EP1027166B1 - Distributeur pour plusieurs milieux melanges avant decharge - Google Patents
Distributeur pour plusieurs milieux melanges avant decharge Download PDFInfo
- Publication number
- EP1027166B1 EP1027166B1 EP98965137A EP98965137A EP1027166B1 EP 1027166 B1 EP1027166 B1 EP 1027166B1 EP 98965137 A EP98965137 A EP 98965137A EP 98965137 A EP98965137 A EP 98965137A EP 1027166 B1 EP1027166 B1 EP 1027166B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- chamber
- dispenser
- closure
- medium
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0078—Arrangements for separately storing several components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
- B05B7/2402—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device
- B05B7/2405—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device using an atomising fluid as carrying fluid for feeding, e.g. by suction or pressure, a carried liquid from the container to the nozzle
Definitions
- the invention relates to a dispenser according to the preamble of Claim 1. It is for media, especially flow or suitable for pourable media that are liquid, mushy, can be powdered or similar. Except a second or a third medium is also used or carried out, the states of matter mentioned apply for each of these media, which are also arbitrary with each other can be discharged mixed.
- the donor is appropriate free to carry with one hand and at the same time with the holding Hand to operate by finger pressure so that under this Pressure force of each of the media in and out of the dispenser Donor is promoted.
- a dispenser with a pump can the medium from a media storage, such as a Bottle, into a pressure or evacuated by increasing the volume Pump chamber sucked in and then reduced in size this chamber pressurized and thereby from the Media outlet are carried out.
- a pump draws in a lifting movement, for example during the return stroke, medium the memory and there is the opposite Stroke, the one stroke, for example the return stroke, from a spring can be driven.
- the medium can even before the dispenser is used for the first time in the pressure chamber be stored so that for complete emptying this pressure accumulator a stroke movement of the discharge actuation only in one direction, namely that of downsizing the pressure chamber, required and an announcing return stroke is not provided.
- EP-A-0 245 895 shows a dispenser in which the Transfer from the first to the second chamber several times back and forth manual pumping takes place, after which the Discharge of the medium is driven by a spring. to Support of the dispenser against the actuating force at Transfer is not intended, which is why the Dispenser against the operating force with its front end to be supported on a surface.
- the invention has for its object to a donor create the disadvantages of known training or of the type described are avoided and in particular improved inclusion of the stored medium a prior redeployment of the Medium or a mixture of separately stored media and / or a simple design with high functional reliability guaranteed.
- the donor includes means by which the Medium under pressure or gradient from a first pressure chamber is to be transferred to a second pressure chamber without this Medium discharged from the media outlet or the outlet channel is flowed through. This allows the medium to start up before this or priming of the donor very well against contamination or Bacteria protected and stored in the first chamber only with the start of the preliminary stroke serving the discharge into the second chamber can be transferred. Can in the second chamber a medium can also be stored, which then with the Medium mixed from the first chamber and as a mixture is carried out. The donor is therefore in one Actuating or working stroke to the previous homogeneous Mixing two media components and the following Discharge of this mixture is suitable.
- the components can react chemically with each other, together in a solution be transferable or in different physical states be saved.
- one of the media can only be one e.g. be compressible or liquid medium, which in the Contrary to another medium in the storage state none Contains active ingredient and possibly is so volatile that it is separates from this other medium after discharge.
- Each of the media mentioned can be used in any of the above Chambers.
- the two chambers are expediently designed so that one Enlargement of one chamber inevitably and simultaneously reduce the size of the other chamber or vice versa can. This can e.g. through one of the two chambers from each other separating as well as in the sense of this reduction and enlargement Movable chamber limits can be reached, for example a flexible partition, like a film, a Slider, such as a displacer or a piston o. Like.
- the transfer from the first to the second chamber could bypassing this chamber boundary, it is advisable through this chamber boundary and / or between two adjacent chamber boundaries, after one the mechanical closure of the two chambers or has been opened depending on the pressure or stroke. On such a closure can automatically close again Valve or one after opening not back in its Locking element returning to the closed position, like one out of one Sealing body to be pushed out, one to be pierced Membrane or the like.
- the separator between the two chambers is appropriate until the completion of the transfer only dependent movable from the gradient of the compressive forces, which in the two Chambers act in opposite directions on the partition.
- Independently of movements of this partition is one of the chambers, in particular the first chamber, variable in volume, for example with a chamber boundary, so opposite the partition is movable, as described with reference to this partition.
- the partition and this chamber boundary counter to each other for example up to the first chamber is empty or the chamber boundary on the partition strikes. Then the chamber boundary takes in the partition Stroke direction with, whereby the second chamber after its eventual Magnification reduced again and then by one only to be opened outlet closure or the media outlet from Dispenser is emptied away.
- Opening the separator is done by moving the partition or the opposite one Chamber delimitation, which the partition wall runs in unison can take along so that the distance between Partition and chamber boundary remains the same. Is the first Chamber with a non-compressible medium, for example a liquid, completely filled, so the entrainment the partition in the stroke direction until the partition lock opens mediated through this medium alone. It can but also a separate one, after the discharge on Donor remaining driving link may be provided, the Driving connection after opening the lock Disengaging clutch members is released. Furthermore, for Opening the separator also a slide valve or a the chamber boundary, the first chamber or the partition slidably penetrating opening member conceivable that is sealed in the chamber boundary. In this Fall needs the partition to open the partition lock not to be moved.
- a non-compressible medium for example a liquid
- the second chamber can expediently be changed in volume against spring force, especially scalable. Instead of a separate, spring remaining on the dispenser, can be done in the second chamber a gas filling, such as sterilized air, be provided. This compressible medium can then be used as Conveying medium the discharge of the other media in the Support mixed flow.
- the second chamber thus serves as Mixing or premixing chamber, which is another mixing or Flow calming chamber can be connected downstream.
- the chamber adjoins the downstream Outlet closure and can be like the second chamber or the open closure designed to be at least one double flow reversal in opposite directions or an annular or toroidal roller flow of the medium effected before this by a significantly narrowed Section of the outlet channel is fed to the media outlet.
- Both or all chambers can be divided by a common, pre-assembled unit may be limited, for example a rigid or inherently rigid body, such as a pipe.
- This Body is cross-section at both ends open, which is at least as large as the clear cross section of the narrowest of the chambers.
- the filling of the first and / or the second chamber can be connected to this, separate from the media outlet, include pre-assembled unit, so that after filling the the respective medium and before assembly on the other parts of the dispenser sterilization, for example cold sterilization with gamma rays is possible.
- the tubular body or the like. can be made in one piece from glass, but also from plastic and constant inside and / or over its entire length Have external cross sections.
- All media or mixing chambers can be in mutual Dependence of volume can be changed. It is also advisable if means are provided which after the actuation of the Donors, especially after the transfer, a minimum retention period of the medium in the second or third chamber enable. During this time, the funds block the Discharge paths of the medium against its discharge pressure and / or the manual operation that is used to generate the Discharge pressure is required.
- a step control with a time delay for the subsequent functional step such as a transfer or a Discharge step, a reaction time of e.g. more than five or eight seconds. During this time, they can immediately previously mixed media until reaching react to each other in a stable state, be it for Solution, mixture or dispersion of the media.
- the lock can also be released manually, for example by rotating the dispenser around its central axis.
- the dispenser 1 has two single or multi-part units 2, 3 on, which also include one-piece components can. They are used to execute the actuation or discharge stroke shortening the dispenser 1 against each other move.
- the entire unit 2 is in one piece Base body 4 formed.
- the second unit 3 also has a one-piece base body 5, which is essential is longer than the body 4 and this at least partially records inside.
- the body 4 forms with its exposed End surface an actuation pressure surface or handle 6.
- a corresponding pressure surface or handle 7 of the body 5 projects radially on both sides with individual surfaces, is offset in the direction of flow relative to the handle 6, points away from the handle 6 and approaches on the working stroke the handle 6.
- the unit 3 has on the base body 5 Media outlet 8 or an atomizer nozzle.
- nozzle channel extends to the edge of the nozzle 8 and is up to this force limited in one piece by the body 5.
- body 9 Completely within the Body 5 lying and held in place on this is a tubular, one-piece chamber body 9 is provided. It sticks out against the direction of flow freely into the body 4, which in turn protrudes freely in the direction of flow and opposite the body 9 is permanently non-contact.
- All components 2 to 9 of the dispenser 1 are in one Axis 10 arranged which is parallel to the flow and Actuation or stroke direction is.
- Chambers 11 to 13 are provided. It's an upstream lying first chamber 11, a downstream one adjoining it second chamber 12 and a downstream of this third chamber 13.
- the chambers are limited 14 to 20 fully limited.
- the storage chamber is on the circumference 11 bounded by a jacket 14. It is separate is formed by the body 9 as a flexible bellows, which axially shortened so that its internal volume is close to zero goes.
- the chamber 11 is at the ends facing away from one another of movable closure parts 16, 17, such as pistons, sliders o. The like. Limited and tightly closed.
- Chamber 12 the be smaller or larger than chamber 11 in the initial volume can, is limited on the outer circumference by a jacket 15, the is formed here by a longitudinal section of the body 9. At both ends facing away from each other, the chamber 12 is like the chamber 11 of inserted and movable in the body 9
- Closure parts 17, 18 limited, for example the piston 17th and an insert 18 located downstream of it, which is axially fixed, but also axially could be slidable. All locking parts 16, 17, 18 are or are directly on the inner circumference of the body 9 guided on this inner circumference and sealed.
- the Coat 14 does not touch the body 9, so that between it and the body 9 an annular space is formed.
- the jacket 14 can closed bellows sections or helical or steep, spiral-shaped bellows constrictions and bellows projections have about its axis 10. This is how its ends lead mutual changes in length due to changes in length an inherently generated torsional stress.
- Chamber 13 is of two closure parts 18, 19, namely the insert 18th and a sleeve-shaped plug 19 is closed. It lies downstream of the insert 18 and is against the direction of flow inserted into the body 9 or through the body 5 educated.
- the chamber 13 is smaller than each of the chambers 11, 12th
- An overflow opening is provided between the chambers 11, 12. It is in the starting position with a valve or Closure 20, here a thin membrane, tightly closed, to which both chambers 11, 12 directly adjoin.
- the Overflow opening passes through the piston 17 in the center and is narrower than the sliding surfaces of the piston 17 or the diameter of the chambers 11 to 13.
- the closure 20 can be at a distance between the ends of the overflow opening or in the plane of one end.
- Puncturing or piercing is a needle-shaped opening member 21 provided. It protrudes from the flow direction Insert 18 and is integrally formed with this.
- the chamber 12 is annular.
- the one-piece piston 17 has two oppositely directed and flared piston lips 22, 23. you go as shell walls from a common one, between them lying piston crown 24.
- the upstream and protruding piston lip 22 seals the annular space around the Coat 14 and takes the associated end portion of this Coat 14 on the inside.
- the jacket 14 extends to the Associated end face of the piston crown 24. It stands radially inwards over the lips 22, 23 and is in one piece with the jacket 14 and the closure 20 formed.
- the Lip 23 projecting freely in the direction of flow also seals with the body 9 from the chamber 12 and takes in the starting position inside the free end of the link 21.
- the Piston 16 slides sealed on the inner circumference of the body 9, extends to the upstream end of the jacket 14 and can also be made in one piece or like the piston 17 be designed as a pre-assembled unit.
- the piston 16 of Channels Outside the chamber 11 or radially within its sliding surfaces or in the area of these sliding surfaces, the piston 16 of Channels. This is how the chamber is reduced 11 the annular space around the jacket 14 against the direction of flow vented.
- Corresponding channels could also be the jacket of the Body 9 upstream immediately adjacent to lip 22 push through radially.
- Chamber 12 Downstream is chamber 12 from an outlet plug 25, like opening and springing back depending on the pressure closing valve, limited.
- Its movable valve body can be designed or aligned as based on the Lip 23 described.
- the valve body 25 lies in a ring on Inner circumference of the other valve body, namely the body 9 and limits the upstream at this point End of chamber 13.
- the radially resilient valve body is formed in one piece with the links 18, 21.
- the Insert 18 touches the body 9 only in the area of single valve seat.
- an extension e.g. a core body 26, in the plug 19 and approximately to the nozzle channel of the Outlet 8 before.
- the Body 26 extends into the valve body of the piston head Insert 18. It is in one piece with this valve body or the links 18, 21 formed. In cross section is the Body 26 much wider than the nozzle channel.
- That downstream lying end or the end face of the body 26 is limited with the opposite one, penetrated by the nozzle channel End face of the plug bore a chamber or device 28 for generating a swirl or swirl flow the medium around the nozzle axis 10. From the axial channels 27 the medium flows radially directly into this chamber 28 and then again axially directly into the nozzle channel.
- valve body of the valve 25 limits with the foot of the Body 26 an annular space narrowed against the direction of flow.
- a corresponding, narrowed in the direction of flow Annulus limits the conical end of the plug 19 with the Inner circumference of the body 9.
- the two, each with an axial distance opposite annular spaces form the two ends the chamber 13. You can make an annular around the axis 10 Roll flow in which the medium in the radial inner area flows against the direction of flow and then only with the opposite redirection directly into the Plug 19 or the channel 27 enters.
- the outlet 8 is at the free end of a slim, tapered connecting piece 29 intended. It stands in the direction of flow above the handle 7 elongated in front. Over the outer circumference of the projection 29 the handle 7 is only on two diametrically opposite one another Pages forward. So the nozzle 29 between two fingers resting on the handles 7 are taken.
- a first lock 30 is provided and for securing it after a first part of the stroke, a second lock 31.
- the nozzle 29 has an outermost jacket 32, which from the outlet 8 against the direction of flow to the handle 7 enough, integrally connects to the plug 19 and the body 9 surrounds for most of its length with radial spacing.
- a transverse plate 33 to the outside. It forms the handle 7.
- the plate 33 goes in an opposite flow direction directed jacket wall 34 over. She has in the area the handle 7 smaller and in the opposite to each other Areas of greater height. So the body can 4 pushed almost completely into this cap 33, 34 become. Closes with a radial distance within the casing 34 a further jacket wall 35 on the inside of the wall 33 on. It extends into the plane against the direction of flow the end edge of the higher portion of the jacket 34 and joins the inside of these higher sections tangentially on.
- the jacket 34 is parallel to the axial view Handle 7 elongated or flat oval.
- the coat 35 and a further jacket 36 are axially symmetrical or cylindrical.
- the jacket 36 lies within the jacket at a radial distance 35, is also opposed to the inside of the wall 33 Flow direction ahead and can be aligned with the jacket 32.
- the body 5 forms all the walls 32 to 36.
- the jacket 36 projects less far than the coats 34, 35.
- the body 4 has a spacing between its ends its outer circumference radially protruding locking member, for example, a snap member 37 or with the circumference Distance distributed snap members. Their is on the inner circumference of the jacket 36 is assigned a counter member 38 of the lock 30.
- the locking member 37 formed by the body 4 can radially after spring inside and the counter member 38 radially outwards. So there a correspondingly high one exerted on the handles 6, 7 Axial force the locking member 37 and thus the unit 2 jerky free. After that, those that counteract the operation remain Forces significantly lower over the entire stroke. Indeed after the first partial route, the barrier 31 is closed Stop effective and thereby the end of this partial route recognizable or perceptible.
- the lock 31 points upstream from the link 37 at a distance the unit 2 has a further stop and locking member 39. It can be spaced from the ends of the body 4 at its Connect the outer circumference and is in the starting position within of the jacket 34 or 35 at its upstream The End.
- the inner circumference of the ring or disc-shaped member 39 closes via a disengageable link, for example one weakened predetermined breaking zone 40, in one piece on the body 4.
- the upstream end face of the shell 36 forms the counter stop 41 for the link 39.
- the unit 2 has a protruding freely in the flow direction Carrier or thrust body for the piston 16, for example a sleeve-shaped plunger 42.
- a sleeve-shaped plunger 42 In the starting position is the downstream end of the plunger 42 with small axial distance from the associated counter surface or from the upstream end of the piston 16 within the Body 9, against which the plunger 42 permanently non-contact remains.
- the plunger 42 is at a radial distance of a longer shield, such as a closed sleeve 43 surround. It protrudes freely in the direction of flow the plunger 42 before and is formed by the body 4 as this. Its upstream end is through an end wall 44 formed. The outside forms the handle 6. From the Wall 44, the two sleeves 42, 43 are free. So that sticks out in the starting position, the sleeve 43 through the jacket 36 to in the coat 32 inside. The sleeve 43 surrounds this upstream lying end of the body 9 and the piston 16 and one Part of chamber 11.
- the body 9 by two separate, one inside the other inserted pipes 14, 15 of different lengths are formed.
- Each has a constant exterior and exterior throughout its length Internal cross-sections.
- the shorter inner tube 14 also closes its outer circumference close to the inner circumference of the tube 15 and is rigidly connected to it, for example by Gluing, welding, press fitting or the like ..
- the upstream lying ends of the tubes 14, 15 are level. So the outer tube 15 projects in the direction of flow arrow 56 the tube 14 before.
- Both tubes 14, 15 consist of different Materials or the same material, for example Glass.
- the tube 14 limits only the narrower chamber 11 and that Tube 15 only the chambers 12, 13. While the Piston lips 22, 23 have the same diameter, they have according to Figures 2 to 5 different diameters.
- the Lip 22 has a smaller diameter than lip 23.
- the piston surface is on which the pressure in chamber 11 acts smaller than the piston area to which the pressure in chamber 12 acts.
- the piston head of the piston 17 forms a stop. He is in the above-mentioned positions with an axial distance of a counter stop, namely the downstream end of the tube 14. So allow thermal expansion in the Chamber 12 a displacement of the piston 17 against the direction of flow. This keeps one in the idle state Chamber 12 resulting excess pressure limited. By appropriate Adjustment of the closing force is not the valve 25 open.
- the medium is pressed out with a link 47. It is complementary to the link 21 and formed by the free end of the mandrel 45 is formed.
- the links 21, 47 are however, designed so that between them according to FIG the circumferentially distributed transition or longitudinal channels 57 open remain, each of which is limited by two links 21, 47 is. Upstream, these channels 47 close to longitudinal channels 48 on. They lie on the outer circumference of the bodies 45, 46 and are open to chamber 11 until the end of the actuation stroke.
- the body 26 ends at the upstream end of the plug 19.
- the body 26 is of one or two intersecting channels or Grooves interspersed.
- the medium flows out of the chamber 13 into it radially and is mixed again at the crossing point, after which it axially enters the outlet channel 27.
- the lies here in the axis 10 and not eccentrically as in FIG. 1 this, since it is only through the bore in the plug 19 is limited.
- the largest inside diameter of the chambers is less than 15 mm, 10 mm or 7 mm.
- the two sections 14, 15 of the body 9 integrally formed with each other.
- the inner circumference of the Section 15 is graded into the narrower inner circumference of the Section 14 on.
- the outer circumference remains over the entire Length of sections 14, 15 constant. This is in the area of the section 14 has a greater wall thickness of the body 9 given.
- the body 9 is again by two Single body, namely two tubes 14, 15 formed.
- the pipe 14 protrudes in the opposite direction 56 via the pipe 15. So is either, as shown, the outer circumference of the body 9 in Area of the projecting part of the tube 14 narrower than in Area of the tube 15 or the same size if the tube 14th has different outer diameters and with its Ring shoulder at the upstream end of the pipe 15 strikes. 5 corresponds to that 4, but with one-piece design of the pipe sections 14, 15.
- the chamber 12 is narrowed, but not as far as according to Fig. 5.
- the associated stroke 53 of the piston 17 is the same as big as or smaller than the stroke 50.
- 42 is the medium from the Chamber 11 on the now open line connection in the chamber 12 pressed. This can be increased by the Piston 17 executes the stroke 54 simultaneously with the stroke 51, until the piston 16 strikes the piston 17 according to FIG. 4 and the Chamber 11 is completely empty.
- the mandrel 45, 46 can then fill the piston bore completely or over the bore entire length or only a part of it.
- the member 21 can exit the piston bore again, so that it has not yet engaged the link 47.
- the unit 16, 42, 45 takes the Piston 17 with a positive fit via the same-sized stroke 55. So the chamber 12 is reduced again, the pressure in it increased and the valve 25 shown in FIG. 4 opened until the Piston 17 strikes insert 18 according to FIG. 5. The medium thereby flows from the chamber 12 into the chamber 13 through a Ring opening. It is from the inner circumference of the jacket 15 and from Limited outer circumference of the insert 18. From chamber 13 the medium flows valve-free to the outlet 8.
- the Hubes 52, 55 penetrates the link 21 into the link 47 and the Piston lip 22 remains either sealing in the area of Section 14 or it leaves section 14 and arrives canceling their sealing effect in the area of the section 15. Finally, as described, the chamber 13 be pressed empty.
- the lock 30 is released at the beginning of the stroke 49.
- the lock 31 is effective by a stop, since the so-called priming of the donor 1 has now ended, namely the tightly closed chamber 12 completely Medium is filled and vented if necessary.
- the priming hub 49 to 51, 53, 54 the discharge stroke 52, 55 or the begins Delivery of the medium from the outlet 8.
- the lock 30 or 31 could also, like 5 recognizable, interlocking locking members on Outer circumference of the body 9 and on the inner circumference of the sleeve 43 exhibit.
- These blocking elements could also be a third Form a lock, which engages at the end of the stroke 49 and with Beginning of the stroke 50 disengages again.
- Each of the chambers 11, 12 can in the initial state with a Liquid, a powder and / or a gas can be filled. It it is also conceivable to reverse the medium Piston 17 or the like from the chamber 12 in the opposite direction 56 in to press the chamber 11, after which the one thus formed Media filling from the chamber 11 in the direction 56 as shown in FIG Chamber 12 described to the outlet 8 is pressed.
- the chamber 11 is filled with liquid.
- On compared to half or a quarter smaller part of the Output volume of chamber 12 is powder and the rest filled with air.
- the liquid flowing out of the chamber 11 mixes in the chamber 12 by swirling with the Powder. It becomes partial or complete in the liquid as well as supported by the eddy currents in the chamber 12 solved. Only then is valve 25 opened and the medium by the eddy currents in the chamber 13 still further mixed. Then the medium leaves the outlet 8 in homogenized Status.
- the chamber 11 is on its outer circumference entire length of the piston 17 or one compared to the displaceable component, namely the piston skirt 14, limited.
- the piston 16 is permanent on its inner circumference sealed and slidably guided.
- the lip 22 lies upstream of chamber 11 and lip 23 downstream from that.
- a cartridge-like unit 16, 17 is provided with sealed chamber 11 formed, which before insertion of the body 4 in the otherwise pre-assembled Unit 3 can be used.
- the body 5 is enough here only over a fraction of the length of the body 9 the downstream end lies the body 5 Stopper 19 against the direction of flow via the handle 7 and forms the upstream end of the body 5.
- the body 9 lies between the handle 7 or the Body 5 and the body 4 in the region of the chamber 12 on the circumference free.
- a viewing window is formed through which the Interior of chamber 12 throughout the actuation stroke or part of it is visible from the outside. This can controls the transfer into the chamber 12 and its emptying become. Corresponding viewing windows can also be used for the chambers 11, 13 may be provided
- the jacket 43 is provided with longitudinal slots here. she extend to its free end. So the jacket 43 with radial clamping force directly on the outer circumference of the body 9 be guided and permanently contactless to the body 5 stay.
- the discharge nozzle 29 is shown in FIG. 7 formed by a tube axially penetrated by the outlet channel 27. It is narrower than the plug 19, stands from the inner end of the plug 19 freely and protrudes through the handle 7 Outside. 4, the body 5 can also counter one Have direction 56 protruding jacket. It is close on the outer circumference of the body 9 and thereby protects the Body 9 against damage. 1 lies the body 9 for this purpose completely inside the body 5, body 9 opposite its upstream end is set back.
- the body 5 according to FIG. 8 is that according to FIG. 7 in essentially the same.
- the discharge nozzle 29 is here flexible pipe or elastic hose. That is as separate component with one end stuck in the body 5 inserted and forms the outlet 8 at the other end the embodiments according to Figures 2 to 4, 7 and 8, 9th can the medium instead of atomized as a drop or bundled Beam are discharged from the outlet 8.
- Fig. 9 shows the oblong to the axis 10 elongated shape of the handle 7 or of the body 5.
- a rod or mandrel-shaped Link 58 On the piston 17 a rod or mandrel-shaped Link 58. It limits the chamber 17 on its entire Length permanently ring-shaped in the core, passes through the pistons 16, 17 and the body 4 and the plunger 42 axially displaceable and is guided in the piston 16, 17 sealed.
- the thorn 58 could also protrude freely in the direction of flow Form opening member 21 with its end, which may already be at the stroke 49 the shutter 20 opens. Link 21 could then form the counter member 47.
- the mandrel 58 could also be axial fixed or in one piece with one of the pistons 16 to 18 be formed or a valve member as a closure 20th provided slide valve form, the valve seat on Piston 17 is provided.
- the opening member 21 formed by a hollow needle made of metal such as stainless steel which, when the medium passes from the chamber 11 to the chamber 12 forms the only passage. He follows the transfer in the opposite direction 56 from the chamber 12 into the Chamber 11, this opening member on the body 5 or Plug 19 may be provided and after the decanting Pierce closures 20 in both displaceable pistons 18, 17, until it is directly connected to the chamber 11 is. During the stroke against direction 56, the piston 18 would Take piston 17 with you and thereby a bypass or a slide valve opened, which the two chambers 11, 12 with each other connected along the inner circumference of section 14 and can be closed again via the discharge stroke.
- the body 9 is useful with the Body 4 relative to the body 5 and the pistons 18, 17 are by stop on the body 5 over the transfer stroke or the discharge stroke.
- the piston 16 can then a fixed against the jacket 14 bottom wall as Chamber limitation can be provided, which is in one piece with the Sheath 14 is formed.
- each closure 20, 25 is as Slider valve designed. Whose are both valve bodies on the one hand by the body 9, 17 and on the other hand by the Body 9, 18, 32 formed.
- the valve 20 has on the inner circumference between sections 14, 15 depressions and / or projections 67 on. They are evenly distributed around axis 10 and are at an angle to it in the same direction. Their height or depth is less than one or half Millimeter. They delimit connecting channels between the chambers 11, 12, the same length greater than the sealing effective length of the valve spool 17. In the starting position the plunger 42 is already on the piston 16.
- the two pistons 16, 17 synchronously by one Piston length shifted until the upstream sealing lip 21st according to the dash-dotted position the upstream Has overflowed ends of the transfer channels.
- the downstream one Lip 23 has the downstream ends of these channels not reached yet.
- the grooves 67 are from the chamber 11 to the chamber 12 between the outer circumference of the piston 17 and the inner circumference of the body 9 open.
- the valve channels 67 form nozzles which the liquid swirls about the axis 10 into the chamber 12 inject so that the on the upper end face 24 of the Piston 17 lying powder of the liquid is mixed.
- the piston 17 When decanting, the piston 17 remains in the opposite direction Piston 18 displaceable in the direction stationary, so that the pressure in the chamber 12 is increased.
- the piston 18 is thereby by correspondingly high friction or a spring yielding rest against the body 9 secured stationary.
- the piston 16 takes the piston 17 in Direction 56 with.
- the chamber 12 is reduced in size the pressure increases until the holding force of the piston 18th is overcome.
- the piston 18 is thereby from its position securing releases and jumps suddenly along its length with enlargement of the chamber 12 in direction 56 in its End position, which is shown with a double-dash line.
- the shutter 20 While the shutter 20 is open, is the upstream end of the tube 9 sealed by the piston 16. If the piston 16 releases the channels 67 via the hub 51 or 55, i.e. the Closure 20 opens, the chamber 12 through the piston 17th closed again.
- the downstream end of the tube 9 is with a sealing member 19 closed.
- the link 19 lies on a ring shoulder End of the tube 9 and with an inner jacket 71 on the outer circumference of the tube 9 close.
- the jacket 71 is in one piece with formed the sheath 32 and protrudes freely against direction 56 in front.
- the piston 18 extends up to this Pipe end.
- the jacket 32 forms after this pipe end an equally wide continuation of the inner circumference of the tube 9. This sequel is as long as or longer than that Piston 18.
- the end position it strikes on the inside the end wall 69, which forms the nozzle channel of the opening 8 limited in one piece and formed in one piece with the jacket 32 is.
- the swirl channels 28 are provided since the piston 18 then the Core 26 forms.
- the continuation mentioned points to the inner circumference the outlet channels 27 as grooves.
- the lock 60 At the end of the stroke 50 and the transfer from the chamber 11 to Chamber 12 is the lock 60, possibly simultaneously with the Lock 31, effective and positively prevents the axial Lifting movement of the unit 2.
- the sleeve 43 has the downstream End a protruding radially over its outer circumference Stop or cam 62 on. He hits on you Counter stop 63 in the interior of the jacket 32 in a form-fitting manner.
- the stop 63 is through a rib 65 of the inner circumference of the Sheath 32 formed and with this about the axis 10 at least 45 °, 90 ° or 160 ° in relation to the stop 62 and the body 5 rotatable.
- the stop 62 could also be opposite the parts 5, 9, 29 can be rotated in this way.
- the coat 32 is rotatable about the axis 10 with a bearing 59.
- the warehouse 59 includes a protruding from the wall 33 in the direction 56 Sleeve 61, on the outer circumference of the jacket 32 and on the Inner circumference of the cam 62 slides.
- the sleeve 61 forms a Continuation of the sleeve 36 with the same inner and outer diameter. Its downstream end is in direction 56 above the Stop 63 extends and points for its inclusion an opening or slot 64.
- the upstream end of the jacket 62 is immediate adjacent to the sleeve 61 in slot segments of the wall 33 rotatably mounted and against the inside with a Snap member 35 secured against axial pulling.
- this said rotation step strikes the link 65 on a side flank the opening 64, so that in the axial movement of the Stop 62 is a stop 66, which is opposite Stop 63 offset in the direction 56 by the strokes 51, 55 and also by a rib on the inner circumference of the jacket 32 is formed.
- the stop 62 is from the stop 63 free, so that the contents of the chamber 12 are compressed via the stroke 51, at the end of this stroke 51 the piston 18 in its end position transferred and then in one go via the hub 55 Chamber 12 can be completely emptied.
- the piston 18 until it stops at the Wall 69 moves faster than the liquid through the channels 27 flows to wall 69 or to the nozzle channel.
- the passage cross sections Capillary channels are the same. This is with the start of the discharge from the outlet 8 through the swirl device 28 a finest atomization guaranteed. It is supported by the before, with and / or after the medium through the outlet 8 escaping air, which is stored in the chamber 12. With the meeting of the stops 62, 63 also meet Stops 39, 41 on top of each other. So is for the beginning of the stroke 51, 55 the high force required.
- the inner jacket 71 is narrower than the inner circumference of the tube 9 so that it can protrude into this.
- the adjoining ends of the tube 9 and the jacket 71st are closed with a piston-like, stationary plug 19, which also forms the nozzle core 26 in one piece and is inserted in the body 5 in the direction 56.
- This plug 19 is permanently connected to the channel 72, 73 Chamber 13 connected, namely with an axial channel 72, whose downstream end merges into a transverse channel 73. Its outer end connects to the outer circumference of the core 26 the upstream end of the channel 27, namely via a Exhaust control 70, like a valve.
- Both closures 20, 25 are here by separate slide valves formed, which separate overflow channels 67, 68 on Inner circumference of the tube 9 are assigned.
- the closure 25th opened and the medium can over the control openings 68 Cross channels flow into channel 72 provided the valve 70 is open.
- This training is particularly suitable high discharge pressures.
- Chamber 12 Before emptying the chamber 12 in the Channel 72 is closed by the open closure 25 Chamber 12 the compressed contents of chamber 13 through carried the channel 72. If this content is air, it is stimulated these immediately afterwards with the mixed Medium to be treated in the patient's mucous membranes.
- the walls 33, 34 form an in Axial view of oval cap.
- the body 5 has no direction 56 opposite the jacket 34 above components.
- the jacket 34 surrounds in Starting position, the locking member 39 and has on its long sides mutually opposite cutouts 74 to reach to the free end of the jacket 34 and from the wall 33 have a distance as large as or larger than that Length of the jacket is 36.
- the handle 6 after the stroke 49 already within the jacket 34 and according 12 the handle 6 reaches the inside of the jacket 34 only during the transfer stroke, during the compression stroke for the chamber 12 or during the compression stroke for the Chamber 13.
- the downstream end of the tube 9 has according to Fig.
- the swirl device 28 is here through depressions formed on the inside of the end wall 69.
- a powder is provided as the medium, this is expedient by freeze drying initially as granular, free-flowing Substance that is subsequently mechanically in finer particles is broken up. In any case, it results a very large surface area that allows quick release in Fluid guaranteed.
- the amount of powder can be a maximum of 5, 2 or 1 mg.
- After partial emptying of chamber 12 can yet another lock 31 take effect, for example the same upstream from member 39 Blocking member of the body 4. This can, especially after Vent the chamber 12, a first part, like a first Half of the non-gaseous content of the chamber 12 in one Nasal opening. At the end of this contract said second lock effective so that the rest of the part this content of the chamber 12 after overcoming this second Lock can be delivered into the second nostril.
- the Empty and filling volume of the chamber 11 is expedient at least 50 or 100 and at most 300 or 200 ⁇ l, in particular between 120 and 150 ⁇ l.
- the empty volume of the chamber In contrast, 12 is at least three or four times larger.
- the piston 16 to 18 and possibly except the closure 20 and the Bellows 14 according to FIG. 1 are all other components of the dispenser 1 inherently or dimensionally stable.
- Figures 10 to 12 are the Pistons 16 to 18 the same and designed as a full body, from which each have several, e.g. three, in the axial direction at a distance has dense projections or beads lying apart. These are ring-shaped around the axis 10 above the piston body before and are in line with the inner circumference of the tube 9.
- Each piston 16 to 18 is opposite the center of its length symmetrical and can therefore be twisted by 180 ° acting in the same way through both ends in the tube 9 be what the automatic or mechanical assembly much easier.
- the bodies 4, 5 can also be in one piece be trained together. You are then at lock 30 connected to each other via a predetermined breaking point, e.g. if the body 4 through longitudinal slots in the body 9 the piston 16 entrains the bottom 44 of an insertion opening for the pre-assembled unit 9, 16, 17, 18 is interspersed and the Handle 6 is laterally outside of this insertion opening.
- a predetermined breaking point e.g. if the body 4 through longitudinal slots in the body 9 the piston 16 entrains the bottom 44 of an insertion opening for the pre-assembled unit 9, 16, 17, 18 is interspersed and the Handle 6 is laterally outside of this insertion opening.
- the bellows 14 according to FIG. 1 be trained according to one of these documents.
- the Chamber 12 can correspond to the chamber 11 by such Bellow be limited.
- the body 9 or everyone of the coats 14, 15 in one piece with the plug 19 or with the Body 5 or in the case of the reverse transfer direction described be formed in one piece with the body 4.
- the length of the dispenser 1 between each other turned ends of the body 4, 5 can be less than 15 cm, 10 cm, 8 cm or 6 cm. Its greatest extent across in contrast to axis 10 is smaller, namely smaller than 10 cm, 5 cm or 3 cm. Over this length, the tube 29th protrude according to Figures 7 and 8. The proportions shown are particularly useful.
Landscapes
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Claims (16)
- Distributeur pour matières, avec un actionnement de décharge, qui comprend deux unités (2, 3) première et deuxième avec des corps de base (4, 5) premiers et deuxièmes, unités qui peuvent être transportées sur une voie de course (de 49 à 52) avec course de service ainsi que dans une direction de course dans différentes positions de service, telles qu'une position initiale (49), dans des positions intermédiaires (50, 51) et dans une position terminale (52), avec des espaces à matières, qui comprennent des chambres (11, 12, 13) avec une chambre à réservoir (11) ainsi qu'un conduit de sortie (27) et une sortie de matières (8), avec des délimitations de chambre (14, 16, 17) délimitant la chambre à réservoir (11) et un moyen de fermeture (20) obturant au moins dans une des positions de service la chambre à réservoir (11), la chambre à réservoir (11) pouvant être raccordée dans une première position de service (50) sous l'effet de l'ouverture du moyen de fermeture (20) par l'actionnement d'une première manette (6) à une chambre de remplissage (12), laquelle peut être agrandie dans son volume dans des deuxièmes positions de service (51) suivantes par la matière qui s'écoule dans celle-ci à partir de la chambre à réservoir (11) ou similaires et laquelle peut être vidée seulement dans des troisièmes positions de service (52) par la sortie de matière (8), caractérisé en ce que une deuxième manette (7) est prévue, laquelle s'approche de la première manette (6) pendant la course de service.
- Distributeur d'après la revendication 1, caractérisé en ce que la chambre de remplissage (12) est fermée par une fermeture de sortie (25) pouvant être ouverte seulement après le transvasement essentiellement complet de la matière à partir de la chambre à réservoir (11), en ce que notamment la chambre de remplissage (12) peut être diminuée dans son volume avant et/ou après l'évacuation de la pression de matière dans la chambre à réservoir (11), et en ce que de préférence les délimitations de chambre comprennent une paroi de séparation (17) délimitant la chambre de remplissage (12) ainsi qu'une paroi coulissante (16) mobile par rapport à celle-ci, laquelle constitue un élément d'actionnement pour le rapetissement et/ou l'agrandissement de la chambre de remplissage (12).
- Distributeur d'après la revendication 1 ou 2, caractérisé en ce que la chambre de remplissage (12) peut être rapetissée contre une force de ressort, en ce que notamment dans la chambre de remplissage (12) sont disposés des moyens à ressort et en ce que de préférence les moyens à ressort comprennent un fluide compressible.
- Distributeur d'après une des revendications précédentes, caractérisé en ce que la chambre à réservoir (11) se trouve en amont par rapport à la chambre de remplissage (12), en ce que notamment les chambres (11, 12, 13) sont délimitées à la circonférence par une enveloppe (9) commune et en ce que de préférence le moyen de fermeture (20) sépare directement les deux chambres (11, 12) entre elles.
- Distributeur d'après une des revendications précédentes, caractérisé en ce que le moyen de fermeture (20) est associé à un coulisseau (17), en ce que notamment le coulisseau (17) est logé de manière coulissante avec des surfaces d'étanchement (22, 23) auprès de la deuxième unité (3) et en ce que de préférence le moyen de fermeture (20) est un élément de fermeture présentant des surfaces de glissement (22, 23) du coulisseau (17) et ouvrant en dépendance de la voie de course (50).
- Distributeur d'après une des revendications précédentes, caractérisé en ce que pour l'ouverture du moyen de fermeture (20) est prévu un élément d'ouverture (16, 21, 42) s'engageant mécaniquement auprès de celui-ci, en ce que notamment l'élément d'ouverture (21) comprend un mandrin de poussée (16, 42) et en ce que de préférence le moyen d'ouverture (21) saille dans la chambre de remplissage (12) contre le sens d'écoulement (56).
- Distributeur d'après une des revendications précédentes, caractérisé en ce que le moyen de fermeture (20) comprend un piston différentiel (17), en ce que notamment le piston différentiel (17) coulisse avec une première lèvre de piston (22) à une surface circonférencielle plus étroite et avec une deuxième lèvre de piston (23) à une autre surface circonférencielle intérieure et en ce que de préférence les chambres (de 11 à 13) sont délimitées par une forure à gradins, dont la section de forure plus étroite délimite la chambre à réservoir (11) et dont une autre section de forure délimite la chambre de remplissage (12).
- Distributeur d'après une des revendications précédentes, caractérisé en ce qu'au moins une des chambres (de 11 à 13) est délimitée par un tuyau (9), en ce que notamment le tuyau (9) est obturé à son extrémité située en aval par un bouchon (19) délimitant le conduit de sortie (27) et/ou par la fermeture de sortie (25) de la deuxième unité (3) et en ce que de préférence l'extrémité située en amont du tuyau (9) est obturée par un piston d'actionnement (16) déplaçable.
- Distributeur d'après une des revendications précédentes, caractérisé en ce qu'à proximité immédiate de la chambre de remplissage (12) et qu'en face de la chambre à réservoir (11) est prévue une pièce d'insertion (18) délimitant le conduit de sortie (27), en ce que notamment la pièce d'insertion (18) forme un élément de d'obturation de sortie d'une soupape de sortie (25) ouvrant en dépendance de la pression et/ou un élément d'ouverture (21) pour le moyen de fermeture de réservoir (20) et en ce que de préférence la pièce d'insertion (18) est disposée de manière mobile sur la deuxième unité (3).
- Distributeur d'après une des revendications précédentes, caractérisé en ce qu'un moyen de fermeture (20, 25) est réalisé en tant que soupape à coulisse, en ce que notamment un corps de soupape de la soupape à coulisse (20, 25) est formé au moyen des délimitations de chambre adjacentes à deux chambres (11, 12 ou encore 12, 13) limitrophes en tant que pistons (17, 18) et en ce que de préférence la délimitation de chambre en amont de la chambre (11) en amont forme un piston-tiroir (16, 17), lequel ferme et ouvre le moyen de fermeture (20, 25) en alternance avec le piston (17, 18).
- Distributeur d'après une des revendications précédentes, caractérisé en ce que la première unité (2) présente pour un rapetissement de la chambre à réservoir (11) un entraíneur (42) joint à une première manette (6), pour une des délimitations de chambre (16), en ce que notamment l'entraíneur (42) comprend un élément d'entraínement saillant librement contre la délimitation de chambre (16) en direction de l'écoulement (56) et en ce que de préférence un élément de protection (43) est prévu entourant au moins une des délimitations de chambre (14, 16) par l'extérieur.
- Distributeur d'après une des revendications précédentes, caractérisé en ce que l'actionnement de décharge est assuré entre la première et la deuxième position de service au moyen d'un moyen de blocage (31) déclenchant subitement sous une force d'actionnement plus élevée et restant déclenché sur la voie de course suivante, en ce que notamment le moyen de blocage (31) comprend un élément d'arrêt (39) assurant entre eux les corps de base (4, 5) à la fin du rapetissement de la chambre à réservoir (11) et en ce que de préférence l'élément d'arrêt (39) est raccordé d'une seule pièce à un des corps de base (4, 5) au moyen d'une zone de rupture (40).
- Distributeur d'après une des revendications précédentes, caractérisé en ce qu'un moyen de blocage de la décharge (60) est prévu pour le blocage du transfert du moyen d'actionnement de décharge de la deuxième position de service dans la troisième, en ce que notamment le moyen de blocage de la décharge peut être déclenché à engagement positif et uniquement par une action de déclenchement qui diffère dans sa direction de la direction d'actionnement de l'action de décharge, et en ce que de préférence l'action de déclenchement est un mouvement rotatif.
- Distributeur d'après la revendication 13, caractérisé en ce que le moyen de blocage de la décharge (60) comprend une soupape de sortie (70), en ce que notamment la soupape de sortie (70) comprend à la deuxième unité (3) un premier corps de soupape (71) et un deuxième corps de soupape (19, 26) pouvant être actionné manuellement par rapport à celui-ci, et en ce que de préférence l'un des corps de soupape forme un noyau de gicleur (26) d'un gicleur de pulvérisation.
- Distributeur d'après la revendication 13 ou 14, caractérisé en ce que le moyen de blocage de la décharge (60) comprend un arrêt pour le moyen d'actionnement de décharge, en ce que notamment l'arrêt comprend un élément d'arrêt (62) à la circonférence extérieure de la première unité (2) et un contre-arrêt (63) à l'intérieur de la deuxième unité (3), et en ce que de préférence par l'action de déclenchement du moyen de blocage de la décharge (60) la sortie des matières (8) est mobile au moins par rapport à un des corps de base (4, 5).
- Distributeur d'après une des revendications précédentes, caractérisé en ce que les matières comprennent en position initiale des matières individuelles cloisonnées de manière étanche les unes par rapport aux autres avec une matière primaire non gazéiforme dans la chambre à réservoir et au moins une matière secondaire dans la chambre de remplissage (12), en ce que notamment la matière secondaire n'est pas gazéiforme au moins en partie, tel que lyophilisée en forme poudreuse et en ce que de préférence la matière secondaire non gazéiforme remplit seulement en partie la chambre de remplissage (12) en position initiale.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19749514 | 1997-11-08 | ||
DE19749513 | 1997-11-08 | ||
DE19749514A DE19749514A1 (de) | 1997-11-08 | 1997-11-08 | Verfahren zum Ausbringen von wenigstens zwei verschiedenen Medien und Spender dafür |
DE19749513 | 1997-11-08 | ||
DE19837127 | 1998-08-17 | ||
DE19837127A DE19837127A1 (de) | 1997-11-08 | 1998-08-17 | Spender für Medien |
PCT/EP1998/006711 WO1999024170A1 (fr) | 1997-11-08 | 1998-10-22 | Distributeur pour plusieurs milieux melanges avant decharge |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1027166A1 EP1027166A1 (fr) | 2000-08-16 |
EP1027166B1 true EP1027166B1 (fr) | 2002-07-10 |
Family
ID=27217911
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02027186A Expired - Lifetime EP1297898B1 (fr) | 1997-11-08 | 1998-10-22 | Distributeur avec aiguille perforante pour matériaux à mélanger pendant la distribution |
EP98965137A Expired - Lifetime EP1027166B1 (fr) | 1997-11-08 | 1998-10-22 | Distributeur pour plusieurs milieux melanges avant decharge |
EP98952735A Expired - Lifetime EP1027165B1 (fr) | 1997-11-08 | 1998-10-22 | Procede permettant de distribuer au moins deux produits differents et distributeur a cet effet |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02027186A Expired - Lifetime EP1297898B1 (fr) | 1997-11-08 | 1998-10-22 | Distributeur avec aiguille perforante pour matériaux à mélanger pendant la distribution |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98952735A Expired - Lifetime EP1027165B1 (fr) | 1997-11-08 | 1998-10-22 | Procede permettant de distribuer au moins deux produits differents et distributeur a cet effet |
Country Status (9)
Country | Link |
---|---|
US (1) | US6626379B1 (fr) |
EP (3) | EP1297898B1 (fr) |
JP (2) | JP4411374B2 (fr) |
AU (2) | AU1031699A (fr) |
CA (1) | CA2307160C (fr) |
DE (5) | DE19749514A1 (fr) |
DK (2) | DK1027165T3 (fr) |
ES (2) | ES2194360T3 (fr) |
WO (2) | WO1999024171A2 (fr) |
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-
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-
1998
- 1998-08-17 DE DE19837127A patent/DE19837127A1/de not_active Withdrawn
- 1998-10-22 EP EP02027186A patent/EP1297898B1/fr not_active Expired - Lifetime
- 1998-10-22 ES ES98952735T patent/ES2194360T3/es not_active Expired - Lifetime
- 1998-10-22 AU AU10316/99A patent/AU1031699A/en not_active Abandoned
- 1998-10-22 WO PCT/EP1998/006712 patent/WO1999024171A2/fr active IP Right Grant
- 1998-10-22 DE DE59811482T patent/DE59811482D1/de not_active Expired - Lifetime
- 1998-10-22 EP EP98965137A patent/EP1027166B1/fr not_active Expired - Lifetime
- 1998-10-22 JP JP2000520242A patent/JP4411374B2/ja not_active Expired - Fee Related
- 1998-10-22 DE DE59807579T patent/DE59807579D1/de not_active Expired - Lifetime
- 1998-10-22 ES ES02027186T patent/ES2222430T3/es not_active Expired - Lifetime
- 1998-10-22 US US09/554,031 patent/US6626379B1/en not_active Expired - Fee Related
- 1998-10-22 DK DK98952735T patent/DK1027165T3/da active
- 1998-10-22 AU AU20475/99A patent/AU2047599A/en not_active Abandoned
- 1998-10-22 DK DK02027186T patent/DK1297898T3/da active
- 1998-10-22 DE DE59804744T patent/DE59804744D1/de not_active Expired - Lifetime
- 1998-10-22 CA CA002307160A patent/CA2307160C/fr not_active Expired - Fee Related
- 1998-10-22 WO PCT/EP1998/006711 patent/WO1999024170A1/fr active IP Right Grant
- 1998-10-22 EP EP98952735A patent/EP1027165B1/fr not_active Expired - Lifetime
-
2005
- 2005-10-18 JP JP2005302445A patent/JP4789089B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2006081917A (ja) | 2006-03-30 |
DK1027165T3 (da) | 2003-07-21 |
WO1999024170A1 (fr) | 1999-05-20 |
DE59804744D1 (de) | 2002-08-14 |
DE19749514A1 (de) | 1999-05-12 |
US6626379B1 (en) | 2003-09-30 |
AU2047599A (en) | 1999-05-31 |
EP1027166A1 (fr) | 2000-08-16 |
AU1031699A (en) | 1999-05-31 |
ES2222430T3 (es) | 2005-02-01 |
EP1027165A2 (fr) | 2000-08-16 |
JP4411374B2 (ja) | 2010-02-10 |
JP2001522717A (ja) | 2001-11-20 |
DK1297898T3 (da) | 2004-10-04 |
EP1297898A2 (fr) | 2003-04-02 |
WO1999024171A2 (fr) | 1999-05-20 |
WO1999024171A3 (fr) | 1999-07-15 |
DE19837127A1 (de) | 1999-05-12 |
DE59811482D1 (de) | 2004-07-01 |
CA2307160C (fr) | 2009-05-05 |
ES2194360T3 (es) | 2003-11-16 |
EP1297898B1 (fr) | 2004-05-26 |
DE59807579D1 (de) | 2003-04-24 |
JP4789089B2 (ja) | 2011-10-05 |
EP1027165B1 (fr) | 2003-03-19 |
CA2307160A1 (fr) | 1999-05-20 |
EP1297898A3 (fr) | 2003-04-09 |
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