EG19750A - Process for preparing of triazole antifugal agents - Google Patents
Process for preparing of triazole antifugal agentsInfo
- Publication number
- EG19750A EG19750A EG6591A EG6591A EG19750A EG 19750 A EG19750 A EG 19750A EG 6591 A EG6591 A EG 6591A EG 6591 A EG6591 A EG 6591A EG 19750 A EG19750 A EG 19750A
- Authority
- EG
- Egypt
- Prior art keywords
- triazole
- preparing
- antifugal agents
- antifugal
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909002375A GB9002375D0 (en) | 1990-02-02 | 1990-02-02 | Triazole antifungal agents |
Publications (1)
Publication Number | Publication Date |
---|---|
EG19750A true EG19750A (en) | 1996-01-31 |
Family
ID=10670334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EG6591A EG19750A (en) | 1990-02-02 | 1991-02-02 | Process for preparing of triazole antifugal agents |
Country Status (42)
Country | Link |
---|---|
US (2) | US5567817A (pl) |
EP (1) | EP0440372B1 (pl) |
JP (2) | JP2625584B2 (pl) |
KR (1) | KR930011039B1 (pl) |
CN (2) | CN1026788C (pl) |
AP (2) | AP9000237A0 (pl) |
AT (1) | ATE90090T1 (pl) |
AU (1) | AU625188B2 (pl) |
BA (1) | BA97298A (pl) |
BG (1) | BG60032B2 (pl) |
BR (1) | BR9100435A (pl) |
CA (2) | CA2285891C (pl) |
CZ (1) | CZ279339B6 (pl) |
DE (2) | DE69100095T2 (pl) |
DK (1) | DK0440372T3 (pl) |
EG (1) | EG19750A (pl) |
ES (1) | ES2055523T4 (pl) |
FI (3) | FI107608B (pl) |
GB (1) | GB9002375D0 (pl) |
HK (1) | HK219396A (pl) |
HU (2) | HU205351B (pl) |
IE (1) | IE64774B1 (pl) |
IL (2) | IL110322A (pl) |
IN (1) | IN176148B (pl) |
IS (1) | IS1629B (pl) |
LU (1) | LU90960I2 (pl) |
LV (1) | LV10615B (pl) |
MA (1) | MA22054A1 (pl) |
MX (1) | MX24363A (pl) |
MY (1) | MY105494A (pl) |
NL (1) | NL300100I2 (pl) |
NO (2) | NO176796C (pl) |
NZ (1) | NZ247205A (pl) |
OA (1) | OA09480A (pl) |
PE (1) | PE31691A1 (pl) |
PL (3) | PL169332B1 (pl) |
PT (1) | PT96617B (pl) |
RO (1) | RO109648B1 (pl) |
RU (2) | RU2036194C1 (pl) |
SK (1) | SK278215B6 (pl) |
YU (1) | YU48105B (pl) |
ZA (1) | ZA91761B (pl) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9002375D0 (en) * | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
GB9121456D0 (en) * | 1991-10-10 | 1991-11-27 | Pfizer Ltd | Triazole antifungal agents |
GB2281297A (en) * | 1993-08-27 | 1995-03-01 | Merck & Co Inc | Quinazoline compounds |
NZ270418A (en) * | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
DE19500379A1 (de) * | 1995-01-09 | 1996-07-11 | Basf Ag | Fluorierte Pyrimidine als Herbizide |
GB9516121D0 (en) * | 1995-08-05 | 1995-10-04 | Pfizer Ltd | Organometallic addition to ketones |
GB9602080D0 (en) * | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
GB9605705D0 (en) * | 1996-03-19 | 1996-05-22 | Pfizer Ltd | Therapeutic agents |
US7193083B2 (en) * | 1996-07-26 | 2007-03-20 | Pfizer, Inc. | Preparation of triazoles by organometallic addition to ketones and intermediates therefor |
GB9713149D0 (en) * | 1997-06-21 | 1997-08-27 | Pfizer Ltd | Pharmaceutical formulations |
CN1081189C (zh) * | 1998-07-17 | 2002-03-20 | 国家医药管理局四川抗菌素工业研究所 | 唑醇类新衍生物及其制备方法和医药用途 |
GB9818258D0 (en) * | 1998-08-21 | 1998-10-14 | Pfizer Ltd | Antifungal compositions |
EP1191948A2 (en) * | 1999-06-11 | 2002-04-03 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
US6391903B1 (en) * | 1999-09-09 | 2002-05-21 | Sankyo Company, Limited | Triazole derivatives having antifungal activity |
US6319933B1 (en) | 2000-04-17 | 2001-11-20 | Basilea Pharmaceutica Ag | Azole derivatives |
WO2002062398A2 (en) | 2001-01-08 | 2002-08-15 | Neorx Corporation | Radioactively labelled conjugates of phosphonates |
HUP0303249A3 (en) | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
EP1458416A1 (en) | 2001-12-13 | 2004-09-22 | Dow Global Technologies Inc. | Treatment of osteomyelitis with radiopharmaceuticals |
IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
CN100379733C (zh) * | 2002-10-08 | 2008-04-09 | 南京康泽医药科技有限公司 | 三唑类抗真菌药物及其制备方法 |
US20040098839A1 (en) * | 2002-11-27 | 2004-05-27 | Pfizer Inc. | Crystallization method and apparatus using an impinging plate assembly |
CA2590687C (en) | 2004-12-14 | 2013-09-10 | Dr. Reddy's Laboratories Ltd. | Process for preparing voriconazole |
US7812045B2 (en) | 2005-03-30 | 2010-10-12 | Daewoong Pharmaceutical Co., Ltd. | Antifungal triazole derivatives |
US8143397B2 (en) * | 2006-02-01 | 2012-03-27 | Medichem S.A. | Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof |
AR061889A1 (es) * | 2006-07-13 | 2008-10-01 | Medichem Sa | Proceso mejorado para la preparacion de voriconazol |
CN1919846B (zh) * | 2006-09-14 | 2013-01-02 | 大道隆达(北京)医药科技发展有限公司 | 伏立康唑及其药用盐、中间体的一种新定向合成制备方法 |
US8680270B2 (en) * | 2006-11-21 | 2014-03-25 | Viamet Pharmaceuticals, Inc. | Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties |
KR100889937B1 (ko) * | 2007-08-06 | 2009-03-20 | 한미약품 주식회사 | 보리코나졸의 제조방법 |
GB2452049A (en) * | 2007-08-21 | 2009-02-25 | Alpharma Aps | Process for the preparation of voriconazole |
CN101575330B (zh) * | 2008-05-05 | 2012-10-31 | 丽珠医药集团股份有限公司 | 伏立康唑广谱抗真菌药物化合物、其组合物及用途 |
US20110224232A1 (en) * | 2008-05-06 | 2011-09-15 | Board Of Regents, The University Of Texas System | Treatment of Pulmonary Fungal Infection With Voriconazole via Inhalation |
JP2009286756A (ja) | 2008-05-30 | 2009-12-10 | Fujifilm Finechemicals Co Ltd | トリアゾール誘導体またはその塩 |
WO2010084505A2 (en) * | 2008-06-06 | 2010-07-29 | Glenmark Pharmaceuticals Limited | Stable topical formulation comprising voriconazole |
US20110312977A1 (en) * | 2009-02-17 | 2011-12-22 | Glenmark Generics Limited | Process for the preparation of voriconazole |
KR101109215B1 (ko) | 2009-06-17 | 2012-01-30 | 보령제약 주식회사 | 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법 |
EA201270283A1 (ru) | 2009-08-19 | 2012-12-28 | Рациофарм Гмбх | Способ получения соэвапоратов и комплексы, содержащие вориконазол и циклодекстрин |
UA108360C2 (uk) | 2009-10-01 | 2015-04-27 | Тверда фармацевтична композиція кортикостероїду, що розпадається у ротовій порожнині | |
WO2011064558A2 (en) | 2009-11-30 | 2011-06-03 | Cipla Limited | Pharmaceutical composition |
ES2529562T3 (es) | 2009-12-30 | 2015-02-23 | Medichem, S.A. | Un derivado de 1-(1H-1,2,4-triazol-1-il)butan-2-ol para uso farmacéutico, y el uso de un derivado de 1-(1H-1,2,4-triazol-1-il)butan-2-ol con forma cristalina sustancialmente indefinida para preparar dicho derivado de 1-(1H-1,2,4-triazol-1-il)butan-2-ol |
KR100971371B1 (ko) * | 2010-02-04 | 2010-07-20 | 동국제약 주식회사 | 신규한 중간체를 이용한 보리코나졸의 제조방법 |
WO2011110198A1 (en) | 2010-03-10 | 2011-09-15 | Synthron B.V. | A process for making voriconazole |
EP2409699B1 (en) | 2010-07-23 | 2014-04-30 | Combino Pharm, S.L. | Stable compositions of voriconazole |
CN101914091B (zh) * | 2010-07-25 | 2015-05-27 | 浙江华海药业股份有限公司 | 一种制备伏立康唑中间体的方法 |
US20140350252A1 (en) | 2011-02-21 | 2014-11-27 | Nitin Maheshwari | Process for the preparation of voriconazole and intermediates thereof |
KR101731155B1 (ko) | 2011-06-15 | 2017-04-27 | 신톤 비.브이. | 안정화된 보리코나졸 조성물 |
EP2561863A1 (en) | 2011-08-22 | 2013-02-27 | Farmaprojects, S.A.U. | Pharmaceutical compositions comprising voriconazole |
RU2014149993A (ru) | 2012-05-11 | 2016-07-10 | Сипла Лимитед | Фармацевтическая композиция |
NZ706764A (en) | 2012-10-15 | 2017-11-24 | Pfizer Ireland Pharmaceuticals | Process for the preparation of voriconazole and analogues thereof |
JP6404235B2 (ja) * | 2013-02-04 | 2018-10-10 | シンジェンタ パーティシペーションズ アーゲー | 新規な殺微生物剤 |
WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
JP6262972B2 (ja) * | 2013-09-17 | 2018-01-17 | 公益財団法人微生物化学研究会 | 化合物、及びその製造方法、並びにボリコナゾールの製造方法 |
BR112017021109A2 (pt) | 2015-04-02 | 2018-07-03 | Bayer Cropscience Ag | derivados de triazol como fungicidas |
CN104987325B (zh) * | 2015-06-30 | 2017-03-29 | 扬子江药业集团南京海陵药业有限公司 | 一种伏立康唑的制备方法 |
CN106117186B (zh) * | 2016-06-12 | 2018-08-24 | 重庆莱美隆宇药业有限公司 | 一种伏立康唑及其中间体的制备方法 |
CN107556294A (zh) * | 2016-06-30 | 2018-01-09 | 陕西合成药业股份有限公司 | 一种新型抗真菌感染药物及其制备方法和用途 |
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CN110198929A (zh) * | 2016-11-28 | 2019-09-03 | 赛力克斯生物私人有限公司 | 用于治疗真菌感染的组合物和方法 |
US11185548B2 (en) | 2016-12-23 | 2021-11-30 | Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases |
WO2018149359A1 (zh) * | 2017-02-17 | 2018-08-23 | 武汉朗来科技发展有限公司 | 三氮唑抗菌衍生物、其药物组合物和用途 |
CN109705102A (zh) | 2019-02-19 | 2019-05-03 | 浙江华海立诚药业有限公司 | 伏立康唑及其中间体的制备方法 |
CN111440152B (zh) * | 2020-05-18 | 2022-09-27 | 浙江诚意药业股份有限公司 | 一种伏立康唑的制备方法 |
CN112079819B (zh) * | 2020-09-24 | 2022-06-17 | 南京易亨制药有限公司 | 一种改进的伏立康唑消旋体制备方法 |
CN114907319B (zh) * | 2021-02-06 | 2024-06-14 | 华创合成制药股份有限公司 | 一种氘代三唑类化合物及其制备方法和用途 |
CN115724829A (zh) * | 2022-12-23 | 2023-03-03 | 天津力生制药股份有限公司 | 一种分离真菌药物中间体杂质的液相色谱制备方法 |
CN118307408A (zh) * | 2024-04-10 | 2024-07-09 | 上海恩氟佳科技有限公司 | 2-氟丙酰乙酸乙酯的制备方法 |
Family Cites Families (61)
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US4927839A (en) * | 1979-03-07 | 1990-05-22 | Imperial Chemical Industries Plc | Method of preventing fungal attack on wood, hides, leather or paint films using a triazole |
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US4259505A (en) * | 1980-03-04 | 1981-03-31 | Ciba-Geigy Corporation | Process for the preparation of 1H-azole derivatives |
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DE3177275D1 (de) * | 1980-08-18 | 1992-04-16 | Ici Plc | Verwendung von triazolylaethanol-derivate und deren zusammensetzungen als nichtlandwirtschaftliche fungizide. |
DE3175673D1 (en) * | 1980-11-19 | 1987-01-15 | Ici Plc | Triazole compounds, a process for preparing them, their use as plant fungicides and fungicidal compositions containing them |
US5204363A (en) * | 1981-03-18 | 1993-04-20 | Imperial Chemical Industries Plc | Heterocyclic compounds |
US5466821A (en) * | 1981-03-18 | 1995-11-14 | Zeneca Limited | Heterocyclic compounds |
EP0061835B1 (en) * | 1981-03-18 | 1989-02-01 | Imperial Chemical Industries Plc | Triazole compounds, a process for preparing them, their use as plant fungicides and fungicidal compositions containing them |
DE3262386D1 (en) * | 1981-06-06 | 1985-03-28 | Pfizer Ltd | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
US4510148A (en) * | 1982-06-12 | 1985-04-09 | Pfizer Inc. | 2-Heterocyclic-1,3-bis(1H-1,2,4-triazol-1-yl)-propan-2-ols as antifungal agents |
ES523184A0 (es) * | 1982-06-17 | 1985-04-01 | Pfizer | Un procedimiento para la preparacion de un compuesto dotado de propiedades fungicidas |
DE3228870A1 (de) * | 1982-08-03 | 1984-02-09 | Bayer Ag, 5090 Leverkusen | Diazolyl-alkanole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel |
US4505919A (en) * | 1982-10-09 | 1985-03-19 | Pfizer Inc. | Antifungal S-arylmethyl- and S-heterocyclylmethyl ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-yl) propan-2-ols |
DE3242236A1 (de) * | 1982-11-15 | 1984-05-17 | Bayer Ag, 5090 Leverkusen | "antimykotische mittel" |
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-
1990
- 1990-02-02 GB GB909002375A patent/GB9002375D0/en active Pending
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1991
- 1991-01-24 DE DE9191300553T patent/DE69100095T2/de not_active Expired - Lifetime
- 1991-01-24 AT AT91300553T patent/ATE90090T1/de active
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- 1991-01-24 EP EP91300553A patent/EP0440372B1/en not_active Expired - Lifetime
- 1991-01-24 DE DE2002199035 patent/DE10299035I2/de active Active
- 1991-01-24 DK DK91300553.4T patent/DK0440372T3/da active
- 1991-01-25 IL IL11032291A patent/IL110322A/en not_active IP Right Cessation
- 1991-01-25 IL IL9704591A patent/IL97045A/en not_active IP Right Cessation
- 1991-01-25 IN IN74DE1991 patent/IN176148B/en unknown
- 1991-01-28 RO RO146821A patent/RO109648B1/ro unknown
- 1991-01-28 AP AP90/00237A patent/AP9000237A0/xx unknown
- 1991-01-28 AP APAP/P/1991/000237A patent/AP223A/en active
- 1991-01-29 PE PE1991180888A patent/PE31691A1/es not_active IP Right Cessation
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- 1991-01-30 CA CA002285891A patent/CA2285891C/en not_active Expired - Lifetime
- 1991-01-30 CA CA002035314A patent/CA2035314C/en not_active Expired - Lifetime
- 1991-01-30 IS IS3671A patent/IS1629B/is unknown
- 1991-01-31 NO NO910368A patent/NO176796C/no not_active IP Right Cessation
- 1991-01-31 PL PL91306940A patent/PL169332B1/pl unknown
- 1991-01-31 KR KR1019910001613A patent/KR930011039B1/ko not_active IP Right Cessation
- 1991-01-31 PL PL91306941A patent/PL169307B1/pl unknown
- 1991-01-31 PL PL91288901A patent/PL167294B1/pl unknown
- 1991-01-31 JP JP3031977A patent/JP2625584B2/ja not_active Expired - Lifetime
- 1991-01-31 MY MYPI91000155A patent/MY105494A/en unknown
- 1991-01-31 MX MX2436391A patent/MX24363A/es unknown
- 1991-01-31 PT PT96617A patent/PT96617B/pt not_active IP Right Cessation
- 1991-02-01 ZA ZA91761A patent/ZA91761B/xx unknown
- 1991-02-01 IE IE34291A patent/IE64774B1/en active Protection Beyond IP Right Term
- 1991-02-01 OA OA59945A patent/OA09480A/xx unknown
- 1991-02-01 MA MA22327A patent/MA22054A1/fr unknown
- 1991-02-01 RU SU914894374A patent/RU2036194C1/ru active
- 1991-02-01 HU HU91366A patent/HU205351B/hu unknown
- 1991-02-01 RU SU5010394A patent/RU2114838C1/ru active
- 1991-02-01 SK SK249-91A patent/SK278215B6/sk active Protection Beyond IP Right Term
- 1991-02-01 YU YU17591A patent/YU48105B/sh unknown
- 1991-02-01 BR BR919100435A patent/BR9100435A/pt not_active Application Discontinuation
- 1991-02-01 FI FI910508A patent/FI107608B/fi active Protection Beyond IP Right Term
- 1991-02-01 CZ CS91249A patent/CZ279339B6/cs not_active IP Right Cessation
- 1991-02-01 AU AU70223/91A patent/AU625188B2/en not_active Expired
- 1991-02-02 EG EG6591A patent/EG19750A/xx active
- 1991-02-02 CN CN91100706A patent/CN1026788C/zh not_active Expired - Lifetime
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1993
- 1993-11-15 LV LVP-93-1224A patent/LV10615B/lv unknown
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1994
- 1994-02-26 CN CN94102354A patent/CN1040504C/zh not_active Expired - Lifetime
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1995
- 1995-05-01 US US08/432,414 patent/US5567817A/en not_active Expired - Lifetime
- 1995-06-09 HU HU95P/P00179P patent/HU211582A9/hu active Protection Beyond IP Right Term
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1996
- 1996-07-18 US US08/683,694 patent/US5773443A/en not_active Expired - Lifetime
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