EP2219595A1 - Polysaccharid-gelformulierung - Google Patents

Polysaccharid-gelformulierung

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Publication number
EP2219595A1
EP2219595A1 EP08855758A EP08855758A EP2219595A1 EP 2219595 A1 EP2219595 A1 EP 2219595A1 EP 08855758 A EP08855758 A EP 08855758A EP 08855758 A EP08855758 A EP 08855758A EP 2219595 A1 EP2219595 A1 EP 2219595A1
Authority
EP
European Patent Office
Prior art keywords
polysaccharide
formulation
inhibitor
sulfate
degradation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08855758A
Other languages
English (en)
French (fr)
Other versions
EP2219595B2 (de
EP2219595B1 (de
Inventor
Dimitrios Stroumpoulis
Christopher S. Mudd
Ahmet Tezel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Industrie SAS
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40676371&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2219595(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Priority to EP19215995.2A priority Critical patent/EP3653199A1/de
Priority to EP16154776.5A priority patent/EP3047844B1/de
Publication of EP2219595A1 publication Critical patent/EP2219595A1/de
Application granted granted Critical
Publication of EP2219595B1 publication Critical patent/EP2219595B1/de
Publication of EP2219595B2 publication Critical patent/EP2219595B2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
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    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A—HUMAN NECESSITIES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A61K8/602—Glycosides, e.g. rutin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
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    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
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    • A61K8/73—Polysaccharides
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/73—Polysaccharides
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A—HUMAN NECESSITIES
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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    • A61K2800/522—Antioxidants; Radical scavengers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
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    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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Definitions

  • Polysaccharides are relatively complex carbohydrates. They are polymers made up of many monosaccharides joined together by glycosidic bonds. They are therefore large, often branched, macromolecules. Polysaccharides, especially hyaluronic acid (HA), have been useful in cosmetic and medical applications. These polymers have been used, for example, as fillers in soft tissue augmentation.
  • HA hyaluronic acid
  • HA functions as a space-filling, structure stabilizing, and cell protective molecule with uniquely malleable physical properties and superb biocompatibility.
  • HA matrices are extremely viscoelastic while preserving a high level of hydration.
  • non-cross-linked as well as cross-linked polysaccharide chains such as HA are subject to degradation through different pathways; (e.g. enzymatic, free radical) thus limiting the polymer's longevity in vivo. It is, therefore, important to develop methods and compositions that decrease the rate of natural decomposition and increase the product's persistence in vivo. There remains an unmet need for having a polysaccharide formulation which has increased longevity by being resistant to degradation.
  • polysaccharide gel e.g. hyaluronic acid, HA
  • HA polysaccharide gel
  • the present disclosure provides methods for encapsulating these formulations to sustain a prolonged longevity or degradation time in vivo.
  • the present disclosure also relates to the preparation of gels that can have pharmaceutical or cosmetic applications.
  • a polysaccharide gel formulation comprising at least one polysaccharide selected from the group consisting of hyaluronic acid, cellulose, chitosan, o-sulfated HA, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratin sulfate, heparin, heparin sulfate, and alginate, and at least one inhibitor of polysaccharide degradation selected from the group consisting of a glycosiaminoglycan, an antioxidant, a flavonoid, a protein, a fatty acid, and combinations thereof.
  • the polysaccharide is cross-linked.
  • the at least one polysaccharide is hyaluronic acid.
  • the glycosiaminoglycan is selected from the group consisting of heparin, heparin sulfate, dermatan sulfate, chondroitin Docket: 18340 PCT (FAC) sulfate, o-sulfated hyaluronic acid, linamarin and amygdalin.
  • the glycosiaminoglycan is chondroitin sulfate and is present at a concentration of about 1% to about 40% by weight.
  • antioxidant is selected from the group consisting of ascorbic acid, melatonin, vitamin C, vitamin E and combinations thereof.
  • the flavonoid is selected from the group consisting of luteolin, apigenin, tangeritin, quercetin, kaempferol, myhcetin, fisetin, isorhamnetin, pachypodol, rhamnazin, hesperetin, naringenin, eriodictyol, homoeriodictyol, taxifolin, dihydroquercetin, dihydrokaempferol, tannic acid, tannis, condensed tannis, hydrolysable tannis and combinations thereof.
  • the flavonoid is tannic acid and is present at a concentration of about 0.0001 to about 1 % by weight.
  • the protein is a serum hyaluronidase inhibitor.
  • the fatty acid is a saturated C1 0 - 22 fatty acid.
  • the formulation further comprises a biocompatible or biodegradable vessel wherein the inhibitor is inside or part of said vessel, wherein the vessel is a liposome, micelle, or polymerized vesicle.
  • the inhibitor provides the formulation with improved rheological properties resulting in less extrusion force required for administration of the formulation compared to a cross-linked polysaccharide gel formulation.
  • a method of producing a polysaccharide gel formulation comprising having an increased degradation time comprising the step of: providing at least one polysaccharide selected from the group consisting of hyaluronic acid, cellulose, chitosan, o-sulfated HA, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratin sulfate, heparin, heparin sulfate, and alginate and incorporating in the polysaccharide at least one inhibitor of polysaccharide degradation selected Docket: 18340 PCT (FAC) from the group consisting of a glycosiaminoglycan, antioxidant, flavonoid, protein and fatty acid.
  • FAC polysaccharide degradation
  • the incorporating step comprises 1) mixing the inhibitor with the polysaccharide at a highly hydrated state thereby encapsulating the inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio.
  • the at least one polysaccharide is cross-linked before incorporation of the at least one inhibitor of polysaccharide degradation using a cross-linker selected from the group consisting of 1 ,4-butanediol diglycidyl ether (BDDE), 1 ,2-bis(2,3- epoxypropoxy)ethylene, 1 -(2,3-epoxypropyl)-2,3-epoxycyclohexane and combinations thereof.
  • BDDE 1,4-butanediol diglycidyl ether
  • 1 BDDE 1,2-bis(2,3- epoxypropoxy)ethylene
  • 1 -(2,3-epoxypropyl)-2,3-epoxycyclohexane 1,3-butanediol diglycidyl ether
  • the incorporating step comprises 1) encapsulating an inhibitor into a biocompatible or biodegradable vessel and 2) combining the at least one polysaccharide and the vessel into a gel formulation.
  • a polysaccharide gel formulation with an increased degradation time comprising cross-linked hyaluronic acid and tannic acid, wherein the tannic acid is present at a concentration of about 0.0001 % to about 1 %.
  • a polysaccharide gel formulation with an increased degradation time comprising cross-linked hyaluronic acid and chondroitin sulfate, wherein the chondroitin sulfate is present at a concentration of about 1 % to about 40%.
  • compositions comprising a polysaccharide gel formulation, a pharmaceutically acceptable carrier, and an active ingredient.
  • the active ingredient is selected from the group consisting of anti-itch, anti-cellulite, anti-scarring, anti- Docket: 18340 PCT (FAC) inflammatory agents, antioxidants, vitamins, moisturizers and combinations thereof.
  • Figure 1 graphically illustrates the extent of enzymatic degradation of polysaccharide gels including chondroitin sulfate A (CSA) using a colorimetric assay.
  • CSA chondroitin sulfate A
  • Figure 2 graphically illustrates the extent of enzymatic degradation of polysaccharide gels including tannic acid (TA) using a colorimetric assay.
  • Figure 3 graphically illustrates the extent of enzymatic degradation of polysaccharide gels both with and without CSA using a soluble HA assay.
  • Figure 4 graphically illustrates the extent of enzymatic degradation of polysaccharide gels both with and without TA using a soluble HA assay.
  • Figure 5 graphically illustrates effects of CSA on the extrusion force of a polysaccharide gel.
  • polysaccharide gel e.g. hyaluronic acid, HA
  • HA hyaluronic acid
  • the polysaccharide gels are cross-linked.
  • the present disclosure also relates to methods for encapsulating these formulations to sustain a prolonged longevity or degradation time in vivo.
  • the present disclosure also relates to the preparation of gels that can have pharmaceutical or cosmetic applications.
  • polysaccharide gel formulations comprising at least one polysaccharide and at least one inhibitor of polysaccharide degradation.
  • the present disclosure further relates to increasing the degradation time of polysaccharide gels by incorporating inhibitors to degradation.
  • Polysaccharide refers to a polymer of more than two monosaccharide molecules, of which the monosaccharides can be Docket 18340 PCT (FAC) identical or different.
  • the polysaccharide of the present disclosure can be cross-linked or not cross-linked.
  • the polysaccharides used herein can be, but are not limited to, HA, cellulose, chitosan, o-sulfated HA, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratin sulfate, heparin, heparin sulfate, and alginate.
  • Inhibitors are molecules that act by targeting and neutralizing specific degradation mechanisms such as enzymatic and free radical degradation.
  • Molecules that display inhibitory activity include but are not limited to glycosiaminoglycans (GAGs), (e.g. heparin, heparan sulfate, dermatan sulfate, chondroitin sulfate, o-sulfated HA, linamarin and amygdalin), antioxidants (e.g. ascorbic acid, melatonin, vitamin C and vitamin E), proteins (e.g. serum hyaluronidase inhibitor) and fatty acids (e.g. saturated Cio to C22 fatty acids).
  • GAGs glycosiaminoglycans
  • antioxidants e.g. ascorbic acid, melatonin, vitamin C and vitamin E
  • proteins e.g. serum hyaluronidase inhibitor
  • fatty acids e.g. saturated Cio to C22
  • Inhibitors are typically molecules orders of magnitude smaller than cross-linked polysaccharide polymers. Due to their small size and higher diffusivity, they are prone to fast adsorption in vivo that could potentially limit their performance.
  • One method of increasing the local half-life of such molecules in vivo is to chemically graft them to the polysaccharide polymer network and deliver them simultaneously.
  • One disadvantage of this method is that the bound molecule may display significantly lower activity compared to the unbound one.
  • the inhibitor concentration can be in the range of about 0.0001% to about 99% by wt, about 0.001% to about 75% by weight, about 0.01 % to about 60% by weight, about 1% to about 50% by weight, about 1 % to about 40% by weight, about 1 % to about 30% by weight, about 1 % to about 20% by weight, about 10% to about 20% by weight, about 20% to about 30% by weight 0.0001 % to about 0.01 % by weight, about 0.0001 % to about 0.1% by weight, about 0.0001% to about 1% by weight, about 0. 001% to about 1% by weight, about 0.01% to about 1% by weight, or about 1% to about 10% by weight.
  • FIG. 18340 PCT Another aspect of the present disclosure relates to a method of producing a polysaccharide gel formulation having reduced degradation comprising providing a polysaccharide and encapsulating an inhibitor of degradation in the polysaccharide.
  • Non-cross-linked as well as cross-linked polysaccharide chains are subject to degradation through different pathways (e.g. enzymatic, free radical) that often limits the polymer's longevity in vivo. It is therefore important to develop ways that decrease the rate of this natural decomposition process and increase the product's persistence in tissues.
  • One method for achieving increased polysaccharide persistence is to encapsulate inhibitor molecules within the polysaccharide polymer network itself or into large vessels within the network that would enable local (injection site), sustained and controlled release of degradation inhibitors. This would also allow avoidance of the natural degradation mechanisms.
  • the present encapsulation method provides a constant supply of degradation inhibitors to the polysaccharide polymer network over a period of weeks. In other embodiments, a constant supply of degradation inhibitors is provided over a period of months.
  • One method of encapsulation is to incorporate the degradation inhibitors within the polysaccharide polymer network either by adsorption or by an encapsulation process.
  • the inhibitors are allowed to mix with the polysaccharide network at a highly hydrated state, followed by dehydration of the network to control the release kinetics (e.g. final swelling ratio of the polymer).
  • a highly hydrated state corresponds to an HA concentration that is less than about 20 mg/ml.
  • the final swelling ratio can be controlled by adjusting the pH or partially dehydrating the polysaccharide network.
  • the contracted network can be sized into particles, mixed with the polysaccharide gel and delivered at the site of the injection. The slow re-hydration of the inhibitor-loaded polysaccharide particles can provide a sustained and controlled delivery of their active content.
  • FIG. 18340 PCT Another aspect of the present disclosure relates to a polysaccharide gel formulation comprising a polysaccharide and an inhibitor of polysaccharide degradation, and further comprising a biocompatible or biodegradable vessel wherein the inhibitor is inside or part of the vessel.
  • Such vessels can be composed of non-covalently or covalently linked self- assembled molecules such as liposomes, micelles, and polymerized vesicles.
  • a liposome is a vesicle composed of one or more bilayer membranes formed of naturally-derived phospholipids with mixed lipid chains (such as egg phosphatidylethanolamine), or of pure surfactant components like dioleoylphosphatidylethanolamine (DOPE).
  • Liposomes usually but not by definition, contain a core of aqueous solution; lipid structures that contain no aqueous material are called micelles.
  • a micelle is an aggregate of surfactant molecules dispersed in a liquid colloid.
  • a typical micelle in aqueous solution forms an aggregate with the hydrophilic "head” regions in contact with surrounding solvent, sequestering the hydrophobic "tail” regions in the micelle center.
  • This type of micelle is known as a normal phase micelle (oil-in-water micelle).
  • Inverse micelles have the headgroups at the centre with the tails extending out (water-in-oil micelle).
  • Micelles are often approximately spherical in shape, however, other forms, including shapes such as ellipsoids, cylinders, and bilayers are also possible.
  • the shape and size of a micelle is a function of the molecular geometry of its surfactant molecules and solution conditions such as surfactant concentration, temperature, pH, and ionic strength.
  • the process of forming micelles is known as micellisation and forms part of the phase behavior of many lipids according to their polymorphism.
  • Another aspect of the present disclosure relates to a method for producing a polysaccharide gel formulation having reduced degradation comprising the steps of 1) providing a polysaccharide, 2) incorporating an inhibitor into a biocompatible or biodegradable vessel and 3) combining said polysaccharide and vessel into a gel formulation.
  • This method of encapsulation thus incorporates the inhibitors into biocompatible and biodegradable vessels that could be delivered at the same time with the Docket: 18340 PCT (FAC) polysaccharide.
  • Such vessels can be composed of non-covalently or covalently linked self-assembled molecules (e.g. micelles, liposomes, and polymerized vesicles).
  • Self-assembly is a term used herein to describe processes in which a disordered system of pre-existing components forms an organized structure or pattern as a consequence of specific, local interactions among the components themselves, without external direction.
  • An additional advantage of the proposed formulation is the increased tune-ability of the final product's rheological properties.
  • Cross- linked polysaccharide gels typically have high viscosity and require considerable force to extrude through a fine needle.
  • Uncross-linked polysaccharides are often used as lubricants to facilitate this extrusion process.
  • uncross-linked HA does not contribute to the persistence of the final product in vivo.
  • the more cross-linked HA is replaced by uncross-linked HA to tune the rheological properties of the dermal filler (for a fixed total HA concentration), the lower the degradation resistance of the product will be.
  • uncross-linked GAGs that are also inhibitors to degradation (e.g. chondroitin sulfate, o-sulfated hyaluronic acid) can be used both to extend the longevity and improve the rheological properties of the final product.
  • chondroitin sulfate, o-sulfated hyaluronic acid e.g. chondroitin sulfate, o-sulfated hyaluronic acid
  • the polysaccharides described herein can be cross-linked or uncross-linked.
  • a cross-linking agent can be used to cross-link the polysaccharides according to the present description.
  • the cross-linking agent may be any agent known to be suitable for cross-linking polysaccharides and their derivatives via their hydroxyl groups.
  • Suitable cross-linking agents include but are not limited to, for example, 1 ,4-butanediol diglycidyl ether (or 1 ,4-bis(2,3-epoxypropoxy)butane or 1 ,4-bisglycidyloxybutane, all of which are commonly known as BDDE), 1 ,2-bis(2,3-epoxypropoxy)ethylene and 1-(2,3- epoxypropyl)-2,3-epoxycyclohexane.
  • BDDE 1 ,2-bis(2,3-epoxypropoxy)ethylene
  • 1-(2,3- epoxypropyl)-2,3-epoxycyclohexane The use of more than one cross-linking agent or a different cross-linking agent is not excluded from the scope of the Docket: 18340 PCT (FAC) present disclosure.
  • the cross-linking agent comprises or consists of BDDE.
  • Dermal fillers can be used to treat moderate to severe facial wrinkles and folds such as nasolabial folds (those lines that extend from the nose to the corners of the mouth).
  • Dermal fillers can be a gel implant that includes HA, a natural complex sugar that bolsters skin elasticity, providing a smooth and supple appearance. It is biocompatible and can supplement the body's natural HA, which aging can deplete.
  • a dermal gel can be injected with a syringe into the mid to deep dermis of the face.
  • the dermis is the subsurface skin layer that contains connective tissue, nerve endings, sweat and oil glands, and blood vessels.
  • Dermal fillers can improve the skins appearance by lifting and adding volume to the wrinkles and folds in the treatment area.
  • compositions comprising the present polysaccharide gel formulation, a cosmetic carrier, and an active ingredient.
  • the cosmetic active ingredients may include but are not limited to antioxidants, vitamins, and moisturizers.
  • cosmetic is an adjective referring to improving the appearance of a surface or covering defects.
  • cosmetic compositions can be used to improve aesthetic rather than functional aspects of a surface.
  • cosmetic compositions are formulated for application as a health and beauty treatment or for affecting personal appearance of the body, for example, keratinous surfaces such as skin, hair, nails, and the like.
  • cosmetically acceptable carrier refers to a material which is suitable for application to keratinous surfaces or other areas of the body. Upon application, cosmetically acceptable carriers are substantially free of adverse reactions with skin and other keratinous surfaces.
  • the cosmetic carriers may take the form of fatty or non-fatty creams, milky suspensions or emulsion-in-oil or oil-in-water types, Docket: 18340 PCT (FAC) lotions, gels or jellies, colloidal or non-colloidal aqueous or oily solutions, pastes, aerosols, soluble tablets or sticks.
  • FAC 18340 PCT
  • formulation and “composition” may be used interchangeably and refer to a combination of elements that is presented together for a given purpose. Such terms are well known to those of ordinary skill in the art.
  • carrier inert carrier
  • acceptable carrier may be used interchangeably and refer to a carrier which may be combined with the presently disclosed polysaccharide gel in order to provide a desired composition.
  • an active ingredient includes but is not limited to a drug.
  • a drug can generally be defined as a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well- being.
  • active ingredients which can be included in the present pharmaceutical composition are anti-itch, anti-cellulite, anti-scarring, and anti-inflammatory agents.
  • Anti-itch agents can include methyl sulphonyl methane, sodium bicarbonate, calamine, allantoin, kaolin, peppermint, tea tree oil and combinations thereof.
  • Anti-cellulite agents can include forskolin, xanthine compounds such as, but not limited to, caffeine, theophylline, theobromine, and aminophyiline, and combinations thereof.
  • Anti-scarring agents can include IFN- ⁇ , fluorouracil, poly(lactic-co-glycolic acid), methylated polyethylene glycol, polylactic acid, polyethylene glycol and combinations thereof.
  • Anti-inflammatory agents can include dexamethasone, prednisolone, Docket: 18340 PCT (FAC) corticosterone, budesonide, estrogen, sulfasalazine, mesalamine and combinations thereof.
  • a polysaccharide such as HA is found naturally in many tissues of the body, such as, but not limited to, skin, cartilage, and the vitreous humor. It is therefore well suited to biomedical applications targeting these tissues.
  • HA can be used in eye surgery (i.e., corneal transplantation, cataract surgery, glaucoma surgery and surgery to repair retinal detachment).
  • HA is also used to treat osteoarthritis of the knee.
  • Such treatments, called visco- supplementation are administered as a course of injections into the knee joint and are believed to supplement the viscosity of the joint fluid, thereby lubricating the joint, cushioning the joint, and producing an analgesic effect.
  • HA has positive biochemical effects on cartilage cells.
  • Oral use of HA has been lately suggested, although its effectiveness needs to be demonstrated. At present, there are some preliminary clinical studies that suggest that oral administration of HA has a positive effect on osteoarthritis.
  • HA Due to its high biocompatibility and its common presence in the extracellular matrix of tissues, HA can be used as a biomaterial scaffold in tissue engineering research. In some cancers, HA levels correlate well with malignancy and poor prognosis. HA is thus often used as a tumor marker for prostate and breast cancer. It may also be used to monitor the progression of the disease. HA may also be used postoperatively to induce tissue healing, notably after cataract surgery. Current models of wound healing propose that larger polymers of HA appear in the early stages of healing to physically make room for white blood cells, which mediate the immune response.
  • a pharmaceutical composition can optionally include one or more agents such as, without limitation, emulsifying agents, wetting agents, sweetening or flavoring agents, tonicity adjusters, preservatives, buffers antioxidants and flavonoids.
  • Tonicity adjustors useful in a pharmaceutical composition of the present disclosure include, but are not limited to, salts such Docket: 18340 PCT (FAC) as sodium acetate, sodium chloride, potassium chloride, mannitol or glycerin and other pharmaceutically acceptable tonicity adjusters.
  • Preservatives useful in the pharmaceutical compositions described herein include, without limitation, benzalkonium chloride, chlorobutanol, thimerosal, phenyl mercuric acetate, and phenyl mercuric nitrate.
  • Various buffers and means for adjusting pH can be used to prepare a pharmaceutical composition, including but not limited to, acetate buffers, citrate buffers, phosphate buffers and borate buffers.
  • antioxidants useful in pharmaceutical compositions are well known in the art and includes for example, sodium metabisulfite, sodium thiosulfate, acetylcysteine, butylated hydroxyanisole and butylated hydroxytoluene.
  • Flavonoids are compounds found in plants that are well known to have diverse beneficial biochemical and antioxidant effects. Subcategories of flavonoids include: flavones, flavonols, flavanonse and flavanonols. Examples of flavonoids include: luteolin, apigenin, tangeritin, quercetin, kaempferol, myricetin, fisetin, isorhamnetin, pachypodol, rhamnazin, hesperetin, naringenin, eriodictyol, homoeriodictyol, taxifolin, dihydroquercetin, dihydrokaempferol, tannic acid, tannis, condensed tannis, and hydrolysable tannis. It is understood that these and other substances known in the art of pharmacology can be included in a pharmaceutical composition of the invention. See for example, Remington's Pharmaceutical Sciences Mac Publishing Company, Easton, PA 16 th Edition 1980.
  • a Dalton (Da) is a unit of mass equal to 1/12 the mass of 12 O and one million Da can be notated as 1 MDa. Docket 18340 PCT (FAC) EXAMPLE 1
  • HA based polysaccharide filler with a HA concentration of 24 mg/mL, about a 6% degree of cross-linking and a G' of about 170 (JUVEDERM® 30) are mixed with 50 ⁇ l of PBS such that the final Docket: 18340 PCT (FAC) HA concentration is the same as in Example 3.
  • the mixture is mechanically homogenized.
  • NaHA, M w 0.5 - 3 MDa
  • sodium hydroxide solution 5-10 g of 1% sodium hydroxide solution
  • BDDE 1,4-butanediol diglycidyl ether
  • the mixture is then placed in a 40-70 0 C oven for 1-4 hrs.
  • the resulting cross-linked hydrogel is neutralized with an equimolar amount of hydrochloric acid (HCI) and swelled in PBS (pH «7).
  • HCI hydrochloric acid
  • PBS pH «7.
  • the mixture is then placed in a 40-70°C oven for 1-4 hrs.
  • the resulting cross-linked hydrogel is neutralized with an equimolar amount of hydrochloric acid (HCI) and swelled in PBS (pH «7) such Docket: 18340 PCT (FAC) that the final HA concentration is the same as in Example 5.
  • HCI hydrochloric acid
  • PBS pH «7
  • FAC 18340 PCT
  • EXAMPLE 7 Enzymatic Degradation Study (Colorimetric Test) Resistance to enzymatic degradation of the HA filling gels prepared in Examples 1 and 2, was evaluated using the Morgan-Elson colorimetric assay. This assay is used to estimate the average molecular weight of the HA chains before and after enzymatic degradation.
  • Hyaluronidase (0.1-10 mg) was added to the HA samples for 10- 250 mins at 37°C followed by 0.1 ml of a 0.8 M potassium tetraborate solution and heating at 100 0 C for 10 mins.
  • the samples were supplemented with 3 ml of a 10% (wt) p-dimethylaminobenzaldehyde solution in acetic acid and incubated at 37 0 C for 10-120 mins.
  • the change in the optical density (OD) at 585 nm post and pre-degradation was used to quantify the extent of degradation in each sample.
  • the OD values of the TA supplemented gels prepared by the methods of the present disclosure are Docket 18340 PCT (FAC) lower than that of the gel prepared by the method of the prior art (Example 4:
  • a SEC-MALS (Size Exclusion Multi- Angle Light Scattering) based soluble HA assay was used. This assay can be used to quantify degradation by evaluating the percentage of soluble HA (defined as the portion of the gel that can pass through a 0.2-1.0 ⁇ m filter) contained in each sample. The change in the amount of soluble HA, pre and post-degradation, can be used to quantify the extent of degradation in each sample.
  • the SEC-MALS tests were performed using an Agilent size exclusion chromatography system equipped with Wyatt light scattering and refractive index units.
  • Hyaluronidase (0.1-10 mg) was added to the HA samples for 10-250 mins at 37°C followed by 0.1 ml of a 0.8 M potassium tetraborate solution and heating at 100 0 C for 10 mins.
  • the samples were diluted in PBS, filtered through a 0.2-1.0 ⁇ m filter and injected into the SEC- MALS system.
  • the soluble HA content before and after the enzymatic degradation as well as their difference are shown in Figure 3.
  • the extrusion force test can be used to determine whether CSA can facilitate the extrusion process, by acting as a lubricant.

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