ES2090297T3 - Produccion de proteinas que utilizan recombinacion homologa. - Google Patents

Produccion de proteinas que utilizan recombinacion homologa.

Info

Publication number
ES2090297T3
ES2090297T3 ES91900640T ES91900640T ES2090297T3 ES 2090297 T3 ES2090297 T3 ES 2090297T3 ES 91900640 T ES91900640 T ES 91900640T ES 91900640 T ES91900640 T ES 91900640T ES 2090297 T3 ES2090297 T3 ES 2090297T3
Authority
ES
Spain
Prior art keywords
gene
target gene
protein production
expression
amplifiable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91900640T
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English (en)
Other versions
ES2090297T5 (es
Inventor
Arthur I Skoultchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Genesys Inc
Original Assignee
Cell Genesys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23714629&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2090297(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cell Genesys Inc filed Critical Cell Genesys Inc
Publication of ES2090297T3 publication Critical patent/ES2090297T3/es
Application granted granted Critical
Publication of ES2090297T5 publication Critical patent/ES2090297T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/206—Pseudochromosomes, minichrosomosomes of yeast origin, e.g. YAC, 2u
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE SUMINISTRAN METODOS Y COMPOSICIONES PARA LA EXPRESION DE GENES DE UN MAMIFERO EN UN CULTIVO. UN GEN AMPLIFICABLE SE INTRODUCE MEDIANTE RECOMBINACION HOMOLOGA EN YUXTAPOSICION A UN GEN DE INTERES, LA COMBINACION RESULTANTE SE TRANSFIERE A UN ANFITRION CONVENIENTE Y EL GEN OBJETIVO SE AMPLIFICA POR MEDIO DEL GEN AMPLIFICABLE. EL ANFITRION DE EXPRESION RESULTANTE PUEDE ENTONCES SER CULTIVADO EN UN CULTIVO CON UNA EXPRESION MEJORADA DEL GEN BUSCADO.
ES91900640T 1989-11-06 1990-11-06 Produccion de proteinas que utilizan recombinacion homologa. Expired - Lifetime ES2090297T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43206989A 1989-11-06 1989-11-06
US432069 1989-11-06

Publications (2)

Publication Number Publication Date
ES2090297T3 true ES2090297T3 (es) 1996-10-16
ES2090297T5 ES2090297T5 (es) 2005-03-01

Family

ID=23714629

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95119039T Expired - Lifetime ES2127458T3 (es) 1989-11-06 1990-11-06 Produccion de proteinas utilizando recombinacion homologa.
ES91900640T Expired - Lifetime ES2090297T5 (es) 1989-11-06 1990-11-06 Produccion de proteinas que utilizan recombinacion homologa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES95119039T Expired - Lifetime ES2127458T3 (es) 1989-11-06 1990-11-06 Produccion de proteinas utilizando recombinacion homologa.

Country Status (14)

Country Link
US (3) US5578461A (es)
EP (3) EP0747485B1 (es)
JP (2) JPH04505104A (es)
KR (1) KR100233781B1 (es)
AT (2) ATE139574T1 (es)
AU (1) AU635844B2 (es)
CA (1) CA2045175C (es)
DE (2) DE69027526T3 (es)
DK (2) DK0452484T3 (es)
ES (2) ES2127458T3 (es)
GR (2) GR3021105T3 (es)
NO (1) NO309238B1 (es)
SG (2) SG88714A1 (es)
WO (2) WO1991006667A1 (es)

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US5981214A (en) 1999-11-09
CA2045175A1 (en) 1991-05-07
EP0452484B2 (en) 2004-07-28
DE69032809T2 (de) 1999-07-08
EP0945515A2 (en) 1999-09-29
EP0945515A3 (en) 2002-08-21
KR100233781B1 (ko) 1999-12-01
EP0452484B1 (en) 1996-06-19
AU7740791A (en) 1991-05-31
DE69027526D1 (de) 1996-07-25
ATE139574T1 (de) 1996-07-15
ATE174058T1 (de) 1998-12-15
DE69032809D1 (de) 1999-01-14
WO1991006667A1 (en) 1991-05-16
NO912642D0 (no) 1991-07-05
SG122763A1 (en) 2006-06-29
CA2045175C (en) 2003-03-18
NO309238B1 (no) 2001-01-02
GR3021105T3 (en) 1996-12-31
SG88714A1 (en) 2002-05-21
DE69027526T2 (de) 1996-12-05
AU635844B2 (en) 1993-04-01
US6015708A (en) 2000-01-18
GR3029328T3 (en) 1999-05-28
JPH04505104A (ja) 1992-09-10
WO1991006666A1 (en) 1991-05-16
ES2127458T3 (es) 1999-04-16
EP0747485B1 (en) 1998-12-02
JP2001186897A (ja) 2001-07-10
EP0747485A1 (en) 1996-12-11
NO912642L (no) 1991-09-05
DK0452484T3 (da) 1996-10-14
ES2090297T5 (es) 2005-03-01
EP0452484A4 (en) 1992-05-13
DE69027526T3 (de) 2005-03-24
US5578461A (en) 1996-11-26
DK0747485T3 (da) 1999-08-16
EP0452484A1 (en) 1991-10-23

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