/EP1785416A3/en not_active Withdrawn
- 2004-09-27 JP JP2006528316A patent/JP4874102B2/ja not_active Expired - Lifetime
- 2004-09-27 DK DK04789167T patent/DK1664033T3/da active
- 2004-09-27 PL PL04789167T patent/PL1664033T3/pl unknown
- 2004-09-27 AT AT04789167T patent/ATE377593T1/de not_active IP Right Cessation
- 2004-09-27 CN CNA2004800346381A patent/CN1886400A/zh active Pending
- 2004-09-27 ES ES04789167T patent/ES2295937T3/es not_active Expired - Lifetime
- 2004-09-27 WO PCT/US2004/031816 patent/WO2005030150A2/en not_active Ceased
- 2004-09-27 AU AU2004275881A patent/AU2004275881A1/en not_active Abandoned
- 2004-09-27 CA CA2539975A patent/CA2539975C/en not_active Expired - Lifetime
- 2004-09-27 DE DE602004009943T patent/DE602004009943T2/de not_active Expired - Fee Related
- 2004-09-27 PT PT04789167T patent/PT1664033E/pt unknown
-
2010
- 2010-06-02 US US12/792,427 patent/US7879904B2/en not_active Expired - Lifetime
- 2010-09-07 JP JP2010200399A patent/JP5525394B2/ja not_active Expired - Lifetime
- 2010-11-24 US US12/954,253 patent/US8962870B2/en active Active
-
2011
- 2011-04-08 JP JP2011086840A patent/JP5629632B2/ja not_active Expired - Lifetime
-
2014
- 2014-07-10 JP JP2014141964A patent/JP6106634B2/ja not_active Expired - Lifetime
-
2015
- 2015-01-23 US US14/604,147 patent/US9402824B2/en not_active Expired - Lifetime
-
2016
- 2016-07-12 JP JP2016137271A patent/JP6216417B2/ja not_active Expired - Lifetime
- 2016-07-27 US US15/220,975 patent/US9820962B2/en not_active Expired - Fee Related
-
2017
- 2017-10-09 US US15/728,049 patent/US10238621B2/en not_active Expired - Lifetime
-
2019
- 2019-01-14 US US16/247,425 patent/US10639293B2/en not_active Expired - Lifetime
-
2020
- 2020-04-15 US US16/849,879 patent/US20200237708A1/en not_active Abandoned
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