EP3708203A1 - Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen - Google Patents

Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen Download PDF

Info

Publication number
EP3708203A1
EP3708203A1 EP20173063.7A EP20173063A EP3708203A1 EP 3708203 A1 EP3708203 A1 EP 3708203A1 EP 20173063 A EP20173063 A EP 20173063A EP 3708203 A1 EP3708203 A1 EP 3708203A1
Authority
EP
European Patent Office
Prior art keywords
needle shield
syringe
remover
shield remover
cap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20173063.7A
Other languages
English (en)
French (fr)
Inventor
Joseph F. Julian
Chuan Li
Philip D ANDERSON
Linas LAURUSONIS
Lior Raday
Ehud Carmel
Lior MARLI
David Daily
Guy Keenan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Biotechnology Ltd
Elcam Medical ACAL
Original Assignee
AbbVie Biotechnology Ltd
Elcam Medical ACAL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45562478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3708203(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AbbVie Biotechnology Ltd, Elcam Medical ACAL filed Critical AbbVie Biotechnology Ltd
Publication of EP3708203A1 publication Critical patent/EP3708203A1/de
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/53—Means to assemble or disassemble

Definitions

  • Automatic injection devices offer an alternative to manually-operated syringes for administering therapeutic agents into patients' bodies and allowing patients to self-administer therapeutic agents.
  • Automatic injection devices may be used to administer medications under emergency conditions, for example, to administer epinephrine to counteract the effects of a severe allergic reaction.
  • Automatic injection devices have also been described for use in administering anti-arrhythmic medications and selective thrombolytic agents during a heart attack. See, for example, U.S. Patent Nos. 3,910,260 ; 4,004,577 ; 4,689,042 ; 4,755,169 ; and 4,795,433 , the entire contents of which are incorporated herein in their entirety by reference.
  • Various types of automatic injection devices are also described in, for example, U.S.
  • an automatic injection device houses a syringe and, when operated, causes the syringe to move forwardly and a needle to project from the housing so that a therapeutic agent contained in the syringe is injected into a patient's body.
  • a conventional automatic injection may include one or more needle shields to protect the syringe needle from damage and accidental contact and to maintain sterility of the injection needle.
  • Needle shields include a soft needle shield that is formed of a flexible material, and a rigid needle shield that is formed of a rigid, inflexible material and that provide greater mechanical protection to the injection needle.
  • Conventional automatic injection devices may also include a removable cap covering the needle shields to provide mechanical protection for the needle shields and to facilitate removal of the needle shields before an injection may be performed.
  • Figures 1A and 1B illustrate an exemplary syringe 100 including a substantially tubular syringe body 102 for holding a therapeutic agent.
  • Figure 1A illustrates a side view of the exemplary syringe 100.
  • Figure 1B illustrates a cross-sectional view of the exemplary syringe 100 bisected along the longitudinal axis L.
  • An injection needle may be coupled at a distal end of the syringe body 102.
  • the injection needle may be covered and protected by a soft needle shield 104 and a rigid needle shield 106 that surrounds the soft needle shield 104.
  • One or more apertures 108 may be provided in a side wall of the rigid needle shield 106 to allow a portion of the soft needle shield 104 to extend through the apertures 108.
  • a ridged portion 110 may be provided in the exterior surface of the rigid needle shield 106.
  • the ridged portion 110 may include one or more alternating outwardly-projecting ridges interspaced with grooves, and may thereby provide a region of higher friction contact for removal of the rigid needle shield 106 from the syringe.
  • Exemplary embodiments provide a needle shield remover that reliably engages with a distal cap of an automatic injection device and with one or more needle shields coupled to a syringe of the device.
  • An exemplary needle shield remover includes one or more inwardly-projecting shield engagement mechanisms that reliably engage with the needle shields, and one or more cap engagement mechanisms that reliably engage with the distal cap.
  • the needle shield remover reliably removes the needle shields (e.g., a soft needle shield and a rigid needle shield) from the syringe, thereby exposing the injection needle for performing an injection.
  • an exemplary needle shield remover is engaged to a needle shield coupled to a syringe, prior to insertion of the syringe and needle shield remover assembly into a housing of the automatic injection device.
  • This exemplary assembly method allows visual inspection, outside the housing of the device, to ensure that the needle shield remover is correctly and reliably engaged to the needle shield before the syringe and needle shield remover assembly is inserted into the housing.
  • an apparatus for removing a needle shield from a syringe.
  • the apparatus includes a tubular member for enclosing the needle shield coupled to the syringe.
  • the apparatus also includes one or more cap engagement mechanisms provided at a distal end of the tubular member and configured for engagement with a distal cap provided for covering a distal end of the syringe.
  • the apparatus also includes one or more shield engagement mechanisms provided at a proximal end of the tubular member and configured for engagement with the needle shield. When the apparatus is pulled away from the syringe, the one or more shield engagement mechanisms exert force against the needle shield to remove the needle shield from the syringe.
  • an automatic injection device in accordance with another exemplary embodiment, includes a syringe, a needle shield coupled to a distal end of the syringe, and a distal cap for covering the needle shield.
  • the automatic injection device also includes a needle shield remover disposed between the needle shield and the distal cap.
  • the needle shield includes a tubular member for enclosing the needle shield coupled to the syringe, one or more cap engagement mechanisms provided at a distal end of the tubular member and engaged with the distal cap, and one or more shield engagement mechanisms provided at a proximal end of the tubular member and engaged with the needle shield.
  • a method for assembling an automatic injection device.
  • the method includes coupling a needle shield to a distal end of a syringe.
  • the method also includes engaging one or more shield engagement mechanisms of a needle shield remover to the needle shield.
  • the method further includes inserting an assembly comprising the syringe, the needle shield and the needle shield remover into a housing of the automatic injection device.
  • a removable distal cap includes a mechanism that snaps into position in a gap formed between the syringe body and the needle shield.
  • the mechanism in the cap allows the needle shield to be removed as well because of its engagement with the cap.
  • a needle shield removal mechanism that consistently fits within the gap formed between the syringe body and the needle shield.
  • Exemplary embodiments address the deficiencies in conventional automatic injection devices by providing a needle shield remover that reliably engages and removes one or more needle shields when a removable distal cap is removed from a distal end of the device.
  • An exemplary needle shield remover may be provided separately from one or more needle shields and from a removable distal cap covering the distal end of the device.
  • the needle shield remover may include one or more inwardly-projecting shield engagement mechanisms that reliably engage with one or more needle shields, and one or more cap engagement mechanisms that reliably engage with the removable distal cap.
  • the exemplary needle shield remover reliably removes the needle shields from the syringe, thereby exposing the injection needle for performing an injection.
  • U.S. Provisional Patent Application No. 61/435,467 filed January 24, 2011 , to which the present application claims priority, teaches some exemplary needle shield removers that employ the concept of "float” relative to a removable distal cap and a needle shield remover attached thereto prior to placement of the removable distal cap onto an automatic injection device.
  • U.S. Provisional Patent Application No. 61/435,467, filed January 24, 2011 also teaches some exemplary needle shield removers that are "floatless” and do not employ the concept of "float” relative to a removable distal cap and a needle shield remover attached to an automatic injection device.
  • float refers to the structure, function and operation of a needle shield remover and a removable distal cap that form a single assembly and, as part of the assembly, slide relative to each other along a longitudinal axis during attachment to an automatic injection device, where the relative movement exceeds acceptable tolerances that account for manufacturing variations in the assembled components.
  • the employment of "float” refers to a single assembly formed of a needle shield remover and a removable distal cap that are pre-assembled before the needle shield remover is engaged to a needle shield. That is, in an automatic injection device that employs "float,” the pre-assembled removable distal cap and needle shield remover form a one-piece assembly that is engaged to the needle shield and the automatic injection device after the syringe is loaded into the automatic injection device.
  • the pre-assembled removable distal cap and needle shield remover are engaged to the automatic injection device in at least two steps in which the distal cap is first engaged to the automatic injection device, and subsequently the needle shield remover is engaged to the needle shield by sliding along a longitudinal axis from a first position to an second engaged position while the distal cap remains engaged to the automatic injection device.
  • exemplary needle shield removers and distal caps taught in the present application are “floatless” and do not rely on the concept of "float” for correctly and reliably assembling a needle shield remover and a removable distal cap in an automatic injection device.
  • the concept of "floatless” or “floatlessness” refers to the structure, function and operation of an exemplary needle shield remover and a removable distal cap that are not pre-assembled as a single assembly and that are not configured to slide relative to each other along a longitudinal axis during attachment to an automatic injection device in order to engage the needle shield remover to the needle shield, where the relative movement exceeds acceptable tolerances that account for manufacturing variations in the assembled components.
  • an exemplary needle shield remover is an assembly engaged to a needle shield attached to a syringe prior to insertion of the syringe and needle shield remover assembly into a housing of the automatic injection device.
  • the removable distal cap is then engaged to the device in a one-step process in which coupling the distal cap to the distal end of the device housing also engages the distal cap with the needle shield remover.
  • the structure, function and operation of the removable distal cap and the needle shield remover in "floatless" embodiments do not accommodate pre-assembly as a one piece assembly and do not accommodate movement of the needle shield remover attached to the removable distal cap from a first position to an engaged position along a longitudinal axis.
  • Automatic injection devices that do not rely on the concept of "float” to assemble an exemplary needle shield remover and a distal cap are advantageous over automatic injection devices that rely on the "float” concept. This is because reliance on the relative movement between the needle shield remover and the distal cap in automatic injection devices that use "float” increases the risk of unreliable and incorrect engagement of the needle shield remover with the needle shield, and thereby reduces robustness of the assembly.
  • the ability, in exemplary embodiments, to assemble the exemplary needle shield remover with the needle shield outside the device housing and outside the distal cap allows visual inspection of the assembly process to ensure that the needle shield remover is correctly and reliably engaged with a gap between the syringe body and the needle shield.
  • automated injection device and "autoinjector,” as used herein, refer to a device that enables a patient to self-administer a therapeutically effective dose of a therapeutic agent, wherein the device differs from a conventional syringe by the inclusion of a mechanism for automatically delivering the therapeutic agent to the patient by injection when the mechanism is engaged.
  • vessel and “container,” as used herein, refer to a syringe or cartridge that may be used in an exemplary automatic injection device for holding a dose of a therapeutic agent.
  • syringe and “cartridge,” as used herein, refer to a sterile barrel portion of an automatic injection device that is filled with a dose of a therapeutic agent prior to distribution or sale of the device to a patient or other non-medical professional for administration of the therapeutic agent to a patient.
  • a distal end of the barrel portion of a syringe may be coupled to a sterile hypodermic injection needle.
  • a distal end of the barrel portion of a cartridge may not be coupled to an injection needle. That is, in exemplary embodiments, a syringe may be a cartridge with a pre-attached injection needle coupled to its barrel portion.
  • Exemplary embodiments described herein with reference to a syringe assembly may also be implemented using a cartridge assembly.
  • exemplary embodiments described herein with reference to a cartridge assembly may also be implemented using a syringe assembly.
  • pre-filled syringe refers to a syringe that is filled with a therapeutic agent immediately prior to administration of the therapeutic agent to a patient, and a syringe that is filled with a therapeutic agent and stored in this pre-filled form for a period of time before administration of the therapeutic agent to a patient.
  • injection needle and "needle,” as used herein, refer to a needle in an automatic injection device that is inserted into a patient's body to deliver a dose of a therapeutic agent into the patient's body.
  • the injection needle may be directly coupled to or may otherwise be in contact with a syringe assembly or a cartridge assembly that holds a dose of the therapeutic agent.
  • the injection needle may be indirectly coupled to the syringe or cartridge assembly, for example, via a syringe needle and/or a transfer mechanism that provides fluid communication between the syringe or cartridge assembly and the injection needle.
  • thermoplastic material refers to a material that has the property of softening or fusing when heated and of hardening and becoming rigid again when cooled. Thermoplastic materials can be re-melted and cooled repeatedly without undergoing any appreciable chemical change.
  • a thermoplastic is a polymer that turns to a liquid when heated and freezes to a very glassy state when cooled sufficiently. Most thermoplastics are high-molecular-weight polymers whose chains associate through weak Van der Waals forces (polyethylene); stronger dipole-dipole interactions and hydrogen bonding (nylon); or even stacking of aromatic rings (polystyrene).
  • thermoplastic polymers differ from thermosetting polymers (vulcanized rubber) as they can, unlike thermosetting polymers, be re-melted and re-molded.
  • thermoplastic materials are addition polymers; e.g., vinyl chain-growth polymers such as polyethylene and polypropylene.
  • pre-injection state refers to a state of an automatic injection device prior to activation of the device, i.e., prior to the start of delivery of a therapeutic agent contained in the device.
  • injection state refers to one or more states of an automatic injection device during the delivery of a therapeutic agent contained in the device.
  • post-injection state refers to completion of delivery of a therapeutically effective dose of a therapeutic agent contained in the device, or removal of the device from the patient prior to completion of delivery of a therapeutically effective dose of the therapeutic agent.
  • patient or “user,” as used herein, refers to any type of animal, human or non-human, that may be administered a substance using exemplary automatic injection devices.
  • proximal refers to a portion, end or component of an exemplary automatic injection device that is farthest from an injection site on a patient's body when the device is held against the patient for an injection or for mimicking an injection.
  • distal refers to a portion, end or component of an exemplary automatic injection device that is closest to an injection site on a patient's body when the device is held against the patient for an injection or for mimicking an injection.
  • planar is used herein, in a broad lay sense, to mean exactly planar or approximately planar within some tolerance from the exactly planar.
  • concave is used herein, in a broad lay sense, to mean exactly concave or approximately concave within some tolerance from the exactly concave.
  • convex is used herein, in a broad lay sense, to mean exactly convex or approximately convex within some tolerance from the exactly convex.
  • elliptical is used herein, in a broad lay sense, to mean exactly elliptical or approximately elliptical within some tolerance from the exactly elliptical.
  • oval is used herein, in a broad lay sense, to mean exactly oval or approximately oval within some tolerance from the exactly oval.
  • rectangular is used herein, in a broad lay sense, to mean exactly rectangular or approximately rectangular within some tolerance from the exactly rectangular.
  • parallel is used herein, in a broad lay sense, to mean exactly parallel or approximately parallel within some tolerance from the exactly parallel.
  • straight is used herein, in a broad lay sense, to mean exactly straight or approximately straight within some tolerance from the exactly straight.
  • adjacent is used herein, in a broad lay sense, to mean immediately adjacent or approximately adjacent within some tolerance.
  • transverse axis is used herein to refer to an axis substantially perpendicular to a longitudinal axis.
  • inwardly-projecting is used herein to refer to one or more tabs or teeth on a needle shield remover extending length wise along a longitudinal axis and having a proximal end attached to a tubular structure of the needle shield remover and a distal end detached from the tubular structure of the needle shield remover and projecting inwardly into an inner cavity of the tubular structure.
  • a needle shield remover may be provided as a separate component from a needle shield for covering an injection needle and from a removable distal cap for covering a distal end of an automatic injection device.
  • the needle shield remover may include one or more cap engagement mechanisms configured for engagement with the removable distal cap so that removal of the distal cap from the device housing automatically removes the needle shield remover as well.
  • the needle shield remover may include one or more inwardly-projecting shield engagement mechanisms configured for directly or indirect engagement with a rigid needle shield (in a device that includes a rigid needle shield) and/or a soft needle shield (in a device that includes a soft needle shield but lacks a rigid needle shield). Since the needle shield remover is engaged to the needle shield, when the needle shield remover is removed from the device housing (e.g., by removal of the distal cap engaged to the needle shield remover), this results in the removal of the needle shield engaged to the needle shield remover.
  • Exemplary needle shield removers are configured and designed for quick, easy and reliable engagement to both the distal cap and to a needle shield.
  • One or more exemplary methods may be used to assemble an exemplary needle shield remover to a needle shield coupled to a syringe.
  • an exemplary needle shield remover may be assembled with a needle shield coupled to a syringe after the syringe has been inserted into the housing of the device.
  • an exemplary needle shield remover - that is provided as a separate component from a distal cap and a syringe - may be assembled with a needle shield coupled to a syringe prior to insertion of the syringe into the housing of the device.
  • the ability to assemble the needle shield remover to the needle shield outside the device housing allows visual inspection of the assembly process to ensure that the needle shield remover reliably engages the needle shield on the syringe before the syringe assembly is inserted into the device housing.
  • assembly of the exemplary needle shield remover in the automatic injection device allows one to be certain that, when the syringe assembly is inserted into the device housing, the needle shield remover is engaged reliably and correctly with the needle shield, thereby resolving the issue of unreliable positioning of needle shield removal mechanisms in conventional automatic injection devices.
  • Figures 2A-2D illustrate an exemplary needle shield remover 200 engaged to a syringe 202 and to a distal cap 204.
  • Figure 2A illustrates a side view of an exemplary needle shield remover engaged to a syringe.
  • Figure 2B illustrates another side view of the exemplary needle shield remover of Figure 2A rotated by about 90 degrees.
  • Figure 2C illustrates a cross-sectional perspective view of the exemplary needle shield remover of Figures 2A and 2B engaged to a syringe and a distal cap.
  • Figure 2D is a bottom view of the exemplary distal cap of Figure 2C showing engagement of the needle shield remover to the distal cap.
  • the length of an exemplary needle shield remover 200 may range from about 10 mm to about 50 mm, but is not limited to this exemplary range.
  • FIGS 2A-2D are presented for the purpose of generally describing the structure, function and operation of an exemplary needle shield remover. Certain specific but non-limiting exemplary embodiments of needle shield removers are described in connection with Figures 5-24 .
  • an injection needle (not pictured) is coupled to the distal end of the syringe 202.
  • the needle is covered with a soft needle shield 206 that is, in turn, positioned within and covered by a rigid needle shield 208. Portions of the soft needle shield 206 may extend through one or more apertures in the rigid needle shield 208 as shown in Figure 2B .
  • the exemplary needle shield remover 200 is positioned over the rigid needle shield 208. The needle shield remover 200 may be used to remove all of the needle shields when the needle shield remover 200 is removed from its engagement to the syringe 202.
  • the exemplary needle shield remover 200 may include a single tubular member. In other exemplary embodiments, the needle shield remover 200 may include two, three or more tubular members. In the exemplary embodiment illustrated in Figures 2A-2D , the exemplary needle shield remover 200 may include a proximal tubular member 210 that, at its distal edge, is integrally coupled to a distal tubular member 212 in some exemplary embodiments.
  • the distal tubular member 212 may have a smaller outer diameter and a shorter length than the proximal tubular member 210, and may extend along a shorter length of the needle shield remover 200 along the longitudinal axis L than the proximal tubular member 210.
  • a transition portion 214 may extend between the proximal tubular member 210 and the distal tubular member 212.
  • An exemplary transition portion 214 may be a stepped transition, a ramped transition, or a combination of both.
  • the distal tubular member 212 may be substantially cylindrical in shape with a substantially circular or oval cross-section.
  • the side wall of the distal tubular member 212 may include one or more platform structures that project longitudinally from the face of the distal tubular member 212 toward a removable distal cap.
  • a platform structure may include a first longitudinally-projecting portion 216a, a second longitudinally-projecting portion 216b, and a transverse portion 216c that extends between the longitudinally-projecting portions 216a, 216b at a distal end of the platform structure.
  • the transverse portion 216c may support one or more cap engagement mechanisms in one exemplary embodiment.
  • an exemplary platform structure may support or define or provide one or more cap engagement mechanisms 218a, 218b that project radially outwardly from the platform structure.
  • Exemplary cap engagement mechanisms may take the form of protrusions, teeth, clips, and other suitable engagement mechanisms.
  • Exemplary cap engagement mechanisms 218a, 218b may have any suitable dimensions and structure.
  • Exemplary lengths of the cap engagement mechanisms may include, but are not limited to, about 1, 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6, 6.5, 7 mm, all intermediate numbers, and the like.
  • a first cap engagement mechanism 218a and a second cap engagement mechanism 218b are provided at opposite sides of the platform structure, i.e., separated from each other by about 180 degrees.
  • the cap engagement mechanisms are provided separately and spaced from each other.
  • a single cap engagement mechanism may be provided to extend in an annular manner around the platform structure.
  • exemplary needle shield removers may include any suitable number of cap engagement mechanisms extending from the platform structure including, but not limited to, one, two, three, four, five, six, seven, and the like.
  • each cap engagement mechanism 218a, 218b may be coupled to or may be provided integrally with the platform structure, and a second end of each cap engagement mechanism 218a, 218b may be suspended over a corresponding gap 220a, 220b between the second end of the cap engagement mechanism and the distal tubular member 212.
  • the cap engagement mechanisms 218a, 218b may be coupled to the cap 204 so that removal of the cap also automatically removes the needle shield remover 200.
  • Figure 2C illustrates a cross-sectional perspective view of the removable distal cap 204 in which a central aperture 226 is provided along longitudinal axis L.
  • Figure 2D is a bottom view of a distal face 222 of the distal cap 204 showing engagement of the needle shield remover 200 to the distal cap 204.
  • One or more inwardly-projecting stop portions 228a, 228b may be provided at the interior surface of the central aperture 226 of the distal cap 204.
  • the inwardly-projecting stop portions 228a, 228b may not extend along the entire periphery of the central aperture 226.
  • the inwardly-projecting stop portions may extend along the entire periphery of the central aperture 226.
  • the one or more cap engagement mechanisms 218a, 218b of the needle shield remover 200 may be made to fit through the aperture 226 of the distal cap 204.
  • inwardly-projecting stop portions 228a, 228b e.g., flanges or raised edges
  • inwardly-projecting stop portions 228a, 228b e.g., flanges or raised edges
  • the needle shield remover 200 allows the needle shield remover 200 to be reliably engaged to the distal cap 204 upon assembly and during removal of the cap 204 from the device housing, thus causing removal of the distal cap 204 from the device housing to automatically remove the needle shield remover 200 as well. Since the needle shield remover 200 is reliably engaged to one or more needle shields 206, 208, removal of the needle shield remover, in turn, automatically removes the needle shields as well.
  • the cap engagement mechanisms 218a, 218b may snap into place in the aperture 226 of the distal cap 204 so that the inwardly-projecting stop portions 228a, 228b are positioned within the gap 220a, 220b of the needle shield remover 200.
  • this decrease in the force may be sensed by a user or automatically by an assembly machine to determine that the inwardly-projecting stop portions 228a, 228b of the distal cap 204 have been reliably positioned within the gap 220a, 220b of the needle shield remover 200.
  • an audible "click” sound may be emitted to provide an audible indication that the distal cap 204 has been successfully engaged with the needle shield remover 200.
  • the proximal tubular member 210 of the needle shield remover 200 may be substantially cylindrical in shape with a substantially circular or oval cross-section.
  • the side wall of the first tubular member 210 may enclose and define a substantially cylindrical cavity for housing the injection needle covered by the soft needle shield 206 and the rigid needle shield 208.
  • the side wall of the proximal tubular member 210 may define and/or include one or more inwardly-projecting shield engagement mechanisms 230a, 230b that are biased by the side wall to reliably remain positioned within a gap 232 formed between the body of the syringe 202 and the proximal edge of the rigid needle shield 208.
  • a first inwardly-projecting shield engagement mechanism 230a and a second inwardly-projecting shield engagement mechanism 230b are provided at opposite sides of the needle shield remover 200, i.e., separated from each other by about 180 degrees.
  • the inwardly-projecting shield engagement mechanisms 230a, 230b may be positioned in the gap 232 during the assembly process and may reliably be positioned in the gap during the use of the device.
  • the inwardly-projecting shield engagement mechanisms 230a, 230b exert force in the direction R against the peripheral edge of the rigid needle shield 208, thereby pulling the rigid needle shield 208 and the soft needle shield 206 away from the syringe body 202 in the direction R and exposing the injection needle for performing an injection.
  • Exemplary inwardly-projecting shield engagement mechanisms 230a, 230b may be configured to bias against the gap 232 with a sufficient force to ensure that when the needle shield remover is removed from the device, the needle shield remover 200 remains engaged with the rigid needle shield 208 and thereby reliably removes the rigid needle shield 208 from the body of the syringe 202.
  • Exemplary inwardly-projecting shield engagement mechanisms 230a, 230b may be configured to interface with the gap 232 over a sufficient area or width to apply a sufficient force to remove the rigid needle shield when the needle shield remover is pulled away from the syringe.
  • a width of an exemplary inwardly-projecting shield engagement mechanism 230a, 230b that interfaces with the gap 232 may range from about 3 mm to about 7 mm, but is not limited to this exemplary range.
  • the edge of the inwardly-projecting shield engagement mechanisms 230a, 230b that interfaces with the gap 232 may be substantially straight.
  • the edge of the inwardly-projecting shield engagement mechanisms 230a, 230b that interfaces with the gap 232 may be serrated.
  • the inner diameter of the needle shield remover 200 at the inwardly-projecting shield engagement mechanisms 230a, 230b may be less than the outer diameter of the rigid needle shield 208.
  • the inner diameter of the needle shield remover 200 at the inwardly-projecting shield engagement mechanisms 230a, 230b may also be less than the outer diameter of the syringe body 202.
  • the inner diameter of the needle shield remover 200 at the inwardly-projecting shield engagement mechanisms 230a, 230b may be substantially equal to the outer diameter of the gap 232 formed between the syringe body and the proximal end of the rigid needle shield 208.
  • This configuration of the inwardly-projecting shield engagement mechanisms 230a, 230b allows the shield engagement mechanisms to snap into place at the gap 232 in a reliable and tight manner so that disengagement requires a minimal threshold level of force. This configuration also prevents creep of the inwardly-projecting shield engagement mechanisms 230a, 230b out of the gap 232 before the needle shield remover 200 is pulled away from the syringe body.
  • An exemplary inner diameter of the needle shield remover 200 may range from about 5 mm to about 20 mm, but is not limited to this exemplary range.
  • An exemplary inner diameter of the needle shield remover 200 may range from about 8 mm to about 11 mm in some exemplary embodiments.
  • An exemplary inner diameter of the needle shield remover 200 may be about 8.5 mm in an exemplary embodiment.
  • An exemplary inner diameter of the needle shield remover 200 may be about 11 mm in another exemplary embodiment.
  • the inwardly-projecting shield engagement mechanisms 230a, 230b may snap into place at the gap 232 as the needle shield remover 200 is inserted over the rigid needle shield 208.
  • the inwardly-projecting shield engagement mechanisms 230a, 230b snap into place at the gap 232, there may be a decrease in the force experienced against insertion of the needle shield remover 200 over the rigid needle shield 208.
  • this decrease in the force may be sensed by a user or automatically by an assembly machine to determine that the inwardly-projecting shield engagement mechanisms 230a, 230b have been successfully engaged to the gap 232.
  • the positioning of the inwardly-projecting shield engagement mechanisms 230a, 230b in the gap 232 may emit an audible "click" sound that provides an audible indication that the needle shield remover 200 has been successfully engaged with the rigid needle shield 208.
  • exemplary needle shield removers may include any suitable number of inwardly-projecting shield engagement mechanisms 230a, 230b including, but not limited to, one, two, three, four, five, six, seven, and the like.
  • Exemplary inwardly-projecting shield engagement mechanisms may take the form of protrusions, teeth, clips, and other suitable engagement mechanisms.
  • the one or more inwardly-projecting shield engagement mechanisms 230a, 230b are configured and positioned to consistently and reliably fit within the gap 232 formed between the body of the syringe 202 and the proximal edge of the rigid needle shield 208.
  • one or more inwardly-projecting shield engagement mechanisms 230a, 230b may be configured and positioned to consistently and reliably engage with an aperture in the rigid needle shield 208 (for example, exemplary aperture 108 illustrated in Figure 1A ).
  • one or more inwardly-projecting shield engagement mechanisms 230a, 230b may be configured and positioned to consistently and reliably engage with a ridged portion in the rigid needle shield 208 (for example, exemplary ridged portion 110 illustrated in Figure 1A ). This allows automatic removal of the rigid needle shield 208 (and an associated soft needle shield 206) by the inwardly-projecting shield engagement mechanisms 230a, 230b of the needle shield remover 200, when the needle shield remover 200 is removed from the device housing by engagement of the needle shield remover 200 with a distal cap 204 that is removed by a user.
  • one or more inwardly-projecting shield engagement mechanisms 230a, 230b of the needle shield remover 200 may be configured and positioned to consistently and reliably engage with the soft needle shield 206.
  • the inwardly-projecting shield engagement mechanisms 230a, 230b may be configured and positioned to engage any other suitable component on the rigid needle shield 208 and/or the soft needle shield 206.
  • the inwardly-projecting shield engagement mechanisms 230a, 230b are provided in a component separate from the rigid needle shield 208 (i.e., in the needle shield remover 200), and the shield engagement mechanisms 230a, 230b are not permanently engaged with the rigid needle shield 208.
  • the inwardly-projecting shield engagement mechanisms 230a, 230b of the needle shield remover 200 may be permanently engaged with the rigid needle shield 208, for example, using glue or epoxy.
  • the side wall of the proximal tubular member 210 of the needle shield remover 200 may also define one or more cutout portions 234 for allowing a user to view the contents of the syringe 202 and/or to view an end-of-injection indicator from outside the device housing. That is, the cutout portions 234 of the proximal tubular member 210 may align with a transparent inspection window or inspection aperture provided in the device housing to allow a user to view the contents of the syringe 202 and/or to view an end-of-injection indicator from outside the device.
  • each cutout portion 234 may be provided at opposite sides of the needle shield remover 200, i.e., separated from each other by about 180 degrees.
  • the cutout portions 234 may be provided in an alternating manner with the inwardly-projecting shield engagement mechanisms 230a, 230b, all of which may be provided at or near the proximal edge of the proximal tubular member 210.
  • each cutout portion 234 may have a substantially concave shape or a semicircular shape, but is not limited to these exemplary shapes.
  • An exemplary width of the cutout portions may range from about 3 mm to about 7 mm, but is not limited to this exemplary range.
  • Exemplary widths of the cutout portions may include, but are not limited to, about 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0 mm, and the like.
  • One or more additional protrusions and/or grooves may be provided in the exterior surface of the proximal tubular member 210 and/or the distal tubular member 212 in order to facilitate engagement of the needle shield remover 200 with another component of the automatic injection device, e.g., a syringe sleeve that cooperatively engages with and covers a proximal portion of the needle shield remover 200, a removable cap 204 that covers a distal portion of the needle shield remover 200, and the like.
  • a syringe sleeve that cooperatively engages with and covers a proximal portion of the needle shield remover 200
  • a removable cap 204 that covers a distal portion of the needle shield remover 200
  • one or more longitudinally-extending grooves 236a, 236b may be provided in the exterior surface of the needle shield remover 200 to movably engage with a syringe sleeve.
  • the syringe sleeve may allow relative movement of the syringe sleeve and/or the needle shield remover 200 along the longitudinal axis L, but may hold the needle shield remover 200 in a substantially fixed axial orientation relative to the syringe sleeve. This ensures that the cutout portions 234 of the needle shield remover 200 are maintained in alignment with a transparent inspection window or inspection aperture provided in the syringe sleeve and with a transparent inspection window or inspection aperture provided in the device housing, thus allowing a user to view the contents of the syringe 202 and/or to view an end-of-injection indicator through the inspection windows or apertures. Certain exemplary embodiments of syringe sleeves are described in connection with Figures 3 and 4 .
  • the needle shield remover 200 may be provided as a separate component from the distal cap 204 of the automatic injection device.
  • a needle shield remover 200 may be provided integrally with the distal cap 204, for example, by integrally coupling the cap engagement mechanisms 218a, 218b of the needle shield remover 200 with the distal cap 204 of the device.
  • An exemplary automatic injection device may include a syringe sleeve that is a structural member for enveloping a portion of a syringe fitted with a needle shield remover.
  • the syringe sleeve may be configured to hold and guide the syringe fitted with a needle shield remover, so that the syringe may move forwardly within and relative to the housing of the device from a retracted position (i.e., farther away from the injection site) to an injection position (i.e., closer to the injection site in which the injection needle projects from an open end of the device housing).
  • the syringe may rest within the syringe sleeve, and both may be housed within the housing of the automatic injection device.
  • exemplary automatic injection devices may not provide a syringe sleeve.
  • An exemplary syringe sleeve may include a transparent inspection window or inspection aperture that may be aligned with both a cutout portion of the needle shield remover and an inspection window or inspection aperture provided the device housing, so that the contents of the syringe may be reliably viewed from outside the device housing.
  • the syringe sleeve may maintain the needle shield remover in a substantially fixed axial orientation so that the cutout portion of the needle shield remover is aligned with the inspection window or inspection aperture of the syringe sleeve and the device housing. This ensures that movement of the needle shield remover within the device does not lead to obscuration of the inspection window or inspection aperture of the device housing.
  • the syringe sleeve may have any suitable configuration, shape and size suitable for accommodating the syringe fitted with the needle shield remover, and for axially orienting the cutout portion of the needle shield remover in alignment with the inspection window or inspection aperture of the device housing.
  • the syringe sleeve may be formed of any suitable material including, but not limited to, thermoplastic polymers, e.g., polycarbonates.
  • Figure 3A illustrates a perspective view of an exemplary syringe sleeve 300.
  • Figure 3B illustrates a cross-sectional perspective view of the exemplary syringe sleeve 300 bisected along a longitudinal axis L.
  • the exemplary syringe sleeve 300 may include a tubular member 302 that may be substantially cylindrical in shape with a substantially circular or oval cross-section.
  • the side wall of the tubular member 302 may enclose and define a substantially cylindrical cavity for housing a syringe fitted with a needle shield remover.
  • the side wall of the tubular member 302 may define and/or include one or more transparent inspection windows or inspection apertures 304 for allowing a user of the device to view the contents of the syringe and/or an indicator.
  • the inspection window or inspection aperture of the tubular member 302 may be aligned with the cutout portion of the needle shield remover and with the inspection window or inspection aperture of the automatic injection device housing to provide a clear unobstructed view of the syringe contents and/or an indicator.
  • the inspection window or inspection aperture 304 may have any suitable configuration, size and shape for allowing viewing of the contents of the syringe.
  • Exemplary shapes of the inspection window or inspection aperture 304 may include, but are not limited to, a substantially elongated oval or elliptical shape, a substantially elongated rectangular shape, and the like.
  • the inspection window or inspection aperture 304 may have a longer length along the longitudinal axis L than a width along a transverse axis.
  • the entire syringe sleeve 300 may be formed of a transparent material.
  • the inspection window or inspection aperture 304 may be the only component of the syringe sleeve 300 that is formed of a transparent material or is an aperture in the tubular member 302.
  • An exterior surface of the tubular member 302 may include one or more raised structures and/or grooves to engage with one or more other components of the automatic injection device.
  • An exemplary raised structure may be one or more longitudinally-extending rails 306, 308 that may fit movably along internal longitudinally-extending grooves and/or protrusions (not pictured) provided on an interior surface of the device housing.
  • the rails 306, 308 may allow the syringe sleeve 300 to move longitudinally relative to the device housing, and may allow the syringe sleeve 300 to be held in a fixed axial orientation relative to the device housing.
  • the rails 306, 308 may extend along the entire length of the tubular member 302.
  • one, two, three, four, five, six rails may be provided in the exterior surface of the tubular member 302, but the number of rails is not limited to these exemplary numbers.
  • Exemplary lengths of the rails 306, 308 or grooves and/or protrusions in the exterior surface of the tubular member 302 may range from about 1 mm to about 6 mm, but are not limited to this exemplary range.
  • An interior surface of the tubular member 302 may include one or more raised structures and/or grooves to engage with one or more other components of the automatic injection device.
  • An exemplary raised structure may be one or more longitudinally-extending rails 310 that may fit movably along internal longitudinally-extending grooves and/or protrusions provided on an exterior surface of a needle shield remover.
  • the rails 310 may allow the syringe sleeve 300 to move longitudinally relative to the needle shield remover and to allow the needle shield remover to move longitudinally relative to the syringe sleeve 300.
  • the rails 310 may also allow the needle shield remover to be held in a fixed axial orientation relative to the syringe sleeve 300.
  • Exemplary lengths of the rails 310 or grooves on the interior surface of the tubular member 302 may range from about 1 mm to about 6 mm, but are not limited to this exemplary range.
  • a proximal portion of the tubular member 302 may be coupled to one or more longitudinally-extending syringe alignment guides 311, 312, 314, 316 for aligning a syringe in a substantially fixed axial orientation relative to the syringe sleeve 300. This ensures that the inspection window or inspection aperture 304 of the tubular member 302 is reliably aligned with a corresponding cutout portion of an exemplary needle shield remover attached to the syringe.
  • syringe alignment guides may be used in exemplary syringe sleeves.
  • a first pair of guides may include a first syringe alignment guide 311 and a second syringe alignment guide 312.
  • a second pair of guides may be provided on an opposite side of the tubular member 302 (i.e., offset from the first pair of guides by about 180 degrees), and may include a third syringe alignment guide 314 and a fourth syringe alignment guide 316.
  • the alignment guides 311 and 312 may be coupled to each other by a first beam 318 extending along a transverse axis between the alignment guides 311 and 312.
  • a tabbed foot 320 may extend outwardly from the first beam 318 to engage with the device housing.
  • the alignment guides 311 and 312 may be coupled together by a second flexible beam 322 extending along a transverse axis between the alignment guides 311 and 312.
  • the second flexible beam 322 may provide a stopping position for the proximal end of the syringe. That is, when a flanged proximal end of the syringe reaches the second flexible beam 322, the syringe may be prevented from farther movement toward the injection site as it has already achieved its injection position.
  • the alignment guides 314 and 316 may be coupled to each other by a first beam 324 extending along a transverse axis between the alignment guides 314 and 316.
  • a tabbed foot 326 may extend outwardly from the first beam 324 to engage with the device housing.
  • the alignment guides 314 and 316 may be coupled together by a second flexible beam 328 extending along a transverse axis between the alignment guides 314 and 316.
  • the second flexible beam 328 may provide a stopping position for the proximal end of the syringe. That is, when a flanged proximal end of the syringe reaches the second flexible beam 328, the syringe may be prevented from farther movement toward the injection site as it has already achieved its injection position.
  • Figure 4A illustrates a perspective view of an assembly of an exemplary syringe sleeve 300 housing an exemplary syringe 400 that is fitted with an exemplary needle shield remover 200 at its distal end.
  • the syringe alignment guides 311, 312, 314, 316 provided at the proximal portion of the syringe sleeve 300 may align the syringe 400 and hold it in a substantially fixed axial orientation relative to the syringe sleeve 300.
  • the needle shield remover 200 and the syringe sleeve 300 overlap each other at some portions, such that the inspection window or inspection aperture 304 of the syringe sleeve 300 overlaps and is aligned with a cutout portion of the needle shield remover 200.
  • Figure 4B illustrates a transverse cross-sectional view of an exemplary assembly in which an exemplary syringe sleeve 300 that houses an exemplary syringe 400 fitted with an exemplary needle shield remover 200.
  • the exemplary syringe sleeve 300 includes four exemplary longitudinally-extending rails 402, 404, 406, 408 on an interior surface of the exemplary syringe sleeve 300.
  • the syringe sleeve 300 partially encloses an exemplary needle shield remover 200 including four corresponding longitudinal grooves 410, 412, 414, 416, respectively.
  • Each rail of the syringe sleeve 300 may engage with a corresponding groove of the needle shield remover 200, so that the needle shield remover 200 is held in a substantially fixed axial orientation relative to the syringe sleeve 300.
  • syringe sleeves other than the exemplary syringe sleeve illustrated in Figures 3A, 3B , 4A and 4B may be used in exemplary automatic injection devices.
  • Figures 5A and 5B illustrate an exemplary needle shield remover 500 having two exemplary inwardly-projecting shield engagement mechanisms for engagement with a rigid needle shield.
  • Figure 5A illustrates a perspective view of the exemplary needle shield remover 500.
  • Figure 5B illustrates a cross-sectional perspective view of the exemplary needle shield remover 500 of Figure 5A bisected along a longitudinal axis L.
  • the exemplary needle shield remover 500 may include a proximal tubular member 502 that, at its distal edge, is integrally coupled to a distal tubular member 504 in some exemplary embodiments.
  • the distal tubular member 504 may have a smaller diameter and a shorter length than the proximal tubular member 502, and may extend along a shorter length of the needle shield remover 500 along the longitudinal axis L than the proximal tubular member 502.
  • a transition portion 506 may extend between the proximal tubular member 502 and the distal tubular member 504.
  • An exemplary transition portion 506 may be a stepped transition, a ramped transition, or a combination of both.
  • the distal tubular member 504 of the needle shield remover 500 may be substantially cylindrical in shape with a substantially circular or oval cross-section.
  • the side wall of the distal tubular member 504 may include one or more platform structures that project longitudinally from the face of the distal tubular member 504 toward a removable distal cap.
  • a platform structure may include a first longitudinally-projecting portion 508a, a second longitudinally-projecting portion 508b, and a transverse portion 508c that extends between the longitudinally-projecting portions 508a, 508b at a distal end of the platform structure.
  • the transverse portion 508c may support one or more cap engagement mechanisms in one exemplary embodiment.
  • an exemplary platform structure may support or define or provide a first outwardly-projecting flexible cap engagement mechanism 510a and a second outwardly-projecting flexible cap engagement mechanism 510b that project radially outwardly from the platform structure.
  • Exemplary cap engagement mechanisms may be any suitable protrusion, projection, teeth, and the like.
  • the cap engagement mechanisms 510a, 510b are provided at opposite sides of the platform structure, i.e., separated from each other by about 180 degrees.
  • exemplary needle shield removers may include any suitable number of cap engagement mechanisms extending from the platform structure including, but not limited to, one, two, three, four, five, six, seven, and the like.
  • each cap engagement mechanisms 510a, 510b may be coupled to or may be provided integrally with the platform structure, and a second end of each cap engagement mechanism 510a, 510b may be suspended over a gap 512a, 512b between the cap engagement mechanisms 510a, 510b and the distal tubular member 504.
  • the cap engagement mechanisms 510a, 510b may be coupled to the distal cap so that removal of the cap also automatically removes the needle shield remover 500.
  • the cap engagement mechanisms 510a, 510b of the needle shield remover 500 may be inserted to fit within a central aperture provided in the distal cap such that one or more inwardly-projecting stop portions (e.g., flanges or raised edges) provided in the central aperture of the distal cap reliably engage the gaps 512a, 512b of the needle shield remover 500.
  • This engagement allows the needle shield remover 500 to be reliably engaged to the distal cap after assembly and during removal of the distal cap from the device housing, thus causing removal of the distal cap from the device housing to automatically remove the needle shield remover 500 as well. Since the needle shield remover 500 is reliably engaged to one or more needle shields, removal of the needle shield remover, in turn, automatically removes the needle shields coupled to a syringe.
  • the needle shield remover 500 may be provided as a separate component from a distal cap of the automatic injection device.
  • a needle shield remover may be provided integrally with the distal cap, for example, by integrally coupling the cap engagement mechanisms 510a, 510b of the needle shield remover 500 with the distal cap of the device.
  • the proximal tubular member 502 of the needle shield remover 500 may be substantially cylindrical in shape with a substantially circular or oval cross-section.
  • the side wall of the proximal tubular member 502 may enclose and define a substantially cylindrical cavity 514 for housing the injection needle covered by a soft needle shield and/or a rigid needle shield coupled to a syringe.
  • the side wall of the proximal tubular member 502 may define and/or include a first inwardly-projecting shield engagement mechanisms 516a and a second inwardly-projecting shield engagement mechanism 516b.
  • the first and second inwardly-projecting shield engagement mechanisms 516a, 516b may be biased by the side wall to reliably remain positioned within a gap formed between the body of a syringe and the proximal edge of a rigid needle shield.
  • Exemplary inwardly-projecting shield engagement mechanisms 516a, 516b may be any suitable protrusion, projection, teeth, and the like.
  • the exemplary inwardly-projecting shield engagement mechanisms 516a, 516b are provided at opposite sides of the needle shield remover 500, i.e., separated from each other by about 180 degrees.
  • the inwardly-projecting shield engagement mechanisms 516a, 516b may be positioned in a gap formed between a syringe body and a rigid needle shield during the assembly process, and may reliably be positioned in the gap during the use of the device.
  • the inwardly-projecting shield engagement mechanisms 516a, 516b exert force in the direction R against the peripheral edge of the rigid needle shield, thereby pulling the rigid needle shield and the soft needle shield away from the syringe body in the direction R and exposing the injection needle for performing an injection.
  • each inwardly-projecting shield engagement mechanisms 516a, 516b may be situated at an aperture 518a, 518b in the proximal tubular member 502.
  • Each inwardly-projecting shield engagement mechanisms 516a, 516b may include a first inclined or radial wall 520a, 520b that extends from a proximal base wall of the aperture 518a, 518b and projects inwardly into the cavity 514 at a first angle relative to the longitudinal axis L.
  • the first inclined or radial wall 520a, 520b may be coupled to or may be integrally formed with an inwardly-projecting second inclined or radial wall 522a, 522b.
  • the second inclined or radial wall 522a, 522b may extend from the first inclined or radial wall inwardly into the cavity 514 at a second angle relative to the longitudinal axis L.
  • the second angle corresponding to the second inclined or radial wall 522a, 522b may be substantially greater than the first angle corresponding to the first inclined or radial wall 520a, 520b, so that the first inclined or radial wall 520a, 520b extends substantially along the longitudinal axis L and the second inclined or radial wall 522a, 522b extends substantially orthogonally to the longitudinal axis L.
  • An exemplary first angle may range from about 0 degree to about 20 degrees relative to the longitudinal axis L toward the cavity 514.
  • An exemplary second angle may range from about 30 degrees to about 60 degrees relative to the longitudinal axis L toward the cavity 514.
  • Providing the shield engagement mechanisms 516a, 516b as part of the proximal tubular member 502 facilitates robust assembly of the needle shield remover 500 in the automatic injection device. Projection of the inclined or radial walls of the shield engagement mechanisms 516a, 516b from the proximal base wall of the aperture 518a, 518b inwardly into the cavity 514 also facilitates robust assembly of the needle shield remover 500 in the device.
  • expansion of the outer diameter of the needle shield remover 500 is minimized during assembly in order to minimize the risk of the shield engagement mechanisms 516a, 516b not being positioned at the gap between the needle shield and the syringe body and to minimize the risk of the shield engagement mechanisms 516a, 516b from becoming disengaged from the gap between the needle shield and the syringe body.
  • Certain conventional needle shield removers include shield engagement mechanisms that are not formed as a part of a tubular member.
  • the shield engagement mechanisms do not extend from a proximal base edge of an aperture or support mechanism.
  • These conventional needle shield removers do not minimize a radially outward movement needle shield removers at the shield engagement mechanisms. This radially outward movement of the conventional needle shield removers reduces the robustness of the assembly process as it increases the risk of positioning the shield engagement mechanisms outside a gap formed between the syringe body and the needle shield.
  • Exemplary first and second inclined or radial walls may have any suitable dimension and structure.
  • Exemplary lengths and widths of the first and second inclined or radial walls may include, but are not limited to, about 1, 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6, 6.5, 7 mm, all intermediate numbers, and the like.
  • the second inclined or radial walls 522a, 522b of the inwardly-projecting shield engagement mechanisms 516a, 516b may be configured to be positioned within a gap formed between a syringe body and a proximal edge of a rigid needle shield.
  • Each second inclined or radial wall 522a, 522b may have a peripheral edge 524a, 524b with a width that provides a sufficiently large interface with the rigid needle shield.
  • the width of the peripheral edge 524a, 524b may range from about 3 mm to about 7 mm, but is not limited to this exemplary range. In an exemplary embodiment, the width is about 4.00 mm.
  • the inwardly-projecting first and second inclined or radial walls 520a, 520b, 522a, 522b cause the inner diameter of the needle shield remover 500 at the inwardly-projecting shield engagement mechanisms 516a, 516b to be less than the outer diameter of the proximal end of the rigid needle shield.
  • the inwardly-projecting first and second inclined or radial walls 520a, 520b, 522a, 522b cause the inner diameter of the needle shield remover 500 at the inwardly-projecting shield engagement mechanisms 516a, 516b to be less than the outer diameter of the syringe body.
  • the inner diameter of the needle shield remover 500 at the inwardly-projecting shield engagement mechanisms 516a, 516b may be substantially equal to the outer diameter of the gap formed between the syringe body and the proximal end of the rigid needle shield.
  • This configuration of the inwardly-projecting shield engagement mechanisms 516a, 516b thereby allows the second inclined or radial walls 522a, 522b to snap into place at the gap in a reliable and tight manner so that disengagement requires at least a minimal threshold level of force.
  • This configuration also prevents creep of the second inclined or radial walls 522a, 522b out of the gap after assembly but before removal by a user.
  • the inwardly-projecting shield engagement mechanisms 516a, 516b may snap into place at the gap formed between the rigid needle shield and the syringe body, as the needle shield remover 500 is inserted over the rigid needle shield.
  • this decrease in the force may be sensed by a user or automatically by an assembly machine to determine that the inwardly-projecting shield engagement mechanisms 516a, 516b have been successfully engaged to the gap formed between the rigid needle shield and the syringe body.
  • the positioning of the inwardly-projecting shield engagement mechanisms 516a, 516b in the gap may emit an audible "click" sound that provides an audible indication that the needle shield remover 500 has been successfully engaged with the rigid needle shield.
  • the needle shield remover 500 may be provided as a separate component from a needle shield of the automatic injection device.
  • a needle shield remover may be provided integrally with the rigid needle shield, for example, by integrally coupling the inwardly-projecting shield engagement mechanisms 516a, 516b of the needle shield remover 500 with the rigid needle shield.
  • the side wall of the proximal tubular member 502 may also define one or more cutout portions 526a, 526b for allowing a user to view of the contents of the syringe and/or to view an indicator from outside the device housing. That is, the cutout portions 526a, 526b of the proximal tubular member 502 align with a transparent inspection window or inspection aperture of the device housing to allow a user to view the syringe contents and/or to view an indicator from outside the device.
  • a first cutout portion 526a and a second cutout portion 526b are provided at opposite sides of the needle shield remover 500, i.e., separated from each other by about 180 degrees.
  • the cutout portions 526a, 526b may be provided in an alternating manner with the inwardly-projecting shield engagement mechanisms 516a, 516b, all of which are provided at or near the proximal edge of the proximal tubular member 502.
  • each cutout portion 526a, 526b may take a substantially concave shape or a semicircular shape, but is not limited to these exemplary shapes.
  • one or more additional protrusions and/or grooves may be provided in the exterior surface of the proximal tubular member 502 and/or the distal tubular member 504 in order to facilitate engagement of the needle shield remover 500 with another component of the automatic injection device, e.g., a syringe sleeve that cooperatively engages with and covers a proximal portion of the needle shield remover, a removable cap that covers a distal portion of the needle shield remover, and the like.
  • a syringe sleeve that cooperatively engages with and covers a proximal portion of the needle shield remover
  • a removable cap that covers a distal portion of the needle shield remover
  • one or more longitudinally-extending grooves 528a, 528b may be provided in the exterior surface of the needle shield remover 500 to movably engage with a syringe sleeve.
  • the syringe sleeve may allow relative movement of the syringe sleeve and/or the needle shield remover along the longitudinal axis L, but may hold the needle shield remover in a substantially fixed axial orientation relative to the syringe sleeve. This ensures that the cutout portions 526a, 526b of the needle shield remover 500 are maintained in alignment with a transparent inspection window or inspection aperture of the syringe sleeve and with a transparent inspection window or inspection aperture of the device housing, thus allowing a user to view the contents of the syringe and/or to view an indicator through the inspection windows or inspection apertures.
  • Figures 6 illustrates a cross-sectional perspective view of the exemplary needle shield remover 500 of Figures 5A and 5B assembled with a syringe 600 and a distal cap 800.
  • the assembly lacks a syringe sleeve.
  • Figure 7 illustrates a cross-sectional perspective view of the exemplary needle shield remover 500 of Figures 5A and 5B assembled with a syringe 600 and a distal cap 800.
  • the assembly includes a syringe sleeve 700.
  • Figure 8 illustrates a front cross-sectional view of the exemplary assembly of Figure 7 including a syringe sleeve 700.
  • Figure 9 illustrates a bottom view of an exemplary distal cap 800 that is applicable to Figures 6-8 .
  • An injection needle 604 may be affixed to a distal end of the syringe 600, a bung 606 may be disposed within the syringe 600, and a dose of a therapeutic agent 608 may be provided to fill the syringe 600.
  • the injection needle 604 may be covered with a soft needle shield 610 and a rigid needle shield 612 disposed over the soft needle shield 610.
  • the exemplary needle shield remover 500 may be disposed over the rigid needle shield 612 so that the inwardly-projecting shield engagement mechanisms 516a, 516b of the needle shield remover 500 fit within a gap between the rigid needle shield 612 and the body of the syringe 600.
  • the cap engagement mechanisms 510a, 510b of the needle shield remover 500 may engage with a distal cap 800 provided to cover the distal portion of the device.
  • the cap engagement mechanisms 510a, 510b may be accommodated within a central aperture 802 provided in the distal cap 800, so that one or more inwardly-projecting stop portions 804a, 804b (e.g., flanges or raised edges) provided in the central apertures 802 of the distal cap 800 are positioned reliably within gaps 512a, 512b proximal to the cap engagement mechanisms 510a, 510b.
  • a single stop portion may extend radially around the periphery of the central aperture 802.
  • a syringe sleeve 700 may be provided over the syringe 600 and the needle shield remover 500 to maintain the needle shield remover 500 in a substantially fixed axial orientation with the device housing.
  • Figures 10A and 10B illustrate an exemplary needle shield remover 1000 having two exemplary inwardly-projecting shield engagement mechanisms for engagement with a rigid needle shield.
  • Figure 10A illustrates a perspective view of the exemplary needle shield remover 1000.
  • Figure 10B illustrates a cross-sectional perspective view of the exemplary needle shield remover 1000 bisected along a longitudinal axis L.
  • the exemplary needle shield remover 1000 may include a proximal tubular member 1002 that, at its distal edge, is integrally coupled to a distal tubular member 1004 in some exemplary embodiments.
  • the distal tubular member 1004 may have a smaller diameter and a shorter length than the proximal tubular member 1002, and may extend along a shorter length of the needle shield remover 1000 along the longitudinal axis L than the proximal tubular member 1002.
  • a transition portion 1006 may extend between the proximal tubular member 1002 and the distal tubular member 1004.
  • An exemplary transition portion 1006 may be a stepped transition, a ramped transition, or a combination of both.
  • the distal tubular member 1004 of the needle shield remover 1000 may be substantially cylindrical in shape with a substantially circular or oval cross-section.
  • the side wall of the distal tubular member 1004 may include one or more platform structures that project longitudinally from the face of the distal tubular member 1004 toward a removable distal cap.
  • a platform structure may include a first longitudinally-projecting portion 1008a, a second longitudinally-projecting portion 1008b, and a transverse portion 1008c that extends between the first and second longitudinally-projecting portions 1008a, 1008b at the distal end of the platform structure.
  • the transverse portion 1008c may support one or more cap engagement mechanisms in one exemplary embodiment.
  • an exemplary platform structure may support or define or provide a first outwardly-projecting flexible cap engagement mechanism 1010a and a second outwardly-projecting flexible cap engagement mechanism 1010b that project radially outwardly from the platform structure.
  • Exemplary cap engagement mechanisms may be any suitable protrusion, projection, teeth, and the like.
  • the cap engagement mechanisms 1010a, 1010b are provided at opposite sides of the platform structure, i.e., separated from each other by about 180 degrees.
  • exemplary needle shield removers may include any suitable number of cap engagement mechanisms extending from the platform structure including, but not limited to, one, two, three, four, five, six, seven, and the like.
  • each cap engagement mechanisms 1010a, 1010b may be coupled to or may be provided integrally with the platform structure, and a second end of each cap engagement mechanism 1010a, 1010b may be suspended over a gap 1012a, 1012b between the cap engagement mechanisms 1010a, 1010b and the distal tubular member 1004.
  • the cap engagement mechanisms 1010a, 1010b may be coupled to the distal cap so that removal of the cap also automatically removes the needle shield remover 1000.
  • the cap engagement mechanisms 1010a, 1010b of the needle shield remover 1000 may be inserted to fit within a central aperture provided in the distal cap such that one or more inwardly-projecting stop portions (e.g., flanges or raised edges) provided in the central aperture of the distal cap reliably engage the gap 1012a, 1012b of the needle shield remover 1000.
  • This engagement allows the needle shield remover 1000 to be reliably engaged to the distal cap after assembly and during removal of the distal cap from the device housing, thus causing removal of the distal cap from the device housing to automatically remove the needle shield remover 1000 as well. Since the needle shield remover 1000 is reliably engaged to one or more needle shields, removal of the needle shield remover, in turn, automatically removes the needle shields coupled to the syringe.
  • the needle shield remover 1000 may be provided as a separate component from a distal cap of the automatic injection device.
  • a needle shield remover may be provided integrally with the distal cap, for example, by integrally coupling the cap engagement mechanisms 1010a, 1010b of the needle shield remover 1000 with the distal cap of the device.
  • the proximal tubular member 1002 of the needle shield remover 1000 may be substantially cylindrical in shape with a substantially circular or oval cross-section.
  • the side wall of the proximal tubular member 1002 may enclose and define a substantially cylindrical cavity 1014 for housing the injection needle covered by a soft needle shield and/or a rigid needle shield coupled to the syringe.
  • the side wall of the proximal tubular member 1002 may define and/or include a first inwardly-projecting shield engagement mechanism 1016a and a second inwardly-projecting shield engagement mechanism 1016b.
  • the first and second inwardly-projecting shield engagement mechanisms 1016a, 1016b may be biased by the side wall to reliably remain positioned within a gap formed between the body of a syringe and the proximal edge of a rigid needle shield.
  • Exemplary inwardly-projecting shield engagement mechanisms 1016a, 1016b may be any suitable protrusion, projection, teeth, and the like.
  • the exemplary inwardly-projecting shield engagement mechanisms 1016a, 1016b are provided at opposite sides of the needle shield remover 1000, i.e., separated from each other by about 180 degrees.
  • the inwardly-projecting shield engagement mechanisms 1016a, 1016b may be positioned in a gap formed between a syringe body and a rigid needle shield during the assembly process, and may reliably be positioned in the gap during the use of the device.
  • the inwardly-projecting shield engagement mechanisms 1016a, 1016b exert force in the direction R against the peripheral edge of the rigid needle shield, thereby pulling the rigid needle shield and the soft needle shield away from the syringe body in the direction R and exposing the injection needle for performing an injection.
  • each inwardly-projecting shield engagement mechanisms 1016a, 1016b may be situated at an aperture 1018a, 1018b that provides an opening in the side wall of the proximal tubular member 1002.
  • Each inwardly-projecting shield engagement mechanisms 1016a, 1016b may include an inwardly-projecting inclined or radial wall 1020a, 1020b that extends from a proximal base wall of the aperture 1018a, 1018b and projects inwardly into the cavity 1014 at an angle relative to the longitudinal axis L.
  • An exemplary angle may range from about 30 degrees to about 60 degrees relative to the longitudinal axis L toward the cavity.
  • Providing the shield engagement mechanisms 1016a, 1016b as part of the proximal tubular member 1002 facilitates robust assembly of the needle shield remover 1000 in the automatic injection device. Projection of the inclined or radial walls of the shield engagement mechanisms 1016a, 1016b from the proximal base wall of the aperture 1018a, 1018b inwardly into the cavity 1014 also facilitates robust assembly of the needle shield remover 1000 in the device.
  • expansion of the outer diameter of the needle shield remover 1000 is minimized during assembly in order to minimize the risk of the shield engagement mechanisms 1016a, 1016b not being positioned at the gap between the needle shield and the syringe body and to minimize the risk of the shield engagement mechanisms 1016a, 1016b from becoming disengaged from the gap between the needle shield and the syringe body.
  • Certain conventional needle shield removers include shield engagement mechanisms that are not formed as a part of a tubular member.
  • the shield engagement mechanisms do not extend from a proximal base edge of an aperture or support mechanism.
  • These conventional needle shield removers do not minimize a radially outward movement needle shield removers at the shield engagement mechanisms. This radially outward movement of the conventional needle shield removers reduces the robustness of the assembly process as it increases the risk of positioning the shield engagement mechanisms outside a gap formed between the syringe body and the needle shield.
  • the proximal tubular member 1002 may be dissected by one or more slots 1001a, 1001b that extend substantially parallel to the longitudinal axis L at radial locations between the shield engagement mechanisms 1016a, 1016b.
  • two exemplary slots 1001a, 1001b may be separated from each other on the proximal tubular member 1002 by about 180 degrees.
  • the slots 1001a, 1001b may facilitate in engaging the shield engagement mechanisms 1016a, 1016b of the needle shield remover 1000 with a rigid needle shield.
  • the slots 1001a, 1001b may allow the shield engagement mechanisms 1016a, 1016b to move radially outwardly as the needle shield remover 1000 is inserted coaxially over a needle shield during assembly, which advantageously allows the needle shield remover 1000 to be engaged to the needle shield without requiring the application of a large amount of force opposite to the direction indicated by arrow R.
  • Application to a large amount force during assembly can result in damage to the needle shields and the syringe, thereby adversely affecting the reliability of the assembled needle shield remover.
  • Exemplary inclined or radial walls may have any suitable dimension and structure.
  • Exemplary lengths and widths of the inclined or radial walls may include, but are not limited to, about 1, 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6, 6.5, 7 mm, all intermediate numbers, and the like.
  • the inclined or radial walls 1020a, 1020b of the inwardly-projecting shield engagement mechanisms 1016a, 1016b may be configured to be positioned within a gap formed between a syringe body and a proximal edge of a rigid needle shield.
  • the inclined or radial wall 1020a, 1020b may have a peripheral edge 1024a, 1024b with a width that provides a sufficiently large interface with the rigid needle shield.
  • the width of the peripheral edge 1024a, 1024b may range from about 3 mm to about 7 mm, but is not limited to this exemplary range. In an exemplary embodiment, the width is about 5.3 mm.
  • the inwardly-projecting inclined or radial walls 1020a, 1020b cause the inner diameter of the needle shield remover 1000 at the inwardly-projecting shield engagement mechanisms 1016a, 1016b to be less than the outer diameter of the proximal end of the rigid needle shield. In an exemplary embodiment, the inwardly-projecting inclined or radial walls 1020a, 1020b cause the inner diameter of the needle shield remover 1000 at the inwardly-projecting shield engagement mechanisms 1016a, 1016b to be less than the outer diameter of the syringe body.
  • the inner diameter of the needle shield remover 1000 at the inwardly-projecting shield engagement mechanisms 1016a, 1016b may be substantially equal to the outer diameter of the gap formed between the syringe body and the proximal end of the rigid needle shield.
  • This configuration of the inwardly-projecting shield engagement mechanisms 1016a, 1016b thereby allows the inclined or radial walls 1020a, 1020b to snap into place at the gap in a reliable and tight manner so that disengagement requires at least a minimal threshold level of force.
  • This configuration also prevents creep of the inclined or radial walls 1020a, 1020b out of the gap after assembly but before removal by a user.
  • the inwardly-projecting shield engagement mechanisms 1016a, 1016b may snap into place at the gap formed between the rigid needle shield and the syringe body, as the needle shield remover 1000 is inserted over the rigid needle shield.
  • this decrease in the force may be sensed by a user or automatically by an assembly machine to determine that the inwardly-projecting shield engagement mechanisms 1016a, 1016b have been successfully engaged to the gap formed between the rigid needle shield and the syringe body.
  • the positioning of the inwardly-projecting shield engagement mechanisms 1016a, 1016b in the gap may emit an audible "click" sound that provides an audible indication that the needle shield remover 1000 has been successfully engaged with the rigid needle shield.
  • the needle shield remover 1000 may be provided as a separate component from a needle shield of the automatic injection device.
  • a needle shield remover may be provided integrally with the rigid needle shield, for example, by integrally coupling the inwardly-projecting shield engagement mechanisms 1016a, 1016b of the needle shield remover 1000 with the rigid needle shield.
  • the side wall of the proximal tubular member 1002 may also define one or more cutout portions 1026a, 1026b for allowing a user to view of the contents of the syringe and/or to view an indicator from outside the device housing. That is, the cutout portions 1026a, 1026b of the proximal tubular member 1002 align with a transparent inspection window or inspection aperture of the device housing to allow a user to view the syringe contents and/or to view an indicator from outside the device.
  • a first cutout portion 1026a and a second cutout portion 1026b are provided at opposite sides of the needle shield remover 1000, i.e., separated from each other by about 180 degrees.
  • the cutout portions 1026a, 1026b may be provided in an alternating manner with the inwardly-projecting shield engagement mechanisms 1016a, 1016b, all of which are provided at or near the proximal edge of the proximal tubular member 1002.
  • each cutout portion 1026a, 1026b may take a substantially concave shape or a semicircular shape, but is not limited to these exemplary shapes.
  • the distal ends of the cutout portions 1026a, 1026b may contiguously join with the dissection slots 1001a, 1001b.
  • one or more additional protrusions and/or grooves may be provided in the exterior surface of the proximal tubular member 1002 and/or the distal tubular member 1004 in order to facilitate engagement of the needle shield remover 1000 with another component of the automatic injection device, e.g., a syringe sleeve that cooperatively engages with and covers a proximal portion of the needle shield remover, a removable cap that covers a distal portion of the needle shield remover, and the like.
  • one or more longitudinally-extending grooves 1028a, 1028b may be provided in the exterior surface of the needle shield remover 1000 to movably engage with a syringe sleeve.
  • the syringe sleeve may allow relative movement of the syringe sleeve and/or the needle shield remover along the longitudinal axis L, but may hold the needle shield remover in a substantially fixed axial orientation relative to the syringe sleeve. This ensures that the cutout portions 1026a, 1026b of the needle shield remover 1000 are maintained in alignment with a transparent inspection window or inspection aperture of the syringe sleeve and with a transparent inspection window or inspection aperture of the device housing, thus allowing a user to view the contents of the syringe and/or to view an indicator through the inspection windows or inspection apertures.
  • Figures 11 illustrates a perspective cross-sectional view of the exemplary needle shield remover 1000 of Figures 10A and 10B assembled with a syringe 600 and a distal cap 800.
  • the assembly lacks a syringe sleeve.
  • Figure 12 illustrates a perspective cross-sectional view of the exemplary needle shield remover 1000 of Figures 10A and 10B assembled with a syringe 600 and a distal cap 800.
  • the assembly includes a syringe sleeve 700.
  • Figure 13 illustrates a front cross-sectional view of the exemplary assembly of Figure 12 including a syringe sleeve 700.
  • Figure 14 illustrates a bottom view of an exemplary distal cap 800 that is applicable to Figures 11-13 .
  • An injection needle 604 may be affixed to a distal end of the syringe 600, a bung 606 may be disposed within the syringe 600, and a dose of a therapeutic agent 608 may be provided to fill the syringe 600.
  • the injection needle 604 may be covered with a soft needle shield 610 and a rigid needle shield 612 disposed over the soft needle shield 610.
  • the exemplary needle shield remover 1000 may be disposed over the rigid needle shield 612 so that the inwardly-projecting shield engagement mechanisms 1016a, 1016b of the needle shield remover 1000 fit within a gap between the rigid needle shield 612 and the body of the syringe 600.
  • the cap engagement mechanisms 1010a, 1010b of the needle shield remover 1000 may engage with a distal cap 800 provided to cover the distal portion of the device.
  • the cap engagement mechanisms 1010a, 1010b may be accommodated within a central aperture 802 provided in the distal cap 800, so that inwardly-projecting stop portions 804a, 804b (e.g., flanges or raised edges) provided in the central aperture of the distal cap are positioned reliably within gaps 1012a, 1012b proximal to the cap engagement mechanisms 1010a, 1010b.
  • a syringe sleeve 700 may be provided over the syringe 600 and the needle shield remover 1000 to maintain the needle shield remover 1000 in a substantially fixed axial orientation with the device housing.
  • Figures 15A and 15B illustrate an exemplary needle shield remover 1500 having three exemplary inwardly-projecting shield engagement mechanisms for engagement with a rigid needle shield.
  • Figure 15A illustrates a perspective view of the exemplary needle shield remover 1500.
  • Figure 15B illustrates a cross-sectional perspective view of the exemplary needle shield remover 1500 bisected along a longitudinal axis L.
  • the exemplary needle shield remover 1500 may include a proximal tubular member 1502 that, at its distal edge, is integrally coupled to a distal tubular member 1504 in some exemplary embodiments.
  • the distal tubular member 1504 may have a smaller diameter and a shorter length than the proximal tubular member 1502, and may extend along a shorter length of the needle shield remover 1500 along the longitudinal axis L than the proximal tubular member 1502.
  • a transition portion 1506 may extend between the proximal tubular member 1502 and the distal tubular member 1504.
  • An exemplary transition portion 1506 may be a stepped transition, a ramped transition, or a combination of both.
  • the distal tubular member 1504 of the needle shield remover 1500 may be substantially cylindrical in shape with a substantially circular or oval cross-section.
  • the side wall of the distal tubular member 1504 may include one or more platform structures 1508 that project longitudinally from the face of the distal tubular member 1504 toward a removable distal cap.
  • a platform structure 1508 may include one or more longitudinally-projecting portions and a transverse portion that extends between the longitudinally-projecting portions at the distal end of the platform structure 1508.
  • one or more platform structures 1508 may support or define or provide a first outwardly-projecting flexible cap engagement mechanism 1510a, a second outwardly-projecting flexible cap engagement mechanism 1510b and a third outwardly-projecting flexible cap engagement mechanism 1510c, that project radially outwardly from the platform structure 1508.
  • Providing three cap engagement mechanisms in this exemplary embodiment provides a larger surface of the needle shield remover that engages with the distal cap than embodiments that include one or two cap engagement mechanism.
  • the exemplary needle shield remover 1500 thereby allows reliably removal of the needle shield remover from the syringe when the distal cap is removed before administration of an injection.
  • Exemplary cap engagement mechanisms may be any suitable protrusion, projection, teeth, and the like.
  • the cap engagement mechanisms 1510a, 1510b, 1510c are spaced from one another around the platform structure 1508, i.e., separated by about 120 degrees.
  • exemplary needle shield removers may include any suitable number of cap engagement mechanisms extending from the platform structure 1508 including, but not limited to, one, two, three, four, five, six, seven, and the like.
  • a first end of each cap engagement mechanisms 1510a, 1510b, 1510c may be coupled to or may be provided integrally with the platform structure 1508, and a second end of each cap engagement mechanism 1510a, 1510b, 1510c may be suspended over a gap (e.g., gap 1512a, 1512b, 1512c) between the cap engagement mechanisms 1510a, 1510b, 1510c and the distal tubular member 1504.
  • a gap e.g., gap 1512a, 1512b, 1512c
  • the cap engagement mechanisms 1510a, 1510b, 1510c may be coupled to the distal cap so that removal of the cap also automatically removes the needle shield remover 1500.
  • the cap engagement mechanisms 1510a, 1510b, 1510c of the needle shield remover 1500 may be inserted to fit within a central aperture provided in the distal cap such that one or more inwardly-projecting stop portions (e.g., flanges or raised edges) provided in the central aperture of the distal cap reliably engage the gaps 1512a, 1512b, 1512c of the needle shield remover 1500.
  • This engagement allows the needle shield remover 1500 to be reliably engaged to the distal cap after assembly and during removal of the distal cap from the device housing, thus causing removal of the distal cap from the device housing to automatically remove the needle shield remover 1500 as well. Since the needle shield remover 1500 is reliably engaged to one or more needle shields, removal of the needle shield remover, in turn, automatically removes the needle shields.
  • the needle shield remover 1500 may be provided as a separate component from a distal cap of the automatic injection device.
  • a needle shield remover may be provided integrally with the distal cap, for example, by integrally coupling the cap engagement mechanisms 1510a, 1510b, 1510c of the needle shield remover 1500 with the distal cap of the device.
  • the proximal tubular member 1502 of the needle shield remover 1500 may be substantially cylindrical in shape with a substantially circular or oval cross-section.
  • the side wall of the proximal tubular member 1502 may enclose and define a substantially cylindrical cavity 1514 for housing the injection needle covered by a soft needle shield and/or a rigid needle shield.
  • the side wall of the proximal tubular member 1502 may define and/or include a first inwardly-projecting shield engagement mechanism 1516a, a second inwardly-projecting shield engagement mechanism 1516b, and a third inwardly-projecting shield engagement mechanism 1516c.
  • the first, second and third inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c may be biased by the side wall to reliably remain positioned within a gap formed between the body of a syringe and the proximal edge of a rigid needle shield.
  • Exemplary inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c may be any suitable protrusion, projection, teeth, and the like.
  • the exemplary inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c may be spaced from one another around the needle shield remover 1500, i.e., separated from each other by about 120 degrees.
  • the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c may be positioned in a gap formed between a syringe body and a rigid needle shield during the assembly process, and may reliably be positioned in the gap during the use of the device.
  • the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c exert force in the direction R against the peripheral edge of the rigid needle shield, thereby pulling the rigid needle shield and the soft needle shield away from the syringe body in the direction R and exposing the injection needle for performing an injection.
  • each inwardly-projecting shield engagement mechanism 1516a, 1516b, 1516c may be situated at an aperture 1518a, 1518b, 1518c that provides an opening in the side wall of the proximal tubular member 1502.
  • Each inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c may include a first inclined or radial wall 1520a, 1520b, 1520c that extends from a proximal wall of the aperture 1518a, 1518b, 1518c into the cavity 1514 at a first angle relative to the longitudinal axis L.
  • the first inclined or radial wall 1520a, 1520b, 1520c may be coupled to or may be integrally formed with an inwardly-projecting second inclined or radial wall 1522a, 1522b, 1522c.
  • the second inclined or radial wall 1522a, 1522b, 1522c may extend from the first inclined or radial wall into the cavity 1514 at a second angle relative to the longitudinal axis L.
  • the second angle corresponding to the second inclined or radial wall 1522a, 1522b, 1522c may be substantially greater than the first angle corresponding to the first inclined or radial wall 1520a, 1520b, 1520c, so that the first inclined or radial wall 1520a, 1520b, 1520c extends substantially along the longitudinal axis L and the second inclined or radial wall 1522a, 1522b, 1522c extends substantially orthogonally to the longitudinal axis L.
  • An exemplary first angle may range from about 0 degree to about 20 degrees relative to the longitudinal axis L toward the cavity 1514.
  • An exemplary second angle may range from about 30 degrees to about 60 degrees relative to the longitudinal axis L toward the cavity 1514.
  • Providing the shield engagement mechanisms 1516a, 1516b, 1516c as part of the proximal tubular member 1502 facilitates robust assembly of the needle shield remover 1500 in the automatic injection device. Projection of the inclined or radial walls of the shield engagement mechanisms 1516a, 1516b, 1516c from the proximal base wall of the aperture 1518a, 1518b, 1518c inwardly into the cavity 1514 also facilitates robust assembly of the needle shield remover 1500 in the device.
  • expansion of the outer diameter of the needle shield remover 1500 is minimized during assembly in order to minimize the risk of the shield engagement mechanisms 1516a, 1516b, 1516c not being positioned at the gap between the needle shield and the syringe body and to minimize the risk of the shield engagement mechanisms 1516a, 1516b, 1516c from becoming disengaged from the gap between the needle shield and the syringe body.
  • Certain conventional needle shield removers include shield engagement mechanisms that are not formed as a part of a tubular member.
  • the shield engagement mechanisms do not extend from a proximal base edge of an aperture or support mechanism.
  • These conventional needle shield removers do not minimize a radially outward movement needle shield removers at the shield engagement mechanisms. This radially outward movement of the conventional needle shield removers reduces the robustness of the assembly process as it increases the risk of positioning the shield engagement mechanisms outside a gap formed between the syringe body and the needle shield.
  • Exemplary first and second inclined or radial walls may have any suitable dimension and structure.
  • Exemplary lengths and widths of the first and second inclined or radial walls may include, but are not limited to, about 1, 2, 2.1,2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8,2.9, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4, 4.1, 4.2, 4.3, 4.4,4.5, 4.6, 4.7, 4.8, 4.9, 5, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6, 6.5, 7 mm, all intermediate numbers, and the like.
  • the second inclined or radial wall 1522a, 1522b, 1522c of the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c may be configured to be positioned within a gap formed between a syringe body and a proximal edge of a rigid needle shield.
  • Providing three inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c in this exemplary embodiment provides a larger surface of the needle shield remover that engages with the rigid needle shield than embodiments that include one or two inwardly-projecting shield engagement mechanism.
  • the exemplary needle shield remover 1500 thereby allows reliably removal of the needle shields from the syringe when the needle shield remover is removed before administration of an injection.
  • the second inclined or radial wall 1522a, 1522b, 1522c may have a peripheral edge 1524a, 1524b, 1524c with a width that provides a sufficiently large interface with the rigid needle shield.
  • the width of the peripheral edge 1524a, 1524b, 1524c may range from about 3 mm to about 7 mm, but is not limited to this exemplary range. In an exemplary embodiment, the width is about 5.4 mm.
  • the greater width of the peripheral edge of the second inclined or radial wall 1522a, 1522b, 1522c also provides a larger surface of the needle shield remover that engages with the rigid needle shield than embodiments that include one or two inwardly-projecting shield engagement mechanism, allowing reliable removal of the needle shields from the syringe when the needle shield remover is removed before administration of an injection
  • the inwardly-projecting first and second inclined or radial walls cause the inner diameter of the needle shield remover 1500 at the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c to be less than the outer diameter of the proximal end of the rigid needle shield. In an exemplary embodiment, the inwardly-projecting first and second inclined or radial walls cause the inner diameter of the needle shield remover 1500 at the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c to be less than the outer diameter of the syringe body.
  • the inner diameter of the needle shield remover 1500 at the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c may be substantially equal to the outer diameter of the gap formed between the syringe body and the proximal end of the rigid needle shield.
  • This configuration of the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c thereby allows the second inclined or radial walls 1522a, 1522b, 1522c to snap into place at the gap in a reliable and tight manner so that disengagement requires at least a minimal threshold level of force.
  • This configuration also prevents creep of the second inclined or radial walls 1522a, 1522b, 1522c out of the gap after assembly but before removal by a user.
  • the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c may snap into place at the gap formed between the rigid needle shield and the syringe body, as the needle shield remover 1500 is inserted over the rigid needle shield.
  • the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c snap into place at the gap, there may be a decrease in the force experienced against insertion of the needle shield remover 1500 over the rigid needle shield. In an exemplary embodiment, this decrease in the force may be sensed by a user or automatically by an assembly machine to determine that the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c have been successfully engaged to the gap formed between the rigid needle shield and the syringe body.
  • the positioning of the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c in the gap may emit an audible "click" sound that provides an audible indication that the needle shield remover 1500 has been successfully engaged with the rigid needle shield.
  • the needle shield remover 1500 may be provided as a separate component from a distal cap of the automatic injection device.
  • a needle shield remover may be provided integrally with the distal cap, for example, by integrally coupling the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c of the needle shield remover 1500 with the distal cap of the device.
  • one or more additional protrusions and/or grooves may be provided in the exterior surface of the proximal tubular member 1502 and/or the distal tubular member 1504 in order to facilitate engagement of the needle shield remover 1500 with another component of the automatic injection device, e.g., a syringe sleeve that cooperative engages with and covers a proximal portion of the needle shield remover, a removable cap that covers a distal portion of the needle shield remover, and the like.
  • Figures 16 illustrates a perspective cross-sectional view of the exemplary needle shield remover 1500 of Figures 15A and 15B assembled with a syringe 600 and a distal cap 800.
  • the assembly lacks a syringe sleeve.
  • Figure 17 illustrates a perspective cross-sectional view of the exemplary needle shield remover 1500 of Figures 15A and 15B assembled with a syringe 600 and a distal cap 800.
  • the assembly includes a syringe sleeve 700.
  • Figure 18 illustrates a front cross-sectional view of the exemplary assembly of Figure 17 including a syringe sleeve 700.
  • Figure 19 illustrates a bottom view of an exemplary distal cap 800 that is applicable to Figures 16-18 .
  • An injection needle 604 may be affixed to a distal end of the syringe 600, a bung 606 may be disposed within the syringe 600, and a dose of a therapeutic agent 608 may be provided to fill the syringe 600.
  • the injection needle 604 may be covered with a soft needle shield 610 and a rigid needle shield 612 disposed over the soft needle shield 610.
  • the exemplary needle shield remover 1500 may be disposed over the rigid needle shield 612 so that the inwardly-projecting shield engagement mechanisms 1516a, 1516b, 1516c of the needle shield remover 1500 fit within a gap between the rigid needle shield 612 and the body of the syringe 600.
  • the cap engagement mechanisms 1510a, 1510b, 1510c of the needle shield remover 1500 may engage with a distal cap 800 provided to cover the distal portion of the device.
  • the cap engagement mechanisms 1510a, 1510b, 1510c may be accommodated within a central aperture 802 provided in the distal cap 800, so that inwardly-projecting stop portions 804a, 804b, 804c (e.g., flanges or raised edges) provided in the central aperture of the distal cap are positioned reliably within gaps 1512a, 1512b, 1512c proximal to the cap engagement mechanisms 1510a, 1510b, 1510c.
  • a syringe sleeve 700 may be provided over the syringe 600 and the needle shield remover 1500 to maintain the needle shield remover 1500 in a substantially fixed axial orientation with the device housing.
  • Figure 20 illustrates a cross-sectional view of an exemplary needle shield remover 2000 bisected along the longitudinal axis L.
  • the needle shield remover 2000 is configured for removing needle shields from a syringe 2002 or an automatic injection device.
  • the syringe 2002 may include any type of syringe typically utilized with an automatic injection device having one or more needle shields, such as a soft needle shield 2004 and a rigid needle shield 2006.
  • the soft needle shield 2004 is positioned within the rigid needle shield 2006, and portions of the soft needle shield 2004 extend through apertures 2008 formed in the rigid needle shield 2006.
  • the needle shield remover 2000 includes a outer wall 2010 which is attached to and depends from (or is formed integrally with) the periphery of an base wall 2012, and one or more inwardly-facing protrusions or teeth 2014 which are biased by the outer wall 2010 in position within a gap formed between the body of the syringe 2002 and the periphery 2016 of the rigid needle shield 2006.
  • the outer wall 2010 and base wall 2012 may have any desired shape or size (e.g., the needle shield remover 2000 may be cylindrical or other shape), and a plurality of outer walls 2010 may be provided (e.g., if the needle shield remover 2000 is square or rectangular in shape).
  • the needle shield remover 2000 defines a cavity that receives the soft needle shield 2004 and the rigid needle shield 2006.
  • a plurality of outer protrusions 2018 may be provided on the outer surface of the outer wall 2010, to facilitate fixed engagement of the needle shield remover 2000 within a removable cap of an automatic injection device to provide a gripping surface to the removable cap. In this manner the removable cap cooperatively engages with the gripping surface defined by the plurality of protrusions 2018 and the plurality of valleys to reliably remove the rigid needle shield 2006 and the soft needle shield 2004 from the syringe or the automatic injection device.
  • the protrusions 2014 exert force against the periphery 2016 of the rigid needle shield 2006, thereby pulling the rigid needle shield 2006 and the soft needle shield 2004 away from the syringe body 2002 and exposing the needle of the syringe 2002 for use. It is noted that the protrusions 2014 may also be configured to fit within the apertures 2008 of the rigid needle shield 2006, or to otherwise contact the rigid needle shield 2006 (e.g., to fit within corresponding recesses formed in the rigid needle shield 2006).
  • Figure 21 illustrates a cross-sectional view of another exemplary needle shield remover 2100 bisected along the longitudinal axis L.
  • the needle shield remover 2100 includes an inner (first) wall 2102 which is positioned coaxially within an outer (second) wall 2104, and which is coupled to the outer wall 2104 by a hollow projection 2106 extending through an aperture formed in a base wall 2108 that is joined at its periphery to the outer wall 2104 (or formed integrally therewith).
  • the inner wall 2102 includes one or more protrusions 2110 extending therefrom which are biased in a gap formed between the syringe body 2112 and the lower periphery 2114 of the rigid needle shield 2116.
  • the inner wall 2102 may be fixedly or rotatably coupled to the outer wall 2104.
  • One or more protrusions 2118 may be formed at a base end of the hollow projection 2106, so as to couple the base wall 2108 and the outer wall 2104.
  • the inner wall 2102 and the outer wall 2104 may have a circular cross section, an elongated cross section, square cross section, rectangular cross section or any other suitable cross section.
  • the outer wall 2104 may be fixedly coupled to inner surfaces of a removable cap of an automatic injection device, and, as shown in Figure 21 , may include one or more protrusions 2120 to facilitate such coupling and to provide a gripping surface for the removable cap.
  • the protrusions may be rings, collars, flanges or other type of protrusion.
  • the outer wall 2104 When the outer wall 2104 is pulled away from the syringe body 2112 (as indicated by arrow R), it pulls the inner wall 2102 away from the syringe body 2112, thereby causing the protrusions 2110 to exert force against the lower periphery 2114 of the rigid needle shield 2116 and to pull the rigid needle shield 2116 and the soft needle shield 2122 away from the syringe 2112 to expose the needle for use.
  • the protrusions 2110 may be positioned at other locations, e.g., they may be positioned to extend into the apertures 2124 in the rigid needle shield 2116 or to contact other locations (e.g., corresponding recesses) on the rigid needle shield 2116.
  • Figure 22 illustrates a cross-sectional view of an exemplary needle shield remover 2200 bisected along the longitudinal axis L.
  • the needle shield remover 2200 includes an outer wall 2202 that depends from and is connected to the periphery of a base wall 2204 (or, formed integrally therewith).
  • the needle shield remover 2200 may have any shape (e.g., cylindrical or other shape).
  • An annular recess 2206 with an annular opening or a plurality of apertures radially spaced circumferentially about the annular recess is provided along one end of the outer wall 2202, and receives removal element 2208, for example, an annular washer, ring or pins having one or more protrusions 2218 extending through corresponding apertures formed in the recess 2206. Ends of the protrusions 2218 are positioned in a gap formed between the syringe body 2212 and the lower periphery 2214 of the rigid needle shield 2216.
  • the needle shield remover 2200 may be fixedly coupled to inner surfaces of a removable cap of an automatic injection device.
  • the protrusions 2218 exert force against the lower periphery 2214 of the rigid needle shield 2216 and pull the rigid needle shield 2216 and the soft needle shield 2220 away from the syringe 2212, thereby exposing the needle for use.
  • the removal element 2208 may be positioned so that the protrusions contact other locations, e.g., they may be positioned to extend into the apertures 2222 of the rigid needle shield 2216 or contact other locations of the rigid needle shield 2216 (e.g., they may contact corresponding recesses formed in the rigid needle shield 2216).
  • FIG 23 illustrates a cross-sectional view of an exemplary needle shield remover 2300 bisected along the longitudinal axis L.
  • the needle shield remover 2300 includes a modified rigid needle shield 2302 having a top aperture 2304, and a captive component 2306 which is coupled to the rigid needle shield 2302.
  • the captive component 2306 includes a hollow axle 2308 that extends through the aperture 2304. Shoulders 2310 of the rigid needle shield 2302 are captured between a peripheral wall 2312 of the captive component 2306 and a transverse annular wall 2314 formed at a lower end of the axle 2308 and positioned between the shoulders 2310 and the soft needle shield 2316. Portions of the soft needle shield 2316 extend through apertures 2318 formed in the rigid needle shield 2302.
  • Protrusions 2320 are provided at a base end of the axle 2308 for coupling (e.g., by way of snap fit) the captive component 2306 to a removable cap of an automatic injection device.
  • the captive component 2306 is pulled away from a syringe (as indicated by arrow R)
  • the transverse annular wall 2314 exerts force against the shoulders 2310, thereby pulling the rigid needle shield 2302 and the soft needle shield 2316 away from a syringe and exposing the needle for use.
  • Figure 24 illustrates a cross-sectional view of an exemplary needle shield remover 2400 bisected along the longitudinal axis L.
  • the needle shield remover 2400 includes an outer wall 2402 extending from and connected to (or formed integrally with) a base wall 2404, and an inner wall 2406 extending from and connected to (or formed integrally with) the base wall 2404.
  • the outer wall 2402 and the inner wall 2406 may be annularly aligned about a central longitudinal axis of the syringe.
  • the outer wall 2402 and the inner wall 2406 may have a circular cross section, an elongated cross section, square cross section, rectangular cross section or any other suitable cross section.
  • a collar or spring clip 2408 extends through apertures formed in one end 2410 of the inner wall 2406, and contact the soft needle shield 2412 through the apertures 2414 of the rigid needle shield 2416.
  • One or more protrusions 2418 are formed at the lower end 2410 of the inner wall 2406 and are positioned in a gap formed between the syringe body 2420 and the lower periphery 2422 of the rigid needle shield 2416.
  • the collar/spring clip 2408 stabilizes the protrusions 2418 to prevent them from creeping out of the gap between the syringe body 2420 and the lower periphery 2422 of the rigid needle shield 2416.
  • outer wall 2402 may be fixedly coupled to inner surfaces of a removable cap of an automatic injection device, and, as shown in Figure 24 , may include one or more protrusions 2424 to facilitate such coupling and to provide a gripping surface for the removable cap.
  • the protrusions may be rings, collars, flanges or other type of protrusion.
  • the collar 2408 and the protrusions 2418 exert force against the rigid needle shield 2416, thereby pulling the rigid needle shield 2416 and the soft needle shield 2412 away from the syringe 2420 and exposing the needle for use. It is noted that the collar/spring clip 2408, and/or the protrusions 2418, may be positioned to contact other locations of the rigid needle shield 2416 and/or the soft needle shield 2412.
  • the needle shield remover 2400 may be fixedly coupled to inner surfaces of a removable cap of an automatic injection device.
  • the various protrusions which contact the rigid needle shield to remove it from the syringe may be permanently attached to the rigid needle shield, e.g., by way of gluing/epoxy.
  • the protrusions need not be permanently attached to the rigid needle shield.
  • Exemplary needle shield removers are configured and designed for quick, easy and reliable engagement to both a distal cap of an automatic injection device and to one or more needle shields covering an injection needle of the device.
  • One or more exemplary methods may be used to assemble an exemplary needle shield remover with the other components of the device.
  • an exemplary needle shield remover may be assembled with a syringe after the syringe has been inserted into the housing of the device.
  • an exemplary needle shield remover - that is provided as a separate component from a distal cap and from a needle shield - may be assembled with a syringe prior to insertion of the syringe into the housing of the device.
  • the ability to assemble the exemplary needle shield remover with the syringe outside the device housing allows visual inspection of the assembly process to ensure that the needle shield remover is correctly and reliably engaged with the needle shield on the syringe before the syringe and needle shield remover assembly is inserted into the device housing.
  • assembly of the exemplary needle shield remover in the automatic injection device allows one to be certain that, when the syringe assembly is inserted into the device housing, the needle shield remover is engaged reliably and consistently with the needle shield. This resolves the issue of component tolerance and unreliable positioning of needle shield removal mechanisms in conventional automatic injection devices.
  • Figure 25 is a flowchart of an exemplary method 2500 for assembling an exemplary needle shield remover with a syringe and a distal cap of an automatic injection device, in which the needle shield remover is assembled with the syringe prior to insertion of the syringe into the housing of an automatic injection device.
  • a suitable injection needle may be coupled to a distal end of the syringe.
  • a bung may be disposed within the syringe to seal the contents of the syringe.
  • the syringe may be filled with a dose of a therapeutic agent.
  • the injection needle may be covered by one or more soft needle shields and/or one or more rigid needle shields.
  • a needle shield remover may be engaged to the rigid needle shield attached to the syringe prior to insertion of the syringe into the housing of the device.
  • the ability to assemble the exemplary needle shield remover to the syringe outside the device housing allows visual inspection of the assembly process to ensure that the needle shield remover reliably engages the needle shield on the syringe before the syringe assembly is inserted into the device housing.
  • one or more inwardly-projecting shield engagement mechanisms of the needle shield remover may be engaged to a gap formed between the proximal end of the rigid needle shield and the syringe body.
  • the shield engagement mechanisms may snap into place at the gap and may not be disengaged during the assembly process.
  • this decrease in the force may be sensed by a user or automatically by an assembly machine to determine that the inwardly-projecting shield engagement mechanisms have been successfully engaged to the needle shield at the gap.
  • positioning of the shield engagement components at the gap may emit an audible "click" sound that provides an audible indication that the needle shield remover has been successfully engaged with the rigid needle shield.
  • one or more inwardly-projecting shield engagement mechanisms of the needle shield remover may be engaged to one or more apertures defined in a rigid needle shield. In another exemplary embodiment, one or more inwardly-projecting shield engagement mechanisms of the needle shield remover may be engaged to one or more ridged portions in the exterior surface of the rigid needle shield.
  • a syringe sleeve may be engaged with the syringe and needle shield remover.
  • the syringe sleeve may be maintained in a substantially fixed axial orientation relative to the device housing.
  • the syringe sleeve may, in turn, maintain the needle shield remover in a substantially fixed axial orientation relative to the syringe sleeve.
  • This assembly aligns the cutout portions of the needle shield remover with the inspection window or inspection aperture of the syringe sleeve and with the inspection window or inspection aperture of the device housing. This allows a user to view the contents of the syringe and/or an end-of-injection indicator through the inspection window or inspection aperture of the device housing.
  • a syringe sleeve may be absent in the automatic injection device and step 2512 may be skipped.
  • the axial orientation of the needle shield remover may be manually or automatically adjusted relative to the device housing so that the cutout portions of the needle shield remover are aligned with the inspection window or inspection aperture of the device housing. This allows a user to view the contents of the syringe and/or to view an indicator through the inspection window or inspection aperture of the device housing.
  • the syringe, needle shield remover and syringe sleeve assembly may be inserted into the device housing through a proximal end of the device housing.
  • a proximal cap may be coupled to the proximal end of the device housing to seal the proximal end.
  • a distal cap may be coupled to the distal end of the device housing so that the distal cap is engaged to both the distal end of the housing and to the needle shield remover in one step.
  • one or more cap engagement mechanisms of the needle shield remover may fit within a central aperture provided in the distal cap.
  • One or more inwardly-projecting stop portions e.g., flanges or raised edges
  • the central aperture of the distal cap may snap into place within a gap formed under the cap engagement mechanisms.
  • this decrease in the force may be sensed by a user or automatically by an assembly machine to determine that the cap engagement mechanisms have been successfully engaged to the distal cap.
  • the engagement of the cap engagement mechanisms with the distal cap may emit an audible "click" sound that provides an audible indication that the needle shield remover has been successfully engaged with the distal cap.
  • Figure 26 illustrates a device view of the exemplary method 2500 of Figure 25 by which an exemplary automatic injection device may be assembled.
  • a syringe assembly 2600 may include a syringe, a needle shield remover 2602 coupled to the syringe, and a syringe sleeve 2604 coupled to the syringe and the needle shield remover 2602.
  • a side wall of the syringe sleeve 2604 may define or include a transparent inspection window or inspection aperture 2606.
  • the syringe assembly 2600 may be assembled before its insertion into a housing 2650 of the automatic injection device.
  • the housing 2650 may have a proximal end 2652 that is open during assembly and that may be covered by a proximal cap (not pictured) after the syringe assembly is inserted into the housing 2650.
  • the housing 2650 may have a distal end 2654 that is open during assembly and that may be covered by a distal cap (not pictured) after the syringe assembly is inserted into the housing 2650.
  • a side wall of the housing 2650 may define or include a transparent inspection window or inspection aperture 2656 through which a user may view the contents of the syringe.
  • the assembled syringe 2600 may be inserted into the device housing 2650 at the proximal end 2652 in the direction represented by arrow R, so that the distal end of the needle shield remover 2602 is disposed at the distal end 2654 of the device housing 2650.
  • the inspection window or inspection aperture 2656 of the housing 2650 is aligned with the inspection window or inspection aperture 2606 of the syringe sleeve 2604.
  • the transparent inspection window or inspection aperture 2606 of the syringe sleeve 2604 is, in turn, aligned with a cutout portion on the needle shield remover 2602, thus allowing a user of the device to view the contents of the syringe and/or to view an end-of-injection indicator through the inspection window or inspection aperture 2656 of the device housing 2650.
  • Figure 27 is a flowchart of an exemplary method 2700 for assembling an exemplary needle shield remover with a syringe and a distal cap of an automatic injection device, in which the needle shield remover is assembled with the syringe after insertion of the syringe into the housing of the device.
  • a suitable injection needle may be coupled to a distal end of the syringe.
  • a bung may be disposed within the syringe to seal the contents of the syringe.
  • the syringe may be filled with a dose of a therapeutic agent.
  • the injection needle may be covered by one or more soft needle shields and/or one or more rigid needle shields.
  • a syringe sleeve may be engaged to the syringe.
  • the syringe sleeve may be maintained in a substantially fixed axial orientation relative to the device housing.
  • the syringe sleeve may, in turn, maintain a needle shield remover in a substantially fixed axial orientation relative to the syringe sleeve.
  • This assembly aligns the cutout portions of the needle shield remover with the inspection window or inspection aperture of the syringe sleeve and with the inspection window or inspection aperture of the device housing. This allows a user to view the contents of the syringe and/or to view an end-of-injection indicator through the inspection window or inspection aperture of the device housing.
  • a syringe sleeve may be absent in the automatic injection device and step 2710 may be skipped.
  • the axial orientation of the needle shield remover may be manually or automatically adjusted relative to the device housing so that the cutout portions of the needle shield remover are aligned with the inspection window or inspection aperture of the device housing. This allows a user to view the contents of the syringe and/or to view an end-of-injection indicator through the inspection window or inspection aperture of the device housing.
  • the syringe and syringe sleeve assembly may be inserted into the device housing through a proximal end of the device housing.
  • a proximal cap may be coupled to the proximal end of the device housing to seal the proximal end.
  • a needle shield remover may be engaged to a distal cap of the automatic injection device.
  • the distal end of the needle shield remover may fit within a central aperture provided in the distal cap.
  • One or more inwardly-projecting stop portions e.g., flanges or raised edges
  • the cap engagement mechanisms snap into place at the gap over the inwardly-projecting stop portions in the central aperture of the distal cap, there may be a decrease in the force experienced against insertion of the distal cap over the needle shield remover.
  • this decrease in the force may be sensed by a user or automatically by an assembly machine to determine that the cap engagement mechanisms have been successfully engaged to the distal cap.
  • the engagement of the cap engagement mechanisms with the distal cap may emit an audible "click" sound that provides an audible indication that the needle shield remover has been successfully engaged with the distal cap.
  • the distal cap and needle shield assembly may be coupled to the distal end of the device housing to cover the distal end, so that the needle shield remover is engaged to the needle shield on the syringe.
  • one or more inwardly-projecting shield engagement mechanisms of the needle shield remover are engaged to a gap formed between the rigid needle shield and the syringe body.
  • the inwardly-projecting shield engagement mechanisms may snap into place at the gap and may not be disengaged during the assembly process. When the inwardly-projecting shield engagement mechanisms snap into place at the gap, there may be a decrease in the force experienced against insertion of the needle shield remover over the rigid needle shield.
  • this decrease in the force may be sensed by a user or automatically by an assembly machine to determine that the inwardly-projecting shield engagement mechanisms have been successfully engaged to the needle shield at the gap.
  • positioning of the shield engagement components at the gap may emit an audible "click" sound that provides an audible indication that the needle shield remover has been successfully engaged with the rigid needle shield.
  • one or more inwardly-projecting shield engagement mechanisms of the needle shield remover may be engaged to one or more apertures defined in a rigid needle shield. In another exemplary embodiment, one or more inwardly-projecting shield engagement mechanisms of the needle shield remover may engaged to one or more ridged portions in the exterior surface of the rigid needle shield.
  • FIG. 28 is a flowchart of an exemplary method 2800 for using an exemplary automatic injection device to administer an injection.
  • An exemplary automatic injection device may be packaged and pre-filled with a therapeutic agent and may be stored in refrigerated storage before use.
  • the packaged automatic injection device may be removed from storage.
  • the automatic injection device may be removed from its packaging and any over-wrap and warmed to room temperature, for example, by leaving the device outside the packaging at room temperature or by warming the device.
  • the user may view the contents of the device through a transparent inspection window or inspection aperture provided in the device housing to ensure that the device contains a volume of the therapeutic agent and to confirm the clarity of the therapeutic agent, if necessary.
  • the injection site on a patient's body may be selected and prepared for the delivery of the therapeutic agent.
  • the user of the automatic injection device may remove the distal cap of the automatic injection device that protects the injection needle and any needle shields protecting the needle.
  • a needle shield remover provided in the device automatically removes all of the needle shields when the user removes the distal cap.
  • the user of the device may position the automatic injection device so that the distal end of the device is positioned at or adjacent to the injection site on the patient's body.
  • a firing button on the device may be depressed or otherwise activated to cause the device to perform an injection at the injection site.
  • the injection site on the patient's body may receive a therapeutically effective dose of the therapeutic agent administered by the device.
  • activating the firing button may cause a syringe to advance within and relative to the device housing so that the injection needle protrudes from an open distal end of the housing, and may cause a bung to move within the syringe to expel the therapeutic agent out of the syringe through the injection needle and into the injection site.
  • the automatic injection device may be removed from the injection site on the patient's body and discarded in an appropriate manner.
  • Exemplary flowcharts are provided herein for illustrative purposes and are non-limiting examples of methods.
  • One of ordinary skill in the art will recognize that exemplary methods may include more or fewer steps than those illustrated in the exemplary flowcharts, and that the steps in the exemplary flowcharts may be performed in a different order than shown.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Environmental & Geological Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP20173063.7A 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen Pending EP3708203A1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161435467P 2011-01-24 2011-01-24
EP12702380.2A EP2667914B1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen
PCT/US2012/022432 WO2012103140A1 (en) 2011-01-24 2012-01-24 Removal of needle shields from syringes and automatic injection devices
EP18210225.1A EP3473283B1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP12702380.2A Division EP2667914B1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen
EP18210225.1A Division-Into EP3473283B1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen
EP18210225.1A Division EP3473283B1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen

Publications (1)

Publication Number Publication Date
EP3708203A1 true EP3708203A1 (de) 2020-09-16

Family

ID=45562478

Family Applications (3)

Application Number Title Priority Date Filing Date
EP18210225.1A Active EP3473283B1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen
EP12702380.2A Active EP2667914B1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen
EP20173063.7A Pending EP3708203A1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP18210225.1A Active EP3473283B1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen
EP12702380.2A Active EP2667914B1 (de) 2011-01-24 2012-01-24 Entfernung eines nadelschutzes von spritzen und automatische injektionsvorrichtungen

Country Status (25)

Country Link
US (5) US8708968B2 (de)
EP (3) EP3473283B1 (de)
JP (3) JP5968914B2 (de)
KR (4) KR101853607B1 (de)
CN (2) CN103608055B (de)
AU (3) AU2012209222B2 (de)
BR (1) BR112013018773A2 (de)
CA (2) CA3010206C (de)
CL (1) CL2013002067A1 (de)
CO (1) CO6831978A2 (de)
CR (1) CR20130400A (de)
DO (1) DOP2013000168A (de)
EC (1) ECSP13012848A (de)
ES (2) ES2859511T3 (de)
GT (1) GT201300183A (de)
IL (2) IL227238A (de)
MX (2) MX342163B (de)
MY (2) MY155753A (de)
PE (1) PE20141543A1 (de)
PH (1) PH12015500495B1 (de)
RU (2) RU2569704C2 (de)
SG (3) SG192115A1 (de)
UA (1) UA112308C2 (de)
WO (1) WO2012103140A1 (de)
ZA (3) ZA201305030B (de)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
CN103316402A (zh) 2006-06-30 2013-09-25 艾伯维生物技术有限公司 自动注射装置
EP2195052B1 (de) 2007-10-02 2019-09-04 Medimop Medical Projects Ltd. Externe arzneimittelpumpe
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
US8177749B2 (en) 2008-05-20 2012-05-15 Avant Medical Corp. Cassette for a hidden injection needle
AU2009249027C1 (en) 2008-05-20 2015-01-22 Avant Medical Corp. Autoinjector system
SG175279A1 (en) 2009-04-29 2011-11-28 Abbott Biotech Ltd Automatic injection device
CN107715256B (zh) 2009-10-16 2020-08-14 詹森生物科技公司 手掌激活型药物递送装置
US9233213B2 (en) 2009-10-16 2016-01-12 Janssen Biotech, Inc. Palm activated drug delivery device
TWI619521B (zh) 2009-12-15 2018-04-01 艾伯維生物技術有限責任公司 自動注射裝置、自動注射方法及防止不發射情況之方法
ES2727275T3 (es) 2010-04-21 2019-10-15 Abbvie Biotechnology Ltd Dispositivo automático de inyección portátil para la liberación controlada de agentes terapéuticos
KR102001050B1 (ko) * 2011-01-24 2019-07-17 엘캠 메디컬 애그리컬처럴 코오퍼레이티브 어소시에이션 리미티드 인젝터
CA2825316C (en) 2011-01-24 2020-05-05 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
JP5968914B2 (ja) 2011-01-24 2016-08-10 アッヴィ バイオテクノロジー リミテッド シリンジおよび自動注入デバイスからの針シールドの取り外し
US9173999B2 (en) 2011-01-26 2015-11-03 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
CA3145238A1 (en) 2011-04-20 2012-10-26 Amgen Inc. Autoinjector apparatus
BR112014005465A2 (pt) 2011-09-09 2017-03-21 Merck Patent Gmbh autoinjetor com injeção de agulha separada
CN104080501B (zh) * 2011-12-15 2016-07-06 Shl集团有限责任公司 盖组件
USD898908S1 (en) 2012-04-20 2020-10-13 Amgen Inc. Pharmaceutical product cassette for an injection device
USD808010S1 (en) 2012-04-20 2018-01-16 Amgen Inc. Injection device
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
EP2703029A1 (de) * 2012-09-04 2014-03-05 Sanofi-Aventis Deutschland GmbH Medikamentenausgabevorrichtung mit Ausrichtungsmechanismus
WO2014143815A2 (en) 2013-03-15 2014-09-18 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
EP2968760B1 (de) 2013-03-15 2024-01-03 Amgen Inc. Medikamentenkassette, autoinjektor und autoinjektorsystem
DK2978478T3 (da) 2013-03-25 2021-08-02 Shl Medical Ag Beskyttelseshætte til en medikamentafgivelsesanordning
TR201900405T4 (tr) 2013-08-29 2019-02-21 Sanofi Sa İlaç konteynerine yönelik başlık.
EP2878321A1 (de) 2013-11-28 2015-06-03 Sanofi-Aventis Deutschland GmbH Nadelsicherheitsvorrichtung und Arzneimittelabgabevorrichtung
EP2923716A1 (de) 2014-03-28 2015-09-30 Sanofi-Aventis Deutschland GmbH Kappe mit Hüllenentfernungsmechanismus
FR3024040B1 (fr) * 2014-07-28 2016-08-19 Aptar Stelmi Sas Protege-aiguille rigide, procede et machine d'assemblage d'un tel protege-aiguille rigide.
WO2016089864A1 (en) 2014-12-03 2016-06-09 Eli Lilly And Company Needle shield puller cap assembly
WO2016128977A1 (en) * 2015-02-10 2016-08-18 Dali Medical Devices Ltd. Safe auto-needle device
US10869966B2 (en) 2015-02-20 2020-12-22 Regeneron Pharmaceuticals, Inc. Syringe systems, piston seal systems, stopper systems, and methods of use and assembly
AU2016235054B2 (en) 2015-03-24 2020-07-16 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
TW201707741A (zh) * 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 針頭護罩之抓握器、蓋子、自動注射器及製造抓握器之方法
JP2018516678A (ja) 2015-06-04 2018-06-28 メディモップ・メディカル・プロジェクツ・リミテッド 薬物送達装置用カートリッジ挿入
JP6860508B2 (ja) 2015-06-18 2021-04-14 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ニードルシールドを覆うためのキャップアセンブリおよびキャップアセンブリを組み立てるための方法
GB2541445B (en) * 2015-08-20 2018-04-18 Owen Mumford Ltd Injection device
DK3341056T3 (da) * 2015-08-24 2022-09-12 Adamis Pharmaceuticals Corp Sprøjteindretninger
EP3341054B1 (de) 2015-08-27 2021-04-14 E3D Agricultural Cooperative Association Ltd. Wiederverwendbare automatische injektionsvorrichtung
US10576207B2 (en) 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
CN108472438B (zh) 2015-10-09 2022-01-28 西医药服务以色列分公司 至预填充的流体储存器的弯曲流体路径附加装置
DK3380172T3 (da) * 2015-11-27 2021-04-26 Sanofi Aventis Deutschland Hætte til injektionsanordning samt injektionsanordning
DK3380146T3 (da) * 2015-11-27 2022-11-07 Sanofi Aventis Deutschland Medikamentadministrationsanordning
US10646643B2 (en) 2016-01-21 2020-05-12 West Pharma. Services IL, Ltd. Needle insertion and retraction mechanism
JP6885960B2 (ja) 2016-01-21 2021-06-16 ウェスト ファーマ サービシーズ イスラエル リミテッド 視覚的インジケータを有する薬剤デリバリデバイス
CN111544704B (zh) 2016-01-21 2022-06-03 西医药服务以色列有限公司 自动注射器中的力牵制
WO2017161076A1 (en) 2016-03-16 2017-09-21 Medimop Medical Projects Ltd. Staged telescopic screw assembly having different visual indicators
US10661024B2 (en) * 2016-03-23 2020-05-26 West Pharmaceutical Services, Inc. Two piece needle shield puller
USD819198S1 (en) 2016-04-28 2018-05-29 Amgen Inc. Autoinjector with removable cap
WO2017223354A1 (en) * 2016-06-22 2017-12-28 Antares Pharma, Inc. Needle-shield remover
US11752275B2 (en) 2016-07-11 2023-09-12 Shl Medical Ag RFID tag enabled shield assembly
KR20210105444A (ko) * 2016-07-11 2021-08-26 에스에이치엘 메디컬 아게 Rfid 태그 사용 가능한 바늘 차폐물
CH712753A2 (de) 2016-07-28 2018-01-31 Tecpharma Licensing Ag Trennen einer Nadelschutzkappe von einem Produktbehälter und Verfahren zum Montieren einer Injektionsvorrichtung.
CN109475703B (zh) * 2016-07-28 2022-04-26 益首药物治疗股份公司 具有带有针保护盖移除元件的外盖的注射装置和用于组装注射装置的方法
CN109562229B (zh) 2016-08-01 2021-07-13 西医药服务以色列有限公司 抗旋转药筒销
AU2017334989B2 (en) * 2016-09-30 2019-08-15 Terumo Kabushiki Kaisha Cap, syringe assembly, and prefilled syringe
EP3525849A1 (de) * 2016-10-13 2019-08-21 SHL Medical AG Unteranordnung, medikamentenabgabevorrichtung und verfahren zur montage einer unteranordnung
FR3058895B1 (fr) * 2016-11-23 2024-01-12 Nemera La Verpilliere Dispositif d'injection presentant un dispositif de retrait de capuchon de seringue ameliore
EP3369444A1 (de) * 2017-03-01 2018-09-05 Sanofi-Aventis Deutschland GmbH Verpackungsvorrichtung, arzneimittelabgabevorrichtung und notfallpackung
GB201706697D0 (en) * 2017-04-27 2017-06-14 Ucb Biopharma Sprl Cap for an injector
EP3618903B1 (de) * 2017-05-01 2021-08-11 SHL Medical AG Nadelschutzentferner
GB2563029B (en) * 2017-05-30 2022-06-08 Janssen Pharmaceuticals Inc Grip accessory for a manual injection device
WO2018222521A1 (en) 2017-05-30 2018-12-06 West Pharma. Services IL, Ltd. Modular drive train for wearable injector
GB2563027B (en) * 2017-05-30 2022-04-06 Janssen Pharmaceuticals Inc Grip accessory for a manual injection device
US10828425B2 (en) * 2017-06-23 2020-11-10 Shl Medical Ag Needle shield remover and a medicament delivery device comprising the needle shield remover
WO2019074788A1 (en) * 2017-10-12 2019-04-18 Eli Lilly And Company NEEDLE PROTECTOR REMOVAL DEVICE FOR A DRUG DELIVERY SYSTEM
WO2019081578A1 (en) * 2017-10-28 2019-05-02 Novo Nordisk A/S SYRINGE HOLDER FOR MEDICAL INJECTOR AND METHOD FOR FORMING MEDICAL INJECTOR ASSEMBLY
DK3706841T3 (da) * 2017-11-07 2023-12-11 Shl Medical Ag Kanyleskjoldsfjerner og medikamentafgivelsesindretning, der omfatter kanyleskjoldsfjerneren
CH714489A2 (de) 2017-12-21 2019-06-28 Tecpharma Licensing Ag Injektionsvorrichtung mit einer Kappe zur Entfernung einer Nadelschutzkappe von einem Produktbehälter und Verfahren zum Vorbereiten einer solchen Injektionsvorrichtung.
CN111683703B (zh) 2017-12-22 2022-11-18 西氏医药包装(以色列)有限公司 适用于不同尺寸的药筒的注射器
US11077242B2 (en) * 2018-02-07 2021-08-03 Fisher Clinical Services GmbH Blinding cap for rigid needle shield and related syringe assembly
EA202092129A1 (ru) 2018-03-13 2021-01-25 Милан Юк Хэлскеа Лтд. Устройства для инъекции лекарственных средств и способы использования
CN112188906B (zh) 2018-05-24 2023-10-27 诺华股份有限公司 药物自动输送装置
US11571518B2 (en) 2018-05-25 2023-02-07 Adamis Pharmaceuticals Corporation Emergency devices
EP3823695A1 (de) 2018-07-20 2021-05-26 SHL Medical AG Sicherheitskappe
WO2020039009A1 (en) 2018-08-21 2020-02-27 Novo Nordisk A/S Shield remover for a syringe
EP3626291A1 (de) 2018-09-21 2020-03-25 Regeneron Pharmaceuticals, Inc. Nadelschutzgriffvorrichtungen und zugehörige verfahren
TWI772669B (zh) * 2018-09-24 2022-08-01 瑞士商瑞健醫療股份有限公司 針護罩移除器和包括有針護罩移除器的藥物輸送裝置
CN109260549B (zh) * 2018-10-09 2020-12-11 江苏采纳医疗科技有限公司 可更换部件自动给药注射器
GB2580142B (en) 2018-12-21 2023-04-12 Janssen Pharmaceuticals Inc Accessory for an injection including a pivotable cover
GB2580141B (en) 2018-12-21 2023-04-12 Janssen Pharmaceuticals Inc Accessory for an injection device including a grip for a needle cap
USD958330S1 (en) 2018-12-21 2022-07-19 Janssen Pharmaceuticals, Inc. Injection device accessory
GB2580133B (en) 2018-12-21 2023-04-12 Janssen Pharmaceuticals Inc Accessory including a slot for a flange of an injection device
ES2943536T3 (es) 2019-02-12 2023-06-14 Lonza Ag Dispositivo de desplazamiento, dispositivo de prueba y método para prueba de fugas de una conexión de una tapa de punta con una jeringa
WO2020173997A1 (en) * 2019-02-26 2020-09-03 Becton Dickinson France Rigid needle shield remover with drop test feature for autoinjector
CN113490521B (zh) 2019-02-26 2023-05-02 贝克顿迪金森法国公司 带有帽的自动注射器
AU2020227896B2 (en) * 2019-02-26 2022-09-08 Becton Dickinson France Rigid needle shield remover for autoinjector
CN113727748A (zh) * 2019-04-26 2021-11-30 贝克顿迪金森法国公司 带有底切的针帽
KR102651644B1 (ko) * 2019-07-18 2024-03-27 에스에이치엘 메디컬 아게 지지 구조체, 약물 전달 장치, 및 조립 방법
WO2021041067A2 (en) * 2019-08-23 2021-03-04 Amgen Inc. Drug delivery device with configurable needle shield engagement components and related methods
US20220347395A1 (en) * 2019-09-05 2022-11-03 Shl Medical Ag A delivery member shield remover assembly
GB2587390A (en) * 2019-09-26 2021-03-31 Owen Mumford Ltd Needle shield remover
USD1010811S1 (en) 2019-09-30 2024-01-09 Amgen Inc. Handheld drug delivery device
AU2020387175B2 (en) 2019-11-19 2024-02-15 E3D A.C.A.L Emergency automatic injection device
USD1030041S1 (en) 2020-01-14 2024-06-04 Amgen Inc. Handheld drug delivery device
USD1030040S1 (en) 2020-01-14 2024-06-04 Amgen Inc. Handheld drug delivery device
US12005244B2 (en) 2020-03-27 2024-06-11 Medivena Sp. Z O.O. Needle-based device based on direct wing-based coupling of a needle shield to a barrel thereof and safety mechanism implemented therein
WO2022054976A1 (ko) 2020-09-08 2022-03-17 (주)유로테크 전립선암 진단 점수 계산 방법 및 그 용도
USD974547S1 (en) 2020-11-05 2023-01-03 Amgen Inc. Handheld drug delivery device
USD973866S1 (en) 2020-11-05 2022-12-27 Amgen Inc. Handheld drug delivery device
USD962423S1 (en) 2020-11-05 2022-08-30 Amgen Inc. Handheld drug delivery device
USD948715S1 (en) 2020-11-06 2022-04-12 West Pharmaceutical Services, Inc. Injection needle shield puller
CH718181A2 (de) 2020-12-17 2022-06-30 Ypsomed Ag Injektionsvorrichtung mit einer Kappe zur Entfernung einer Nadelschutzkappe von einem Produktbehälter und Verfahren zum Vorbereiten einer solchen Vorrichtung.
CH718182A2 (de) 2020-12-17 2022-06-30 Ypsomed Ag Injektionsvorrichtung mit einer Kappe zur Entfernung einer Nadelschutzkappe von einem Produktbehälter und Verfahren zum Vorbereiten einer solchen Vorrichtung.
WO2022171533A1 (en) * 2021-02-15 2022-08-18 Shl Medical Ag Syringe carrier
USD985117S1 (en) 2021-03-10 2023-05-02 Amgen Inc. Handheld drug delivery device
USD985118S1 (en) 2021-03-10 2023-05-02 Amgen Inc. Handheld drug delivery device
USD985116S1 (en) 2021-03-10 2023-05-02 Amgen Inc. Handheld drug delivery device
USD985119S1 (en) 2021-03-30 2023-05-02 Amgen Inc. Handheld drug delivery device
USD999906S1 (en) 2021-06-24 2023-09-26 UCB Biopharma SRL Gripper for auto-injector needle shield
WO2023062132A1 (en) 2021-10-13 2023-04-20 Magna Mirrors Holding Gmbh Vehicular overhead console with light transmissive panel
GB2612054A (en) * 2021-10-20 2023-04-26 Owen Mumford Ltd Needle shield remover
GB2613642A (en) * 2021-12-13 2023-06-14 Owen Mumford Ltd A needle shield remover
WO2024039707A1 (en) * 2022-08-18 2024-02-22 Amgen Inc. Needle shield assembly for a syringe
WO2024078893A1 (en) * 2022-10-12 2024-04-18 Shl Medical Ag Drug injection device

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910260A (en) 1972-03-01 1975-10-07 Survival Technology Method and apparatus of treating heart attack patients prior to the establishment of qualified direct contact personal care
US3941130A (en) 1975-03-18 1976-03-02 Tibbs Robert C Sequential trigger release for injection device
US4004577A (en) 1972-12-04 1977-01-25 Survival Technology, Inc. Method of treating heart attack patients prior to the establishment of qualified direct contact personal care
US4261358A (en) 1979-10-01 1981-04-14 Walter Vargas Automatic syringe plunger
US4689042A (en) 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4795433A (en) 1985-05-20 1989-01-03 Survival Technology, Inc. Automatic injector for emergency treatment
US4964866A (en) * 1989-11-22 1990-10-23 Becton, Dickinson And Company Needle sheath assembly
US5085642A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5092843A (en) 1990-04-12 1992-03-03 Survival Technology, Inc. Dispersion multichamber auto-injector
US5102393A (en) 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
US5137516A (en) * 1989-11-28 1992-08-11 Glaxo Group Limited Triggered application device for medicament to be more descriptive of the invention
US5267963A (en) 1992-08-21 1993-12-07 Nicholas Bachynsky Medication injection device
US6149626A (en) 1997-10-03 2000-11-21 Bachynsky; Nicholas Automatic injecting syringe apparatus
US6270479B1 (en) 1998-10-26 2001-08-07 Pharmacia Ab Autoinjector
WO2008005315A2 (en) 2006-06-30 2008-01-10 Abbott Biotechnology Ltd. Automatic injection device
WO2009040603A1 (en) * 2007-09-25 2009-04-02 Becton Dickinson France Autoinjector with deshielder comprising tamper evidence means

Family Cites Families (338)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2459875A (en) 1944-09-11 1949-01-25 Marvin L Folkman Syringe and ampoule
US2398544A (en) 1945-01-06 1946-04-16 Marshall L Lockhart Hypodermic injector
US2565081A (en) 1948-09-15 1951-08-21 Emma C Maynes Device for operating hypodermic syringes
US2591457A (en) 1948-09-15 1952-04-01 Emma C Maynes Syringe operating device
DE902776C (de) 1949-08-17 1954-01-28 August Rooseboom Selbsttaetiger Injektionsapparat mit Ampulle
US2701566A (en) 1950-02-07 1955-02-08 Becton Dickinson Co Injection apparatus
BE531562A (de) 1953-09-02
US2960087A (en) 1954-02-16 1960-11-15 Auguste Rooseboom Hypodermic injection apparatus
DK97966C (da) 1954-10-27 1964-02-10 Astra Apotekarnes Kem Fab Injektionssprøjte.
US3055362A (en) 1956-05-16 1962-09-25 Auguste Rooseboom Hypodermic injection apparatus
NL106573C (de) 1957-05-31
US2888924A (en) 1958-02-25 1959-06-02 Russell P Dunmire Hypodermic syringes
US3051173A (en) 1960-05-12 1962-08-28 Alvin P Johnson Veterinary hypodermic syringe
US3330279A (en) 1963-10-18 1967-07-11 Sarnoff Automatic hypodermic syringe
US3314428A (en) 1963-12-04 1967-04-18 Alvin P Johnson Veterinary hypodermic syringe
US3403679A (en) 1964-12-11 1968-10-01 Secr Defence Brit Hypodermic injection apparatus with a secondary capsule-collapsing means
US3543603A (en) 1968-01-10 1970-12-01 Rex Chainbelt Inc Automatic quick release mechanism
US3605743A (en) 1968-10-14 1971-09-20 Raul Olvera Arce Hypodermic syringe
DE1957833A1 (de) 1968-11-21 1970-07-02 Maurice Steiner Injektionsspritze,insbesondere von dem Patienten selbst gehandhabte Injektionsspritze
US3618603A (en) 1969-01-29 1971-11-09 Levenson M F Syringe
BE755224A (fr) 1969-08-25 1971-02-24 Philips Nv Seringue d'injection
DE2019296A1 (de) 1970-04-22 1971-11-04 Walter Dr Stein Injektionsgeraet,insbesondere Injektionsspritze mit portionierter Packung
US3712301A (en) 1971-01-11 1973-01-23 Survival Technology Gun type hypodermic injector with rapid cartridge displacement within holder
BE795162A (fr) 1972-02-10 1973-08-08 Philips Nv Injektie-inrichting
US3797488A (en) 1972-07-10 1974-03-19 Ampoules Inc Ampoule applicator with one-way clutch
JPS5319071Y2 (de) 1973-06-07 1978-05-20
FR2237643B1 (de) 1973-07-17 1978-03-17 Steiner Maurice
US3882863A (en) 1973-08-01 1975-05-13 Survival Technology Hypodermic injection device having cannula covered with resilient sheath
US4031893A (en) 1976-05-14 1977-06-28 Survival Technology, Inc. Hypodermic injection device having means for varying the medicament capacity thereof
US4106770A (en) 1976-09-01 1978-08-15 Gray John M Hypodermic syringe projectile
US4178928A (en) 1977-08-10 1979-12-18 Tischlinger Edward A Self injector
SU787035A1 (ru) 1978-01-11 1980-12-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Устройство дл введени лекарственных препаратов
US4202314A (en) 1978-11-20 1980-05-13 Busygin Valery P Device for injection of medicinal preparations
US4226235A (en) 1979-01-25 1980-10-07 Survival Technology, Inc. Plural injecting device
US4258713A (en) 1979-07-23 1981-03-31 Wardlaw Stephen C Automatic disposable hypodermic syringe
US4275729A (en) 1979-10-29 1981-06-30 Jules Silver Adjustable dosage syringe
AU549690B2 (en) 1981-06-29 1986-02-06 Sherwood Services Ag Pin prick device to pierce skin
ATE15860T1 (de) 1981-07-27 1985-10-15 Duphar Int Res Automatische injektionsspritze.
US4437859A (en) 1981-08-03 1984-03-20 Drs Infusion Systems, Inc. Hydraulic syringe drive
US4394863A (en) 1981-10-23 1983-07-26 Survival Technology, Inc. Automatic injector with cartridge having separate sequentially injectable medicaments
US4425120A (en) 1982-04-15 1984-01-10 Sampson Norma A Shielded hypodermic syringe
DE3367854D1 (en) 1982-10-27 1987-01-15 Duphar Int Res Automatic injection device
US4530695A (en) 1982-12-31 1985-07-23 N.J. Phillips Pty. Limited Injector
US4578064A (en) 1983-12-21 1986-03-25 Survival Technology Inc. Plural dosage automatic injector with improved safety
US4573976A (en) 1984-05-24 1986-03-04 Dolores A. Smith Shielded needle
US4678461A (en) 1984-11-01 1987-07-07 Survival Technology, Inc. Automatic injector with improved glass container protector
DE3566866D1 (en) 1984-11-02 1989-01-26 Duphar Int Res Automatic injection device
US4627445A (en) 1985-04-08 1986-12-09 Garid, Inc. Glucose medical monitoring system
US4723937A (en) 1985-05-20 1988-02-09 Survival Technology, Inc. Plural dosage automatic injector with a by-pass fitment
DE3673317D1 (de) 1985-10-11 1990-09-13 Duphar Int Res Automatische spritze.
WO1987002254A1 (en) 1985-10-11 1987-04-23 Physionic Gesellschaft Für Medizin- Und Systemtech Injection syringe
US4664653A (en) 1986-02-24 1987-05-12 Sagstetter William E Manually operated reusable injection apparatus
DE3773048D1 (de) 1986-05-15 1991-10-24 Duphar Int Res Automatische injektionsspritze.
DE3631229A1 (de) 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
DE3645245C2 (de) 1986-11-14 1994-01-27 Haselmeier Wilhelm Fa Injektionsgerät
US4795432A (en) 1987-02-19 1989-01-03 Karczmer Claude M Shield assembly for hypodermic injection devices
DE3709783C1 (de) 1987-03-25 1988-04-14 Blendax Werke Schneider Co Dosierspritze
DE3715258C2 (de) 1987-05-08 1996-10-31 Haselmeier Wilhelm Fa Injektionsgerät
DE3715340C2 (de) 1987-05-08 1995-10-19 Haselmeier Wilhelm Fa Injektionsgerät
US4927416A (en) 1987-12-02 1990-05-22 National Medical Device Corporation User-protective hypodermic syringe holder
GB8809115D0 (en) 1988-04-18 1988-05-18 Turner R C Syringes
GB8819977D0 (en) 1988-08-23 1988-09-21 Medimech Ltd Automatic injectors
US4902279A (en) 1988-10-05 1990-02-20 Autoject Systems Inc. Liquid medicament safety injector
US5244465A (en) 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
US4929237A (en) 1988-11-07 1990-05-29 David Medway Hypodermic needle protection device
US4955868A (en) 1988-11-28 1990-09-11 Edward Klein Disposable safety medical syringe
IT1227658B (it) 1988-12-01 1991-04-23 Vittorio Boschetti B Siringa monouso con rientro e blocco dell'ago a fine iniezione a scopo di evitare il reimpiego
ES2019792A6 (es) 1990-01-17 1991-07-01 Caralt Batlle Jaime Jeringuilla hipodrmica de un solo uso.
ES2009709A6 (es) 1989-01-24 1989-10-01 Villar Pascual Jose Antonio Jeronguilla de seguridad monouso.
US4923447A (en) 1989-02-17 1990-05-08 Morgan Michael W Syringe assembly
US4966592A (en) 1989-05-05 1990-10-30 Burns Cameron A Protective sleeve for hypodermic needle
USD322479S (en) 1989-06-02 1991-12-17 Terumo Kabushiki Kaisha Holder for lancet
US5407431A (en) 1989-07-11 1995-04-18 Med-Design Inc. Intravenous catheter insertion device with retractable needle
US4994034A (en) 1989-07-11 1991-02-19 Botich Michael J Retractable needle hypodermic syringe system
US5085641A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use auto-injector with improved cap structure
WO1991013643A1 (fr) 1990-03-08 1991-09-19 Jean Guerineau Seringe a aiguille auto-escamotable
GB2243552A (en) 1990-03-21 1991-11-06 Transfertec Limited Improvements in or relating to single-use syringes
DK0467173T3 (da) 1990-07-19 1996-03-11 Nardino Righi Engangssikkerhedssprøjte
DK285990A (da) 1990-11-30 1992-05-31 Nujenko Pty Ltd Sproejteenhed
AU114410S (en) 1990-12-21 1992-06-29 Glaxo Group Ltd An injector
GB9100819D0 (en) 1991-01-15 1991-02-27 Medimech Int Ltd Subcutaneous injector
US5376080A (en) 1991-01-30 1994-12-27 Petrussa; Gian L. Single use retractable needle syringe
US5098400A (en) * 1991-02-14 1992-03-24 Sherwood Medical Company Needle shield
GB9111600D0 (en) 1991-05-30 1991-07-24 Owen Mumford Ltd Improvements relating to injection devices
EP0518416A1 (de) 1991-06-13 1992-12-16 Duphar International Research B.V Injektionsvorrichtung
RU2004256C1 (ru) 1991-06-26 1993-12-15 Липов Борис Петрович, Сафронов Игорь Николаевич Инъектор
EP0525525B1 (de) 1991-07-24 1995-05-03 Medico Development Investment Company Injektor
US5259840A (en) 1991-09-03 1993-11-09 Boris Craig R Locking syringe
US5242240A (en) 1991-10-17 1993-09-07 Minnesota Scientific, Inc. Clamping device for a surgical retractor
USD346219S (en) 1991-11-25 1994-04-19 Actimed Plast AB Erection pump
US5263934A (en) 1991-11-28 1993-11-23 Haak Abraham Van Den Stroke limiting syringe with retractable needle
DK194291D0 (da) 1991-11-29 1991-11-29 Novo Nordisk As Sproejte til automatisk injektion.
AU3260993A (en) 1992-01-07 1993-08-03 Sti International Limited Automatic injectors
GB9200219D0 (en) 1992-01-07 1992-02-26 Medimech Int Ltd Automatic injectors
AT398037B (de) 1992-01-10 1994-08-25 Med Plastic Ag Vorrichtung zur selbst-injektion
US5201708A (en) 1992-02-03 1993-04-13 Timothy A. Kershenstine Self-locking safety syringe
EP0562671B1 (de) 1992-03-27 1996-05-29 Duphar International Research B.V Automatische Spritze
US5267972A (en) 1992-07-20 1993-12-07 Anderson Wayne W Hypodermic syringe with needle guard
US5224936A (en) 1992-10-15 1993-07-06 Brian Gallagher Automatic self-protecting hypodermic needle assembly
US5295975A (en) 1992-10-28 1994-03-22 Lockwood Jr Hanford N Hypodermic needle safety device with sliding outer cover
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
GB9223183D0 (en) 1992-11-05 1992-12-16 Medimech Int Ltd Improvements related to auto injectors
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
WO1994011041A1 (en) 1992-11-19 1994-05-26 R G S.A.S. Di Rosaria Galli & C. Disposable auto-injector for prefilled syringes
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
IT1256577B (it) 1992-12-11 1995-12-11 Ermanno Greco Dispositivo predisposto per la somministrazione automatica di un farmaco per via intradermica.
US5346480A (en) 1992-12-14 1994-09-13 Q-Med, Inc. Syringe with retractable needle
US5298024A (en) 1992-12-28 1994-03-29 Frank Richmond Multi-liquid medicament delivery system with reflex valves
FR2701211B1 (fr) 1993-02-08 1995-05-24 Aguettant Lab Instrument doseur, notamment d'injection
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
WO1994021316A1 (en) 1993-03-24 1994-09-29 Owen Mumford Limited Improvements relating to injection devices
DK55693D0 (da) 1993-05-13 1993-05-13 Radiometer As Afskydningsmekanisme til afskydning af en kanyle placeret i forbindelse med en beholder, samt et beholderemne omfattende en saadan afskydningsmekanisme
US5540664A (en) 1993-05-27 1996-07-30 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5358489A (en) 1993-05-27 1994-10-25 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5433712A (en) 1993-06-10 1995-07-18 Donald E. Stiles Self-sheathing hypodermic syringe
US5425715A (en) 1993-08-05 1995-06-20 Survival Technology, Inc. Reloadable injector
US5620421A (en) 1993-12-09 1997-04-15 Schmitz; William L. Syringe injector system
FR2715071B1 (fr) 1994-01-17 1996-03-01 Aguettant Lab Injecteur automatique de médicament.
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
CA2191472C (en) 1994-05-30 2005-07-12 Herbert Bechtold Injection device
GB9412301D0 (en) 1994-06-17 1994-08-10 Safe T Ltd Hollow-needle drugs etc applicators
US5645534A (en) 1994-06-24 1997-07-08 Becton Dickinson And Company Time of last injection indicator for medication delivery pen
EP0955951B1 (de) 1994-07-01 2005-08-24 Edwards Lifesciences Corporation Vorrichtung zum gewinnen von autologen, mikrovaskulären endothelialen zellen enthaltendem fettgewebe
US5637094A (en) 1994-11-04 1997-06-10 Pos-T-Vac, Inc. Multiple dosage syringe
US5993421A (en) 1994-12-02 1999-11-30 Science Incorporated Medicament dispenser
GB9504878D0 (en) 1995-03-10 1995-04-26 Weston Medical Ltd Viscously coupled actuator
GB9506087D0 (en) * 1995-03-24 1995-05-10 Owen Mumford Ltd Improvements relating to medical injection devices
FR2733155B1 (fr) 1995-04-18 1997-09-19 Tebro Auto-injecteur rechargeable
FR2733687B1 (fr) * 1995-05-04 1997-10-03 Brunel Marc Procede de fabrication d'un dispositif d'injection du type pre-rempli renfermant une dose de liquide a injecter, et dispositif d'injection realise
FR2736553B1 (fr) 1995-07-12 1998-01-09 Soc Et Et D Applic Tech Sedat Seringue d'injection, notamment de produits medicaux liquides, a protecteur d'aiguille mobile
US5591138A (en) 1995-08-10 1997-01-07 Vaillancourt; Vincent L. Protected needle assembly
US5735818A (en) 1995-10-11 1998-04-07 Science Incorporated Fluid delivery device with conformable ullage
US5658259A (en) 1995-10-19 1997-08-19 Meridian Medical Technologies, Inc. Dental cartridge assembly auto-injector with protective needle cover
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US5807335A (en) 1995-12-22 1998-09-15 Science Incorporated Fluid delivery device with conformable ullage and fill assembly
US5634906A (en) 1995-12-27 1997-06-03 Habley Medical Technology Corporation Needle hiding shield for a dose metering syringe
CN103275221B (zh) 1996-02-09 2016-08-17 艾伯维生物技术有限公司 结合人TNFα的人抗体
DE19604838A1 (de) 1996-02-12 1997-08-14 Alfred Von Schuckmann Vorrichtung zum Ausgeben von Flüssigkeit in abgeteilten Mengen
US6277098B1 (en) 1996-03-12 2001-08-21 Novo Nordisk A/S Injection device with electronic presentation of set doses
US5817111A (en) 1996-03-28 1998-10-06 Riza; Erol D. Open loop suture snare
IT1284642B1 (it) 1996-05-02 1998-05-21 Ermanno Greco Perfezionamenti alle siringhe automatiche per iniezione
EP1579814A3 (de) 1996-05-17 2006-06-14 Roche Diagnostics Operations, Inc. Verfahren und Vorrichtung zur Probenahme und Analyse von Körperflüssigkeit
GB9612724D0 (en) * 1996-06-18 1996-08-21 Owen Mumford Ltd Improvements relating to injection devices
WO1998001170A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Automatic needle insertion mechanism
ATE307628T1 (de) 1996-07-05 2005-11-15 Tecpharma Licensing Ag Injektionsgerät zum injizieren von flüssigkeit
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
SE9604162D0 (sv) 1996-11-13 1996-11-13 Astra Ab Membrane
US6203530B1 (en) 1997-01-28 2001-03-20 Pos-T-Vac, Inc. Auto-injection device
US20070142776A9 (en) 1997-02-05 2007-06-21 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
BR9700930A (pt) 1997-02-07 1998-12-08 Rhone Poulenc Rorer Gmbh Unidade para venda que se destina a aplicação parenteral um dispositivo para a execução da aplicação parenteral bem como uma unidade de recarga destinada á unidade para venda acima mencionada
AU6719198A (en) 1997-02-12 1998-09-08 Sergio Restelli Disposable safety syringe
DE29703820U1 (de) 1997-03-03 1998-07-02 Medico Development Investment Co., Ascona Injektionsgerät
US6277097B1 (en) 1997-03-25 2001-08-21 Novo Nordisk A/S Injection system
US6979307B2 (en) 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
GB9714948D0 (en) 1997-07-16 1997-09-17 Owen Mumford Ltd Improvements relating to injection devices
GB9716065D0 (en) 1997-07-31 1997-10-01 Owen Mumford Ltd Improvements relating to injection devices
CA2300930C (en) 1997-08-21 2007-10-16 Owen Mumford Limited Improvements relating to injection devices
AU9202398A (en) 1997-09-29 1999-04-23 Becton Dickinson & Company Injection device and drug cartridge for preventing cross-use of the device and drug cartridge
US5931817A (en) 1997-09-12 1999-08-03 Becton Dickinson And Company Pen needle assembly
WO1999022792A1 (en) 1997-11-03 1999-05-14 Ermanno Greco Self-injection device
FR2770404B1 (fr) 1997-11-05 2000-01-28 Sedat Injecteur automatique a retraction d'aiguille en fin d'injection
CA2315146C (en) 1997-12-16 2008-11-18 Meridian Medical Technologies, Inc. Automatic injector for administrating a medicament
IT1304761B1 (it) 1998-01-20 2001-03-29 Nardino Righi Siringa monouso di sicurezza.
DE29801168U1 (de) 1998-01-24 1999-08-12 Medico Dev Investment Co Injektionsgerät
FR2774294B1 (fr) 1998-02-04 2000-04-14 Marc Brunel Dispositif d'injection automatique d'une dose de produit medicamenteux
US7056306B1 (en) 1998-02-05 2006-06-06 Mdc Investment Holdings, Inc. Fluid sampling device with retractable needle
GB9803084D0 (en) 1998-02-14 1998-04-08 Owen Mumford Ltd Improvements relating to medical injection devices
US6319233B1 (en) 1998-04-17 2001-11-20 Becton, Dickinson And Company Safety shield system for prefilled syringes
GB9808408D0 (en) 1998-04-18 1998-06-17 Owen Mumford Ltd Improvements relating to injection devices
DE19821933C1 (de) 1998-05-15 1999-11-11 Disetronic Licensing Ag Vorrichtung zur Verabreichung eines injizierbaren Produkts
DE19822031C2 (de) 1998-05-15 2000-03-23 Disetronic Licensing Ag Autoinjektionsgerät
US6645181B1 (en) 1998-11-13 2003-11-11 Elan Pharma International Limited Drug delivery systems and methods
US6312412B1 (en) 1998-12-02 2001-11-06 V. C. Saied, M.D. Apparatus and method for painless intramuscular or subcutaneous injections
GB9903475D0 (en) 1999-02-17 1999-04-07 Owen Mumford Ltd Improvements relating to injection devices
AU6414400A (en) 1999-07-27 2001-02-13 Pharma Consult Ges.M.B.H. Device for automatically injecting injection liquids
US6213987B1 (en) 1999-08-02 2001-04-10 Michael N. Hirsch Shroud for a used hypodermic syringe needle
US6277099B1 (en) 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
DE60015996T2 (de) 1999-09-07 2005-11-10 Computer Controlled Syringe Inc., London Zurückziehbare nadelanordnung
US6102896A (en) 1999-09-08 2000-08-15 Cambridge Biostability Limited Disposable injector device
WO2001019428A2 (en) 1999-09-13 2001-03-22 Vitro Diagnostics, Inc. Multi-dose syringe driver
US6171285B1 (en) 1999-10-06 2001-01-09 R. Steven Johnson Retractable syringe
FR2799375B1 (fr) * 1999-10-07 2002-01-18 Marc Brunel Dispositif d'injection a usage unique
US6673035B1 (en) 1999-10-22 2004-01-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
ATE440628T1 (de) 1999-11-18 2009-09-15 Tyco Healthcare Automatischer sicherheits-nadelschutz
GB9927715D0 (en) 1999-11-24 2000-01-19 Safe T Ltd Hollow-needle devices
JP4295821B2 (ja) 1999-11-29 2009-07-15 エム ディー シー インベストメント ホールディングス インコーポレイテッド 安全針アセンブリと医療用機器との組み合せ
RU2169584C1 (ru) 2000-01-17 2001-06-27 Лисовой Дмитрий Григорьевич Инъектор
GB0003790D0 (en) 2000-02-18 2000-04-05 Astrazeneca Uk Ltd Medical device
AU4158401A (en) 2000-02-23 2001-09-03 Abbott Lab Syringes and syringe systems for selectively dispensing controlled amounts of a therapeutic substance
DE10009814B4 (de) 2000-03-01 2008-03-06 Tecpharma Licensing Ag Einweg-Injektorkappe
DE10009815B4 (de) 2000-03-01 2009-07-16 Tecpharma Licensing Ag Injektionsgerät mit einer Nadelabdeckung
US6322540B1 (en) 2000-03-10 2001-11-27 International Technology Group Safe needle device for syringe
US6475194B2 (en) 2000-04-05 2002-11-05 Gem Plastics, Inc. Safety syringe
US6547763B2 (en) 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
USD461555S1 (en) 2000-05-25 2002-08-13 Jean Marc Binet Safety syringe
US6517517B1 (en) 2000-06-08 2003-02-11 Mayo Foundation For Medical Education And Research Automated injection device for administration of liquid medicament
KR100795503B1 (ko) 2000-06-08 2008-01-16 메리디안 메디칼 테크놀로지즈 인코포레이티드 건식/습식 자동주입기 어셈블리
NO312059B1 (no) 2000-06-23 2002-03-11 Syringus As En kanyletildekkingsmekanisme, en kanyleholder og en injeksjonsspröyte
WO2002009794A1 (en) 2000-07-28 2002-02-07 Mdc Investment Holdings, Inc. Retractable needle medical device for injecting fluid from a pre-filled cartridge
US6986760B2 (en) 2000-08-02 2006-01-17 Becton, Dickinson And Company Pen needle and safety shield system
AU2001281753A1 (en) 2000-08-29 2002-03-13 Novo-Nordisk A/S Automatic injection device with torsion function for retraction of needle
US6413237B1 (en) 2000-08-31 2002-07-02 Becton, Dickinson And Company Hypodermic syringe with selectively retractable needle
US6964647B1 (en) 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
US6953445B2 (en) 2000-10-10 2005-10-11 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
FR2815543B1 (fr) 2000-10-19 2003-10-24 Sedat Seringue d'auto-injection d'un melange extemporane
SE518981C2 (sv) 2000-12-14 2002-12-17 Shl Medical Ab Autoinjektor
US6387078B1 (en) 2000-12-21 2002-05-14 Gillespie, Iii Richard D. Automatic mixing and injecting apparatus
US6673049B2 (en) 2001-02-15 2004-01-06 Disetronic Licensing Ag Injection device for injecting fluid
AUPR373001A0 (en) 2001-03-14 2001-04-12 Glenord Pty Ltd Improved non-reusable syringe
US6802827B2 (en) 2001-06-26 2004-10-12 Stig O. Andersson Hypodermic implant device
GB0118419D0 (en) 2001-07-28 2001-09-19 Owen Mumford Ltd Improvements relating to injection devices
EP1281410A1 (de) 2001-08-03 2003-02-05 Sergio Restelli Spritze mit automatisches Sicherung
FR2830765B1 (fr) 2001-10-15 2004-07-23 Plastic Omnium Cie Dispositif de securite pour une seringue
US6494863B1 (en) 2001-10-15 2002-12-17 Retractable Technologies, Inc. One-use retracting syringe with positive needle retention
US6796967B2 (en) 2001-10-22 2004-09-28 Nps Pharmaceuticals, Inc. Injection needle assembly
US7569035B1 (en) 2001-11-02 2009-08-04 Meridian Medical Technologies, Inc. Automatic injector with anti-coring needle
ATE350086T1 (de) 2001-11-09 2007-01-15 Alza Corp Zusammenschiebbarer spritzenbehälter
US20030105430A1 (en) 2001-11-30 2003-06-05 Elan Pharma International Limited Wil House Automatic injector
US6872194B2 (en) 2002-01-31 2005-03-29 Safety Syringes, Inc. Disposable self-shielding syringe guard
EP1334740A1 (de) 2002-02-11 2003-08-13 Sergio Restelli Sicherheitsspritze aus Glas und Sicherheitskit für Glasspritze
ES2547444T3 (es) 2002-02-15 2015-10-06 Antares Pharma, Inc. Inyector con canal de derivación
US7033338B2 (en) 2002-02-28 2006-04-25 Smiths Medical Md, Inc. Cartridge and rod for axially loading medication pump
GB0205066D0 (en) 2002-03-05 2002-04-17 Owen Mumford Ltd Improvements relating to injection devices
AU2003208948A1 (en) 2002-03-13 2003-09-29 Eli Lilly And Company Method of treating a medical condition with a portable medication delivery device
WO2003080160A1 (en) 2002-03-18 2003-10-02 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
US6976976B2 (en) 2002-03-27 2005-12-20 Safety Syringes, Inc. Syringe with needle guard injection device
US20030187401A1 (en) 2002-03-27 2003-10-02 Safety Syringes, Inc. Syringe with integral safety system
US7004929B2 (en) 2002-03-29 2006-02-28 Mdc Investment Holdings, Inc. Safety pre-filled cartridge injector
GB2388033A (en) 2002-05-02 2003-11-05 Pa Consulting Services Automatic injection device
SI1503816T1 (sl) 2002-05-02 2007-08-31 Cilag Gmbh Int Naprava za vbrizganje
US7247151B2 (en) 2002-05-09 2007-07-24 Adam Slawson Injector with shielded needle
US6808507B2 (en) 2002-05-10 2004-10-26 Cambridge Biostability Ltd. Safety injectors
GB0211294D0 (en) 2002-05-17 2002-06-26 Owen Mumford Ltd Improvements relating to injection devices
US6979316B1 (en) 2002-05-23 2005-12-27 Seedlings Life Science Ventures Llc Apparatus and method for rapid auto-injection of medication
US20050171476A1 (en) 2002-05-24 2005-08-04 Judson Jared A. Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
US20030229308A1 (en) 2002-06-05 2003-12-11 Israil Tsals Injector adapter and combination thereof
GB0214452D0 (en) 2002-06-22 2002-07-31 Liversidge Barry P Medical needle assemblies
US20100160869A1 (en) 2002-06-22 2010-06-24 Barry Peter Liversidge Medical Needle Assemblies
TWI314464B (en) 2002-06-24 2009-09-11 Alza Corp Reusable, spring driven autoinjector
DE10229122B4 (de) 2002-06-28 2006-09-07 Tecpharma Licensing Ag Verabreichungsgerät mit rücksetzbarer Betätigungssperre
CN100462111C (zh) 2002-07-02 2009-02-18 松下电器产业株式会社 医用自动给药器
FR2842428B1 (fr) 2002-07-19 2004-10-08 Becton Dickinson France Dispositif d'injection d'un produit, notamment a usage medical
WO2004011065A1 (en) 2002-07-31 2004-02-05 Alza Corporation Injection device providing automatic needle retraction
US7001364B1 (en) 2002-08-13 2006-02-21 Parham Farhi Needle safety cap device
US20040039337A1 (en) 2002-08-21 2004-02-26 Letzing Michael Alexander Portable safety auto-injector
CA2500195C (en) 2002-09-24 2009-07-21 Shl Medical Ab Injecting device
US7699816B2 (en) 2002-10-15 2010-04-20 Tecpharma Licensing Ag Injection device with priming stroke
CN100506305C (zh) 2002-11-25 2009-07-01 特克法马许可公司 包括针保护设备的注射装置
EP1572268A1 (de) 2002-11-25 2005-09-14 Tecpharma Licensing AG Vorrichtung zum automatischen injizieren eines wirkstoffes
AU2003275895B2 (en) 2002-11-25 2009-02-05 Tecpharma Licensing Ag Auto-injector comprising a resettable releasing safety device
GB0229345D0 (en) 2002-12-17 2003-01-22 Safe T Ltd Hollow needle applicators
GB2396816A (en) 2002-12-17 2004-07-07 Pa Consulting Services Injection device
US6767336B1 (en) 2003-01-09 2004-07-27 Sheldon Kaplan Automatic injector
WO2004067068A1 (en) 2003-01-24 2004-08-12 Alza Corporation Collapsible syringe cartridge
USD494270S1 (en) 2003-02-04 2004-08-10 Sherwood Services Ag Electrosurgical pencil with multiple scallops
US6932794B2 (en) 2003-04-03 2005-08-23 Becton, Dickinson And Company Medication delivery pen
US6805686B1 (en) 2003-05-06 2004-10-19 Abbott Laboratories Autoinjector with extendable needle protector shroud
US6926697B2 (en) 2003-05-13 2005-08-09 Robert Malenchek Adaptor for converting a non-safety syringe into a safety syringe
GB0315600D0 (en) 2003-07-04 2003-08-13 Owen Mumford Ltd Improvements relating to automatic injection devices
US7500963B2 (en) 2003-07-22 2009-03-10 Safety Syringes, Inc. Systems and methods for automatic medical injection with safeguard
US20050027255A1 (en) 2003-07-31 2005-02-03 Sid Technologies, Llc Automatic injector
EP1502613A1 (de) 2003-08-01 2005-02-02 Novo Nordisk A/S Gerät mit Rückziehvorrichting für eine Nadel
DE10339794A1 (de) 2003-08-28 2005-04-07 Tecpharma Licensing Ag Verabreichungsvorrichtung mit einer Schutzkappenabziehvorrichtung und einer Nadelschutzhülsenblockiereinrichtung
DE10340586A1 (de) 2003-09-03 2005-04-07 Tecpharma Licensing Ag Abmischvorrichtung für Mehrkammerampulle
FR2860162B1 (fr) 2003-09-26 2006-06-02 Becton Dickinson France Dispositif de protection d'un appareil d'injection
GB0406458D0 (en) 2003-10-09 2004-04-28 Liversidge Barry P Safety medical needle assemblies
US20050085776A1 (en) 2003-10-16 2005-04-21 Edgar Hommann Injection device for administering a fluid product
USD518175S1 (en) 2003-10-31 2006-03-28 Wilson-Cook Medical Inc. Handle for medical devices, and medical device assemblies using a handle
US20050096597A1 (en) 2003-11-03 2005-05-05 Becton, Dickinson And Company Safety shield system for a syringe
US7497847B2 (en) 2003-11-03 2009-03-03 Becton, Dickinson And Company Safety shield system for a syringe
US7635348B2 (en) 2003-11-04 2009-12-22 Meridian Medical Technologies, Inc. Container for medicament automatic injector and automatic injector adapted therefor
US20050101919A1 (en) 2003-11-07 2005-05-12 Lennart Brunnberg Device for an injector
GB2410188B (en) 2004-01-23 2006-01-25 Medical House Plc Injection device
GB0403335D0 (en) * 2004-02-14 2004-03-17 Liversidge Barry P Medical injector handling device
ITTO20040169A1 (it) 2004-03-15 2004-06-15 Teksid Aluminum S R L Sistema di tenuta per recipienti ad alte pressioni ed alte temperature
US20050222539A1 (en) 2004-03-30 2005-10-06 Pediamed Pharmaceuticals, Inc. Automatic injection device
ATE426422T1 (de) 2004-04-29 2009-04-15 Abbott Lab Autoinjektor mit ausfahrbarer nadelschutzabdeckung
GB2414405B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414403B (en) 2004-05-28 2009-01-07 Cilag Ag Int Injection device
AU2005247153C1 (en) * 2004-05-28 2012-01-19 Cilag Gmbh International Injection device
GB2414400B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414399B (en) 2004-05-28 2008-12-31 Cilag Ag Int Injection device
GB2414406B (en) 2004-05-28 2009-03-18 Cilag Ag Int Injection device
GB2414404B (en) 2004-05-28 2009-06-03 Cilag Ag Int Injection device
GB2414402B (en) 2004-05-28 2009-04-22 Cilag Ag Int Injection device
US20050273054A1 (en) 2004-06-03 2005-12-08 Florida Atlantic University Epinephrine auto-injector
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
WO2006007642A1 (en) 2004-07-16 2006-01-26 Unitract Syringe Pty Ltd Syringe needle sheath
US20060100588A1 (en) 2004-07-23 2006-05-11 Lennart Brunnberg Needle handling device
US7449012B2 (en) 2004-08-06 2008-11-11 Meridian Medical Technologies, Inc. Automatic injector
US20060047250A1 (en) 2004-08-30 2006-03-02 Hickingbotham Dyson W Fluid delivery device
DE102004042581B4 (de) 2004-09-02 2022-09-15 Ypsomed Ag Auto-Pen für Zweikammerampulle
US20060069350A1 (en) 2004-09-30 2006-03-30 Buenger David R Medical syringe injector pen
US20060069354A1 (en) 2004-09-30 2006-03-30 Buenger David R Syringe activation device
US8092420B2 (en) 2004-11-24 2012-01-10 Becton, Dickinson And Company Automatic reconstitution injector device
US7905352B2 (en) * 2004-12-06 2011-03-15 Washington Biotech Corporation Kits containing medicine injection devices and containers
US20060129122A1 (en) 2004-12-06 2006-06-15 Wyrick Ronald E Method and apparatus for delivering epinephrine
GB0500366D0 (en) * 2005-01-08 2005-02-16 Liversidge Barry P Medical needle safety devices
US8062252B2 (en) 2005-02-18 2011-11-22 Becton, Dickinson And Company Safety shield system for a syringe
US20090240210A1 (en) 2005-03-14 2009-09-24 Global Medisafe Holdings Limited Auto retractable syringe
FR2884723B1 (fr) * 2005-04-20 2008-03-14 Becton Dickinson France Soc Pa Dispositif de protection d'un dispositif d'injection
CN100544784C (zh) 2005-04-26 2009-09-30 刘文杰 针头回缩式注射器的筒式推杆及针头回缩可控式注射器
US7694828B2 (en) 2005-04-27 2010-04-13 Biomet Manufacturing Corp. Method and apparatus for producing autologous clotting components
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
AU2006304009A1 (en) 2005-10-11 2007-04-26 Eli Lilly And Company Apparatus for injecting a pharmaceutical
US7919264B2 (en) 2005-11-01 2011-04-05 Abbott Biotechnology Ltd. Methods and compositions for determining the efficacy of a treatment for ankylosing spondylitis using biomarkers
US20070161960A1 (en) 2006-01-12 2007-07-12 Fu-Yuan Li Lancet device
EP1996262A2 (de) 2006-03-21 2008-12-03 Tyco Healthcare Group LP Passives sperrringsicherheitsschild für einspritzvorrichtungen
RU2466740C2 (ru) 2006-04-05 2012-11-20 Эбботт Байотекнолоджи Лтд. Очистка антитела
GB2438590B (en) 2006-06-01 2011-02-09 Cilag Gmbh Int Injection device
USD629509S1 (en) 2006-09-06 2010-12-21 Abbott Biotechnology Ltd. Automatic injection device
USD622374S1 (en) 2006-09-06 2010-08-24 Abbott Biotechnology Ltd. Automatic injection device
CN100563740C (zh) 2006-09-28 2009-12-02 明辰股份有限公司 医疗药物安全注射装置及用于医疗药物注射的推杆组合件
GB0620117D0 (en) * 2006-10-11 2006-11-22 Liversidge Barry P Safety needle pack
JP5014835B2 (ja) 2007-02-28 2012-08-29 株式会社山越 雨水浸透桝、及び既設雨水桝の雨水浸透桝化工法
US9044378B2 (en) 2007-05-31 2015-06-02 Safety Syringes, Inc. Anti-needle stick safety device or system for use with drugs requiring reconstitution
GB2451664B (en) 2007-08-08 2012-06-20 Cilag Gmbh Int Injection device
US20090157012A1 (en) 2007-12-13 2009-06-18 University Of Victoria Innovation And Development Corporation Syringe with extendable and retractable needle
SI2240222T1 (en) * 2008-01-11 2018-08-31 Ucb Biopharma Sprl SYSTEMS FOR MEDICATION OF PATIENTS WITH REVOMATOID ARTS
WO2009158145A2 (en) 2008-05-30 2009-12-30 Allergan, Inc. Injection device for soft-tissue augmentation fillers, bioactive agents and other biocompatible materials in liquid or gel form
US8900197B2 (en) * 2008-06-20 2014-12-02 West Pharmaceutical Services, Inc. Automatic injection mechanism with frontal buttress
JP5161712B2 (ja) 2008-09-03 2013-03-13 キヤノン株式会社 撮像装置、及び撮像方法
US8398602B2 (en) 2008-11-14 2013-03-19 Panasonic Corporation Carrying case and syringe system with same
GB2465389A (en) * 2008-11-17 2010-05-19 Owen Mumford Ltd Syringe needle cover remover
EP2393537B1 (de) * 2009-02-06 2023-05-10 Embecta Corp. Einweg-stiftnadel mit wiederverwendbaren vorbeugefunktionen
SG175279A1 (en) 2009-04-29 2011-11-28 Abbott Biotech Ltd Automatic injection device
GB0907534D0 (en) * 2009-05-01 2009-06-10 Owen Mumford Ltd Injection devices
ES2944912T3 (es) * 2009-05-26 2023-06-27 Shl Medical Ag Conjunto de cubierta de aguja
TWI519330B (zh) * 2009-06-02 2016-02-01 賽諾菲阿凡提斯德意志有限公司 使用者可選擇式之醫療模組
EP2490735B1 (de) * 2009-10-21 2015-09-16 Owen Mumford Limited Autoinjektor
TWI619521B (zh) 2009-12-15 2018-04-01 艾伯維生物技術有限責任公司 自動注射裝置、自動注射方法及防止不發射情況之方法
EP2361648A1 (de) * 2010-02-18 2011-08-31 Sanofi-Aventis Deutschland GmbH Entfernung eines schützenden Nadelschirms
ES2727275T3 (es) 2010-04-21 2019-10-15 Abbvie Biotechnology Ltd Dispositivo automático de inyección portátil para la liberación controlada de agentes terapéuticos
KR102001050B1 (ko) 2011-01-24 2019-07-17 엘캠 메디컬 애그리컬처럴 코오퍼레이티브 어소시에이션 리미티드 인젝터
CA2825316C (en) 2011-01-24 2020-05-05 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
JP5968914B2 (ja) 2011-01-24 2016-08-10 アッヴィ バイオテクノロジー リミテッド シリンジおよび自動注入デバイスからの針シールドの取り外し
USD677380S1 (en) 2011-01-24 2013-03-05 Abbvie Biotechnology Ltd. Automatic injection device
CA2829773A1 (en) 2011-03-18 2012-09-27 Abbvie Inc. Systems, devices and methods for assembling automatic injection devices and sub-assemblies thereof

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910260A (en) 1972-03-01 1975-10-07 Survival Technology Method and apparatus of treating heart attack patients prior to the establishment of qualified direct contact personal care
US4004577A (en) 1972-12-04 1977-01-25 Survival Technology, Inc. Method of treating heart attack patients prior to the establishment of qualified direct contact personal care
US3941130A (en) 1975-03-18 1976-03-02 Tibbs Robert C Sequential trigger release for injection device
US4261358A (en) 1979-10-01 1981-04-14 Walter Vargas Automatic syringe plunger
US4689042A (en) 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4755169A (en) 1985-05-20 1988-07-05 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4795433A (en) 1985-05-20 1989-01-03 Survival Technology, Inc. Automatic injector for emergency treatment
US5085642A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5102393A (en) 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
US4964866A (en) * 1989-11-22 1990-10-23 Becton, Dickinson And Company Needle sheath assembly
US5137516A (en) * 1989-11-28 1992-08-11 Glaxo Group Limited Triggered application device for medicament to be more descriptive of the invention
US5092843A (en) 1990-04-12 1992-03-03 Survival Technology, Inc. Dispersion multichamber auto-injector
US5267963A (en) 1992-08-21 1993-12-07 Nicholas Bachynsky Medication injection device
US6149626A (en) 1997-10-03 2000-11-21 Bachynsky; Nicholas Automatic injecting syringe apparatus
US6270479B1 (en) 1998-10-26 2001-08-07 Pharmacia Ab Autoinjector
US6371939B2 (en) 1998-10-26 2002-04-16 Pharmacia Ab Autoinjector
WO2008005315A2 (en) 2006-06-30 2008-01-10 Abbott Biotechnology Ltd. Automatic injection device
WO2009040603A1 (en) * 2007-09-25 2009-04-02 Becton Dickinson France Autoinjector with deshielder comprising tamper evidence means

Also Published As

Publication number Publication date
RU2695566C2 (ru) 2019-07-24
AU2018201781B2 (en) 2019-12-05
US20180304030A1 (en) 2018-10-25
US20220072238A1 (en) 2022-03-10
MX350384B (es) 2017-09-04
US20120238961A1 (en) 2012-09-20
JP2017221731A (ja) 2017-12-21
KR20140023891A (ko) 2014-02-27
US20160220765A1 (en) 2016-08-04
US20140288503A1 (en) 2014-09-25
BR112013018773A2 (pt) 2016-10-25
DOP2013000168A (es) 2014-07-15
KR101702339B1 (ko) 2017-02-03
JP5968914B2 (ja) 2016-08-10
EP3473283B1 (de) 2020-12-09
IL253556B (en) 2021-04-29
GT201300183A (es) 2014-12-12
ES2714424T3 (es) 2019-05-28
JP6850061B2 (ja) 2021-03-31
KR101853607B1 (ko) 2018-05-03
ZA201305030B (en) 2019-01-30
NZ612784A (en) 2015-09-25
US9339610B2 (en) 2016-05-17
MY155753A (en) 2015-11-30
WO2012103140A1 (en) 2012-08-02
CO6831978A2 (es) 2014-01-10
JP6200558B2 (ja) 2017-09-20
US10022503B2 (en) 2018-07-17
SG10201600575WA (en) 2016-02-26
CA2824454C (en) 2018-10-23
CR20130400A (es) 2014-02-13
AU2018201781A1 (en) 2018-04-05
CL2013002067A1 (es) 2014-05-09
AU2012209222A1 (en) 2013-05-02
RU2013139355A (ru) 2015-03-10
CA3010206C (en) 2020-04-07
JP2016195794A (ja) 2016-11-24
KR101989342B1 (ko) 2019-06-14
NZ729529A (en) 2018-08-31
AU2015238907B2 (en) 2017-12-21
RU2569704C2 (ru) 2015-11-27
EP2667914A1 (de) 2013-12-04
CA3010206A1 (en) 2012-08-02
IL253556A0 (en) 2017-09-28
ZA201607088B (en) 2018-05-30
EP3473283A1 (de) 2019-04-24
CN105709312B (zh) 2019-11-05
AU2015238907A1 (en) 2015-10-29
CN103608055B (zh) 2016-05-18
CA2824454A1 (en) 2012-08-02
IL227238A (en) 2017-07-31
AU2012209222A8 (en) 2013-08-29
RU2015146916A (ru) 2019-01-11
JP2014506492A (ja) 2014-03-17
MX342163B (es) 2016-09-19
PH12015500495A1 (en) 2016-04-04
ECSP13012848A (es) 2015-03-31
KR20170013418A (ko) 2017-02-06
CN105709312A (zh) 2016-06-29
EP2667914B1 (de) 2018-12-05
AU2015238907B9 (en) 2018-05-24
PE20141543A1 (es) 2014-11-23
PH12015500495B1 (en) 2016-04-04
SG10201707191UA (en) 2017-10-30
AU2012209222B2 (en) 2015-07-09
MY185270A (en) 2021-04-30
KR20170097789A (ko) 2017-08-28
US8708968B2 (en) 2014-04-29
KR20180045062A (ko) 2018-05-03
MX2013008598A (es) 2013-08-12
ZA201607089B (en) 2018-05-30
ES2859511T3 (es) 2021-10-04
UA112308C2 (uk) 2016-08-25
RU2015146916A3 (de) 2019-05-14
SG192115A1 (en) 2013-08-30
CN103608055A (zh) 2014-02-26
NZ711448A (en) 2017-03-31

Similar Documents

Publication Publication Date Title
AU2018201781B2 (en) Removal of needle shields from syringes and automatic injection devices
NZ729529B2 (en) Removal of needle shields from syringes and automatic injection devices
NZ711448B2 (en) Removal of needle shields from syringes and automatic injection devices
NZ612784B2 (en) Removal of needle shields from syringes and automatic injection devices

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20200505

AC Divisional application: reference to earlier application

Ref document number: 2667914

Country of ref document: EP

Kind code of ref document: P

Ref document number: 3473283

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40037731

Country of ref document: HK

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20230502

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230331