EP1503630B1 - Methode de production d'un produit laitier sans lactose - Google Patents

Methode de production d'un produit laitier sans lactose Download PDF

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Publication number
EP1503630B1
EP1503630B1 EP03725236A EP03725236A EP1503630B1 EP 1503630 B1 EP1503630 B1 EP 1503630B1 EP 03725236 A EP03725236 A EP 03725236A EP 03725236 A EP03725236 A EP 03725236A EP 1503630 B1 EP1503630 B1 EP 1503630B1
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EP
European Patent Office
Prior art keywords
milk
lactose
retentate
permeate
ultrafiltration
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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EP03725236A
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German (de)
English (en)
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EP1503630A1 (fr
Inventor
Olli Tossavainen
Janne Sahlstein
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Valio Oy
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Valio Oy
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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A23C9/1422—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of milk, e.g. for separating protein and lactose; Treatment of the UF permeate
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
    • A23C9/1206—Lactose hydrolysing enzymes, e.g. lactase, beta-galactosidase

Definitions

  • the invention relates to a process for producing lactose-free milk products and particularly to the use of different membrane techniques in the production of milk products.
  • Membrane techniques are known separation processes used both at the molecular and ionic levels. Such processes consume little energy and enable the concentration and fractionation of milk. Energy is saved for instance because the use of membrane techniques does not require a phase change in dewatering as do condensation and evaporation.
  • membrane filtration processes of four basic types are in use, each of which serves a different purpose of use. According to the separation ability, these four basic types are, from the one having the smallest pore size to the one having the largest pore size, reverse osmosis (RO), nanofiltration (NF), ultrafiltration (UF) and microfiltration (MF). Of these, reverse osmosis is generally used for concentration, ultrafiltration and microfiltration for fractionation, and nanofiltration for both concentration and fractionation.
  • RO reverse osmosis
  • NF nanofiltration
  • UF ultrafiltration
  • MF microfiltration
  • Microfiltration, ultrafiltration and nanofiltration are membrane separation processes, wherein liquid is filtered through a semi-permeable membrane.
  • a semi-permeable membrane is a membrane that lets through only part of the components in a solution.
  • the system may also comprise a preliminary filter for filtering off the largest or precipitated components.
  • Osmosis is the spontaneous movement of a liquid through a semi-permeable membrane from a dilute solution through the membrane to a more concentrated solution.
  • a reverse osmosis device the flow is reversed by an increase in the pressure of the concentrated solution to exceed the osmotic pressure.
  • Reverse osmosis enables the separation of the dissolved salts.
  • the liquid (permeate) obtained from reverse osmosis is pure enough to be discharged in a sewer.
  • the most common use of reverse osmosis is the production of drinking water from seawater.
  • membrane techniques enables the separation of milk components by bringing milk to flow at a raised pressure through a membrane.
  • the components that are smaller than the pore size of the membrane will then pass through the membrane (permeate) and the larger components are retained behind the membrane (retentate). In other words, two flows that leave the separation system are always generated.
  • a well known process in the field is the conventional enzymatic process of removing lactose, the process comprising the step of adding lactase into milk, thus resulting in the conversion of more than 80% of the lactose into monosaccharides, i.e. glucose and galactose.
  • the problem is the unacceptably sweet taste of the milk, caused by the monosaccharides.
  • WO publication 00/45643 discloses a process that aims at retaining the organoleptic characteristics of milk. According to the publication, this is achieved by reducing the amount of lactose so as to reach a lactose to protein ratio of about 1:1, and then treating the milk with lactase in order to convert the residual lactose into monosaccharides. According to the publication, the amount of lactose can be reduced either by ultrafiltration or diafiltration.
  • the essential characteristic of the process presented is the reduction of the lactose to protein ratio. This is also achieved by increasing the amount of protein either by concentrating the original milk or by adding protein into the milk in any process step.
  • Finnish publication 104 783 B1 di loses a process for preparing a whey salt powder from whey or a permeate from milk ultrafiltration.
  • the process comprises nanofiltration, concentration and drying of the whey or the permeate.
  • the whey salt powder obtained by the process is usable as a substitute for conventional table salt (NaCl).
  • EP publication 226 035 B1 discloses a process for specific chromatographic separation of lactose from milk.
  • milk is fractionated in such a manner that a lactose fraction is separated and the salts remain in the protein fraction or the protein/fat fraction.
  • the advantage of the process is that instead of a permeate, a pure lactose solution is obtained and that all substances significant to the taste, including salts, remain in the milk.
  • chromatographic separation is a time-consuming and complex process.
  • Another problem in chromatographic separation is the high purchase price of the equipment, since conventional dairies do not usually have such equipment.
  • WO 93/022037 publication discloses a process for membrane filtration of milk for regulating milk solids components.
  • ultrafiltration, nanofiltration and reverse osmosis can be used.
  • the salts are returned in form of an RO-retentate to a feed pipe of an ultrafiltration unit.
  • the disadvantage of the process is that the RO-retentate returned to the UF-filtration has only minor effect on the salt content of the UF-retentate.
  • FR patent application 2125137 describes a process for producing a lactose-free milk product by the steps of ultrafiltration and a reverse osmosis whereby a permeate from the ultrafiltration is treated by reverse osmosis, thus obtaining one fraction retained by reverse osmosis and containing lactose, and another fraction passed through a filtration membrane and containing mineral salts and water.
  • the latter fraction i.e. permeate
  • the composition and concentration of the salts to be retained/passed into RO-permeate cannot be controlled by this two-step process.
  • the object of the invention is thus to provide a process for solving the above problems.
  • the object of the invention is achieved by a process that is characterized by what is stated in the independent claims. Preferred embodiments of the invention are described in the dependent claims.
  • the invention is based on the surprising observation that the salts that are eliminated in association with conventional ultrafiltration can be returned to the milk product using the process of the invention, wherein the milk product is ultrafiltered, nanofiltered and concentrated by means of reverse osmosis, followed by the addition of salt to the UF retentate.
  • the thus obtained low-lactose milk product can then be subjected to hydrolysis, where the residual lactose is converted into monosaccharides by means of the lactase enzyme, resulting in a substantially lactose-free milk product.
  • An advantage of the process of the invention is that the organoleptic characteristics of the milk product are retained.
  • the outflows generated, the NF retentate and the RO permeate can be easily further processed.
  • the NF retentate contains mostly lactose and water, and the RO permeate contains essentially only water.
  • the obtained RO permeate is pure enough to be used for instance as rinsing water in equipment washing.
  • Another advantage is that the process of the invention enables the production of a milk product containing only components originating from milk. However, this is not necessary to the invention, but in the process of the invention, other substances may also be added to the milk product, if necessary.
  • FIG. 1 shows a block diagram of a process of an embodiment of the invention.
  • the invention relates to a process for producing a lactose-free milk product, characterized by the steps of subjecting the milk product to ultrafiltration, nanofiltration and concentration by reverse osmosis, and adding salt to the UF retentate.
  • the process of the invention enables the elimination of lactose from the milk without any effect on the organoleptic characteristics of the milk product to be produced, since the salts that are eliminated in association with the elimination of lactose can be restored and/or replaced.
  • the process of the invention preferably comprises the steps of
  • the salt to be added is preferably whey salt, which is for instance a RO retentate prepared from a whey nanofiltration permeate or chromatographically separated salt powder.
  • the whey salt to be added can be either pulverized or a solution.
  • the UF retentate and the RO retentate made from the milk ultrafiltration permeate and to be added thereto may also originate from different processes.
  • FIG. 1 shows a block diagram of an embodiment of the invention.
  • the percentages refer to percentages of weight, If not otherwise stated.
  • the UF permeate generated in the ultrafiltration milk typically contains about 4.3% lactose and about 0.4% ash, its dry matter-content being between 5.0 and 5.5%.
  • Suitable membranes are for instance GR81 PP and GR61 PP, manufactured by Danish Separation Systems, Denmark.
  • the permeate (NF permeate) generated in the nanofiltration contains mainly univalent salts and urea, its dry matter content being between 0.1 and 0.3%.
  • the NF retentate generated in the nanofiltration contains lactose (about 90% of the dry matter) and its dry matter content is between 20 and 24%.
  • Suitable membranes are for instance Desal 5-(Osmonics Inc., USA) and NF45 (Filmtec, USA).
  • the permeate (RO permeate) generated in the reverse -osmosis contains mainly only water.
  • the RO retentate generated in the reverse osmosis typically contains 0.5 to 2% ash, its dry matter content being between 1 and 3%.
  • Suitable membranes are for instance Nanomax-95, manufactured by Millipore Corp., USA.
  • milk in an embodiment of the invention, is standardized to the desired fat content before ultrafiltration.
  • the fat content may vary between 0 and 7%, being preferably between 0 and 4.5%. If the fat content in milk exceeds 7%, then cream is generally involved.
  • the process of the invention can also be used for the production of lactose-free cream.
  • the milk may also be heat-treated, i.e. pasteurized, before ultrafiltration.
  • Pasteurization refers to the heating of liquid foodstuffs (particularly milk) to a temperature of 60 to 90°C to destroy pathogens.
  • the process of the invention also preferably comprises an enzymatic hydrolysis step, wherein the residual lactose is converted into monosaccharides by means of lactase, i.e. ⁇ -D-galactosidase.
  • lactase i.e. ⁇ -D-galactosidase.
  • lactases suitable for use in the process of the invention are commercially available. These include for instance lactases produced by Kluyveromyces fragilis (e.g. HA-lactase, Chr. Hansen A/S, Denmark) or lactases produced by Kluyveromyces lactis (e.g. Validase, Valley Research Inc., USA).
  • the hydrolysis preferably lasts for 1 to 36 hours and it is performed at a temperature of 5 to 70°C, preferably 6 to 15°C.
  • the manufacturers of commercial enzymes give the optimal hydrolysis conditions for their enzymes in their own instructions.
  • the dry matter content of the milk product obtained by the process of the invention can be adjusted by the addition of water.
  • the process of the invention can also be used for producing lactose-free milk powder, i.e. the milk obtained is dried.
  • the production of powder is particularly suitable for the production of fat-free lactose-free milk powder, but fatty powders may also be produced.
  • the milk Before the milk product is packed, the milk can be heat-treated for instance by pasteurization (72°C, 15 s.), by ELS treatment (130°C, 1 to 2 s.) or by UHT treatment (138°C, 2 to 4 s.).
  • the process of the present invention is particularly suitable for the treatment of cow's milk.
  • the term 'milk' refers to any normal secretion obtained from the mammary glands of mammals, such as cow's, goat's, horse's or sheep's milk.
  • the term 'standardized milk' refers to milk whose fat content is normalized at the desired level.
  • the milk product produced by the process of the invention may be for instance milk, yoghurt, curdled milk, curd cheese or a sour milk drink, such as sour milk or buttermilk.
  • the process also enables the adjustment of the dry matter content as desired, the product then being a liquid, jelly or a solid substance.
  • the product obtained by the process of the invention can be either ingested as such or added as an additive to a-foodstuff or as part thereof.
  • the foodstuffs can be products of for instance the dairy industry, meat-processing industry, prepared food industry, beverage industry, bakery industry or confectionery industry.
  • the UF permeate (10L) was further nanofiltered at room temperature by concentration coefficient 4 through Millipore Nanomax-50 nanofiltration membranes, whereby univalent ions passed through the membrane (NaCl, retention ⁇ 65%), (7,5 L).
  • the main component of the UF permeate was lactose, which was retained in the retentate portion in the nanofiltration.
  • salts were eliminated from the UF permeate, i.e. the lactose portion (2.5 L), and therefore the nanofiltration retentate was suitable for further use as a low-mineral lactose fraction.
  • the nanofiltration permeate (7.5 L) was concentrated at room temperature using reverse osmosis membranes Nanomax-95 (Millipore) by concentration coefficient 10, whereby the salts contained by the nanopermeate were concentrated in the reverse osmosis retentate (NaCl retention > 94%).
  • the thus obtained RO retentate is usable in the production of lactose-free milk in the restoration of salts.
  • Fat-free or for instance 3.5% fat-containing lactose-free milk can be produced in the same way.
  • the starting milk has to be fat-free or have a fat content of 3.5%.
  • a concentrate (RO retentate) made from the permeate from the nanofiltration of whey is taken, the composition of the concentrate being similar to that of the RO retentate made from the UF permeate of milk (Tables 1 and 2).
  • the RO retentate obtained from the nanofiltration of whey can be used in the production of lactose-free milk, as can the RO retentate obtained from the UF permeate of milk.
  • the milk produced in accordance with example 1 or 2 can also be dried to a powder.
  • the milk is pasteurized at 75°C ⁇ 3°C/3 min. and evaporated to a 40 to 45% dry matter content. It is then fed into a spray drier. Drying with a laminar drier (Filtermat) is performed at the corresponding drying values as normal lactose-hydrolyzed milk powders.
  • the production of powder is particularly suitable for the production of fat-free lactose-free milk powder, but fatty powders may also be produced.
  • lactose-free milk products according to examples 1 to 3 can be used for further processing of conventional, but lactose-free products.
  • Lactose-free milk can be used to produce lactose-free cream by adjusting the fat content of the product suitable before the hydrolysis of the lactose.
  • Lactose-free milk can similarly be used to produce sour milk by adding milk souring agent to the milk and letting the milk become sour as in normal sour milk production.
  • Lactose-free ice cream can be produced in the same way as from normal milk.
  • almost all feasible milk products can be produced lactose-free by means of conventional production technology. Minor changes in the parameters of the production of the different products may be required when lactose-free milk is used.

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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Water Supply & Treatment (AREA)
  • Microbiology (AREA)
  • Dairy Products (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Claims (8)

  1. Procédé de production d'un produit laitier sensiblement sans lactose ou sans lactose caractérisé par les stades:
    a) d'ultrafiltration de lait,
    b) de nanofiltration du perméat UF obtenu de l'ultra filtration,
    c) de concentration du perméat NF obtenu au stade b) par osmose inverse,
    d) d'utilisation du rétentat RO obtenu au stade c) comme sel à ajouter au rétentat UF, et
    e) d'hydrolyse du produit laitier au moyen de lactase.
  2. Procédé suivant la revendication 1, caractérisé par l'addition d'un autre sel au rétentat UF outre le rétentat RO.
  3. Procédé suivant la revendication 2, caractérisé en ce que l'autre sel est un sel de lactossérum.
  4. Procédé suivant la revendication 1, caractérisé en ce que l'hydrolyse prend de 1 à 36 heures.
  5. Procédé suivant la revendication 4, caractérisé en que l'on effectue l'hydrolyse à une température de 5 à 70 ° C.
  6. Procédé suivant l'une quelconque des revendications précédentes, caractérisé en ce que l'on conditionne le lait à une teneur souhaitée en matière grasse et on le pasteurise avant l'ultra filtration.
  7. Procédé suivant l'une quelconque des revendications précédentes, caractérisé en ce qu'il consiste aussi à ajuster la teneur en matière sèche du produit laitier en ajoutant de l'eau.
  8. Procédé suivant l'une quelconque des revendications précédentes, caractérisé par
    a) l'ultrafiltration de lait à un coefficient de concentration de 1 à 4,
    b) la nanofiltration du perméat UF obtenu de l'ultra filtration à un coefficient de concentration de 1 à 6.
    c) la concentration du perméat NF obtenu au stade b) par osmose inverse à un coefficient de concentration de 2 à 20.
EP03725236A 2002-05-14 2003-05-13 Methode de production d'un produit laitier sans lactose Expired - Lifetime EP1503630B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI200331006T SI1503630T1 (sl) 2002-05-14 2003-05-13 Postopek za izdelavo brezlaktoznega mlecnega produkta

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20020907 2002-05-14
FI20020907A FI115752B (fi) 2002-05-14 2002-05-14 Menetelmä käytettäväksi vähälaktoosisen tai laktoosittoman maitotuotteen valmistamiseksi
PCT/FI2003/000366 WO2003094623A1 (fr) 2002-05-14 2003-05-13 Methode de production d'un produit laitier sans lactose

Publications (2)

Publication Number Publication Date
EP1503630A1 EP1503630A1 (fr) 2005-02-09
EP1503630B1 true EP1503630B1 (fr) 2007-10-24

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EP03725236A Expired - Lifetime EP1503630B1 (fr) 2002-05-14 2003-05-13 Methode de production d'un produit laitier sans lactose

Country Status (21)

Country Link
US (1) US7829130B2 (fr)
EP (1) EP1503630B1 (fr)
JP (2) JP2005525116A (fr)
KR (1) KR100901012B1 (fr)
CN (1) CN1287673C (fr)
AT (1) ATE376362T1 (fr)
AU (1) AU2003227788B2 (fr)
BR (1) BR0309846B1 (fr)
DE (1) DE60317057T2 (fr)
DK (1) DK1503630T3 (fr)
ES (1) ES2295580T3 (fr)
FI (1) FI115752B (fr)
HR (1) HRP20041055B1 (fr)
IL (1) IL165149A (fr)
MX (1) MXPA04011243A (fr)
NO (1) NO326737B3 (fr)
PL (1) PL208750B1 (fr)
PT (1) PT1503630E (fr)
RU (1) RU2308196C2 (fr)
WO (1) WO2003094623A1 (fr)
ZA (1) ZA200408903B (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2907393A1 (fr) 2014-02-17 2015-08-19 DMK Deutsches Milchkontor GmbH Produits du lait dénué du lactose
EP3123869A1 (fr) 2015-07-25 2017-02-01 DMK Deutsches Milchkontor GmbH Procédé pour la preparation de produits du lait sans lactose
EP3123868A1 (fr) 2015-07-25 2017-02-01 DMK Deutsches Milchkontor GmbH Procédé pour la preparation de produits du lait avec teneur en lactose définie
EP3123870A1 (fr) 2015-07-25 2017-02-01 DMK Deutsches Milchkontor GmbH Procédé pour la preparation de produits du lait sans lactose
EP3158871A1 (fr) 2015-10-19 2017-04-26 DMK Deutsches Milchkontor GmbH Procédé pour la préparation de produits laitiers avec teneur en lactose définie
EP3251515A1 (fr) 2016-06-02 2017-12-06 DMK Deutsches Milchkontor GmbH Procédé pou la preparation de produits du lait sans lactose
EP3590346A1 (fr) 2018-07-03 2020-01-08 DMK Deutsches Milchkontor GmbH Produits du lait avec douceur elevée

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CN1899054A (zh) * 2006-07-17 2007-01-24 颜贻谦 去糖牛奶的制作方法
JP5448819B2 (ja) * 2006-08-30 2014-03-19 プロラクタ バイオサイエンス，インコーポレイテッド 無菌乳およびその組成物を得る方法
CA2706722C (fr) 2006-11-29 2016-01-12 Prolacta Bioscience, Inc. Compositions de lait humain et procedes destines a fabriquer et utiliser ces compositions
JP5616066B2 (ja) 2006-12-08 2014-10-29 プロラクタ バイオサイエンス，インコーポレイテッド ヒト脂質組成物ならびにその製造および使用方法
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FI120953B (fi) * 2007-06-26 2010-05-31 Valio Oy Menetelmä hyvin säilyvän vähälaktoosisen tai laktoosittoman maitotuotteen valmistamiseksi
ITUD20070180A1 (it) * 2007-10-01 2009-04-02 Parmalat Spa Procedimento per ottenere latte a basso contenuto di zuccheri
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DK176760B1 (da) 2007-10-03 2009-06-29 Arla Foods Amba Process for producing lactose-free milk
US20110206806A1 (en) * 2007-11-02 2011-08-25 Shakeel Ur-Rehman Methods for Recovering Lactase Enzyme
LT5581B (lt) * 2007-11-10 2009-07-27 Vytautas FEDARAVIČIUS Baltyminio pieno produkto su l-argininu gamybos būdas
US20100285175A1 (en) 2007-12-03 2010-11-11 Novozymes A/S Method for Producing a Dairy Product
US20110177224A1 (en) * 2008-03-03 2011-07-21 Daniel Perlman Stabilization of omega-3 fatty acids in oil-water emulsions
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CN101361507B (zh) * 2008-06-24 2012-05-09 内蒙古蒙牛乳业（集团）股份有限公司 一种无乳糖低脂牛奶及其制备方法
CN101317599B (zh) * 2008-06-24 2011-12-28 内蒙古蒙牛乳业（集团）股份有限公司 一种无乳糖全脂牛奶及其制备方法
US20090317514A1 (en) * 2008-06-24 2009-12-24 Sizer Charles E Process For Making A Shelf-Stable Milk Based Beverage Concentrate
US10080372B2 (en) * 2008-08-29 2018-09-25 Valio Ltd. Low-lactose and lactose-free milk product and process for production thereof
US8986768B2 (en) 2008-08-29 2015-03-24 Valio Ltd. Low-lactose and lactose-free milk product and process for production thereof
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EP3123869A1 (fr) 2015-07-25 2017-02-01 DMK Deutsches Milchkontor GmbH Procédé pour la preparation de produits du lait sans lactose
EP3123868A1 (fr) 2015-07-25 2017-02-01 DMK Deutsches Milchkontor GmbH Procédé pour la preparation de produits du lait avec teneur en lactose définie
EP3123870A1 (fr) 2015-07-25 2017-02-01 DMK Deutsches Milchkontor GmbH Procédé pour la preparation de produits du lait sans lactose
EP3158871A1 (fr) 2015-10-19 2017-04-26 DMK Deutsches Milchkontor GmbH Procédé pour la préparation de produits laitiers avec teneur en lactose définie
EP3251515A1 (fr) 2016-06-02 2017-12-06 DMK Deutsches Milchkontor GmbH Procédé pou la preparation de produits du lait sans lactose
EP3590346A1 (fr) 2018-07-03 2020-01-08 DMK Deutsches Milchkontor GmbH Produits du lait avec douceur elevée

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US20050214409A1 (en) 2005-09-29
CN1652690A (zh) 2005-08-10
NO20045426L (no) 2004-12-13
PT1503630E (pt) 2007-11-09
US7829130B2 (en) 2010-11-09
BR0309846A (pt) 2005-03-29
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JP5027286B2 (ja) 2012-09-19
ATE376362T1 (de) 2007-11-15
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HRP20041055A2 (en) 2004-12-31
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NO326737B1 (no) 2009-02-09
EP1503630A1 (fr) 2005-02-09

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