EE05167B1 - Stabiilsed farmatseutilised lahuspreparaadid survestatud doseerivatele inhalaatoritele - Google Patents

Stabiilsed farmatseutilised lahuspreparaadid survestatud doseerivatele inhalaatoritele

Info

Publication number
EE05167B1
EE05167B1 EEP200200649A EEP200200649A EE05167B1 EE 05167 B1 EE05167 B1 EE 05167B1 EE P200200649 A EEP200200649 A EE P200200649A EE P200200649 A EEP200200649 A EE P200200649A EE 05167 B1 EE05167 B1 EE 05167B1
Authority
EE
Estonia
Prior art keywords
metered dose
dose inhalers
stable pharmaceutical
pharmaceutical solution
solution formulations
Prior art date
Application number
EEP200200649A
Other languages
English (en)
Estonian (et)
Inventor
Lewis David
Ganderton David
Meakin Brian
Brambilla Gaetano
Ferraris Alessandra
Original Assignee
Chiesi Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8163952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE05167(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farmaceutici S.P.A. filed Critical Chiesi Farmaceutici S.P.A.
Publication of EE200200649A publication Critical patent/EE200200649A/xx
Publication of EE05167B1 publication Critical patent/EE05167B1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53861,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • A61K9/124Aerosols; Foams characterised by the propellant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EEP200200649A 2000-05-22 2000-05-22 Stabiilsed farmatseutilised lahuspreparaadid survestatud doseerivatele inhalaatoritele EE05167B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2000/004635 WO2001089480A1 (en) 2000-05-22 2000-05-22 Stable pharmaceutical solution formulations for pressurised metered dose inhalers

Publications (2)

Publication Number Publication Date
EE200200649A EE200200649A (et) 2004-06-15
EE05167B1 true EE05167B1 (et) 2009-06-15

Family

ID=8163952

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200649A EE05167B1 (et) 2000-05-22 2000-05-22 Stabiilsed farmatseutilised lahuspreparaadid survestatud doseerivatele inhalaatoritele

Country Status (40)

Country Link
US (3) US6716414B2 (fa)
EP (4) EP1157689B1 (fa)
JP (1) JP5392880B2 (fa)
CN (1) CN1213732C (fa)
AR (1) AR029523A1 (fa)
AT (4) ATE419832T1 (fa)
AU (2) AU2000250701B2 (fa)
BE (1) BE2011C032I2 (fa)
BG (1) BG65883B1 (fa)
BR (1) BR0015884A (fa)
CA (1) CA2411047C (fa)
CY (6) CY1108833T1 (fa)
CZ (1) CZ303833B6 (fa)
DE (5) DE60144304D1 (fa)
DK (4) DK1157689T3 (fa)
DZ (1) DZ3358A1 (fa)
EA (1) EA005179B1 (fa)
EE (1) EE05167B1 (fa)
ES (4) ES2320194T3 (fa)
FR (1) FR11C0041I2 (fa)
HR (1) HRP20021025B1 (fa)
HU (2) HU230804B1 (fa)
IL (2) IL152955A0 (fa)
JO (1) JO2310B1 (fa)
LT (1) LTC1787639I2 (fa)
LU (1) LU91875I2 (fa)
ME (2) ME00220B (fa)
MX (1) MXPA02011414A (fa)
MY (2) MY127145A (fa)
NL (1) NL300393I2 (fa)
NO (3) NO342935B1 (fa)
PE (1) PE20011323A1 (fa)
PT (4) PT1787639E (fa)
SA (1) SA01220126B1 (fa)
SI (4) SI1466594T1 (fa)
SK (1) SK286694B6 (fa)
TN (1) TNSN01074A1 (fa)
TW (1) TWI284047B (fa)
UA (1) UA73986C2 (fa)
WO (1) WO2001089480A1 (fa)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
IT1303788B1 (it) * 1998-11-25 2001-02-23 Chiesi Farma Spa Formulazioni di aerosol medicinali.
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
EP1523976A3 (en) * 1999-11-23 2005-06-22 Glaxo Group Limited Pharmaceutical formulations of salmeterol
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
SK286694B6 (sk) * 2000-05-22 2009-03-05 Chiesi Farmaceutici S.P.A. Aerosólový farmaceutický prostriedok
US20060257324A1 (en) 2000-05-22 2006-11-16 Chiesi Farmaceutici S.P.A. Pharmaceutical solution formulations for pressurised metered dose inhalers
ATE312639T1 (de) * 2000-05-23 2005-12-15 Glaxo Group Ltd Aerosolbehälter für salmeterol xinafoate
FI20002177A0 (fi) * 2000-10-02 2000-10-02 Orion Yhtymae Oyj Uusi yhdistelmä astman hoitoon
EP1241113A1 (en) 2001-03-12 2002-09-18 CHIESI FARMACEUTICI S.p.A. Inhaler with means for improving chemical stability of medicinal aerosol solution contained therein
ES2292713T3 (es) * 2001-03-30 2008-03-16 Jagotec Ag Formulaciones medicinales en aerosol.
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
TR200401980T4 (tr) 2001-07-02 2004-09-21 Chiesi Farmaceutici S.P.A. Aerosol olarak uygulama için en uygun hale getirilmiş tobramisin formülasyonu
US7306925B2 (en) 2001-11-09 2007-12-11 Vanderbilt University Phage antibodies to radiation-inducible neoantigens
US7906102B2 (en) 2001-10-03 2011-03-15 Vanderbilt University Ligands to radiation-induced molecules
EP1340492A1 (en) * 2002-03-01 2003-09-03 CHIESI FARMACEUTICI S.p.A. Aerosol formulations for pulmonary administration of medicaments having systemic effects
PT3384931T (pt) * 2002-03-01 2019-09-26 Chiesi Farm Spa Formulaçâo superfina de formoterol
EP1415647A1 (en) * 2002-10-23 2004-05-06 CHIESI FARMACEUTICI S.p.A. "Long-acting beta-2 agonists ultrafine formulations"
US20040166065A1 (en) 2002-08-14 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosol formulation for inhalation comprising an anticholinergic
SI1530464T1 (sl) * 2002-08-14 2008-12-31 Boehringer Ingelheim Pharma Aerosolna formulacija za inhalacijo, ki vsebuje antiholinergik
US7244742B2 (en) * 2002-08-17 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
DE10237739A1 (de) * 2002-08-17 2004-02-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalative Arzneimittel enthaltend ein neues Anticholinergikum in Kombination mit Corticosteroiden und Betamimetika
EP1452179A1 (en) * 2003-02-27 2004-09-01 CHIESI FARMACEUTICI S.p.A. Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid
US20050003024A1 (en) * 2003-03-04 2005-01-06 The Procter & Gamble Company Regulation of mammalian hair growth
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
AU2004262902B2 (en) * 2003-07-29 2009-07-30 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising betamimetics and an anticholinergic
US20050026948A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
CA2534120C (en) * 2003-07-31 2012-09-11 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising anticholinergics and a betamimetic
WO2005013945A2 (en) * 2003-08-05 2005-02-17 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising steroids and a betamimetic
RU2362551C2 (ru) * 2003-09-15 2009-07-27 Вектура Лимитед Фармацевтические композиции для лечения преждевременной эякуляции при помощи легочной ингаляции
GB0323684D0 (en) 2003-10-09 2003-11-12 Jagotec Ag Improvements in or relating to organic compounds
AR041873A1 (es) * 2003-10-30 2005-06-01 Pablo Cassara Srl Lab Una formulacion farmaceutica en aerosol adecuada para la inhalacion oral o nasal que contienen glucocorticoides en solucion estable al almacenamiento; un metodo para estabilzar formulaciones y uso de un agente estabilizante
EP1595531A1 (en) * 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
KR20070000476A (ko) * 2004-02-27 2007-01-02 키에시 파르마슈티시 엣스. 피. 에이. 압축화 계량된 도스흡입용 안정된 약제용액 제제
UA88894C2 (ru) * 2004-02-27 2009-12-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Стабильные фармацевтические композиции в виде растворов для ингаляторов с дозатором, которые находятся под давлением
JP2007537170A (ja) * 2004-05-13 2007-12-20 チエシイ・ファルマセウテイシイ・エス・ペー・アー 化学的安定性が改良された薬用エーロゾル配合物製品
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
GB0501956D0 (en) * 2005-01-31 2005-03-09 Arrow Internat Nebulizer formulation
JP5259193B2 (ja) * 2005-02-25 2013-08-07 チエシイ・ファルマセウテイシイ・エス・ペー・アー 加圧下にある用量計量型吸入器用の金属イオン封鎖剤を含む薬用エーロゾル配合物
WO2006105401A2 (en) * 2005-03-30 2006-10-05 Schering Corporation Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist
DE102005055960A1 (de) * 2005-11-24 2007-07-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
GB0525680D0 (en) * 2005-12-16 2006-01-25 Peplin Ltd Therapeutic compositions
US20070286814A1 (en) * 2006-06-12 2007-12-13 Medispray Laboratories Pvt. Ltd. Stable aerosol pharmaceutical formulations
GB0613761D0 (en) * 2006-07-11 2006-08-23 Norton Healthcare Ltd A pharmaceutical formulation and method for the preparation thereof
EP1982709A1 (en) 2007-04-19 2008-10-22 CHIESI FARMACEUTICI S.p.A. Use of a composition comprising formoterol and beclomethasone dipropionate for the prevention or treatment of an acute condition of asthma
US8227027B2 (en) * 2007-12-07 2012-07-24 Presspart Gmbh & Co. Kg Method for applying a polymer coating to an internal surface of a container
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
GB0801876D0 (en) * 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations
US20090208424A1 (en) * 2008-02-19 2009-08-20 Todd Maibach Compositions and methods for delivery of solution to the skin
WO2009134524A2 (en) * 2008-02-26 2009-11-05 Elevation Pharmaceuticals, Inc. Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
US20100055045A1 (en) 2008-02-26 2010-03-04 William Gerhart Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
WO2010048384A2 (en) * 2008-10-23 2010-04-29 Sepracor Inc. Arformoterol and tiotropium compositions and methods for use
EP2201934A1 (en) * 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Tiotropium aerosol formulation products with improved chemical stability
EP2414560B1 (de) 2009-03-31 2013-10-23 Boehringer Ingelheim International GmbH Verfahren zur beschichtung einer oberfläche eines bauteils
EP3508239B1 (de) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalationseinrichtung und zerstäuber
DK2482799T3 (da) 2009-10-02 2014-09-01 Chiesi Farma Spa Farmaceutiske aerosolformuleringer af formoterol og beclometasondipropionat
GB0918150D0 (en) * 2009-10-16 2009-12-02 Jagotec Ag Improved formulations
GB0918149D0 (en) 2009-10-16 2009-12-02 Jagotec Ag Improved medicinal aerosol formulation
NZ599295A (en) 2009-11-25 2014-06-27 Boehringer Ingelheim Int Nebulizer
EP2504051B1 (en) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
EP3020393B1 (en) 2009-12-16 2020-10-07 3M Innovative Properties Company Formulations and methods for controlling mdi particle size delivery
CN102665678B (zh) * 2009-12-23 2014-07-02 奇斯药制品公司 用于copd的联合治疗
PE20160853A1 (es) * 2009-12-23 2016-09-14 Chiesi Farm Spa Terapia combinada para enfermedad pulmonar obstructiva cronica (epoc)
NZ600789A (en) 2009-12-23 2014-09-26 Chiesi Farma Spa Aerosol formulation for copd
WO2011160932A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Nebulizer
WO2012010854A1 (en) 2010-07-23 2012-01-26 Cipla Limited Inhalation formulations comprising carmoterol in combination with a corticosteroid
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013019730A1 (en) 2011-07-29 2013-02-07 The Washington University Antibodies to tip-1 and grp78
GB201200504D0 (en) * 2011-12-19 2012-02-22 Teva Branded Pharmaceutical Prod R & D Inc An inhaler
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
RS57687B1 (sr) * 2013-12-30 2018-11-30 Chiesi Farm Spa Pod pritiskom stabilan aerosolni rastvor kompozicije glikopironijum bromida i kombinacije formoterola
DK3096737T3 (en) * 2013-12-30 2018-06-25 Chiesi Farm Spa STABLE PRESSURE AEROSOL SOLUTION COMPOSITION OF GLYCOPYRRONIUM BROMIDE AND FORMOTEROL COMBINATION
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
EA032599B1 (ru) 2014-05-07 2019-06-28 Бёрингер Ингельхайм Интернациональ Гмбх Небулайзер, индикаторное устройство и контейнер
WO2015169430A1 (en) 2014-05-07 2015-11-12 Boehringer Ingelheim International Gmbh Nebulizer
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
WO2016014939A1 (en) 2014-07-24 2016-01-28 Washington University Compositions targeting radiation-induced molecules and methods of use thereof
CN104225739A (zh) * 2014-09-30 2014-12-24 四川普锐特医药科技有限责任公司 一种医用定量吸入气雾剂
CA3007050C (en) 2015-12-04 2020-12-08 Mexichem Fluor S.A. De C.V. Pharmaceutical composition comprising a formoterol compound
US10098837B2 (en) 2016-07-28 2018-10-16 Chiesi Farmaceutici S.P.A. Combination therapy for COPD
WO2018148595A1 (en) 2017-02-10 2018-08-16 Washington University Antibodies to tip1 and methods of use thereof
JOP20200314A1 (ar) 2018-06-04 2020-12-06 Lupin Inc تركيبات صيدلانية مستقرة لأجهزة إستنشاق جرعات مضغوطة معايرة الجرعة
WO2020152548A1 (en) * 2019-01-24 2020-07-30 Glenmark Pharmaceuticals Limited Stable aerosol inhalation compositions of formoterol
CN112137957B (zh) 2019-06-26 2022-07-29 长风药业股份有限公司 一种药用吸入气雾剂及其制备方法
IL293328A (en) 2019-12-02 2022-07-01 Chiesi Farm Spa Stainless steel canister for pressurized metered dose inhalers
CN113244490A (zh) 2020-01-28 2021-08-13 奇斯药制品公司 包含缓冲药物制剂的加压定量吸入器
GB202001537D0 (en) * 2020-02-05 2020-03-18 Consort Medical Plc Pressurised dispensing container
MX2022009643A (es) 2020-02-20 2022-09-07 Chiesi Farm Spa Inhaladores dosificadores presurizados que comprenden una formulacion farmaceutica amortiguada.
US12042514B2 (en) 2020-05-01 2024-07-23 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
US11642372B2 (en) * 2020-05-01 2023-05-09 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
US11826382B2 (en) 2020-05-01 2023-11-28 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
WO2022023515A1 (en) 2020-07-31 2022-02-03 Chemo Research , S.L. Combination therapy for inhalation administration
MX2023003754A (es) * 2020-10-09 2023-04-24 Chiesi Farm Spa Formulacion farmaceutica para inhalador presurizado de dosis medidas.
GB2614901A (en) 2022-01-21 2023-07-26 Nanopharm Ltd Inhalable formulations
CN119585256A (zh) 2022-04-06 2025-03-07 拉普特医疗公司 趋化因子受体调节剂及其用途
US20250302742A1 (en) 2022-05-27 2025-10-02 Chiesi Farmaceutici S.P.A. A pharmaceutical formulation for pressurised metered dose inhaler
WO2023227782A1 (en) 2022-05-27 2023-11-30 Chiesi Farmaceutici S.P.A. A pharmaceutical formulation for pressurised metered dose inhaler
WO2026006658A1 (en) 2024-06-27 2026-01-02 Lupin Inc. Stable pharmaceutical compositions for pressurized metered dose inhalers

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361306A (en) 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3622053A (en) 1969-12-10 1971-11-23 Schering Corp Aerosol inhaler with flip-up nozzle
MX3864E (es) 1975-05-27 1981-08-26 Syntex Corp Un proceso para prepara el compuesto cristalino 6-fluiro-11b 21-dihiroxi-16 17-isopropilidendioxipregna-1 4-dien-3 20-diona
US4185100A (en) 1976-05-13 1980-01-22 Johnson & Johnson Topical anti-inflammatory drug therapy
US4499108A (en) * 1983-06-08 1985-02-12 Schering Corporation Stable pleasant-tasting albuterol sulfate pharmaceutical formulations
GB8334494D0 (en) * 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
IT1196142B (it) 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
US5192528A (en) 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
GB8828477D0 (en) * 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
US5225183A (en) 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
IE67185B1 (en) 1990-02-02 1996-03-06 Fisons Plc Propellant compositions
CA2098298A1 (en) 1990-12-19 1992-06-20 Susan M. Milosovich Aerosol formulations
US6006745A (en) 1990-12-21 1999-12-28 Minnesota Mining And Manufacturing Company Device for delivering an aerosol
EP0504112A3 (en) * 1991-03-14 1993-04-21 Ciba-Geigy Ag Pharmaceutical aerosol formulations
US5874063A (en) * 1991-04-11 1999-02-23 Astra Aktiebolag Pharmaceutical formulation
ATE171630T1 (de) 1991-05-21 1998-10-15 Abbott Lab Aerosolinhalationsvorrichtung
US5435297A (en) 1991-08-29 1995-07-25 Christoph Klein Medical device for inhaling metered aerosols
NZ244439A (en) 1991-09-25 1994-01-26 Fisons Plc Pressurised aerosol compositions comprising hydrofluoroalkane, dispersed
IL104068A (en) 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
JP3908269B2 (ja) * 1991-12-18 2007-04-25 スリーエム カンパニー 懸濁エアゾール製剤
DE4230876A1 (de) 1992-03-17 1993-09-23 Asta Medica Ag Druckgaspackungen unter verwendung von polyoxyethylen-glyceryl-oleaten
NZ259192A (en) * 1992-12-09 1997-05-26 Boehringer Ingelheim Pharma Aerosol medicament comprising water-sensitive or solvent-sensitive active agent, hfc propellant stabilised by addition of (in)organic acid
SE9203743D0 (sv) * 1992-12-11 1992-12-11 Astra Ab Efficient use
AU4066693A (en) 1992-12-23 1994-07-19 Bernhard Hugemann Compacted drug body for use in the mechanical generation of inhalable active-substance particles
CA2156075C (en) 1993-03-17 2004-06-22 Daniel C. Duan Aerosol formulation containing a dispersing aid
US5569450A (en) * 1993-03-17 1996-10-29 Minnesota Mining And Manufacturing Company Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
US6596260B1 (en) 1993-08-27 2003-07-22 Novartis Corporation Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol
ES2145254T3 (es) 1993-12-20 2000-07-01 Minnesota Mining & Mfg Formulaciones de aerosoles que contienen flunisolida.
GB9425160D0 (en) 1994-12-10 1995-02-08 Glaxo Group Ltd Medicaments
CZ288146B6 (en) * 1994-12-22 2001-05-16 Astra Ab Pharmaceutical aerosol preparation, process of its preparation and use
GB9426252D0 (en) * 1994-12-24 1995-02-22 Glaxo Group Ltd Pharmaceutical composition
DE4446891A1 (de) 1994-12-27 1996-07-04 Falk Pharma Gmbh Stabile wäßrige Budesonid-Lösung
US5653961A (en) 1995-03-31 1997-08-05 Minnesota Mining And Manufacturing Company Butixocort aerosol formulations in hydrofluorocarbon propellant
HU219899B (hu) * 1995-04-14 2001-09-28 Glaxo Wellcome Inc. Inhalálóberendezés flutikaszon-propionát adagolására mért dózisban
DE69637257T2 (de) * 1995-04-14 2008-06-12 Smithkline Beecham Corp. Verfahren zur Herstellung eines Dosierinhalators
EE04005B1 (et) 1995-04-14 2003-04-15 Glaxo Wellcome Inc. Salmeterooli doseeriv inhalaator
JP3573213B2 (ja) 1995-04-14 2004-10-06 グラクソ、ウェルカム、インコーポレーテッド ベクロメタゾンジプロピオネート用計量投与用吸入器
US6135628A (en) * 1995-10-13 2000-10-24 Boehringer Ingelheim Pharmceuticals, Inc. Method and apparatus for homogenizing aerosol formulations
GB9612297D0 (en) 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
WO1998001147A1 (en) 1996-07-08 1998-01-15 Rhone-Poulenc Rorer Limited Medicinal cyclosporin-a aerosol solution formulation
AU3811897A (en) 1996-07-24 1998-02-10 Oglios Therapeutics, Inc. Antisense oligonucleotides as antibacterial agents
GB9616237D0 (en) * 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
GB9620187D0 (en) 1996-09-27 1996-11-13 Minnesota Mining & Mfg Medicinal aerosol formulations
US6413496B1 (en) 1996-12-04 2002-07-02 Biogland Ireland (R&D) Limited Pharmaceutical compositions and devices for their administration
IES80485B2 (en) * 1996-12-04 1998-08-12 Bioglan Ireland R & D Ltd Pharmaceutical compositions and devices for their administration
WO1998034595A1 (de) 1997-02-05 1998-08-13 Jago Research Ag Medizinische aerosolformulierungen
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US5891419A (en) 1997-04-21 1999-04-06 Aeropharm Technology Limited Environmentally safe flunisolide aerosol formulations for oral inhalation
US6000537A (en) * 1997-06-10 1999-12-14 U.S. Philips Corporation Housing with readable side walls for a disc-shaped information carrier
GB2326334A (en) * 1997-06-13 1998-12-23 Chiesi Farma Spa Pharmaceutical aerosol compositions
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6324827B1 (en) * 1997-07-01 2001-12-04 Bp Corporation North America Inc. Method of generating power in a dry low NOx combustion system
BR7702049U (pt) 1997-09-05 1999-09-14 Chiesi Farma Spa Bico pulverizador para utilização em inalador oral para medicamentos aerossóis
NZ504021A (en) 1997-10-17 2003-04-29 Systemic Pulmonary Delivery Lt Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication
EP1075278A1 (en) * 1998-01-13 2001-02-14 AstraZeneca UK Limited PHARMACEUTICAL COMPOSITIONS COMPRISING A COMPOUND HAVING DOPAMINE (D 2?) RECEPTOR AGONIST ACTIVITY AND A COMPOUND (B) HAVING $g(b) 2?-ADRENORECEPTOR AGONIST ACTIVITY
US6045784A (en) 1998-05-07 2000-04-04 The Procter & Gamble Company Aerosol package compositions containing fluorinated hydrocarbon propellants
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
BR9911351A (pt) * 1998-06-18 2001-03-13 Boehringer Ingelheim Pharma Formulações farmacêuticas para aerossóis com duas ou mais substâncias ativas
US6451285B2 (en) * 1998-06-19 2002-09-17 Baker Norton Pharmaceuticals, Inc. Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant
US6241969B1 (en) 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
ES2234266T3 (es) * 1998-07-24 2005-06-16 Jago Research Ag Formulaciones medicas para aerosoles.
CA2338680C (en) * 1998-08-04 2008-10-14 Jago Research Ag Medicinal aerosol formulations
US6136294C1 (en) * 1998-09-22 2002-09-24 Aeropharm Technology Inc Amino acid stabilized medical aerosol formulation
DE19847969A1 (de) 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Lagerfähig flüssige Formulierung mit Formoterol
ID29605A (id) * 1998-10-17 2001-09-06 Boehringer Ingelheim Pharma Konsentrat bahan aktif dengan formoterol, yang sesuai untuk penyimpanan
PL200941B1 (pl) 1998-11-13 2009-02-27 Jagotec Ag Suchy proszkowy preparat inhalacyjny
IT1303788B1 (it) * 1998-11-25 2001-02-23 Chiesi Farma Spa Formulazioni di aerosol medicinali.
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6290930B1 (en) 1998-12-18 2001-09-18 Baker Norton Pharmaceuticals, Inc. Pharmaceutical solution aerosol formulations containing fluoroalkanes and budesonide
US6004537A (en) * 1998-12-18 1999-12-21 Baker Norton Pharmaceuticals, Inc. Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol
GB9902689D0 (en) * 1999-02-08 1999-03-31 Novartis Ag Organic compounds
HUP0200185A3 (en) 1999-03-05 2006-07-28 Chiesi Farma Spa Improved powdery pharmaceutical compositions for inhalation
US6315985B1 (en) 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
AU2206801A (en) 1999-12-24 2001-07-09 Alan Leslie Cripps Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
SK286694B6 (sk) 2000-05-22 2009-03-05 Chiesi Farmaceutici S.P.A. Aerosólový farmaceutický prostriedok
EP1340492A1 (en) * 2002-03-01 2003-09-03 CHIESI FARMACEUTICI S.p.A. Aerosol formulations for pulmonary administration of medicaments having systemic effects
PT3384931T (pt) * 2002-03-01 2019-09-26 Chiesi Farm Spa Formulaçâo superfina de formoterol
EP1595531A1 (en) * 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers

Also Published As

Publication number Publication date
EA005179B1 (ru) 2004-12-30
CY1108968T1 (el) 2014-04-09
ES2359991T3 (es) 2011-05-30
NO2019030I1 (no) 2019-07-11
CA2411047A1 (en) 2001-11-29
BE2011C032I2 (fa) 2020-08-20
LTC1787639I2 (lt) 2021-05-25
LU91875I2 (fr) 2011-11-21
CZ303833B6 (cs) 2013-05-22
CY1113028T1 (el) 2016-04-13
WO2001089480A1 (en) 2001-11-29
CA2411047C (en) 2009-08-04
DE122011100049I1 (de) 2012-01-19
NO20025568D0 (no) 2002-11-20
NO342935B1 (no) 2018-09-03
US7018618B2 (en) 2006-03-28
MXPA02011414A (es) 2003-06-06
SI1787639T1 (sl) 2011-07-29
US6716414B2 (en) 2004-04-06
EP1466594B1 (en) 2008-12-03
HK1058900A1 (en) 2004-06-11
ES2318217T3 (es) 2009-05-01
HU230804B1 (hu) 2018-06-28
SA01220126B1 (ar) 2007-04-03
CY1111570T1 (el) 2015-10-07
CY2011014I2 (el) 2015-10-07
CY1108833T1 (el) 2014-07-02
AU2000250701B2 (en) 2004-07-01
PT1466594E (pt) 2009-02-13
EP2223682B1 (en) 2012-01-18
HUP0302007A2 (hu) 2003-09-29
HUP0302007A3 (en) 2006-07-28
HRP20021025B1 (hr) 2013-11-22
BG65883B1 (bg) 2010-04-30
FR11C0041I2 (fr) 2015-09-04
DK1787639T3 (da) 2011-05-09
ES2380790T3 (es) 2012-05-18
DK1157689T3 (da) 2009-03-16
NO2019003I1 (no) 2019-01-16
ATE541563T1 (de) 2012-02-15
JO2310B1 (en) 2005-09-12
CY2009009I2 (el) 2014-04-09
UA73986C2 (uk) 2005-10-17
CN1213732C (zh) 2005-08-10
EP1787639B1 (en) 2011-03-23
ES2320194T3 (es) 2009-05-20
SI2223682T1 (sl) 2012-04-30
ATE419832T1 (de) 2009-01-15
DE60137282D1 (de) 2009-02-26
PE20011323A1 (es) 2002-01-22
HRP20021025A2 (en) 2004-02-29
ATE415945T1 (de) 2008-12-15
AR029523A1 (es) 2003-07-02
TWI284047B (en) 2007-07-21
PT1157689E (pt) 2009-03-23
LTPA2011011I1 (lt) 2019-08-26
DK1466594T3 (da) 2009-03-02
BG107256A (bg) 2003-06-30
DE122009000035I1 (de) 2009-11-05
EP1157689A1 (en) 2001-11-28
DE60144304D1 (de) 2011-05-05
CN1452479A (zh) 2003-10-29
DK2223682T3 (da) 2012-03-19
CY2011014I1 (el) 2015-10-07
HUS1800032I1 (hu) 2018-08-28
TNSN01074A1 (fr) 2005-11-10
US20040047809A1 (en) 2004-03-11
IL152955A0 (en) 2003-06-24
PT1787639E (pt) 2011-06-08
ATE502624T1 (de) 2011-04-15
CY2009009I1 (el) 2014-04-09
NL300393I2 (en) 2010-02-01
EP1157689B1 (en) 2009-01-07
AU5070100A (en) 2001-12-03
PL359149A1 (en) 2004-08-23
FR11C0041I1 (fa) 2011-04-11
NO20025568L (no) 2002-11-20
EE200200649A (et) 2004-06-15
AU2000250701A1 (en) 2002-02-21
MEP32108A (en) 2010-10-10
JP5392880B2 (ja) 2014-01-22
JP2003534266A (ja) 2003-11-18
US20060083693A1 (en) 2006-04-20
EP2223682A1 (en) 2010-09-01
EP1787639A3 (en) 2009-02-25
EP1466594A3 (en) 2004-12-01
SK16522002A3 (sk) 2003-04-01
SI1157689T1 (sl) 2009-06-30
BR0015884A (pt) 2003-07-08
MY143733A (en) 2011-07-15
DZ3358A1 (fr) 2001-11-29
SI1466594T1 (sl) 2009-06-30
DE60136864D1 (de) 2009-01-15
IL152955A (en) 2010-02-17
NL300393I1 (en) 2009-09-01
EA200201058A1 (ru) 2003-04-24
ME00220B (me) 2010-10-10
CZ20023835A3 (cs) 2003-04-16
EP1787639A2 (en) 2007-05-23
EP1466594A2 (en) 2004-10-13
MY127145A (en) 2006-11-30
US20020025299A1 (en) 2002-02-28
SK286694B6 (sk) 2009-03-05
PT2223682E (pt) 2012-03-22

Similar Documents

Publication Publication Date Title
EE05167B1 (et) Stabiilsed farmatseutilised lahuspreparaadid survestatud doseerivatele inhalaatoritele
EE04259B1 (et) Survestatud doseerivad inhalaatorid (MDId)
DK1306082T3 (da) Afmålte dosisinhalatorer under tryk og farmaceutiske aerosolformuleringer
EP1068874A4 (en) MEDICINE DISPENSING DEVICE IN THE FORM OF AN INHALATOR
NO20032836D0 (no) Utmålt-dose-inhalator for salmeterol-xinafoat
BRPI0507225A2 (pt) formulações estáveis de solução farmacêutica para inaladores pressurizados de dose medida
IL177103A0 (en) Stable pharmaceutical solution formulations for pressurized metered dose inhalers
ZA200606577B (en) Stable pharmaceutical solution formulations for pressurized metered dose inhalers
DK1173244T3 (da) Pulverinhalator til kombineret medikament
GB0004761D0 (en) Metered dose inhaler
GB0018674D0 (en) Metered dose inhaler
GB0004798D0 (en) Metered dose inhaler
GB0018624D0 (en) Metered dose inhaler
GB0018625D0 (en) Metered dose inhaler
GB0018652D0 (en) Metered dose inhaler
GB0018653D0 (en) Metered dose inhaler
GB0004763D0 (en) Metered dose inhaler
GB0018675D0 (en) Metered dose inhaler

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20101231