ES2056953T3 - Complejo de hierro-citrato, procedimiento para su fabricacion y su aplicacion farmaceutica. - Google Patents
Complejo de hierro-citrato, procedimiento para su fabricacion y su aplicacion farmaceutica.Info
- Publication number
- ES2056953T3 ES2056953T3 ES88730208T ES88730208T ES2056953T3 ES 2056953 T3 ES2056953 T3 ES 2056953T3 ES 88730208 T ES88730208 T ES 88730208T ES 88730208 T ES88730208 T ES 88730208T ES 2056953 T3 ES2056953 T3 ES 2056953T3
- Authority
- ES
- Spain
- Prior art keywords
- iron
- procedure
- manufacture
- pharmaceutical application
- citrate complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/265—Citric acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
Abstract
LA INVENCION TRATA DE UN COMPLEJO MICELAR DE CITRATO DE HIERRO, QUE POSEEN LA COMBINACION DE 10.6% DE CARBONO, 2.62% DE HIDROGENO, 56.2% DE OXIGENO, 32% DE HIERRO Y 4.6% DE SODIO, EL PESO MOLECULAR DE 33000 APROXIMADAMENTE. (MEDIDA HPLC - LALLLS) Y LA FORMULA EMPIRICA (C31 H92 O110 FE20 NA7)N. PROCEDIMIENTO PARA SU REPRESENTACION Y SU UTILIZACION FARMACEUTICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21904/87A IT1222654B (it) | 1987-09-14 | 1987-09-14 | Complesso micellare di ferro-citrato |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2056953T3 true ES2056953T3 (es) | 1994-10-16 |
Family
ID=11188516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88730208T Expired - Lifetime ES2056953T3 (es) | 1987-09-14 | 1988-09-09 | Complejo de hierro-citrato, procedimiento para su fabricacion y su aplicacion farmaceutica. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5206265A (es) |
| EP (1) | EP0308362B1 (es) |
| JP (1) | JP2950840B2 (es) |
| AT (1) | ATE106073T1 (es) |
| AU (1) | AU627696B2 (es) |
| DE (1) | DE3889702D1 (es) |
| ES (1) | ES2056953T3 (es) |
| IT (1) | IT1222654B (es) |
| WO (1) | WO1989002426A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5110965A (en) * | 1990-08-16 | 1992-05-05 | W.R. Grace & Co.-Conn. | Process for the preparation of salts of iron amino and hydroxy carboxylic acid complexes |
| US8093423B2 (en) | 2003-02-19 | 2012-01-10 | Globoasia, Llc | Pharmaceutical-grade ferric organic compounds, uses thereof and method of making same |
| TWI335218B (en) | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| CN101378658A (zh) * | 2006-01-30 | 2009-03-04 | 环亚有限公司 | 治疗慢性肾病的方法 |
| CN102573807A (zh) | 2009-07-21 | 2012-07-11 | 凯克斯生物制药公司 | 柠檬酸铁剂型 |
| JP5648120B2 (ja) | 2010-03-23 | 2015-01-07 | ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ | 鉄欠乏症および鉄欠乏性貧血の治療および予防用の鉄（ｉｉｉ）錯体化合物 |
| EP2666764A4 (en) | 2011-01-18 | 2016-03-02 | Japan Tobacco Inc | BETA-OXIDIZED IRON HYDROXIDE SUBSTANTIALLY FREE IRON CITRATE |
| PT2691376E (pt) | 2011-03-29 | 2016-03-02 | Vifor (International) Ag | Compostos de complexo de fe(iii) para o tratamento e profilaxia de deficiências de ferro e anemias por deficiência de ferro |
| ES2548407T3 (es) | 2011-05-31 | 2015-10-16 | Vifor (International) Ag | Compuestos de complejos de 2,4-dioxo-1-carbonilo de Fe(III) para su uso en el tratamiento y la profilaxis de estados de deficiencia de hierro y anemias por deficiencia de hierro |
| US9731999B2 (en) | 2011-09-23 | 2017-08-15 | Iqbal Gill | Chemical admixtures for hydraulic cements |
| JP6172691B2 (ja) | 2012-12-21 | 2017-08-02 | ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ | 鉄欠乏症候群と鉄欠乏性貧血の治療と予防のための鉄（ｉｉｉ）錯体化合物 |
| EP3233783A4 (en) * | 2014-12-17 | 2018-06-27 | Biophore India Pharmaceuticals Pvt. Ltd. | Improved method for the synthesis of ferric oraganic compounds |
| CN105985232B (zh) * | 2015-02-02 | 2018-05-22 | 安徽省新星药物开发有限责任公司 | 一种高含铁量的枸橼酸铁及其制备方法 |
| WO2018137708A1 (zh) * | 2017-01-26 | 2018-08-02 | 重庆莱美药业股份有限公司 | 一种纳米炭-铁复合体系及其组合物、制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB682724A (en) * | 1949-09-13 | 1952-11-12 | Adolf Christian Josef Opferman | Process for the manufacture of ferro-calcium-citrate |
| US2904573A (en) * | 1957-05-06 | 1959-09-15 | Ortho Pharma Corp | Ferrous citrate complex |
| US2955981A (en) * | 1957-12-31 | 1960-10-11 | American Cyanamid Co | Prevention of iron-deficiency anemias in suckling mammals |
| US2957806A (en) * | 1959-01-06 | 1960-10-25 | Schwarz Arzneimittelfabrik G M | Process for raising blood serum iron levels and controlling anemia |
| US3091626A (en) * | 1960-06-20 | 1963-05-28 | Scherer Corp R P | Method of making ferrous citrate |
| SE351366B (es) * | 1965-06-08 | 1972-11-27 | Teikoku Hormone Mfg Co Ltd | |
| US4400535A (en) * | 1980-01-17 | 1983-08-23 | Dr. Madaus & Co. | Acidic alkali citrate and compositions for adjusting the pH of urine |
| JPH01134158A (ja) * | 1987-11-18 | 1989-05-26 | Noritz Corp | 自動風呂用給湯装置 |
-
1987
- 1987-09-14 IT IT21904/87A patent/IT1222654B/it active
-
1988
- 1988-09-09 JP JP63507048A patent/JP2950840B2/ja not_active Expired - Lifetime
- 1988-09-09 DE DE3889702T patent/DE3889702D1/de not_active Expired - Lifetime
- 1988-09-09 AT AT88730208T patent/ATE106073T1/de active
- 1988-09-09 AU AU23204/88A patent/AU627696B2/en not_active Ceased
- 1988-09-09 WO PCT/DE1988/000568 patent/WO1989002426A1/de unknown
- 1988-09-09 EP EP88730208A patent/EP0308362B1/de not_active Expired - Lifetime
- 1988-09-09 US US07/646,789 patent/US5206265A/en not_active Expired - Fee Related
- 1988-09-09 ES ES88730208T patent/ES2056953T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3889702D1 (de) | 1994-07-07 |
| JP2950840B2 (ja) | 1999-09-20 |
| EP0308362A1 (de) | 1989-03-22 |
| AU627696B2 (en) | 1992-09-03 |
| US5206265A (en) | 1993-04-27 |
| JPH03502570A (ja) | 1991-06-13 |
| IT8721904A0 (it) | 1987-09-14 |
| WO1989002426A1 (en) | 1989-03-23 |
| IT1222654B (it) | 1990-09-12 |
| EP0308362B1 (de) | 1994-05-25 |
| ATE106073T1 (de) | 1994-06-15 |
| AU2320488A (en) | 1989-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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