ES2127458T3 - Produccion de proteinas utilizando recombinacion homologa. - Google Patents

Produccion de proteinas utilizando recombinacion homologa.

Info

Publication number
ES2127458T3
ES2127458T3 ES95119039T ES95119039T ES2127458T3 ES 2127458 T3 ES2127458 T3 ES 2127458T3 ES 95119039 T ES95119039 T ES 95119039T ES 95119039 T ES95119039 T ES 95119039T ES 2127458 T3 ES2127458 T3 ES 2127458T3
Authority
ES
Spain
Prior art keywords
gene
target gene
protein production
expression
amplifiable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95119039T
Other languages
English (en)
Inventor
Arthur I Skoultchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Genesys Inc
Original Assignee
Cell Genesys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23714629&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2127458(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cell Genesys Inc filed Critical Cell Genesys Inc
Application granted granted Critical
Publication of ES2127458T3 publication Critical patent/ES2127458T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/206—Pseudochromosomes, minichrosomosomes of yeast origin, e.g. YAC, 2u
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE SUMINISTRAN METODOS Y COMPOSICIONES PARA LA EXPRESION DE GENES DE MAMIFEROS EN CULTIVO.UN GEN AMPLIFICABLE SE INTRODUCE POR RECOMBINACION HOMOLOGICA EN YUXTAPOSICION A UN GEN DIANA, LA COMBINACION RESULTANTE DEL GEN AMPLIFICABLE Y EL GEN DIANA TRANSFERIDO A UN HUESPED CONVENIENTE Y UN GEN DIANA AMPLIFICADO POR MEDIO DE UN GEN AMPLIFICABLE.EL HUESPED DE LA EXPRESION RESULTANTE PUEDE DESPUES DEJARSE CRECER EN CULTIVO CON EXPRESION MEJORADA DEL GEN DIANA.
ES95119039T 1989-11-06 1990-11-06 Produccion de proteinas utilizando recombinacion homologa. Expired - Lifetime ES2127458T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43206989A 1989-11-06 1989-11-06

Publications (1)

Publication Number Publication Date
ES2127458T3 true ES2127458T3 (es) 1999-04-16

Family

ID=23714629

Family Applications (2)

Application Number Title Priority Date Filing Date
ES91900640T Expired - Lifetime ES2090297T5 (es) 1989-11-06 1990-11-06 Produccion de proteinas que utilizan recombinacion homologa.
ES95119039T Expired - Lifetime ES2127458T3 (es) 1989-11-06 1990-11-06 Produccion de proteinas utilizando recombinacion homologa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES91900640T Expired - Lifetime ES2090297T5 (es) 1989-11-06 1990-11-06 Produccion de proteinas que utilizan recombinacion homologa.

Country Status (14)

Country Link
US (3) US5578461A (es)
EP (3) EP0945515A3 (es)
JP (2) JPH04505104A (es)
KR (1) KR100233781B1 (es)
AT (2) ATE174058T1 (es)
AU (1) AU635844B2 (es)
CA (1) CA2045175C (es)
DE (2) DE69027526T3 (es)
DK (2) DK0452484T3 (es)
ES (2) ES2090297T5 (es)
GR (2) GR3021105T3 (es)
NO (1) NO309238B1 (es)
SG (2) SG88714A1 (es)
WO (2) WO1991006666A1 (es)

Families Citing this family (253)

* Cited by examiner, † Cited by third party
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JPH04505104A (ja) 1992-09-10
DE69027526D1 (de) 1996-07-25
DK0747485T3 (da) 1999-08-16
EP0452484A1 (en) 1991-10-23
DE69027526T2 (de) 1996-12-05
DE69032809T2 (de) 1999-07-08
EP0945515A2 (en) 1999-09-29
DK0452484T3 (da) 1996-10-14
SG122763A1 (en) 2006-06-29
AU7740791A (en) 1991-05-31
EP0452484A4 (en) 1992-05-13
US5578461A (en) 1996-11-26
EP0747485B1 (en) 1998-12-02
US5981214A (en) 1999-11-09
ATE139574T1 (de) 1996-07-15
DE69032809D1 (de) 1999-01-14
ATE174058T1 (de) 1998-12-15
NO309238B1 (no) 2001-01-02
NO912642D0 (no) 1991-07-05
GR3029328T3 (en) 1999-05-28
AU635844B2 (en) 1993-04-01
WO1991006666A1 (en) 1991-05-16
CA2045175A1 (en) 1991-05-07
KR100233781B1 (ko) 1999-12-01
CA2045175C (en) 2003-03-18
JP2001186897A (ja) 2001-07-10
EP0452484B2 (en) 2004-07-28
NO912642L (no) 1991-09-05
ES2090297T5 (es) 2005-03-01
EP0452484B1 (en) 1996-06-19
SG88714A1 (en) 2002-05-21
US6015708A (en) 2000-01-18
WO1991006667A1 (en) 1991-05-16
EP0945515A3 (en) 2002-08-21
DE69027526T3 (de) 2005-03-24
EP0747485A1 (en) 1996-12-11
GR3021105T3 (en) 1996-12-31
ES2090297T3 (es) 1996-10-16

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