EP1297898A2 - Pulvérisateur de particules avec aide fluidique - Google Patents

Pulvérisateur de particules avec aide fluidique Download PDF

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Publication number
EP1297898A2
EP1297898A2 EP02027186A EP02027186A EP1297898A2 EP 1297898 A2 EP1297898 A2 EP 1297898A2 EP 02027186 A EP02027186 A EP 02027186A EP 02027186 A EP02027186 A EP 02027186A EP 1297898 A2 EP1297898 A2 EP 1297898A2
Authority
EP
European Patent Office
Prior art keywords
needle
media
dispenser
dispenser according
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02027186A
Other languages
German (de)
English (en)
Other versions
EP1297898B1 (fr
EP1297898A3 (fr
Inventor
Stefan Ritsche
Karl-Heinz Fuchs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptar Radolfzell GmbH
Original Assignee
Erich Pfeiffer GmbH
Ing Erich Pfeiffer GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erich Pfeiffer GmbH, Ing Erich Pfeiffer GmbH filed Critical Erich Pfeiffer GmbH
Publication of EP1297898A2 publication Critical patent/EP1297898A2/fr
Publication of EP1297898A3 publication Critical patent/EP1297898A3/fr
Application granted granted Critical
Publication of EP1297898B1 publication Critical patent/EP1297898B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0078—Arrangements for separately storing several components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
    • B05B7/2402—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device
    • B05B7/2405—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device using an atomising fluid as carrying fluid for feeding, e.g. by suction or pressure, a carried liquid from the container to the nozzle

Definitions

  • the invention relates to the application of media, in particular pharmaceutical products in atomized, jet or drop form and a donor for it.
  • WO 96/24439 shows a disposable dispenser in which one liquid drug containing through a rubber stopper sealed glass ampoule is inserted into a sleeve that has a Breakage connection is connected to a donor.
  • This has a protruding nose adapter with a spray nozzle at the end.
  • a central shaft or stamp inside this adapter carries a needle in the middle, which is activated by manual pushing in the sleeve in the adapter pierces the rubber plug. The The shaft then presses the rubber stopper into the ampoule as a piston and thus generates the application pressure.
  • a thin hollow needle such as a steel needle
  • a metal adapter provided that on the outside as a relatively thick solid metal ring the needle has been attached. It allowed one to attack Assembly tool and was by means of an annular Locking teeth pressed into the shaft. This arrangement has changed proven and was due to the reliable assembly without Damage to the sensitive tip is considered inevitable. However, it requires the metal adapter as a separate part, which the Costs and also the metal content in what is otherwise almost sorted by type Donor increased.
  • This disposable atomizer is very reliable and for the application liquid medication, especially for those who should be absorbed by the body very quickly, e.g. through the Nasal mucosa, with also intolerances for the Digestive tract, which could occur with oral intake, avoided become.
  • there are drugs that are no longer in liquid form Time are stable.
  • US 3,756,390 relates to an injection syringe, the two by one Breakthrough foil separate spaces for liquid and Powder.
  • a nozzle connects to the powder chamber, into the after Removing a protective cap a needle can be used. To Breaking through the release film, the two media together mixed. Then the protective cap is removed, the needle used and carried out after the air-out spraying.
  • a similar procedure is in US 3,595,439 A for one Mixing cartridge for 2-component dental material.
  • GB 1 453 591 describes an ampoule which is pierceable End plug for a liquid chamber and one Has intermediate plugs to a powder chamber. When stabbing a needle connected to a drip, for example the intermediate plug pushed out so that both media can mix with each other. Through an extra channel, the Enter the mixture into the drip chamber.
  • JP 8-280807 A shows an adapter that is one of a Has aluminum foil sealed liquid chamber. This can placed on a container of freeze-dried pharmaceutical become. To the other side of the with a screw cap sealed adapter can be attached to a pump atomizer who pierces the aluminum foil with his suction tube and so Liquid chamber and powder container connects together. This to be assembled from three separate parts before use Dispenser is not very helpful for uncomplicated use.
  • the object of the invention is to provide a dispenser for dispensing to create at least two different media, the particular one easier and more cost-effective in terms of needle output is to be manufactured and assembled.
  • the invention defined in claim 1 enables the very thin and sensitive needle with the necessary tightness damage-free without attaching this adapter. To do this, she is between the entire central area between the two ends of the needle encompassing ribs of a larger bore in the shaft and at the end pressed into a hole with a press fit, which is a lot longer is than the needle diameter. It rests on one shoulder within this hole and can thus freely towards the outlet opening communicate. When inserting, the needle becomes the tip of it supporting end held by a collet holding a central pin has, which engages in the needle and thus a crush and Damage to the sensitive tip prevented. This is important because damage-free tip for piercing the sealing plug is just as necessary as with an injection needle to avoid that the needle penetrates the container or piston wall Detaches particles that clog the discharge opening or even into the Airways of the patient.
  • the invention also provides a dispenser in which a liquid is used Carrier medium used for a particulate solid medium and the separately stored media only before they are released be mixed together.
  • particulate Solid state medium is to be understood that it is not a gas, liquid, Paste or in solid form, but usually dry with one certain fluidity or flowability is present, in particular is powdery to granular. So it is possible the two media to be kept separately from each other, the active ingredient usually in the particulate medium can be present in dry form. It can e.g. is a pharmaceutical product that is in the form of a freeze-dried powder.
  • Carrier medium is used. It can either be a slurry (Dispersion) or a solution that then comes together is applied, preferably as a spray, but also as a drop or beam.
  • the liquid is chosen in this way can be that the absorption through the mucous membranes particularly is promoted. Preservatives can be dispensed with.
  • the particulate solid medium should best be powder, but at least flowable or free-flowing and with the liquid be easy to mix, so in the relatively short, available Intimate mixing or even solution in the liquid is possible at times is. But it is possible that the particles also in the form of so-called Microcapsules are present, i.e. from a skin covered Ingredients exist.
  • the solid state medium is usually the space in which it is is not filled in completely. This becomes a partial one relatively large volume of gas, such as air or of an inert gas promoting the stabilization of the product.
  • this gas can with the introduction of the liquid be compacted so that finally when they are spreading, i.e. opening the solid state storage or a mixing room already a certain There is initial pressure, e.g. for good atomization from the start at worries.
  • the dispenser can have a liquid space, pressure generating means for Generate a discharge pressure and to convey the liquid in a media storage for a separate from the liquid space powdery or free-flowing solid medium and one Have outlet opening for the mixture.
  • the pressure generating agent it can be a thrust piston pump, the cylinder of which Liquid space can be.
  • the dispenser 11 shown in FIG. 1 is a disposable atomizer that spreads its entire batch in one stroke. It has a housing 12, which has an elongated adapter section 13. It sticks out an oval in plan view, protruding on two sides epaulette-like actuation shoulder 14 of the housing in the middle. On the shoulder 14 closes opposite the adapter directed housing jacket 15, depending on its flatter sides has an actuating cutout 16.
  • the actuating surface 17 is one Sleeve 18 accessible with a finger, which is a glass ampoule 19, from Supported webs 20 in the sleeve, which takes up a liquid space 21 contains.
  • Sleeve 18 and ampoule 19 have the shape of elongated, deep, circular cylindrical container.
  • a ring 23 is formed, which in a snap connection 24 on the underside of the shoulder 14, adjacent to the interior 25 of the substantially hollow adapter 13, is included.
  • the ampoule 19 contains both the Liquid space 21 and also a media space or storage 43. Accordingly, there is in the ampoule 19 except one Media storage 43 sealing piston 26 a Separating liquid space 21 from the media store 43 Intermediate piston 55, the two in the rest state shown Separates spaces from each other. To connect them is a Wall of the ampoule 19 molded connection channel 35a provided that its exit in the media storage 43a in Idle state is completed by the intermediate piston 55.
  • the media space 21 in the ampoule 19 is made of one rubber-like material existing plug 26th completed, the sealing on the circular cylindrical wall of the Media room 21 is present. It is relatively elongated and has everyone of its end faces central recesses 28, which by a central web 29 are separated, which forms a pierceable membrane.
  • the sleeve 18 and the ampoule 19 protrude centrally and centrally in the Interior of the adapter 13 and are there with the outer wall the sleeve 18 and an upper flange 30 of the ampoule 19 lateral webs 31 guided in the interior 25 of the adapter 13, and over the length of an actuation path.
  • a piston tappet 34 extends centrally to briefly inside the adapter 13 in front of the ampoule 19 or its closure 26 in the form of a stopper.
  • a connecting channel 35 which to the Inner channel 36 of a hollow steel needle 37 connects, to which Plug turned, a tip 38 formed by chamfering is.
  • the shaft 34 is sealing in a nozzle section 56 of the adapter 13 used, which is integral with the housing 12 (and thus with the Adapter 13) is formed.
  • the hemispherical adapter end is 57 also integrally formed with this, in which the nozzle-shaped outlet opening 44 is provided.
  • the shaft contains its upper end face that cooperating with the outlet nozzle Vertebral channel formation 45.
  • the steel needle 37 is in the shaft added almost through the entire shaft 34 to just before the upper face of which is sufficient.
  • the needle usually one Outside diameter less than a millimeter and one has correspondingly small wall thickness, and to form a sharp one and burr-free tip 38 is very carefully sharpened, is directly in one Bore 58 of the shaft inserted.
  • This hole has one much larger diameter than the needle 37, however, this leads by e.g. four radially inwards from the inner wall of the bore projecting webs 59, which in the region of the end face 52 of the shaft 34 begin with an insertion bevel 60. They ensure accurate Centering and prevent the thin needle from kinking when Deploy. They range from the free end of the shaft to one Fitting bore 61, i.e. about the biggest and especially for preventing of the important central region of the needle.
  • a fitting hole 61 is pressed, which is dimensioned so that it one allows tight fit of the needle in it.
  • a shoulder 62 in this Fitting hole forms an upper stop for pressing in the needle.
  • the fitting bore covers the top end of the needle just above one Length that is greater than a multiple, e.g. Five times the outer diameter the needle.
  • the fitting hole is at its upper end with the outlet chamber 46 in connection.
  • the spray nozzle creates a conical spray with the help of a Vertebral channel formation 45 at the front end of the shaft 34. This lies against the inside of the outlet nozzle 44, so that it is spiral Trained channels emerge that make for a swirl of them quickly through flowing liquid or mixture.
  • the liquid space 21 is filled with a liquid that is intended to be with your Flowing out with a particulate solid medium 51 in Mix media storage 43 to solve this or untangle or disperse it together with the Apply liquid.
  • the solid state medium is one pharmaceutically active substance, mostly in powder form.
  • the liquid mostly consists mainly of water, which is sterile and possibly physiologically adapted to the body fluid. There are but other liquids or liquid additives are also possible also promotes the effectiveness of the solid medium or can have triggering properties. There can be one Two component action between the liquid and the Solid state medium arise.
  • the Liquid space 21 is filled with the liquid 50 and through the Sealing plug 26 is sealed off.
  • the plunger 37 is tight above the web 29. This is located in the media store 43 Solid-state medium 51, but at the same time usually an even larger one Amount of air passing through the spaces between the two Particles is due, but may also be present in addition the particles do not have to be filled in too compactly.
  • the elongated adapter 13 in brought the appropriate donation position, for example in a Nostril inserted.
  • the user grabs the donor by overlay two fingers on the shoulders 14 while his thumb on the Actuating surface 17 presses. It must be a relatively high one first Apply actuation pressure to the predetermined breaking points that the Form material bridges 22 between the ring 23 and the sleeve 18 to destroy. These also ensure tamper evidence. Most of all will but ensured that the user operated with a certain power and speed really comes to an end. A interim interruption would, for example, cause the Atomizer and possibly the mixture of substances impair or prevent full spreading.
  • the sleeve / ampoule 18/19 moves upwards, i.e. in the inside 25 of the adapter 13.
  • the needle-like plunger 37 pierces the web 29 in the plug 26 and the lower one End face 52 of the shaft 34, which has a slightly smaller diameter has as the media space 43, meets the end face 53 of the Sealing plug 26. This forms the piston of one Thrust piston pump, the cylinder of the glass ampoule 19 is formed.
  • the needle 37 pierces the web 29 in the closure 26, it opens it mainly through the interior of the hollow needle 37 formed outlet channel 36 opposite the media storage 43.
  • Der Shaft 34 presses the piston 26 down and compresses it in Media storage 43 located solid medium 51 and the therein contained air (or a corresponding inert gas).
  • This will also the intermediate piston 55 is pushed down and gives the Connection channel 35a free in the ampoule wall. This could also be formed by a corresponding elevation of this wall, the would then release an overflow channel on both sides.
  • the Liquid 50 flows from the liquid space 21 into the Media storage 43 mixes there with the medium 51 and is with the corresponding discharge pressure via the needle bore 36 Exhaust opening 44 passed.
  • the unit sleeve / ampoule 18/19 slides, guided by the webs 31, inside 25 of the nose adapter 13 upwards.
  • the air also forms one Pre-compression, which promotes the start of the atomization phase.
  • the arrangement could be made so that the medium is placed in the area of the ampoule near the bottom and the liquid about that. In this case the liquid would go down first flow, mix there with the medium and then again through the Flow the liquid chamber through to the outlet. This may a particularly intimate mixture can be brought about.
  • the dispenser consists of very few parts.
  • the Inserted shaft 34 with the needle mounted therein.
  • the donor will completed by the unit sleeve / ampoule 18/19 with Sealing plug 26 and intermediate piston 55 which hold the liquid and Separate media chamber.
  • the assembly of the dispenser according to Fig. 3 is very simple.
  • the needle without the annular adapter 39 can be mounted as shown in FIG. 1.
  • the ribs 59 guide the needle as it enters bore 58 without making it too large Oppose longitudinal resistance. Only when the needle is passed between the ribs over most of its length them into the fitting bore 61, where they are sealing and also mechanical is pressed in against being pulled off.
  • the needle stands how to recognizes from the drawing only over a relatively small part of theirs Length, usually less than a third, from the shaft 34. So is the section most at risk of buckling, which is in the middle of the Needle lies when applying the force to press it into the Fitting bore 61 already guided against buckling between the ribs.
  • the sensitive tip 28 of the needle in the Pressing process is not damaged. Therefore, with one Tool worked that the needle with a kind from the outside Grips collet (in the area protruding from the shaft), but additionally has a center pin that goes into the needle bore engages and so the needle against crushing and damage to the Lace secures.
  • the pre-assembled shaft can then partially with its upper beveled offset end are pressed into the socket 56.
  • the pre-assembled unit from the sleeve and inserted ampoule 19 is attached to the housing 12 via the snap lock 24.
  • the ampoule was first filled with the liquid, after which the Intermediate piston 55 attached and then the solid medium in the overlying media storage 43a has been filled. After that the plug 26 was placed.
  • the main difference is that of sleeve 18 and ampoule 19 existing unit containing the media.
  • the sleeve 18, which means the predetermined breaking ring 32 is attached to the housing 12 contains the Liquid space 21 in its lower, its bottom 17 facing Area.
  • There is a plastic plunger 37a formed centrally in the Sleeve protrudes upwards and has a cross-shaped cross section.
  • An inner sleeve 19a is inserted in a piston-like sealing manner, which has a pierceable membrane 29a on its bottom.
  • This Sleeve seals off the liquid space from above. she is by means of a predetermined breaking ring 32 into the interior 25 of the nose adapter 13 used.
  • the predetermined breaking ring works with material bridges 33 such as Breaking ring 23 described.
  • the inner sleeve 19a forms a cylinder for a storage / mixing chamber 43a which is upward from a conversely sleeve-shaped, serving as a piston plug 26a is completed.
  • the Liquid 50 is filled into the liquid space 21 and the solid medium 50 in the media storage 43a. This is through the Sealing plug 26a closed.
  • the inner sleeve 19a is in accordance with Art a piston inserted into the sleeve 18, which thus the cylinder one second thrust piston pump on this dispenser forms and closes the Liquid space 21 upwards.
  • the predetermined breaking closure 32 When actuated, the predetermined breaking closure 32 is broken first. Then the plunger 37a penetrates through the membrane 29a and sets over the channels formed in its cross-section the connection between the liquid space 21 and the media reservoir 43a. The the Piston-like lower part of the fluid chamber 21, which reduces the size Inner sleeve 19a conveys the liquid 50 into the media storage space 43a, which thereby enlarges by being under the resulting Media pressure pushes the plug 26a upward.
  • Fig. 3 shows the end of this mixing phase, in which the liquid and the Solid state medium mix. It is ended by how 3 shows the bottom of the inner sleeve 19a on the bottom 17 of the sleeve 18th is applied. It is then only a common mixing space 43a available. The air previously present in the media space 43a can be depending on the resistance of the sealing plug 26a more or compress less and maintain a basic pressure in the mixing chamber receive.
  • the predetermined breaking lock 32 can be set so that the user when he has reached the position shown in Fig. 3, a new, must apply increased pressure. This ensures that in the mixing chamber 43a a sufficient time for mixing, if necessary Solution of the components arises.
  • This will make the mixture 50/51 from the Mixing chamber 43d over that formed by the needle bore 36 Exhaust channel transported to the outlet opening 44 and there under the Application pressure atomized or otherwise output.
  • the application phase could be activated by means of a rotation Stop in addition to or instead of the predetermined breaking ring 32 in time be delimited. It is also possible to use a piercing needle instead Rotary slide valve to be used, which is opened by this rotation.
  • the mixing phase of the Application phase to be spatially and temporally separated, although everything essentially follows one another directly, so no danger there is that the solid medium is damaged in the mixed phase. It is also possible to have these two phases on two different ones Distribute actuation strokes instead of two axially one after the other horizontal lifting sections. It is also possible to go through corresponding subdivision or sequence of strokes one at a first stroke premixed batch in two consecutive Applying partial application strokes, for example, for a medication to be applied in succession to both nostrils of a patient. Also a multiple dispenser or reloadable dispenser according to the above principle described is possible.

Landscapes

  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP02027186A 1997-11-08 1998-10-22 Distributeur avec aiguille perforante pour matériaux à mélanger pendant la distribution Expired - Lifetime EP1297898B1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE19749514 1997-11-08
DE19749513 1997-11-08
DE19749514A DE19749514A1 (de) 1997-11-08 1997-11-08 Verfahren zum Ausbringen von wenigstens zwei verschiedenen Medien und Spender dafür
DE19749513 1997-11-08
DE19837127 1998-08-17
DE19837127A DE19837127A1 (de) 1997-11-08 1998-08-17 Spender für Medien
EP98952735A EP1027165B1 (fr) 1997-11-08 1998-10-22 Procede permettant de distribuer au moins deux produits differents et distributeur a cet effet

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP98952735.3 Division 1998-10-22

Publications (3)

Publication Number Publication Date
EP1297898A2 true EP1297898A2 (fr) 2003-04-02
EP1297898A3 EP1297898A3 (fr) 2003-04-09
EP1297898B1 EP1297898B1 (fr) 2004-05-26

Family

ID=27217911

Family Applications (3)

Application Number Title Priority Date Filing Date
EP02027186A Expired - Lifetime EP1297898B1 (fr) 1997-11-08 1998-10-22 Distributeur avec aiguille perforante pour matériaux à mélanger pendant la distribution
EP98965137A Expired - Lifetime EP1027166B1 (fr) 1997-11-08 1998-10-22 Distributeur pour plusieurs milieux melanges avant decharge
EP98952735A Expired - Lifetime EP1027165B1 (fr) 1997-11-08 1998-10-22 Procede permettant de distribuer au moins deux produits differents et distributeur a cet effet

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP98965137A Expired - Lifetime EP1027166B1 (fr) 1997-11-08 1998-10-22 Distributeur pour plusieurs milieux melanges avant decharge
EP98952735A Expired - Lifetime EP1027165B1 (fr) 1997-11-08 1998-10-22 Procede permettant de distribuer au moins deux produits differents et distributeur a cet effet

Country Status (9)

Country Link
US (1) US6626379B1 (fr)
EP (3) EP1297898B1 (fr)
JP (2) JP4411374B2 (fr)
AU (2) AU1031699A (fr)
CA (1) CA2307160C (fr)
DE (5) DE19749514A1 (fr)
DK (2) DK1027165T3 (fr)
ES (2) ES2194360T3 (fr)
WO (2) WO1999024171A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2970955A1 (fr) * 2011-01-27 2012-08-03 Valois Sas Dispositif de distribution de produit fluide.
US11206872B2 (en) 2020-04-07 2021-12-28 Consumernext Labs Gmbh Stable-foam dispensing device and cartridge

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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DE19933330A1 (de) * 1999-07-16 2001-01-18 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
DE19944211A1 (de) * 1999-09-15 2001-03-22 Pfeiffer Erich Gmbh & Co Kg Vorrichtung zum ggf. zerstäubten Ausbringen eines insbesondere flüssigen Mediums
DE19944209A1 (de) * 1999-09-15 2001-03-22 Pfeiffer Erich Gmbh & Co Kg Spender zum ggf. zerstäubten Ausbringen eines insbesondere flüssigen Mediums aus einem Behältnis
DE10006026A1 (de) * 2000-02-10 2001-08-23 Birgit Vaassen Applikator mit zwei Schaften
FR2832080B1 (fr) 2001-11-15 2004-09-24 Valois Sa Dispositif de distribution de produit fluide
DE20120398U1 (de) 2001-12-17 2002-03-07 G. Pohl-Boskamp GmbH & Co., 25551 Hohenlockstedt Sprühkopf
US7021561B2 (en) * 2001-12-18 2006-04-04 Becton, Dickinson And Company Spray device and method
FR2838110B1 (fr) 2002-04-04 2005-05-06 Valois Sa Dispositif de distribution de produit fluide
DE10218782A1 (de) 2002-04-22 2003-11-20 Pfeiffer Erich Gmbh & Co Kg Dosiervorrichtung mit wenigstens zwei Medienräumen
FR2842428B1 (fr) * 2002-07-19 2004-10-08 Becton Dickinson France Dispositif d'injection d'un produit, notamment a usage medical
FR2847834B1 (fr) * 2002-12-02 2006-06-02 Valois Sas Dispositif de distribution de produit fluide
DE10315936A1 (de) * 2003-04-03 2004-10-28 Ing. Erich Pfeiffer Gmbh Austragsvorrichtung für zumindest ein Medium
DE10343329A1 (de) 2003-09-11 2005-04-07 Ing. Erich Pfeiffer Gmbh Dosiervorrichtung mit einem ein- oder mehrteiligen Dosiergehäuse
FR2861995A1 (fr) * 2003-11-10 2005-05-13 Mb Innovation Dispositif a usage unique de pulverisation d'un fluide medicamenteux
JP4446794B2 (ja) * 2004-05-10 2010-04-07 ダイキョーニシカワ株式会社 部材の結合構造
US20060207596A1 (en) * 2005-03-18 2006-09-21 Fairfield Clinical Trials, Llc Device and method for delivery of combination nasal medication
EP1712292A1 (fr) * 2005-04-11 2006-10-18 Helbling Technik Bern AG Dispositif de distribution pour livrer un fluide ayant une chambre de dosage et une soupape à coulisse
DE102005024439A1 (de) * 2005-05-24 2006-12-07 Boehringer Ingelheim International Gmbh Zerstäuber
FR2887232B1 (fr) * 2005-06-21 2010-11-05 Rexam Dispensing Sys Embout poussoir pour distributeur de produit liquide
JP4458364B2 (ja) * 2005-10-18 2010-04-28 キヤノン株式会社 液体吐出装置および該吐出装置に用いる液体吐出用カートリッジ
DE102005057685A1 (de) 2005-12-01 2007-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator und Speicher für eine trockene Arzneimittelformulierung sowie diesbezügliche Verfahren und Verwendung
US20070158463A1 (en) * 2006-01-04 2007-07-12 Mey-Chu Lan Liquid spraying device with return-preventing structure
US20070212307A1 (en) * 2006-02-10 2007-09-13 Daniel Wermeling Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same
CA2642638A1 (fr) * 2006-02-14 2007-08-23 Battelle Memorial Institute Systeme de comptage precis
JP2008049127A (ja) * 2006-07-24 2008-03-06 Canon Inc 吸入装置
US8028933B2 (en) * 2006-11-27 2011-10-04 Nils Friis Shower additive dispenser
CA2675030C (fr) 2007-01-09 2015-06-09 Mystic Pharmaceuticals, Inc. Dispositifs a cartouche intranasaux
US8683995B2 (en) 2007-05-16 2014-04-01 Mystic Pharmaceuticals, Inc. Dose dispensing containers
EP2164799B1 (fr) * 2007-05-16 2018-12-26 Mystic Pharmaceuticals, Inc. Conteneurs de distribution de doses à unité de combinaison
US9248076B2 (en) 2007-05-16 2016-02-02 Mystic Pharmaceuticals, Inc. Dose dispensing containers
JP2010538925A (ja) * 2007-09-14 2010-12-16 ミスティック ファーマシューティカルズ， インコーポレイテッド 深絞り容器成形方法
WO2009050449A1 (fr) * 2007-10-16 2009-04-23 Leafgreen Limited Distributeur à pompe manuel
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JP2006081917A (ja) 2006-03-30
DK1027165T3 (da) 2003-07-21
WO1999024170A1 (fr) 1999-05-20
EP1027166B1 (fr) 2002-07-10
DE59804744D1 (de) 2002-08-14
DE19749514A1 (de) 1999-05-12
US6626379B1 (en) 2003-09-30
AU2047599A (en) 1999-05-31
EP1027166A1 (fr) 2000-08-16
AU1031699A (en) 1999-05-31
ES2222430T3 (es) 2005-02-01
EP1027165A2 (fr) 2000-08-16
JP4411374B2 (ja) 2010-02-10
JP2001522717A (ja) 2001-11-20
DK1297898T3 (da) 2004-10-04
WO1999024171A2 (fr) 1999-05-20
WO1999024171A3 (fr) 1999-07-15
DE19837127A1 (de) 1999-05-12
DE59811482D1 (de) 2004-07-01
CA2307160C (fr) 2009-05-05
ES2194360T3 (es) 2003-11-16
EP1297898B1 (fr) 2004-05-26
DE59807579D1 (de) 2003-04-24
JP4789089B2 (ja) 2011-10-05
EP1027165B1 (fr) 2003-03-19
CA2307160A1 (fr) 1999-05-20
EP1297898A3 (fr) 2003-04-09

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