EE03567B1 - Klavulaanhappe eraldamine fermentatsioonilahusest ultrafiltrimisega - Google Patents
Klavulaanhappe eraldamine fermentatsioonilahusest ultrafiltrimisegaInfo
- Publication number
- EE03567B1 EE03567B1 EE9800060A EE9800060A EE03567B1 EE 03567 B1 EE03567 B1 EE 03567B1 EE 9800060 A EE9800060 A EE 9800060A EE 9800060 A EE9800060 A EE 9800060A EE 03567 B1 EE03567 B1 EE 03567B1
- Authority
- EE
- Estonia
- Prior art keywords
- ultrafiltration
- separation
- fermentation broth
- clavulanic acid
- clavulanic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D503/10—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D503/12—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 unsubstituted in position 6
- C07D503/14—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 unsubstituted in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, other than a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, attached in position 3
- C07D503/16—Radicals substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical
- C07D503/18—Radicals substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/02—Separating microorganisms from their culture media
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9500265A SI9500265A1 (en) | 1995-08-28 | 1995-08-28 | Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration |
PCT/GB1996/002083 WO1997008175A1 (en) | 1995-08-28 | 1996-08-27 | Isolation of clavulanic acid from fermentation broth by ultrafiltration |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9800060A EE9800060A (et) | 1998-08-17 |
EE03567B1 true EE03567B1 (et) | 2001-12-17 |
Family
ID=20431679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9800060A EE03567B1 (et) | 1995-08-28 | 1996-08-27 | Klavulaanhappe eraldamine fermentatsioonilahusest ultrafiltrimisega |
Country Status (20)
Country | Link |
---|---|
US (2) | US6127358A (xx) |
EP (1) | EP0859780A1 (xx) |
JP (1) | JP2000512125A (xx) |
KR (1) | KR19990035966A (xx) |
CN (1) | CN1101396C (xx) |
AU (1) | AU714892B2 (xx) |
BG (1) | BG63086B1 (xx) |
CA (1) | CA2226683C (xx) |
CZ (1) | CZ31898A3 (xx) |
EE (1) | EE03567B1 (xx) |
HU (1) | HU221353B1 (xx) |
NZ (1) | NZ316136A (xx) |
PL (1) | PL324855A1 (xx) |
RO (1) | RO116813B1 (xx) |
RU (1) | RU2169151C2 (xx) |
SI (1) | SI9500265A1 (xx) |
SK (1) | SK10398A3 (xx) |
UA (1) | UA59343C2 (xx) |
WO (1) | WO1997008175A1 (xx) |
ZA (1) | ZA967273B (xx) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT400033B (de) | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
SI9500074A (en) * | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
AT403375B (de) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | Verfahren zur fällung von alkalisalzen der clavulansäure |
ES2105988B1 (es) * | 1996-03-15 | 1998-07-01 | Antibioticos Sa | Procedimiento para purificar 7-sustituido-amino-desacetoxi-cefalosporinas mediante el empleo de membranas de filtracion. |
GB0022841D0 (en) * | 2000-09-18 | 2000-11-01 | Smithkline Beecham Plc | Process |
JP2004094465A (ja) * | 2002-08-30 | 2004-03-25 | Fujitsu Ltd | 解析支援装置 |
WO2008132531A1 (en) * | 2007-04-27 | 2008-11-06 | Council Of Scientific And Industrial Research | Process for the preparation of clavulanic acid employing streptomyces clavuligerus mtcc 1142 in a solid state fermentation |
CN102838624B (zh) * | 2012-09-07 | 2014-10-29 | 安徽普朗膜技术有限公司 | 一种从发酵液中纯化克拉维酸的方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3873425A (en) * | 1971-11-19 | 1975-03-25 | Tatsuyoshi Kobayashi | Process for producing itaconic acid |
GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
IE41110B1 (en) * | 1974-04-20 | 1979-10-24 | Beecham Group Ltd | Esters of clavulanic acid |
IE41109B1 (en) * | 1974-04-20 | 1979-10-24 | Beecham Group Ltd | Novel -lactam antibiotic from streptomyces clavuligerus |
US4140764A (en) * | 1974-12-18 | 1979-02-20 | Beecham Group Limited | β-Lactamase inhibitors and process for their preparation |
US4148880A (en) * | 1975-08-13 | 1979-04-10 | Pfizer Inc. | Mixture of antibiotics produced by a species of actinoplanes |
GB1563103A (en) * | 1975-10-13 | 1980-03-19 | Beecham Group Ltd | Process for the preparation of clavulanic acid |
GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
JPS5791196A (en) * | 1980-11-27 | 1982-06-07 | Takeda Chem Ind Ltd | Separation of inosine, guanosine or their mixture from cell bodies and high polymeric substances |
JPS6070092A (ja) * | 1983-09-26 | 1985-04-20 | Ajinomoto Co Inc | グルタミン酸発酵液からのグルタミン酸結晶の取得法 |
MX7417E (es) * | 1984-10-27 | 1988-10-14 | Antibioticos Sa | Metodo para la preparacion de acido clavulanico y sus derivados |
IT1221982B (it) * | 1987-07-08 | 1990-08-31 | Mini Ricerca Scient Tecnolog | Antibiotici ab 006 e processo per la loro produzione |
DE3730868A1 (de) * | 1987-09-15 | 1989-03-23 | Henkel Kgaa | Verfahren zur abtrennung von biotechnisch hergestellten wertstoffen aus einer fermenterbruehe durch querstrom-mikro- und/oder ultrafiltration |
ES2010144A6 (es) * | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | Un procedimiento de floculacion-coagulacion de caldos de fermentacion de streptomyces sp. que permite la obtencion directa de liquidos completamente transparentes. |
US5024937A (en) * | 1989-04-06 | 1991-06-18 | Dow Corning Corporation | Method for processing aqueous fermentation broths |
EP0431679B1 (en) * | 1989-12-05 | 1994-10-19 | Merck & Co. Inc. | Method of stabilizing recombinant hepatitis B virus surface proteins from yeast |
JPH0475595A (ja) * | 1990-07-17 | 1992-03-10 | Kanebo Ltd | フェニル配糖体の製造法 |
US5268283A (en) * | 1990-10-05 | 1993-12-07 | Miles Inc. | Method for the production of detergent builder formulations utilizing spray granulated citric acid and salts thereof |
DE4031854A1 (de) * | 1990-10-08 | 1992-04-09 | Basf Ag | Mikroorganismus und verfahren zur gewinnung von anthranilsaeure |
JP2615272B2 (ja) | 1991-03-22 | 1997-05-28 | 日本碍子株式会社 | 蛋白質溶液中の蛋白有価物の回収方法 |
AT399155B (de) * | 1992-03-26 | 1995-03-27 | Lek Tovarna Farmacevtskih | Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung |
SI9300296B (sl) | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
EP0719778A1 (en) * | 1993-03-26 | 1996-07-03 | Gist-Brocades N.V. | Diamine salts of clavulanic acid |
WO1995011295A1 (en) * | 1993-10-22 | 1995-04-27 | Gist-Brocades N.V. | An improved process to recover an aqueous fermentation broth |
AT400846B (de) * | 1994-02-25 | 1996-03-25 | Fermic S A De C V | Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure |
SI9400107A (en) * | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
JP3617091B2 (ja) * | 1994-11-30 | 2005-02-02 | 味の素株式会社 | 塩基性アミノ酸の精製方法 |
SI9500074A (en) * | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
SI9500134B (sl) * | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
ES2101658B1 (es) * | 1995-11-23 | 1998-03-01 | Antibioticos Sa | Nuevo procedimiento de produccion de acido clavulanico y sus sales. |
-
1995
- 1995-08-28 SI SI9500265A patent/SI9500265A1/sl not_active IP Right Cessation
-
1996
- 1996-08-27 AU AU68297/96A patent/AU714892B2/en not_active Ceased
- 1996-08-27 WO PCT/GB1996/002083 patent/WO1997008175A1/en not_active Application Discontinuation
- 1996-08-27 US US09/000,375 patent/US6127358A/en not_active Expired - Fee Related
- 1996-08-27 KR KR1019980700627A patent/KR19990035966A/ko not_active Application Discontinuation
- 1996-08-27 NZ NZ316136A patent/NZ316136A/en unknown
- 1996-08-27 CA CA002226683A patent/CA2226683C/en not_active Expired - Fee Related
- 1996-08-27 SK SK103-98A patent/SK10398A3/sk unknown
- 1996-08-27 HU HU9802532A patent/HU221353B1/hu not_active IP Right Cessation
- 1996-08-27 UA UA98020991A patent/UA59343C2/uk unknown
- 1996-08-27 EP EP96928571A patent/EP0859780A1/en not_active Withdrawn
- 1996-08-27 CN CN96196471A patent/CN1101396C/zh not_active Expired - Fee Related
- 1996-08-27 EE EE9800060A patent/EE03567B1/xx not_active IP Right Cessation
- 1996-08-27 JP JP09509986A patent/JP2000512125A/ja not_active Ceased
- 1996-08-27 CZ CZ98318A patent/CZ31898A3/cs unknown
- 1996-08-27 RU RU98104924/04A patent/RU2169151C2/ru not_active IP Right Cessation
- 1996-08-27 RO RO98-00301A patent/RO116813B1/ro unknown
- 1996-08-27 PL PL96324855A patent/PL324855A1/xx unknown
- 1996-08-28 ZA ZA9607273A patent/ZA967273B/xx unknown
-
1998
- 1998-02-16 BG BG102253A patent/BG63086B1/bg unknown
-
2000
- 2000-08-14 US US09/638,473 patent/US6274575B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU714892B2 (en) | 2000-01-13 |
CA2226683A1 (en) | 1997-03-06 |
JP2000512125A (ja) | 2000-09-19 |
CN1193975A (zh) | 1998-09-23 |
WO1997008175A1 (en) | 1997-03-06 |
EE9800060A (et) | 1998-08-17 |
HUP9802532A2 (hu) | 1999-03-29 |
CN1101396C (zh) | 2003-02-12 |
HU221353B1 (en) | 2002-09-28 |
BG63086B1 (bg) | 2001-03-30 |
US6127358A (en) | 2000-10-03 |
EP0859780A1 (en) | 1998-08-26 |
CA2226683C (en) | 2002-04-30 |
US6274575B1 (en) | 2001-08-14 |
SI9500265A1 (en) | 1997-02-28 |
RU2169151C2 (ru) | 2001-06-20 |
RO116813B1 (ro) | 2001-06-29 |
CZ31898A3 (cs) | 1998-07-15 |
AU6829796A (en) | 1997-03-19 |
NZ316136A (en) | 1998-09-24 |
ZA967273B (en) | 1997-03-04 |
KR19990035966A (ko) | 1999-05-25 |
HUP9802532A3 (en) | 1999-04-28 |
BG102253A (en) | 1998-08-31 |
SK10398A3 (en) | 1998-07-08 |
PL324855A1 (en) | 1998-06-22 |
UA59343C2 (uk) | 2003-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE283264T1 (de) | Zwischenprodukte zur herstellung von metallproteinasehemmern | |
DE69620240D1 (de) | Herstellung von levulinsäure aus kohlenhydrathaltigen materialien | |
DE69516182D1 (de) | Aminonitrile zwischenprodukte zur herstellung von alamindiessigsaüre | |
DE3689572D1 (de) | Verfahren zur Isolierung von Genen zur Biosynthese von Antibiotika. | |
MA22970A1 (fr) | Procede de praparation de nouveaux composes. | |
FI980630A0 (fi) | Menetelmä klavulaanihapon valmistamiseksi | |
FR2629096B1 (fr) | Procede d'oxygenation controlee d'un mout de fermentation alcoolique, et installation correspondante | |
DE69209510D1 (de) | Fermentationsprozess zur herstellung von natamycin | |
DE69533773D1 (de) | Verfahren zur Herstellung von Isolationsgraben | |
DE69706621D1 (de) | Oxidationsverfahren zur Herstellung von Chinacridonpigmenten | |
ID23892A (id) | Metode pembuatan asam l-glutamat melalui fermentasi | |
EE03567B1 (et) | Klavulaanhappe eraldamine fermentatsioonilahusest ultrafiltrimisega | |
ID16007A (id) | Metode untuk pemisahan dari asam 2-hidroksi -4-metil tio butirat atau mha | |
AU7788591A (en) | Improved nucleic acid separation method | |
AU9264598A (en) | Statin production by fermentation | |
FR2666095B1 (fr) | Production de la l-lysine par fermentation. | |
AU1092588A (en) | Expression of the p. falciparum circumsporozoite protein by yeast | |
EE03393B1 (et) | Protsess enantiomeerselt puhta asetidiin-2-karboksüülhappe saamiseks | |
DE69705770D1 (de) | Oxidationsverfahren zur Herstellung von Chinacridonpigmenten | |
AU5814696A (en) | The preparation of carboxylic acid derivatives | |
AU2643495A (en) | Assay for pathogenicity of anti-dna antibodies | |
DE69616085D1 (de) | Aminonitril-zwischenprodukte zur herstellung von 2-hydroxyethyliminodiessigsäure | |
AU5556298A (en) | Purification of fermented clavulanic acid | |
FI913280A (fi) | Mikrobiologiskt foerfarande foer oxidering av metylgrupper. | |
MD300F1 (ro) | Procedeu de obtinere a culturii de elita a trihogramei Trichogramma evanescens V |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
MM4A | Lapsed by not paying the annual fees |
Effective date: 20040827 |