EE03561B1 - L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetod - Google Patents
L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetodInfo
- Publication number
- EE03561B1 EE03561B1 EEP199900361A EEP9900361A EE03561B1 EE 03561 B1 EE03561 B1 EE 03561B1 EE P199900361 A EEP199900361 A EE P199900361A EE P9900361 A EEP9900361 A EE P9900361A EE 03561 B1 EE03561 B1 EE 03561B1
- Authority
- EE
- Estonia
- Prior art keywords
- carnitine
- preparation
- hygroscopic salts
- stable non
- salts
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical class C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 title abstract 3
- 239000002002 slurry Substances 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000011837 pasties Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000409A IT1289974B1 (it) | 1997-02-25 | 1997-02-25 | Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine |
| PCT/EP1998/001039 WO1998038157A1 (en) | 1997-02-25 | 1998-02-24 | Process for the preparation of stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9900361A EE9900361A (et) | 2000-04-17 |
| EE03561B1 true EE03561B1 (et) | 2001-12-17 |
Family
ID=11376175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP199900361A EE03561B1 (et) | 1997-02-25 | 1998-02-24 | L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetod |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6271258B1 (de) |
| EP (1) | EP1019362B1 (de) |
| JP (1) | JP2001513096A (de) |
| KR (1) | KR100538788B1 (de) |
| CN (1) | CN1248967A (de) |
| AT (1) | ATE222233T1 (de) |
| AU (1) | AU724276B2 (de) |
| BR (1) | BR9807761A (de) |
| CA (1) | CA2281630C (de) |
| CZ (1) | CZ290893B6 (de) |
| DE (1) | DE69807245T2 (de) |
| DK (1) | DK1019362T3 (de) |
| EE (1) | EE03561B1 (de) |
| ES (1) | ES2182290T3 (de) |
| HU (1) | HUP0001674A3 (de) |
| IL (1) | IL131256A (de) |
| IS (1) | IS5160A (de) |
| IT (1) | IT1289974B1 (de) |
| NO (1) | NO994110L (de) |
| NZ (1) | NZ337188A (de) |
| PL (1) | PL188762B1 (de) |
| PT (1) | PT1019362E (de) |
| SK (1) | SK115399A3 (de) |
| TR (1) | TR199902043T2 (de) |
| WO (1) | WO1998038157A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1312018B1 (it) | 1999-03-19 | 2002-04-04 | Fassi Aldo | Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina. |
| KR100461572B1 (ko) * | 1999-03-27 | 2004-12-14 | 삼성정밀화학 주식회사 | Ｌ-카르니틴 칼슘 염과 이의 제조방법 |
| CA2383814C (en) * | 1999-09-03 | 2010-08-17 | Sigma-Tau Healthscience S.P.A. | Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same |
| IT1316988B1 (it) * | 2000-02-10 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine. |
| IT1317013B1 (it) * | 2000-04-12 | 2003-05-26 | Biosalts Srl | Sostanze dolcificanti, particolarmente per il caffe' ed il the'. |
| ITRM20020055A1 (it) * | 2002-02-04 | 2003-08-04 | Aldo Fassi | Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti |
| ES2385046T3 (es) * | 2005-07-05 | 2012-07-17 | Lonza Ag | Procedimiento de secado por pulverización para producir un polvo o granulado de carnitina seco |
| US7523176B2 (en) * | 2005-08-02 | 2009-04-21 | International Business Machines Corporation | Method, apparatus, and computer program product for reconfiguring a storage area network to support the execution of an application automatically upon execution of the application |
| MX2008005936A (es) * | 2005-11-07 | 2008-10-01 | Perque Llc | Composiciones para regular trastornos metabolicos y metodos de uso de las mismas. |
| CN101209975B (zh) * | 2006-12-29 | 2010-12-01 | 沈阳科硕营养科技有限公司 | 左旋肉碱富马酸钙及其制备方法与用途 |
| JP2011068563A (ja) * | 2008-09-09 | 2011-04-07 | Mitsubishi Rayon Co Ltd | カルニチンフマル酸塩及びその製造方法 |
| KR101291186B1 (ko) * | 2010-07-23 | 2013-09-13 | 주식회사 셀트리온제약 | Ｌ-카르니틴 1,5-나프탈렌다이설폰산염 및 이를 포함하는 약제학적 조성물 |
| EP2425834A1 (de) * | 2010-09-06 | 2012-03-07 | Lonza Ltd. | Verfahren zur Herstellung von L-Carnitin-Tartrat |
| CN108383741A (zh) * | 2018-03-16 | 2018-08-10 | 开原亨泰化工有限公司 | 一种制备左旋肉碱成盐的新方法 |
| CN118638020B (zh) * | 2024-08-08 | 2024-11-19 | 杭州海尔希畜牧科技有限公司 | L-天门冬氨酸l(-)肉碱(1:1)的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1230610A (en) * | 1983-11-02 | 1987-12-22 | Vincenzo Iannella | Process for the the preparation of l(-)carnitine hydrochloride and of l(-)carnitine inner salt |
| DE3463261D1 (en) * | 1983-12-28 | 1987-05-27 | Sigma Tau Ind Farmaceuti | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
| US5073376A (en) * | 1989-12-22 | 1991-12-17 | Lonza Ltd. | Preparations containing l-carnitine |
| DE4111913A1 (de) * | 1991-04-12 | 1992-10-15 | Degussa | Verfahren zur herstellung von l-carnitin aus d,l-carnitinnitrilsalzen |
| CH682485A5 (de) * | 1991-08-13 | 1993-09-30 | Lonza Ag | Verfahren zur Herstellung optisch aktiver Carbonsäuren durch Racematspaltung. |
| TW397686B (en) * | 1993-08-11 | 2000-07-11 | Takeda Chemical Industries Ltd | Antacid compositions and pharmaceutical compositions |
| IT1272290B (it) * | 1994-06-20 | 1997-06-16 | Avantgarde Spa | Sale della l-carnitina e composizioni farmaceutiche che lo contengono per il trattamento di affezioni cutanee |
| IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
| CN1177807C (zh) * | 1996-05-31 | 2004-12-01 | 希格马托制药工业公司 | 稳定的、非吸湿性的l(-)肉碱和链烷酰基l(-)肉碱的盐和其制备方法以及含有此盐的固体口服组合物 |
-
1997
- 1997-02-25 IT IT97MI000409A patent/IT1289974B1/it active IP Right Grant
-
1998
- 1998-02-24 BR BR9807761A patent/BR9807761A/pt not_active IP Right Cessation
- 1998-02-24 PT PT98913582T patent/PT1019362E/pt unknown
- 1998-02-24 CA CA002281630A patent/CA2281630C/en not_active Expired - Fee Related
- 1998-02-24 PL PL98335350A patent/PL188762B1/pl not_active IP Right Cessation
- 1998-02-24 CN CN98802829A patent/CN1248967A/zh active Pending
- 1998-02-24 CZ CZ19993028A patent/CZ290893B6/cs not_active IP Right Cessation
- 1998-02-24 KR KR10-1999-7007778A patent/KR100538788B1/ko not_active Expired - Fee Related
- 1998-02-24 HU HU0001674A patent/HUP0001674A3/hu unknown
- 1998-02-24 NZ NZ337188A patent/NZ337188A/xx unknown
- 1998-02-24 AT AT98913582T patent/ATE222233T1/de not_active IP Right Cessation
- 1998-02-24 IL IL13125698A patent/IL131256A/xx not_active IP Right Cessation
- 1998-02-24 SK SK1153-99A patent/SK115399A3/sk unknown
- 1998-02-24 JP JP53728998A patent/JP2001513096A/ja not_active Ceased
- 1998-02-24 TR TR1999/02043T patent/TR199902043T2/xx unknown
- 1998-02-24 EE EEP199900361A patent/EE03561B1/xx not_active IP Right Cessation
- 1998-02-24 DK DK98913582T patent/DK1019362T3/da active
- 1998-02-24 ES ES98913582T patent/ES2182290T3/es not_active Expired - Lifetime
- 1998-02-24 WO PCT/EP1998/001039 patent/WO1998038157A1/en not_active Ceased
- 1998-02-24 US US09/355,804 patent/US6271258B1/en not_active Expired - Fee Related
- 1998-02-24 AU AU68229/98A patent/AU724276B2/en not_active Ceased
- 1998-02-24 DE DE69807245T patent/DE69807245T2/de not_active Expired - Fee Related
- 1998-02-24 EP EP98913582A patent/EP1019362B1/de not_active Expired - Lifetime
-
1999
- 1999-08-20 IS IS5160A patent/IS5160A/is unknown
- 1999-08-25 NO NO994110A patent/NO994110L/no not_active Application Discontinuation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20030224 |