BG101118A - Лечебни съединения - Google Patents

Лечебни съединения

Info

Publication number
BG101118A
BG101118A BG101118A BG10111897A BG101118A BG 101118 A BG101118 A BG 101118A BG 101118 A BG101118 A BG 101118A BG 10111897 A BG10111897 A BG 10111897A BG 101118 A BG101118 A BG 101118A
Authority
BG
Bulgaria
Prior art keywords
relates
therapeutical
therapeutical compounds
derivatives
compounds
Prior art date
Application number
BG101118A
Other languages
English (en)
Other versions
BG63435B1 (bg
Inventor
Stanley Chamberlain
George KOSZALKA
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of BG101118A publication Critical patent/BG101118A/bg
Publication of BG63435B1 publication Critical patent/BG63435B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Изобретението се отнася до бензимидазолови производни и тяхното използване в лечебната медицина за лечение или профилактика на вирусни инфекции, по-специално на такива, причинени от вирусите на херпеса. Изобретението се отнася също до получаването на бензимидазоловите производни и на фармацевтичните препарати, които ги съдържат.
BG101118A 1994-07-07 1997-01-06 Лечебни съединения BG63435B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides
PCT/GB1995/001597 WO1996001833A1 (en) 1994-07-07 1995-07-06 Therapeutic compounds

Publications (2)

Publication Number Publication Date
BG101118A true BG101118A (bg) 1998-04-30
BG63435B1 BG63435B1 (bg) 2002-01-31

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101118A BG63435B1 (bg) 1994-07-07 1997-01-06 Лечебни съединения

Country Status (44)

Country Link
US (4) US6077832A (bg)
EP (1) EP0769017B1 (bg)
JP (1) JP3225045B2 (bg)
KR (1) KR100376075B1 (bg)
CN (2) CN1052010C (bg)
AP (1) AP736A (bg)
AT (1) ATE193298T1 (bg)
AU (1) AU702248B2 (bg)
BG (1) BG63435B1 (bg)
BR (1) BR9508237A (bg)
CY (1) CY2249B1 (bg)
CZ (1) CZ290800B6 (bg)
DE (1) DE69517172T2 (bg)
DK (1) DK0769017T3 (bg)
EE (1) EE03568B1 (bg)
ES (1) ES2147294T3 (bg)
FI (1) FI117629B (bg)
GB (1) GB9413724D0 (bg)
GE (1) GEP20002298B (bg)
GR (1) GR3033744T3 (bg)
HK (1) HK1003711A1 (bg)
HR (1) HRP950382B1 (bg)
HU (1) HU227679B1 (bg)
IL (1) IL114492A (bg)
IS (1) IS1812B (bg)
MD (1) MD1838G2 (bg)
MX (1) MX9606732A (bg)
MY (1) MY117892A (bg)
NO (1) NO308854B1 (bg)
NZ (1) NZ288722A (bg)
OA (1) OA10339A (bg)
PL (1) PL181136B1 (bg)
PT (1) PT769017E (bg)
RO (1) RO117699B1 (bg)
RU (1) RU2145963C1 (bg)
SA (1) SA95160202B1 (bg)
SK (1) SK282046B6 (bg)
TJ (1) TJ270B (bg)
TR (1) TR199500832A2 (bg)
TW (1) TW418196B (bg)
UA (1) UA66744C2 (bg)
WO (1) WO1996001833A1 (bg)
YU (1) YU49443B (bg)
ZA (1) ZA955644B (bg)

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GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
IL125447A0 (en) 1996-01-23 1999-03-12 Univ Michigan Modified benzimidazole nucleosides as antiviral agents
US6475388B1 (en) 1996-11-13 2002-11-05 Transgenomic, Inc. Method and system for RNA analysis by matched ion polynucleotide chromatography
US6576133B2 (en) 1996-11-13 2003-06-10 Transgenomic, Inc Method and system for RNA analysis by matched ion polynucleotide chromatography
GB2319961A (en) * 1996-12-07 1998-06-10 Glaxo Group Ltd Pharmaceutical composition for treatment of restenosis
WO1998035977A1 (en) 1997-02-13 1998-08-20 Glaxo Group Limited Benzimidazole derivatives
US6455507B1 (en) 1997-06-10 2002-09-24 Smithkline Beecham Corporation Benzimidazole derivatives
WO1999006424A1 (en) 1997-07-30 1999-02-11 The Regents Of The University Of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
JP2007526017A (ja) 2003-06-25 2007-09-13 エイセル インコーポレイテッド 組織修復用に調整されたマトリクス組成物
WO2005063788A1 (ja) * 2003-12-26 2005-07-14 Kissei Pharmaceutical Co., Ltd. ベンズイミダゾール誘導体及びその医薬用途
JPWO2006115137A1 (ja) * 2005-04-22 2008-12-18 キッセイ薬品工業株式会社 ２−アミノベンズイミダゾール誘導体及びその医薬用途
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
WO2012138907A2 (en) * 2011-04-05 2012-10-11 Translational Genomics Research Institute Solid forms of curcumin
EP2867010A1 (en) 2012-06-29 2015-05-06 The Procter & Gamble Company Textured fibrous webs, apparatus and methods for forming textured fibrous webs
WO2014145852A2 (en) 2013-03-15 2014-09-18 Knopp Biosciences Llc Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators
US9481653B2 (en) 2014-09-12 2016-11-01 Knopp Biosciences Llc Benzoimidazol-1,2-yl amides as Kv7 channel activators
WO2016086060A1 (en) * 2014-11-26 2016-06-02 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
SG11202008030WA (en) 2018-03-19 2020-10-29 Knopp Biosciences Llc Kv7 channel activators compositions and methods of use
US20210395289A1 (en) 2020-06-23 2021-12-23 Biometrix Technology Inc Novel benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent or anti-virus agent comprising the same
WO2024081308A1 (en) 2022-10-12 2024-04-18 Takeda Pharmaceutical Company Limited Method of preparing maribavir

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Also Published As

Publication number Publication date
DK0769017T3 (da) 2000-09-11
OA10339A (en) 1997-10-07
FI117629B (fi) 2006-12-29
EE9700013A (et) 1997-06-16
SK168896A3 (en) 1997-09-10
HU227679B1 (en) 2011-11-28
CN1052010C (zh) 2000-05-03
IS1812B (is) 2002-05-15
BR9508237A (pt) 1999-06-01
IL114492A (en) 2002-05-23
PT769017E (pt) 2000-09-29
IS4394A (is) 1996-12-09
WO1996001833A1 (en) 1996-01-25
PL181136B1 (pl) 2001-06-29
CN1159194A (zh) 1997-09-10
US6077832A (en) 2000-06-20
KR100376075B1 (ko) 2004-02-18
CY2249B1 (en) 2003-07-04
HU9700034D0 (en) 1997-02-28
FI970032A (fi) 1997-01-03
HRP950382A2 (en) 1997-08-31
ZA955644B (en) 1997-01-06
PL318062A1 (en) 1997-05-12
FI970032A0 (fi) 1997-01-03
AP9600895A0 (en) 1997-01-31
US20010003744A1 (en) 2001-06-14
US5998605A (en) 1999-12-07
BG63435B1 (bg) 2002-01-31
EE03568B1 (et) 2001-12-17
JPH10502356A (ja) 1998-03-03
ES2147294T3 (es) 2000-09-01
IL114492A0 (en) 1995-11-27
CZ290800B6 (cs) 2002-10-16
GB9413724D0 (en) 1994-08-24
SA95160202B1 (ar) 2005-04-16
GR3033744T3 (en) 2000-10-31
MD1838G2 (ro) 2002-08-31
NO970040D0 (no) 1997-01-06
MX9606732A (es) 1997-04-30
AU2805195A (en) 1996-02-09
YU45095A (sh) 1999-03-04
AP736A (en) 1999-03-09
CZ4097A3 (en) 1997-08-13
HRP950382B1 (en) 2000-12-31
HUT77285A (hu) 1998-03-30
TW418196B (en) 2001-01-11
TJ270B (en) 2000-08-07
CN1236616A (zh) 1999-12-01
NZ288722A (en) 1998-07-28
RO117699B1 (ro) 2002-06-28
JP3225045B2 (ja) 2001-11-05
NO308854B1 (no) 2000-11-06
MY117892A (en) 2004-08-30
UA66744C2 (en) 2004-06-15
GEP20002298B (en) 2000-11-25
RU2145963C1 (ru) 2000-02-27
DE69517172T2 (de) 2000-10-19
EP0769017B1 (en) 2000-05-24
AU702248B2 (en) 1999-02-18
NO970040L (no) 1997-01-29
US6307043B1 (en) 2001-10-23
MD1838F2 (en) 2002-01-31
ATE193298T1 (de) 2000-06-15
YU49443B (sh) 2006-03-03
EP0769017A1 (en) 1997-04-23
HK1003711A1 (en) 1998-11-06
DE69517172D1 (de) 2000-06-29
TR199500832A2 (tr) 1996-06-21
SK282046B6 (sk) 2001-10-08

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