EP1186312B1 - Dispositif distributeur de substances - Google Patents
Dispositif distributeur de substances Download PDFInfo
- Publication number
- EP1186312B1 EP1186312B1 EP01114759A EP01114759A EP1186312B1 EP 1186312 B1 EP1186312 B1 EP 1186312B1 EP 01114759 A EP01114759 A EP 01114759A EP 01114759 A EP01114759 A EP 01114759A EP 1186312 B1 EP1186312 B1 EP 1186312B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- discharge
- partial
- actuation
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
- A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking
Definitions
- the invention relates to a discharge device for media, as described, for example, in EP 0 245 895 A1 is known.
- a discharge device for media is in particular for the discharge of at least one pharmaceutical Drug-containing media determined.
- the medium to be discharged is in stored in a container.
- This container has separate ones Chambers on.
- Each of the chambers is a media component introduced, wherein the media components together the give to be discharged medium.
- the container in turn is in one Housing arranged, which has a discharge opening for the discharge of Medium comprises. It is a respect to the housing relatively movable Actuating provided. By the actuation of the actuating means First, a connection between the chambers of the Container made.
- Examples of media divided into different subcomponents can be obtained in the longer term and not together as a mixture are permanently stable, are widely used in pharmaceutical applications to find.
- a freeze-dried Powder a so-called lyophilisate
- an aqueous carrier liquid is to dissolve or be discharged together with this is the substance mixture is not stable.
- two liquid media components in their Mixture are not stable, but individually and separately are long-term storage.
- a dispenser where media components are separated from each other stored a container and mixed together are dischargeable is for example, from the generic EP 0 245 895 A1 known.
- an actuating means provided to the mixing process of the media components perform together and then discharge the medium. In doing so, you need to mix the media components together several pump strokes are performed with the actuating means. After completion of the pump strokes, with complete mixing of the Media components together, there is a discharge, wherein during the discharge stroke the total amount of the medium is discharged.
- WO 91/10460 describes a hypodermic syringe with a mixing device according to the preamble of claim 1.
- the injection needle penetrates when Inserting the syringe barrel into the device a plug, the Syringe cylinder limited.
- EP 1 066 846 A1 also relates to a hypodermic syringe in which the End seal penetrated by the back of the hypodermic needle becomes.
- US Pat. No. 5,427,280 describes an atomizer for two partial strokes, the are delimited from each other by means of a slotted guide. Here is no component mixture made.
- US Pat. No. 4,962,868 describes a dispenser which according to Art a hypodermic works and in the case with a backdrop with resilient detents is provided, the successive Operahübe to separate from each other.
- the discharge device in particular for discharging a at least one pharmaceutical agent-containing medium is determined, has a container in which the medium in the form of Stored media components, wherein the media components in are introduced from each other separate chambers. The media components together make up the medium to be discharged.
- the container is arranged in a housing having a discharge opening for discharge of medium.
- an actuating means is provided which regarding the housing is relatively movable. Including one is Understand arrangement in which the container indirectly in a sleeve is arranged, which is held in the housing, wherein the Actuating means is arranged relatively movable to the sleeve. A Actuation of the actuating means initially leads to the production a connection between the chambers of the container.
- the Actuation of the actuating means is according to the invention in a first sectionbetutz and in a number of subsequent Partbet effetistswege divided.
- the first actuation path finds doing mixing the media components to the be discharged medium instead.
- Each of the subsequent partial operations the actuating means is the atomized discharge of a assigned to part of the medium.
- the number of subsequent partial operations is advantageously at least two, especially two. But it is also possible that only one subsequent partial operation is provided, so the entire discharged medium in a subsequent partial operation unsubscribe. In particular, in this case it makes sense if the first part operation and the first subsequent partial operation by means of a continuous, continuous operation of the actuating means he follows.
- Discharge device It is particularly advantageous in such a design of the Discharge device that does not have a variety of part operations of the Actuator is required to mix the Media components to produce the medium, but this through a single partial actuation takes place.
- the further operations serve in each case for the discharge of a defined partial batch.
- the chambers of the Container separated by plugs, which in the container are arranged.
- the Container overflow channels are formed, which are positioned so that during the first partial actuation of the actuating means, the Chambers separating plugs into a position in the area the overflow can be brought so that over the overflow the chambers are interconnected.
- the slotted guide on pressure point means, wherein at the beginning of each subsequent partial actuation pressure point means to be overcome.
- the slotted guide for each Partial operation has a linear, linear guide section, wherein the guide portions are offset from each other so that they are each limited by a stop and that between two Partial operations each one different from the partial operation Switching operation fürzu lead is.
- Embodiments are preferred, wherein at least the toggle operation between two subsequent part operations be carried out automatically.
- Particularly preferred are Embodiments, wherein for the automatic implementation of Switching actuator power storage are provided during the Implementation of the previous partial operation to be biased.
- the container is in a sleeve arranged fixed in position.
- the sleeve is in turn to the housing arranged relatively movable and from a starting position in one Discharge position available.
- the container In the starting position, the container aligned by the sleeve in the housing of the discharge held.
- the container is hermetically sealed. From this starting position the sleeve can be brought into the discharge position, wherein during the placement in this position, a fluidic Connection between the first, to the discharge of the Discharge device is directed towards aligned chamber.
- the bringing of the sleeve from the Starting position in the discharge position during the first Partial operation takes place.
- container-side closure plug preferably with a crimp closure attached to the container, arranged from a housing side, Pierced a needle having a discharge channel.
- the slotted guide between sleeve and Actuating means is formed, and preferably at least one Gleitstein on the actuating means and the at least one Sliding track of the slotted guide are formed on the sleeve.
- the container is a first, the Discharge opening of the discharge facing chamber and has at least one other chamber.
- the chambers are preferably with axially displaceable in the container plug from each other separated.
- the last of the chambers is also with a stopper closed, on this affects the actuating means.
- Adhesion between the actuating means and container can be produced, by means of which the container from the initial position in which the container hermetically sealed, in the discharge position, in the a fluidic connection between the discharge opening and the first chamber is manufactured, is available.
- the first partial operation limiting stop is designed such that the container is placed in a discharge position in which the fluidic connection between the first chamber and the discharge opening is made.
- Embodiments in which the container is two Chambers, wherein in the first chamber preferably a dry, especially soluble media component, such as a lyophilisate, is introduced and wherein in the second chamber a carrier medium, preferably a particular liquid solvent as Media component is introduced. It is also advantageous if two, in particular an equal discharge effecting subsequent partial operations are feasible.
- Figures 1 to 3 each show illustrations of a preferred one Donor in his unconfirmed starting position.
- FIG. 1 is a sectional view through the invention Discharge device shown.
- the discharge device 11 has a Housing 17 with a discharge opening 18 for discharging the medium on.
- a needle 20 for example by means of a Filler 21 b, arranged, which is suitable, the discharge channel 21st between the first chamber 39 of the container 12 and the discharge opening 18 to form.
- On the housing 17 are inwardly projecting locking lugs 37 formed, which engage behind the locking ring 38 of the sleeve 34 can and are therefore suitable for a defined discharge position of Set sleeve 37 in the housing 17.
- the actuating means 19 is arranged.
- the actuating surface is substantially radially to the extent of Pipe sections trained and manually operated.
- the pipe sections have different lengths.
- the inner tube section is from the Diameter forth designed so that it can be inserted into the container 12 is.
- the outer tube section whose Axialerstrekung preferably longer than that of the inner pipe section, slides along the sleeve 34. Between sleeve 34 and actuating means 19 is a slotted guide formed in the Fign. 2 and 3 is shown.
- a sleeve 34 is arranged, which serves as a receptacle for the container 12 serves for the medium.
- the container 12 at its front end is closed with a crimp closure 22
- the container 12 thereby in the sleeve 34th be attached to the sleeve 34 is a catch for the Crimp sleeve 22 is formed.
- three ribs 49 are provided for this purpose.
- the sleeve 34 also extends over at least part of the axial length of the container 12.
- the sleeve 34 extends almost to the rear end of the Housing 17. So that a rotationally secure mounting of the sleeve 34 in the Housing 17 is ensured, the housing 17 has a on a Axial section extending toothing 25a on its inside on. In this toothing 25a on the housing engages one of the sleeve trained teeth 25b. The teeth 25a, 25b prevent by their mutual engagement that the sleeve 34th is rotated relative to the housing 17.
- the sleeve 34 in the housing 17 performs an axial movement.
- the lengths of the teeth must be designed so that the sleeve 34 from the initial position 35 shown in the Austrag ein is available and the gears are still in mutual interference and not pending.
- the container 12 is arranged.
- the container 12 is for example via the crimp sleeve of the crimp closure 22 in the Sleeve 34 held.
- the container 12 is preferably around a glass container.
- Such containers are for example Capsules or carpules. In place of glass containers can also Containers of a plastic are used.
- the container must only the requirements for tightness, sterility and stability as well Strength suffice. Furthermore, it should be easy to make.
- the container 12 has two chambers, namely a first chamber 13 a and further chamber 13b. The two chambers are through a stopper 14 separated from each other. The plug is in the illustrated starting position in a position in which he has the two chambers completely separated from each other.
- the plug 14 is axially in the Container 12 displaced. He can be put in a position where it is located in the region of the overflow channel 15. In this case is then a connection between the two chambers 13a, 13b produced.
- the overflow 15, in particular as a by-pass is formed, this has a length that is slightly larger than that axial length of the plug 14.
- the discharge opening 18th the discharge device 11 facing side of the container 12 through closed a crimp closure 22.
- a Crimp closure becomes a plug sealingly in the opening of the Container 12 is placed, held by a crimp ring and partially pressed onto the container 12.
- the crimp ring is on one side Matterschkante of the container 12, which is designed for this purpose, held.
- the first chamber 13a is a media component, for example the lyophilisate 40, introduced. This is exactly this amount Media component has been introduced into the first chamber, the the discharge of the desired number of partial batches required is. A very accurate dosage of the amount of media component is possible.
- the first chamber 13a also includes a gas bubble 39.
- the gas bubble may in particular by an inert gas, through Clean room air or be formed by normal ambient air. It can be advantageous, the filled carpule and thus the gas then sterilize.
- the gas should be as free as possible of any kind of foreign matter and impurities. In particular, it is here to make sure that the gas of the gas bubble does not interfere with the Chamber 13a introduced media component reacts in a manner which interferes with their effectiveness or durability.
- the housed remaining media components In the other chambers 13b, wherein in the illustrated embodiment only one more chamber 13b is present, are the housed remaining media components.
- the carrier medium 41 is in particular a solvent for the lyophilisate 40.
- the another chamber 13b as completely as possible with the carrier medium 41st filled.
- Carrier medium 41 are preferably water or aqueous Solutions, such as alcohol-containing solutions in question. Water-based carrier media 41 are typically suitable to dissolve the lyophilizate 40 or take such that a uniform mixing of the carrier medium with the lyophilisate 40 or the other, introduced into the first chamber 13a Media component is guaranteed.
- the Fign. 2 and 3 show, in each case in a partially sectioned illustration, the Discharge device of Fig. 1 of two opposite Pages.
- the sleeve 34 is substantially shown uncut, so that the formation of the slotted guide 26th between the actuating means 19 and the sleeve 34 is visible.
- the discharge device 11 closed with a protective cap 16.
- This protective cap 16 is removable. It serves to protect the discharge opening 18 Pollution.
- the protective cap 16 is designed to that it simultaneously assumes the function of a child safety. This happens for example by the fact that the cap on certain To be gripped and compressed easily must, so that it is removable from the housing 18.
- the actuation lock is intended to actuate the actuation element 19 prevent as far and as long as the cap 16 on the Discharge device 11 is placed.
- the sleeve 34 is held in the housing 17 of the discharge device 11. It is in the starting position 35. In the starting position 35, the sleeve 34 is held by the locking lugs 37 which the locking ring 38 behind. In this case, the sleeve 34 is axially in the direction of the Discharge opening 18 slidably and arrives at the end of this Displacement path in the discharge position, not shown. About the Teeth 25a, 25b on the inside of the housing 17 and at the Sleeve 34 ensures that the sleeve 34 is not in the housing 17th is rotatable.
- a link guide 26 is formed between the actuating means 19, which is also in the Housing 17, or in the sleeve 34, wherein the guide preferably through the sleeve 34 and the container 12, is a link guide 26 is formed.
- the slide tour is through Slotted tracks 32, 33 - in accordance with the illustrated Embodiment formed in the sleeve 34 - and therein guided sliding blocks 30, - formed on the actuating means 19 are - formed.
- a first slide track 32 and on the opposite, shown in Fig. 3 side, a second slide track 33 is formed.
- the two gateways have different functions.
- the first slide track 32 serves to divide the actuating travel c of the actuating means 19 into the first partial operating travel a and the subsequent partial operating travel b .
- Task of the second slide track 33 is essentially to carry out the implementation of the automatic changeover between the other part operations. In the illustrated embodiment, it is provided that the switching operation between the first part of a and the first subsequent partial operation b is done manually and not automatically. By an appropriate design of the second slide track 33 but it would also be possible that this switching operation also takes place automatically.
- An advantage of a manual changeover operation at this time is that it can remind the user that, if shaking of the discharge device 11 occurs, it may be necessary or desirable for good mixing between the media components to form the discharged medium the subsequent part operations are performed, to which a discharge of medium is assigned.
- the first slide track 32 in which the actuating means-side sliding block 30 is guided divides the actuating travel c of the actuating means 19 in a first Partbetutz a and a plurality of subsequent Partbet2011istswege b , wherein the first Partbet2011istsweg the first part operation and the subsequent Partbet2011istswege b are each associated with a subsequent partial operation ,
- the subdivision of the actuation path c in the partial operation paths is carried out in each case by a stop 28, which is formed at the end of a part of the associated Partbetrucistsweg linear guide portion 42.
- the linear guide portions 42 are steppedly offset from one another.
- a broad section is formed such that the sliding block 30 can be aligned by turning the actuating means 19 with respect to the sleeve 34 and thus the housing 17 to the next linear guide section 42.
- the Vermosweg is limited in each case by a stop 31.
- pressure point means 27 are formed. The pressure point means ensure that at the beginning of the actuation process, the actuating force of the actuating means 19 exceeds a threshold, so that the full implementation of a partial actuation is ensured in each case.
- material webs 48 are formed at the beginning of the partial operation paths, which have at least one predetermined breaking point and are broken when the minimum force is exceeded.
- a retaining ring 23 on the housing or on the sleeve 34 is arranged, which supported there and are connected via predetermined breaking points 24 with the actuating means 19.
- the first partial operation can only take place when the minimum force required for the first partial operation is exceeded.
- the protective cap 16 must be removed become. This can also be an actuation lock for the actuator 19 be lifted. At the same time can provide a positional protection for maintaining the starting position 35 for the sleeve 34 are lifted with the container 12 held therein, so that the container 12 together with the sleeve 34 in by the locking lugs 37 defined discharge position can be brought.
- the actuating means 19 In order for the mixing of the media components of the first chamber 13a with the media component of the further chamber 13b, ie the carrier medium 41, the actuating means 19 must be moved into the housing 17 in the direction of the discharge opening 18.
- the sliding blocks 30 slide in the slotted guide 26 with the two slide tracks 32, 33. Due to the required minimum actuation force to overcome the breaking forces of the predetermined breaking point 24 is a complete first partial operation over the entire first Crystalbetuschist a until reaching the stop 28 at the end of the first linear guide portion 42 of the first slide track 32.
- the retraction lock 47 of the first slide track 32 retraction or retraction of the actuating element 19 is prevented.
- the stopper 14 arranged at the end of the container 12, which is in frictional connection with the actuating means 19, is pushed in the direction of the discharge opening 18. Due to the incompressible liquid located in the further chamber 13b-the carrier medium 41-the middle stopper 14, which separates the first chamber 13a from the further chamber 13b, is also pushed forward in the direction of the discharge opening 18. This movement of the plug 14 between the two chambers 13a, 13b takes place until the carrier medium 41 can flow past this plug 14 through the overflow channel 15 into the first chamber 13a.
- the lyophilisate 40 Simultaneously with the movement of the plug 14 between the two chambers 13a, 13b, the lyophilisate 40, which is located in the first chamber 13a, pushed forward, ie in the direction of the discharge opening 18. By the inflowing carrier medium 41, the lyophilisate 40 is slowly dissolved. The two media components produce dischargeable media.
- the plug located in the crimp closure 22 is thereby slowly pierced by the tip of the needle 20.
- the overpressure can escape from the first chamber 13a, the frictional connection between the sleeve 34 and actuating means 19 is then interrupted.
- the sliding block 30, which is guided in the first slide track 32, comes into abutment with the stopper 28. It is now pressed further and thereby pushed the sleeve 34 together with the container 12 held therein further forward until the locking lugs 37, the locking ring 38th engage behind.
- the sliding block 30 of first slide track 32 secures against retraction, can in this Position for generating the medium and for good mixing or the good resolution of the media components with each other or each other, the container 17 are shaken.
- the rear plugs 14 are fully moved towards the front plug 14, so the volume of the further chamber 13b is reduced to zero and the entire carrier medium 41 has been displaced into the first chamber 13a.
- the discharge device In order to carry out the first subsequent partial actuation, that is to say the first discharge of medium through the discharge opening 18, the discharge device must first be used at the place of application.
- the housing 17 with the discharge opening 18 must be inserted into one of the two nostrils of a patient.
- the actuating means 19 must be rotated clockwise to the stop 31 of the two cam tracks 32, 33 of the guide slot 26. A reverse rotation is prevented by the reverse rotation lock 43 of the second slide track 33 after completion of this switching operation.
- the toothing 25a, 25b between sleeve 34 and housing 17 prevents inadvertent rotation of the sleeve 34 in the housing 17.
- the first subsequent partial operation over the subsequent sectionbetquestionedistsweg b away, now takes place by applying an actuating force on the actuating means 19, at its bottom engages and is directed in the direction of the discharge opening 18.
- the pressure point means 27 of the first slide track it is a material web 48, which is formed at the beginning of the associated linear guide portion 42, overcome.
- the pressure point means preferably has predetermined breaking points.
- the actuating force Before carrying out the second, last subsequent partial operation, the actuating force must be lowered to the actuating means 19. Thus, the contact pressure of the Gances 30 is reduced to the stop 28.
- the prestressed energy accumulator 29 now continues to turn the sleeve 34 until the sliding blocks 30 reach the next stop 31.
- the energy storage device 29 is then relaxed, the sliding block 30 of the first slide track 32 is located immediately before the second pressure point means 27 and the last linear guide section 42.
- the second application is carried out by operating the actuating means 19 again in the same way and with the same effect as in the first subsequent partial operation. Again, a pressure point means 27 is destroyed again.
- the discharge of the medium from the first chamber 13 a is achieved by further displacement of the two plugs 14 of the container 12 in the direction of the discharge opening 18.
- the media volume that is discharged is determined by the actuation path of the subsequent partial actuation, here in the first partial actuation as well as in the second partial actuation of the partial actuation path b .
- the container, an ampoule, capsule or carpule is now emptied. Relevant parts of the discharge device are destroyed after use and can not be reused. It is therefore a disposable system and can then be recycled. It is advantageous that the discharge is mainly made of plastic, which can be selected according to type.
- the crimp closure and the needle are formed as metallic parts, wherein optionally also the crimp closure is made of plastic.
- the plugs 14 are often made of an elastomer or rubber. They too can be recycled. So is particularly advantageous in such a design of the discharge the low use of different materials and the small number of metallic components. No metallic springs, pins or other metallic elements other than those mentioned above are required.
- the subsequent partial operations which serve the discharge of medium, can be carried out directly one after the other and without any additional hand movements.
- the handle of the discharge so it is easy to perform despite the required mixture of the medium from the media components.
- An essential advantage of the invention is to be seen in this simple handling.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Packaging For Recording Disks (AREA)
- Filling Or Emptying Of Bunkers, Hoppers, And Tanks (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Photographic Developing Apparatuses (AREA)
Claims (16)
- Dispositif de décharge, notamment pour des substances contenant au moins une matière active pharmaceutique, présentant un récipient (12), dans lequel est stockée la substance à décharger, sachant que le récipient (12) présente des chambres (13a, 13b) séparées, dans lesquelles se trouve respectivement un des éléments constitutifs de la substance (40, 41), qui donnent ensemble la substance à décharger, sachant que le récipient (12) est disposé dans un boítier (17) qui présente une ouverture de décharge (18) pour la décharge de la substance, sachant qu'on prévoit un moyen d'actionnement (19) relativement mobile par rapport au boítier (17) dont l'actionnement produit d'abord un raccord entre les chambres du récipient, sachant que la voie d'actionnement (c) du moyen d'actionnement (19) est subdivisée en une première voie d'actionnement partielle (a) et en un certain nombre de voies d'actionnement partielles (b) suivantes, sachant qu'un mélange des éléments constitutifs de la substance (40, 41) a lieu pendant la première voie d'actionnement partielle (a) pour obtenir la substance à décharger et sachant que tout actionnement partiel ultérieur du moyen d'actionnement (19) est associé à la décharge d'une dose partielle de substance bien définie, caractérisé en ce que le récipient (12) est disposé dans le boítier (17) de manière déplaçable par un actionnement du moyen d'actionnement (19) à partir d'un position initiale, dans laquelle le récipient (12) est fermé de manière étanche, dans une position de décharge, dans laquelle est produit un raccord fluidique entre le récipient (12) et l'ouverture de décharge (18) en raison du déplacement, et en ce que l'ouverture de décharge (18) est réalisée pour une décharge nébulisée de la substance.
- Dispositif de décharge d'après la revendication 1, caractérisé en ce que les chambres (13a, 13b) sont séparées au moyen de bouchons (14) disposés dans le récipient (12).
- Dispositif de décharge d'après la revendication 1 ou 2, caractérisé en ce que le récipient (12) présente des conduits de by-pass (15), sachant que, pendant le premier actionnement partiel (a), les bouchons (14) séparant les chambres (13a, 13b) peuvent être portés dans une position dans le domaine des conduits de by-pass (15), de façon que les chambres sont raccordées par les conduits de by-pass (15).
- Dispositif de décharge d'après une des revendications précédentes, caractérisé en ce qu'on prévoit un guidage à coulisse (26) pour la subdivision de la voie d'actionnement (c) en voies d'actionnement partielles (a, b).
- Dispositif de décharge d'après la revendication 4, caractérisé en ce que le guidage à coulisse (26) présente des moyens à point de poussée (27), sachant que des moyens à point de poussée (27) sont à surmonter au début de chaque actionnement partiel ultérieur.
- Dispositif de décharge d'après la revendication 4 ou 5, caractérisé en ce que le guidage à coulisse (26) présente une section de guidage (42) linéaire pour chaque actionnement partiel, sachant que les sections de guidage (42) sont décalées les unes par rapport aux autres de telle manière qu'elles sont respectivement limitées par un arrêt (28) et que, entre deux actionnements partiels, il faut effectuer respectivement un actionnement de commutation qui diffère de l'actionnement partiel.
- Dispositif de décharge d'après la revendication 6, caractérisé en ce qu'au moins les actionnements de commutation entre deux actionnements partiels (b) consécutifs sont effectués automatiquement.
- Dispositif de décharge d'après la revendication 7, caractérisé en ce qu'on prévoit des accumulateurs d'énergie (29), qui sont précontraints pendant un actionnement partiel et qui servent à effectuer automatiquement l'actionnement de commutation suivant.
- Dispositif de décharge d'après une des revendications précédentes, caractérisé en ce que le récipient (12) est disposé en position fixe dans une douille (34), sachant que la douille (34) est relativement mobile par rapport au boítier (17) et qu'elle est déplaçable de la position initiale (35) à la position de décharge, sachant que dans la position de décharge le raccord fluidique est établi entre la première chambre (13a) du récipient et l'ouverture de décharge (18).
- Dispositif de décharge d'après la revendication 9, caractérisé en ce que le déplacement de la douille (34) de la position initiale (35) à la position de décharge à lieu pendant le premier actionnement partiel (a), sachant que pour produire le raccordement fluidique entre l'ouverture de décharge (18) et la première chambre (13a) du récipient (12), une aiguille (20) située du côté du boítier et présentant un conduit de décharge (21) perce un bouchon situé du côté du récipient et maintenu de préférence par une fermeture à sertissage (22).
- Dispositif de décharge d'après la revendication 9 ou 10, caractérisé en ce que le guidage à coulisse (26) est réalisé entre la douille (34) et le moyen d'actionnement (19) et que de préférence au moins le coulisseau (30) est réalisé sur le moyen d'actionnement (19) et qu'au moins l'une des voies de coulisse (32, 33) du guidage à coulisse (26) est réalisée sur la douille (34).
- Dispositif de décharge d'après une des revendications de 6 à 11, caractérisé en ce que l'actionnement de commutation entre le premier actionnement partiel (a) et le premier actionnement partiel suivant (b) à lieu par une rotation du moyen d'actionnement par rapport au boítier (12), sachant que l'angle de rotation est déterminé par des arêtes de butée (31) du guidage à coulisse (26) et sachant qu'une rotation de la douille (34) par rapport au boítier (17) est empêchée de préférence par d'une denture (25a, 25b).
- Dispositif de décharge d'après une des revendications précédentes, caractérisé en ce que le récipient (12) présente une première chambre (13a) orientée vers l'ouverture de décharge (18) du dispositif de décharge (11) et au moins une autre chambre (13b), qui sont dotées du bouchon (14) qui est axialement déplaçable dans le récipient et qui sépare les chambres l'une de l'autre et les referme, et d'un bouchon (14) qui referme la dernière des chambres (13b) et sur lequel agit le moyen d'actionnement (19).
- Dispositif de décharge d'après une des revendications précédentes, caractérisé en ce que la première chambre (13a) orientée vers l'ouverture de décharge (18) présente un volume contenant une bulle de gaz (39), sachant que pendant le premier actionnement partiel (a) on peut produire par compression de la bulle de gaz (39) un engagement par adhérence entre le moyen d'actionnement (19) et le boítier (12), engagement par lequel le récipient (12) peut être porté de la position initiale (35), dans laquelle le récipient (12) est fermé hermétiquement, dans la position de décharge, dans laquelle est établi un raccordement fluidique entre l'ouverture de décharge (18) et la première chambre (13a).
- Dispositif de décharge d'après une des revendications de 1 à 14, caractérisé en ce que le récipient (12) présente deux chambres (13a, 13b), sachant que dans la première chambre (13a) on trouve de préférence un composant de substance sèche notamment soluble, de préférence un lyophilisat (40) et sachant que dans la deuxième chambre (13b) on trouve, en tant que composant de substance, une substance de base (41), de préférence un solvant notamment liquide.
- Dispositif de décharge d'après une des revendications précédentes, caractérisé en ce qu'on peut effectuer deux actionnements partiels (b) consécutifs, qui produisent notamment une décharge de dimension identique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10036594 | 2000-07-27 | ||
DE10036594A DE10036594A1 (de) | 2000-07-27 | 2000-07-27 | Austragvorrichtung für Medien |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1186312A2 EP1186312A2 (fr) | 2002-03-13 |
EP1186312A3 EP1186312A3 (fr) | 2003-04-23 |
EP1186312B1 true EP1186312B1 (fr) | 2005-12-28 |
Family
ID=7650399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01114759A Expired - Lifetime EP1186312B1 (fr) | 2000-07-27 | 2001-06-25 | Dispositif distributeur de substances |
Country Status (4)
Country | Link |
---|---|
US (1) | US6679248B2 (fr) |
EP (1) | EP1186312B1 (fr) |
AT (1) | ATE314105T1 (fr) |
DE (2) | DE10036594A1 (fr) |
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DE10164452A1 (de) * | 2001-12-21 | 2003-07-03 | Pfeiffer Erich Gmbh & Co Kg | Spender für Medien |
DE10218782A1 (de) * | 2002-04-22 | 2003-11-20 | Pfeiffer Erich Gmbh & Co Kg | Dosiervorrichtung mit wenigstens zwei Medienräumen |
FR2844775B1 (fr) * | 2002-09-20 | 2006-02-10 | Valois Sas | Dispositif de distribution de produit fluide |
WO2005102058A2 (fr) * | 2004-04-23 | 2005-11-03 | Mystic Pharmaceuticals, Inc. | Systeme d'administration de medicament en doses unitaires multiples |
DE102006047674A1 (de) * | 2006-09-28 | 2008-04-03 | Karl Storz Gmbh & Co. Kg | Schraubendreher zum Handhaben einer Schraube im menschlichen oder tierischen Körper |
WO2008086413A2 (fr) | 2007-01-09 | 2008-07-17 | Mystic Pharmaceuticals, Inc. | Dispositifs à cartouche intranasaux |
DE102007016811A1 (de) * | 2007-04-05 | 2008-10-09 | Tecpharma Licensing Ag | Vorrichtung zur Verabreichung eines fluiden Wirkstoffes aus einer Mehrkammerampulle |
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CN103707452B (zh) * | 2007-09-14 | 2017-05-03 | 神秘制药公司 | 深冲压容器形成方法 |
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-
2000
- 2000-07-27 DE DE10036594A patent/DE10036594A1/de not_active Withdrawn
-
2001
- 2001-06-25 AT AT01114759T patent/ATE314105T1/de not_active IP Right Cessation
- 2001-06-25 EP EP01114759A patent/EP1186312B1/fr not_active Expired - Lifetime
- 2001-06-25 DE DE50108515T patent/DE50108515D1/de not_active Expired - Lifetime
- 2001-07-19 US US09/909,306 patent/US6679248B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6679248B2 (en) | 2004-01-20 |
EP1186312A2 (fr) | 2002-03-13 |
DE10036594A1 (de) | 2002-02-07 |
US20020023641A1 (en) | 2002-02-28 |
DE50108515D1 (de) | 2006-02-02 |
EP1186312A3 (fr) | 2003-04-23 |
ATE314105T1 (de) | 2006-01-15 |
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