EP1290988B1 - Implant delivery assembly with expandable coupling/decoupling mechanism - Google Patents

Implant delivery assembly with expandable coupling/decoupling mechanism Download PDF

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Publication number
EP1290988B1
EP1290988B1 EP02027844A EP02027844A EP1290988B1 EP 1290988 B1 EP1290988 B1 EP 1290988B1 EP 02027844 A EP02027844 A EP 02027844A EP 02027844 A EP02027844 A EP 02027844A EP 1290988 B1 EP1290988 B1 EP 1290988B1
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EP
European Patent Office
Prior art keywords
catheter
coil
assembly
implant
pusher
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP02027844A
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German (de)
English (en)
French (fr)
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EP1290988A1 (en
Inventor
Ivan Sepetka
U Hiram Chee
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Boston Scientific Ltd Barbados
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Boston Scientific Ltd Barbados
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Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Priority to EP05004642A priority Critical patent/EP1537838B1/en
Publication of EP1290988A1 publication Critical patent/EP1290988A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214—Coils or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12068—Details concerning the detachment of the occluding device from the introduction device detachable by heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12081—Details concerning the detachment of the occluding device from the introduction device detachable by inflation

Definitions

  • the present invention generally relates to surgical instruments. More particularly, the invention relates to delivery assemblies for delivering an occlusive device, such as an embolic coil, to a selected site within a mammal using an expandable coupling or decoupling mechanism.
  • an occlusive device such as an embolic coil
  • the coils normally are made of a radiopaque, biocompatible metal such as platinum, gold, tungsten or alloys of these and other metals. In treating aneurysms, it is common to place a number of coils within the aneurysm. The coils occlude the site by posing a physical barrier to blood flow and by promoting thrombus formation at the site.
  • Coils have typically been placed at the desired site within the vasculature using a catheter and a pusher.
  • the site is first accessed by the catheter.
  • the sites are accessed with flexible, small diameter catheters such as those shown in U.S. Patent Nos. 4,739,768 and 4,813,934.
  • the catheter may be guided to the site through the use of guidewires (see U.S. Patent No. 4,884,579) or by flow-directed means such as balloons placed at the distal end of the catheter.
  • Use of guidewires involves the placement of relatively long, torqueable proximal wire sections within the catheter attached to more flexible distal end wire sections designed to be advanced across sharp bends at vessel junctions.
  • the guidewire is visible using x-ray techniques and allows a catheter to be navigated through extremely tortuous vessels, even those surrounded by soft tissue such as the brain.
  • the catheter lumen is cleared by removing the guidewire (if a guidewire has been used), and one or more coils are placed into the proximal open end of the catheter and advanced through the catheter with a pusher.
  • Pushers are wires having distal ends adapted to engage and push the coil through the catheter lumen as a pusher itself is advanced through the catheter.
  • the coil reaches the distal end of the catheter, it is discharged from the catheter by the pusher into the vascular site.
  • the plunging action of the pusher and the coil can make it difficult to position the coil at the site in a controlled manner and with a fine degree of accuracy. Inaccurate placement of the coil can be problematic because once the coil has left the catheter, it is difficult to reposition or retrieve the coil.
  • Interlocking Detachable Coils which incorporate mechanical release mechanisms and Guglielmi Detachable Coils (GDCs), which utilize electrolytically actuated release mechanisms, have been developed to enable more accurate placement of coils within a vessel.
  • U.S. Patent No. 5,261,916 One technique for detaching an embolic coil is shown in U.S. Patent No. 5,261,916. According to that technique, a coil having an enlarged portion is mated with a pusher having a keyway adapted to receive the enlarged portion of the coil in an interlocking relationship. The joint between the pusher and the coil is covered by a coaxial member. The coaxial member is movable by sliding the member axially. As the coaxial member is moved away from the junction where the coil's member engages the keyway of the pusher, the coil is freed from the catheter assembly and the pusher may then be removed.
  • FIG. 5 Another IDC device for placement of coils is shown in U.S. Patent No. 5,234,437.
  • This device includes a coil having a helical portion at least one end and a pusher wire having a distal end that is threaded inside on the helical coil by use of a threaded section on the outside of the pusher.
  • the device operates by engaging the proximal end of the coil with a sleeve and unthreading the pusher from the coil. Once the pusher is free, the sleeve may be used to push the coil out into the targeted treatment area.
  • U.S. Patent No. 5,312,415 discloses the use of a catheter having a constricted or feathered end to retain a number of embolic coils on a guidewire for precise placement using a pusher sheath.
  • Electrolytic coil detachment is disclosed in U.S. Patent Nos. 5,122,136 and 5,354,295. As disclosed in U.S. Patent No. 5,122,136, the coil is bonded via a metal-to-metal joint to the distal end of the pusher.
  • the pusher and coil are made of dissimilar metals.
  • the coil-carrying pusher is advanced through the catheter to the site and a small electrical current is passed through the pusher-coil assembly. The current causes the joint between the pusher and the coil to be severed via electrolysis.
  • the pusher may then be retracted leaving the detached coil at an exact position within the vessel. Since no significant mechanical force is applied to the coil during electrolytic detachment, highly accurate coil placement is readily achieved.
  • the electric current may facilitate thrombus formation at the coil site.
  • the only perceived disadvantage of this method is that the electrolytic release of the coil may require a period of time that may inhibit rapid detachment of the coil from the pusher.
  • US-A-5 167 624 discloses a method and apparatus for passing an embolus into and through the lumen of a catheter to reach a destination in a blood vessel or the like.
  • the embolus takes the form of a coiled spring which is uncoiled prior to being inserted in the lumen of the catheter.
  • the coil is a pusher coil and is retained temporarily in a fixed position in the lumen by frictional engagement of the coil spring against the interior wall defining the lumen.
  • a stream of pressurized fluid is injected into the proximal end of the catheter lumen.
  • FR-A-2 696 636 discloses an arrangement in which a pusher coil is capable of being displaced from the distal tip of a catheter.
  • US-A-4 327 734 discloses an arrangement in which a balloon catheter is in communication with a source of fluid.
  • the balloon is detachable from a cannula as a result of being inflated through the introduction of fluid along the cannula.
  • the mouth of the inflated balloon is expandable and is arranged to self-seal, containing the fluid from the fluid source used to expand the balloon, thereby to maintain the detached balloon in its inflated condition for an extended period of time so as to create a vessel occlusion.
  • an occlusive implant delivery assembly for occluding a site in a mammal, as defined in cl. 1.
  • a catheter apparatus comprising the occlusive implant delivery assembly of the above first aspect of the present invention, a catheter and a syringe, the delivery assembly being arranged to be received in the catheter and the syringe being arranged to be coupled to the lumen of the elongated carrier member for use in increasing the hydraulic pressure within the lumen.
  • occlusive implant delivery assembly provides for a rapid response decoupling or detachment mechanism that does not effect significant migration of the implant during release.
  • the assembly includes an occlusive implant device, such as an embolic coil, a pusher or device to carry the implant to the selected location, and an expandable mechanism that is expanded or contracted to release the implant at the selected site.
  • the invention advantageously incorporates a release mechanism that simply involves unloading a locking force, which is preferably uniformly applied, thereby avoiding the transmission of any significant force to the implant during release.
  • the locking members preferably have generally, smooth, rounded configurations so that they do not catch and dislodge previously positioned coils upon retraction.
  • the occlusive implant delivery assembly includes an occlusive implant; a pusher having a proximal section and a distal section; a coupling having first and second portions, the first portion being coupled to the distal section of the pusher and the second portion being coupled to the implant; and an inflatable member having a proximal portion and a distal portion, the proximal portion being coupled to the distal section of the pusher. At least a portion of the inflatable member is disposed in the coupling such that when inflated, it expands the coupling and decouples the coupling from either the implant or the pusher.
  • the inflatable member and coupling are configured so that the hydraulic pressure generated by the inflatable member is applied uniformly to the inner circumferential surface of the coupling.
  • any force that may be applied to the implant in the radial direction is countered by an equal, but opposite force, thereby avoiding implant displacement during release.
  • the coupling is cylindrical with an essentially uniform radius and the inflatable member is essentially symmetrical about its longitudinal axis in the inflated and uninflated states.
  • the implant delivery assembly comprises an occlusive implant having a tubular portion; a pusher having a proximal section and a distal section; and an inflatable member having a first portion coupled to the distal section of the pusher and a second portion disposed in the tubular portion of the implant such that upon inflation of the inflatable member the implant and member tend to separate. More specifically, the coil slides off of the inflatable member.
  • this construction provides an advantageously simple one-piece decoupling mechanism, which can be readily manufactured.
  • the inflatable member and tubular portion also are configured as described above so that the hydraulic pressure generated by the inflatable member is applied uniformly to the inner circumferential surface of the tubular portion.
  • the inner surface of the tubular portion is essentially symmetrical about its longitudinal axis and the inflatable member is essentially symmetrical about its longitudinal axis when inflated or deflated to provide an essentially uniformly distributed force to the inner circumference of the tubular section.
  • an occlusive implant delivery assembly employs an expandable mechanism, which is expanded or contracted, to decouple and release the implant at the desired site.
  • an embolic coil type implant will be described for purposes of example.
  • the operation of the assembly generally comprises the steps of (1) advancing a catheter through a vessel lumen, for example, to the vicinity of the site to be occluded (e.g., an aneurysm, vascular malformation, or arterial venous fistula), (2) advancing the implant delivery assembly through and beyond the catheter to the location, and (3) radially expanding or contracting the release mechanism to detach the implant from the assembly.
  • a vessel lumen for example, to the vicinity of the site to be occluded (e.g., an aneurysm, vascular malformation, or arterial venous fistula)
  • the implant delivery assembly through and beyond the catheter to the location
  • radially expanding or contracting the release mechanism to detach the implant from the assembly.
  • Catheter apparatus 2 suitable for guiding the occlusive implant delivery assembly and providing actuation pressure for the hydraulically actuated release mechanism embodiments is shown.
  • Catheter apparatus 2 generally includes a catheter 4, syringe 6 and sidearms (adapters) 8A and 8B.
  • Catheter 4 generally comprises an elongate tubular member having proximal and distal end portions 10 and 12.
  • the catheter is preferably between about 50-300 cm in length, and typically between about 60-200 cm in length.
  • the catheter also is designed for accessing a vessel site at which, for example, vasoocclusion is desired.
  • the vessel site may be within a small diameter vessel having 2-5 mm lumen diameter and accessible by way of a tortuous vessel path which may involve sharp vessel turns and multiple vessel branches.
  • the catheter preferably has a small diameter, flexible construction with a lumen diameter of less than about 1 mm (40 mil), and preferably between about 0.2 - 0.76 mm (8-30 mil). Catheters of this type, which are typically used for accessing deep brain vascular sites, are commercially available.
  • the elongated tubular member or catheter 4 is secured at its proximal end 10 to sidearm 8A, which is of conventional design for introducing fluids or apparatus into the catheter.
  • Sidearm 8B which is otherwise essentially similar in construction to sidearm 8A, can include a tubular extension 14 that surrounds a portion of the pusher as shown in FIG. 1.
  • Mandrel 54, 56 or 68 which extends through the pusher, as will be discussed below in connection with FIGS. 9-15, extends through one tube of sidearm 8B.
  • the discharge tip of syringe 6, which is used in conjunction with the embodiments shown in FIGS. 2-11 is fluidly coupled to the other tube of sidearm 8B and, thus, the inner lumen of pusher 26 through which the aforementioned mandrels extend.
  • Syringe 6 is of conventional construction and includes a cylindrical barrel 18 and a plunger 20 that is reciprocally mounted therein.
  • a stopcock 22 preferably is provided in the discharge piece of the syringe for opening or closing the fluid connection between the syringe and pusher lumen.
  • the stopcock can be provided in a connector (not shown) that couples the discharge piece of the syringe to sidearm 8B.
  • Occlusive implant delivery assembly 24 generally comprises a pusher or elongated carrier member 26, a coil type occlusive implant 28 and a decoupling or release mechanism for releasing the implant from the assembly.
  • coil 28 is shown in the drawings as a uniform diameter helical coil wire, it may have other configurations. It is important, however, that the coil be dimensioned to be able to be advanced through a catheter that is sized to access the desired site.
  • the coil may be made of radiopaque, biocompatible metal such as platinum, gold, tungsten, stainless steel or alloys of these metals.
  • the coil comprises platinum, gold, tungsten or alloys of these metals so that its location at the site may be readily viewed radiographically.
  • the coils will typically be made of 0.05 to 0.15 mm diameter platinum wire that is wound to have an inner diameter of 0.15 to 0.96 mm with a minimum pitch (i.e., the windings are close or tight).
  • the length of the wound wire i.e., the coil
  • the coil will normally be in the range of 0.5 to 60 cm, and preferably 0.5 to 40 cm.
  • the coil has a preferred length of about 0.5 to 20 cm.
  • the coil can have any shape.
  • it can be formed so that it takes an essentially linear configuration in which it may be advanced through the catheter and assume a randomly oriented configuration, such as helical, after it is released from the catheter and in a relaxed state as disclosed in U.S. Patent No. 4,994,069, which is hereby incorporated herein by reference.
  • the delivery assembly shown in FIGS. 2-6 generally comprises a pusher or elongated carrier member 26, coil 28 and coupling 30.
  • the pusher has a tubular construction to provide a lumen for fluidly coupling a source of pressurized fluid, such as syringe 6, and an inflatable member utilized in decoupling the coil from the pusher, as will be described in more detail below.
  • Pusher 26 also preferably has a proximal section that is rigid enough to facilitate torque transmission to the distal portion of the pusher.
  • the distal section of the pusher may be constructed to be more flexible than the proximal portion to facilitate navigation of the distal section into very tiny vessels encountered in the brain, for example.
  • proximal tubular section of pusher 26 (designated with reference numeral 32) is a metal tube, preferably a stainless steel tube, and the distal section of pusher 26, section 34, comprises a coil 36, which is wrapped in a flexible, elastomeric film 38 to fluidly seal the spaces between the coil windings. Film 38 also overlaps section 34 to seal the juncture between section 34 an coil 36. Film 38 can be in the form of shrinkwrap and, thus, applied to coil 36 and proximal section 34 with conventional shrinkwrap techniques. Coil 36 and, thus, distal coiled section 34 is secured to the proximal tubular section 32 by welding, soldering, brazing, or adhesive.
  • the pusher comprises a rigid plastic tube which can be ground with a tapered distal section to achieve the desired flexibility.
  • Suitable materials for this configuration include PEEK and polyimide.
  • the inner diameter of the distal section in this configuration preferably is significantly less than the outer diameter of the proximal section to which the balloon can attached (e.g., glued).
  • the lumen which provides for fluid flow between the source of pressurized fluid and the balloon, has a diameter of about 0.178 mm (0.007 inch) throughout its length and the distal section has an outer diameter of about 0.356 mm (0.014 inch).
  • the outer diameter of the proximal section depends on the application.
  • the outer diameter of the proximal section may be about 0.41 to 0.46 mm (0.016 to 0.018 inch).
  • a conventional inflatable balloon 40 having a construction similar to those used in conventional balloon catheters, is secured to the distal end of coil 36 by adhesive, for example, such that a fluid tight path is formed between the interior of the balloon and the central lumen of pusher 26, which is formed by proximal and distal sections 32, 34 of pusher 26.
  • balloon 40 extends into tube 42, which is also secured to implant coil 28 by welding, soldering, brazing or adhesive.
  • coupling 30 comprises a tubular member or split tube having slots formed in the axial direction and which open into the end of the tube that is directly coupled to the distal portion of pusher coil 38.
  • the tube to pusher coupling can be accomplished by a pressure fit, welding, soldering, brazing or adhesive.
  • Slots 42 form multiple segments 44 in tubular coupling 30 and facilitate displacement of those segments to effect release of the coil implant from the pusher, as will be described in more detail below. Although a two slot configuration is shown, other multiples of slots can be used to facilitate displacement of the proximal portion of the coupling as well as other conventional jaw or latch clamping configurations.
  • Tubular coupling 30 can be made from platinum, stainless steel or plastic that is biocompatible with the environment in which the coupling will be placed.
  • the coupling 30 preferably also has a very thin wall of about 0.025 to 0.0076 mm (0.001 to 0.0003 inches).
  • FIGS. 2-6 The implant delivery assembly of FIGS. 2-6 will be further described by way of the following operative example which is provided merely for exemplary purposes and is not intended to limit the invention to a particular application.
  • catheter 4 may include a guidewire usable therewith to guide the distal end of the catheter toward the desired or selected occlusion site.
  • Guidewires of this type are commercially available, and generally include an elongate wire having a tapered, wire-wound distal end region which is adapted to be advanced through a tortuous vessel path, with the catheter being moved axially along the advanced guidewire.
  • the catheter is cleared. For example, if a guidewire has been used to position the catheter, it is withdrawn from within the catheter.
  • the implant delivery assembly as shown in FIG. 2, is introduced into the proximal end portion of catheter 4, and advanced toward the distal end portion of catheter 4.
  • the proximal end of pusher 26 is manipulated via sidearm 8B, to which it is attached, so that coupling 30 and coil implant 28 extend beyond the distal end of the catheter with coupling 30 free of the catheter and the coil positioned exactly at the desired site (FIG. 4).
  • Stopcock 22 is then placed in an open position and the plunger of syringe 6 advanced to inflate balloon 40 as shown in FIG. 5.
  • balloon 40 As balloon 40 is inflated, it further opens split tube or coupling 30, i.e., segments 44 are displaced radially outward to decouple coupling 30 and coil 28 from pusher 26 without transmitting any significant force to coil 28.
  • the balloon is then deflated by retracting the plunger in syringe 6, thereby releasing coupling 30 from balloon 40 so that the pusher can be retracted without altering the position of coil 28.
  • the catheter is withdrawn from the vessel.
  • coupling 30' has its proximal portion fixedly secured to the distal end of coiled portion 34.
  • coupling 30' includes end walls 48 at its distal end for overlapping end piece or cap 50 provided at the proximal end of coil implant 28'. That is the end walls, which generally form jaws, releasably secure coil 28' to coupling 30' and, thus, releasably secure coil 28' to pusher 26.
  • Coupling 30' also differs from coupling 30 in that slots 42' are formed in the distal portion of the coupling.
  • the release or decoupling mechanism simply comprises a balloon.
  • the balloon extends from the pusher with its proximal portion close fit within coil 28.
  • the balloon is inflated, and as the balloon expands, the coil slides off the end of the balloon as will be described in more detail below.
  • the decoupling mechanism of FIGS. 9-11 comprises a balloon 40' having its open end secured to the distal coiled section 34 of pusher 26, for example, by adhesive.
  • Balloon 40' is packed into the proximal portion of coil 28 such that the balloon frictionally engages the inner surface of coil 28 and secures the coil to the balloon.
  • the balloon is constructed such that, when in the deflated state, the balloon has a plurality of circumferentially extending ribs 52, which preferably are configured to have a pitch corresponding to that of the coil so that the ribs can snugly fit between the windings of the coil.
  • the ribs can be formed by placing a mandrel into the balloon, wrapping a thread around the balloon in the regions where the ribs are desired to be located, and then dipping the balloon, mandrel and thread assembly in a reservoir of elastomeric material, such as silicon, to form an outer ribbed elastomeric coating for the balloon.
  • elastomeric material such as silicon
  • the decoupling mechanism of the embodiment illustrated in FIGS. 9-11 also preferably includes a mandrel 54 which extends from outside sidearm 8B through catheter 12 via the interior lumen of pusher 26 and into balloon 40'.
  • Mandrel 54 facilitates inserting balloon 40' within coil 28 and preferably is sized to force the outer wall of the balloon against the inner circumferential surface of coil 28 to enhance the interlocking connection between the coil and balloon.
  • the pusher and the mandrel are advanced through catheter 4 until coil 28 is positioned at the desired location (FIG. 9).
  • the mandrel is then retracted or withdrawn from the balloon and the syringe actuated to inflate the balloon 40' as described above (FIG. 10).
  • mandrel 54 is sized so that when placed in the pusher lumen, sufficient space between the mandrel and the inner surface of the proximal and distal sections 32, 34 of pusher 26 is formed. In this manner, the interior of balloon 40' can be fluidly coupled to the syringe 6 when stopcock 22 is in the open position and the mandrel is in the pusher.
  • the balloon inflates and stretches, the ribs generally flatten and the proximal end of coil 28 slides off the distal end portion of balloon 40'.
  • the balloon can be retracted as it is inflated.
  • the end of the balloon can be positioned where the proximal end of the coil is desired to be finally located.
  • the proximal end of the coil will ultimately be located at the distal end of the balloon.
  • the balloon position can be determined by conventional means such as radiographic techniques.
  • the pusher can then be retracted as shown in FIG. 11 and the balloon deflated. The procedure is repeated if the delivery of additional coils is desired.
EP02027844A 1994-12-22 1995-12-19 Implant delivery assembly with expandable coupling/decoupling mechanism Expired - Lifetime EP1290988B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05004642A EP1537838B1 (en) 1994-12-22 1995-12-19 Implant delivery assembly with coupling/decoupling mechanism

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US363264 1994-12-22
US08/363,264 US5814062A (en) 1994-12-22 1994-12-22 Implant delivery assembly with expandable coupling/decoupling mechanism
EP95309242A EP0717969A3 (en) 1994-12-22 1995-12-19 Assembly for positioning an implant, with extensible coupling or decoupling mechanism

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP95309242A Division EP0717969A3 (en) 1994-12-22 1995-12-19 Assembly for positioning an implant, with extensible coupling or decoupling mechanism

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP05004642A Division EP1537838B1 (en) 1994-12-22 1995-12-19 Implant delivery assembly with coupling/decoupling mechanism

Publications (2)

Publication Number Publication Date
EP1290988A1 EP1290988A1 (en) 2003-03-12
EP1290988B1 true EP1290988B1 (en) 2005-03-16

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EP02027844A Expired - Lifetime EP1290988B1 (en) 1994-12-22 1995-12-19 Implant delivery assembly with expandable coupling/decoupling mechanism
EP95309242A Withdrawn EP0717969A3 (en) 1994-12-22 1995-12-19 Assembly for positioning an implant, with extensible coupling or decoupling mechanism
EP05004642A Expired - Lifetime EP1537838B1 (en) 1994-12-22 1995-12-19 Implant delivery assembly with coupling/decoupling mechanism

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EP95309242A Withdrawn EP0717969A3 (en) 1994-12-22 1995-12-19 Assembly for positioning an implant, with extensible coupling or decoupling mechanism
EP05004642A Expired - Lifetime EP1537838B1 (en) 1994-12-22 1995-12-19 Implant delivery assembly with coupling/decoupling mechanism

Country Status (9)

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US (4) US5814062A (ja)
EP (3) EP1290988B1 (ja)
JP (3) JP3228493B2 (ja)
AT (2) ATE437616T1 (ja)
AU (1) AU4056095A (ja)
CA (1) CA2165597C (ja)
DE (2) DE69535987D1 (ja)
ES (1) ES2236432T3 (ja)
IL (1) IL116413A0 (ja)

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EP1290988A1 (en) 2003-03-12
IL116413A0 (en) 1996-03-31
ATE437616T1 (de) 2009-08-15
JP2007260441A (ja) 2007-10-11
EP0717969A3 (en) 1996-11-27
EP0717969A2 (en) 1996-06-26
JP4063485B2 (ja) 2008-03-19
ES2236432T3 (es) 2005-07-16
JPH08238320A (ja) 1996-09-17
EP1537838A1 (en) 2005-06-08
JP2001095810A (ja) 2001-04-10
DE69534089T2 (de) 2006-04-06
JP3228493B2 (ja) 2001-11-12
US6849081B2 (en) 2005-02-01
ATE290834T1 (de) 2005-04-15
US6238415B1 (en) 2001-05-29
AU4056095A (en) 1996-06-27
CA2165597A1 (en) 1996-06-23
CA2165597C (en) 2000-07-18
DE69535987D1 (de) 2009-09-10
JP4441692B2 (ja) 2010-03-31
US20050154417A1 (en) 2005-07-14
US5814062A (en) 1998-09-29
DE69534089D1 (de) 2005-04-21
US20010002438A1 (en) 2001-05-31
EP1537838B1 (en) 2009-07-29

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