EE03568B1 - Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine - Google Patents

Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine

Info

Publication number
EE03568B1
EE03568B1 EE9700013A EE9700013A EE03568B1 EE 03568 B1 EE03568 B1 EE 03568B1 EE 9700013 A EE9700013 A EE 9700013A EE 9700013 A EE9700013 A EE 9700013A EE 03568 B1 EE03568 B1 EE 03568B1
Authority
EE
Estonia
Prior art keywords
preparation
benzimidazole derivatives
benzimidazole
derivatives
Prior art date
Application number
EE9700013A
Other languages
English (en)
Estonian (et)
Other versions
EE9700013A (et
Inventor
Dawes Chamberlain Stanley
Walter Koszalka George
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of EE9700013A publication Critical patent/EE9700013A/xx
Publication of EE03568B1 publication Critical patent/EE03568B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EE9700013A 1994-07-07 1995-07-06 Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine EE03568B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides
PCT/GB1995/001597 WO1996001833A1 (en) 1994-07-07 1995-07-06 Therapeutic compounds

Publications (2)

Publication Number Publication Date
EE9700013A EE9700013A (et) 1997-06-16
EE03568B1 true EE03568B1 (et) 2001-12-17

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700013A EE03568B1 (et) 1994-07-07 1995-07-06 Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine

Country Status (44)

Country Link
US (4) US6077832A (bg)
EP (1) EP0769017B1 (bg)
JP (1) JP3225045B2 (bg)
KR (1) KR100376075B1 (bg)
CN (2) CN1052010C (bg)
AP (1) AP736A (bg)
AT (1) ATE193298T1 (bg)
AU (1) AU702248B2 (bg)
BG (1) BG63435B1 (bg)
BR (1) BR9508237A (bg)
CY (1) CY2249B1 (bg)
CZ (1) CZ290800B6 (bg)
DE (1) DE69517172T2 (bg)
DK (1) DK0769017T3 (bg)
EE (1) EE03568B1 (bg)
ES (1) ES2147294T3 (bg)
FI (1) FI117629B (bg)
GB (1) GB9413724D0 (bg)
GE (1) GEP20002298B (bg)
GR (1) GR3033744T3 (bg)
HK (1) HK1003711A1 (bg)
HR (1) HRP950382B1 (bg)
HU (1) HU227679B1 (bg)
IL (1) IL114492A (bg)
IS (1) IS1812B (bg)
MD (1) MD1838G2 (bg)
MX (1) MX9606732A (bg)
MY (1) MY117892A (bg)
NO (1) NO308854B1 (bg)
NZ (1) NZ288722A (bg)
OA (1) OA10339A (bg)
PL (1) PL181136B1 (bg)
PT (1) PT769017E (bg)
RO (1) RO117699B1 (bg)
RU (1) RU2145963C1 (bg)
SA (1) SA95160202B1 (bg)
SK (1) SK282046B6 (bg)
TJ (1) TJ270B (bg)
TR (1) TR199500832A2 (bg)
TW (1) TW418196B (bg)
UA (1) UA66744C2 (bg)
WO (1) WO1996001833A1 (bg)
YU (1) YU49443B (bg)
ZA (1) ZA955644B (bg)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
ATE227734T1 (de) * 1995-08-18 2002-11-15 Univ Michigan 5'-substitutierte-ribofuranosyl benzimidazolen als antivirale.
GB9518465D0 (en) * 1995-09-09 1995-11-08 Smithkline Beecham Seiyaku Kk Pharmaceuticals
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
AU2253297A (en) * 1996-01-23 1997-08-20 Regents Of The University Of Michigan, The Imidazo{1,2-a}pyridine c-nucleosides as antiviral agents
US6576133B2 (en) 1996-11-13 2003-06-10 Transgenomic, Inc Method and system for RNA analysis by matched ion polynucleotide chromatography
US6475388B1 (en) 1996-11-13 2002-11-05 Transgenomic, Inc. Method and system for RNA analysis by matched ion polynucleotide chromatography
GB2319961A (en) * 1996-12-07 1998-06-10 Glaxo Group Ltd Pharmaceutical composition for treatment of restenosis
WO1998035977A1 (en) 1997-02-13 1998-08-20 Glaxo Group Limited Benzimidazole derivatives
CA2293470C (en) 1997-06-10 2008-05-13 Glaxo Group Limited Benzimidazole derivatives
US6455506B1 (en) 1997-07-30 2002-09-24 Smithkline Beecham Corporation Lyxofuranosyl benzimidazoles as antiviral agents
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807355D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
EP1644011A1 (en) 2003-06-25 2006-04-12 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
WO2005063788A1 (ja) * 2003-12-26 2005-07-14 Kissei Pharmaceutical Co., Ltd. ベンズイミダゾール誘導体及びその医薬用途
JPWO2006115137A1 (ja) * 2005-04-22 2008-12-18 キッセイ薬品工業株式会社 ２−アミノベンズイミダゾール誘導体及びその医薬用途
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US9447050B2 (en) 2011-04-05 2016-09-20 The Translational Genomics Research Institute Solid forms of curcumin
WO2014004939A1 (en) 2012-06-29 2014-01-03 The Procter & Gamble Company Textured fibrous webs, apparatus and methods for forming textured fibrous webs
ES2885424T3 (es) 2013-03-15 2021-12-13 Knopp Biosciences Llc Imidazo(4,5-B)piridin-2-il amidas como activadores del canal Kv7
HUE064331T2 (hu) * 2014-09-12 2024-03-28 Biohaven Therapeutics Ltd Benzoimidazol-1,2-il amidok mint KV7 csatorna aktivátorok
US10478431B2 (en) 2014-11-26 2019-11-19 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
MX2020009693A (es) 2018-03-19 2021-01-08 Knopp Biosciences Llc Composiciones y metodos de uso de los activadores del canal kv7.
US20210395289A1 (en) 2020-06-23 2021-12-23 Biometrix Technology Inc Novel benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent or anti-virus agent comprising the same
WO2024081308A1 (en) 2022-10-12 2024-04-18 Takeda Pharmaceutical Company Limited Method of preparing maribavir

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399987A (en) * 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) * 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
DE2130030A1 (de) * 1971-06-18 1972-12-21 Bayer Ag Fungizide und bakterizide Mittel
US4002623A (en) * 1974-08-07 1977-01-11 Pfizer Inc. Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines
FR2549938B1 (fr) * 1983-07-25 1987-08-07 Fonderie Soc Gen De Bruleur a premelange gazeux et chaudiere equipee d'un tel bruleur
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
DK405988A (da) * 1987-07-29 1989-01-30 Hoffmann La Roche Benzimidazolderivater
IT1226100B (it) * 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
WO1992018517A1 (en) * 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
ZA923640B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
WO1994008456A1 (en) * 1992-10-21 1994-04-28 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
JP6217655B2 (ja) * 2015-01-15 2017-10-25 トヨタ自動車株式会社 電力変換装置

Also Published As

Publication number Publication date
MD1838F2 (en) 2002-01-31
BG63435B1 (bg) 2002-01-31
AP736A (en) 1999-03-09
HRP950382B1 (en) 2000-12-31
GB9413724D0 (en) 1994-08-24
RO117699B1 (ro) 2002-06-28
HK1003711A1 (en) 1998-11-06
IS1812B (is) 2002-05-15
JP3225045B2 (ja) 2001-11-05
NO970040L (no) 1997-01-29
CZ4097A3 (en) 1997-08-13
UA66744C2 (en) 2004-06-15
EE9700013A (et) 1997-06-16
NO308854B1 (no) 2000-11-06
NO970040D0 (no) 1997-01-06
TJ270B (en) 2000-08-07
TR199500832A2 (tr) 1996-06-21
ATE193298T1 (de) 2000-06-15
IS4394A (is) 1996-12-09
MD1838G2 (ro) 2002-08-31
IL114492A0 (en) 1995-11-27
GEP20002298B (en) 2000-11-25
US6077832A (en) 2000-06-20
CY2249B1 (en) 2003-07-04
CZ290800B6 (cs) 2002-10-16
AU2805195A (en) 1996-02-09
ES2147294T3 (es) 2000-09-01
GR3033744T3 (en) 2000-10-31
CN1159194A (zh) 1997-09-10
FI970032A (fi) 1997-01-03
HU227679B1 (en) 2011-11-28
EP0769017A1 (en) 1997-04-23
KR100376075B1 (ko) 2004-02-18
HU9700034D0 (en) 1997-02-28
US6307043B1 (en) 2001-10-23
AU702248B2 (en) 1999-02-18
HRP950382A2 (en) 1997-08-31
DE69517172T2 (de) 2000-10-19
YU45095A (sh) 1999-03-04
BR9508237A (pt) 1999-06-01
PL318062A1 (en) 1997-05-12
SK282046B6 (sk) 2001-10-08
US20010003744A1 (en) 2001-06-14
MX9606732A (es) 1997-04-30
FI970032A0 (fi) 1997-01-03
YU49443B (sh) 2006-03-03
CN1052010C (zh) 2000-05-03
FI117629B (fi) 2006-12-29
PT769017E (pt) 2000-09-29
DK0769017T3 (da) 2000-09-11
TW418196B (en) 2001-01-11
OA10339A (en) 1997-10-07
BG101118A (bg) 1998-04-30
SK168896A3 (en) 1997-09-10
HUT77285A (hu) 1998-03-30
EP0769017B1 (en) 2000-05-24
NZ288722A (en) 1998-07-28
US5998605A (en) 1999-12-07
PL181136B1 (pl) 2001-06-29
WO1996001833A1 (en) 1996-01-25
MY117892A (en) 2004-08-30
DE69517172D1 (de) 2000-06-29
JPH10502356A (ja) 1998-03-03
CN1236616A (zh) 1999-12-01
AP9600895A0 (en) 1997-01-31
ZA955644B (en) 1997-01-06
SA95160202B1 (ar) 2005-04-16
RU2145963C1 (ru) 2000-02-27
IL114492A (en) 2002-05-23

Similar Documents

Publication Publication Date Title
EE03568B1 (et) Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine
EE03231B1 (et) Tetratsüklilised derivaadid, nende valmistamismeetod ja kasutamine
EE03482B1 (et) Kinasoliiniderivaadid, nende valmistamismeetod ja kasutamine
FI964395A (fi) Uudet erytromysiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä
FI955913A (fi) Uudet erytromysiinijohdannaiset, menetelmät niiden valmistamiseksi ja niiden käyttö lääkkeinä
CY2013003I2 (el) Φωσφονοκεφεμικα παραγωγα, διαδικασια για την παρασκευη τους, και χρηση αυτων
FI955235A0 (fi) Oksatsolidiinionijohdannaiset, niiden valmistus ja käyttö
EE03338B1 (et) Tromboosivastane ravim, selle valmistamise protsess ja kasutamine
DE69525418T2 (de) Benzimidazol-derivate
EE04721B1 (et) Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
EE9900147A (et) Oksadiasoolid, nende saamismeetodid ja kasutamine ravimitena
EE9800302A (et) Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat
EE9800265A (et) Erütromütsiini derivaadid, nende valmistamismeetod ja kasutamine ravimitena
EE03921B1 (et) N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod ja kasutamine
EE9600172A (et) Puriin-6-ooni derivaadid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja ravimid
EE9900112A (et) 2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE03682B1 (et) Asendatud bensimidasooli derivaadid, protsessid nende valmistamiseks ning nende kasutamine
EE9800200A (et) Bensoüülguanidiini derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
EE03878B1 (et) 5-O-desosaminüül-6-O-metüülerütronoliid A derivaadid, nende valmistamismeetod ja kasutamine bioaktiivsete ühendite valmistamiseks
EE9800145A (et) Fenüülamidiini derivaadid, meetodid nende valmistamiseks ja nende kasutamine arstimitena
EE200000651A (et) Asoolid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
FI964310A (fi) Imidatsolijohdannainen ja menetelmä sen valmistamiseksi
FI941914A (fi) 2-amino-4-kinoliinidihydropyridiinejä, menetelmiä niiden valmistamiseksi ja niiden käyttö
FI953956A (fi) 2,3-rengaskondensoidut 1,4-dihydropyridiinit, menetelmät niiden valmistamiseksi ja niiden käyttö lääkkeinä
FI942912A (fi) Substituoidut bentsimidatsolit, menetelmä niiden valmistamiseksi sekä niiden käyttö

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231