ITRM20010729A1 - Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione. - Google Patents

Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione.

Info

Publication number
ITRM20010729A1
ITRM20010729A1 IT2001RM000729A ITRM20010729A ITRM20010729A1 IT RM20010729 A1 ITRM20010729 A1 IT RM20010729A1 IT 2001RM000729 A IT2001RM000729 A IT 2001RM000729A IT RM20010729 A ITRM20010729 A IT RM20010729A IT RM20010729 A1 ITRM20010729 A1 IT RM20010729A1
Authority
IT
Italy
Prior art keywords
acetyl
carnitine
salt
procedure
preparation
Prior art date
Application number
IT2001RM000729A
Other languages
English (en)
Inventor
Aldo Fassi
Original Assignee
Aldo Fassi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aldo Fassi filed Critical Aldo Fassi
Priority to IT2001RM000729A priority Critical patent/ITRM20010729A1/it
Priority to US10/207,993 priority patent/US6673837B2/en
Priority to ES02793335T priority patent/ES2339432T3/es
Priority to DE60235318T priority patent/DE60235318D1/de
Priority to AU2002358989A priority patent/AU2002358989A1/en
Priority to AT02793335T priority patent/ATE457300T1/de
Priority to PT02793335T priority patent/PT1453791E/pt
Priority to EP02793335A priority patent/EP1453791B1/en
Priority to DK02793335.7T priority patent/DK1453791T3/da
Priority to SI200230893T priority patent/SI1453791T1/sl
Priority to CNB028248260A priority patent/CN1250521C/zh
Priority to HU0402545A priority patent/HU230034B1/hu
Priority to JP2003554628A priority patent/JP4902940B2/ja
Priority to CA2468234A priority patent/CA2468234C/en
Priority to PCT/IT2002/000743 priority patent/WO2003053911A1/en
Priority to KR1020047008307A priority patent/KR100860386B1/ko
Priority to PL371130A priority patent/PL207877B1/pl
Publication of ITRM20010729A1 publication Critical patent/ITRM20010729A1/it
Priority to HK05105831A priority patent/HK1073295A1/xx
Priority to CY20101100377T priority patent/CY1110684T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/02—Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IT2001RM000729A 2001-12-12 2001-12-12 Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione. ITRM20010729A1 (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
IT2001RM000729A ITRM20010729A1 (it) 2001-12-12 2001-12-12 Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione.
US10/207,993 US6673837B2 (en) 2001-12-12 2002-07-31 Acetyl L-carnitine salt with a dicarboxylic organic acid and process for preparing same
SI200230893T SI1453791T1 (sl) 2001-12-12 2002-11-25 Acetil l karnitin sol z dikarboksilično organskokislino in postopek za njeno pripravo
HU0402545A HU230034B1 (hu) 2001-12-12 2002-11-25 Acetil-L-karnitin szerves dikarbonsavval alkotott sója és eljárás előállítására
AU2002358989A AU2002358989A1 (en) 2001-12-12 2002-11-25 Acetyl l-carnitine salt with a dicarboxilic organic acid and process for preparing same
AT02793335T ATE457300T1 (de) 2001-12-12 2002-11-25 Dikarbonsäuresalze des acetyl-l-carnitins und verfahren zu ihrer herstellung
PT02793335T PT1453791E (pt) 2001-12-12 2002-11-25 Sal de acetil l-carnitina associado a um ácido orgânico dicarboxílico e processo para preparar o mesmo
EP02793335A EP1453791B1 (en) 2001-12-12 2002-11-25 Acetyl l-carnitine salt with a dicarboxilic organic acid and process for preparing same
DK02793335.7T DK1453791T3 (da) 2001-12-12 2002-11-25 Dicarboxylsyresalte af acetyl-L.camitin og fremgangsmåde til fremstilling heraf
ES02793335T ES2339432T3 (es) 2001-12-12 2002-11-25 Sal de acetil l-carnitina con un acido dicarboxilico organico y procedimiento de preparacion.
CNB028248260A CN1250521C (zh) 2001-12-12 2002-11-25 乙酰基l－肉碱酸式富马酸盐及其制备方法
DE60235318T DE60235318D1 (de) 2001-12-12 2002-11-25 Dikarbonsäuresalze des acetyl-l-carnitins und verfahren zu ihrer herstellung
JP2003554628A JP4902940B2 (ja) 2001-12-12 2002-11-25 ジカルボキシル有機酸とのアセチルｌ−カルニチンの塩およびその調製方法
CA2468234A CA2468234C (en) 2001-12-12 2002-11-25 Acetyl l-carnitine fumarate and process for preparing the same
PCT/IT2002/000743 WO2003053911A1 (en) 2001-12-12 2002-11-25 Acetyl l-carnitine salt with a dicarboxilic organic acid and process for preparing same
KR1020047008307A KR100860386B1 (ko) 2001-12-12 2002-11-25 디카복실 유기산과의 아세틸 ｌ-카르니틴 염 및 이의 제조방법
PL371130A PL207877B1 (pl) 2001-12-12 2002-11-25 Sól acetylo L-karnityny z organicznymi kwasami dikarboksylowymi oraz metody jej otrzymywania
HK05105831A HK1073295A1 (en) 2001-12-12 2005-07-11 Acetyl l-carnitine acid fumarate and process for preparing the same
CY20101100377T CY1110684T1 (el) 2001-12-12 2010-04-27 Αλας ακετυλο-l-καρνιτινης με δικαρβοξυλικο οργανικο οξυ και μεθοδος για την παρασκευη αυτου

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001RM000729A ITRM20010729A1 (it) 2001-12-12 2001-12-12 Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione.

Publications (1)

Publication Number Publication Date
ITRM20010729A1 true ITRM20010729A1 (it) 2003-06-12

Family

ID=11455916

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2001RM000729A ITRM20010729A1 (it) 2001-12-12 2001-12-12 Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione.

Country Status (19)

Country Link
US (1) US6673837B2 (it)
EP (1) EP1453791B1 (it)
JP (1) JP4902940B2 (it)
KR (1) KR100860386B1 (it)
CN (1) CN1250521C (it)
AT (1) ATE457300T1 (it)
AU (1) AU2002358989A1 (it)
CA (1) CA2468234C (it)
CY (1) CY1110684T1 (it)
DE (1) DE60235318D1 (it)
DK (1) DK1453791T3 (it)
ES (1) ES2339432T3 (it)
HK (1) HK1073295A1 (it)
HU (1) HU230034B1 (it)
IT (1) ITRM20010729A1 (it)
PL (1) PL207877B1 (it)
PT (1) PT1453791E (it)
SI (1) SI1453791T1 (it)
WO (1) WO2003053911A1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173618B2 (en) * 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
CN101209975B (zh) * 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
JP2012092036A (ja) * 2010-10-26 2012-05-17 Mitsubishi Rayon Co Ltd カルニチンの塩の製造方法
JP2014525324A (ja) * 2011-08-31 2014-09-29 ザ プロクター アンド ギャンブル カンパニー 接着された強化層を有するファスニング部材
JP5933383B2 (ja) * 2012-07-26 2016-06-08 ロート製薬株式会社 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法
JP6100939B2 (ja) * 2016-02-26 2017-03-22 ロート製薬株式会社 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法
JP6964876B2 (ja) * 2017-11-27 2021-11-10 株式会社古川リサーチオフィス オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same

Also Published As

Publication number Publication date
CA2468234C (en) 2010-02-23
PT1453791E (pt) 2010-04-14
SI1453791T1 (sl) 2010-11-30
WO2003053911A1 (en) 2003-07-03
CA2468234A1 (en) 2003-07-03
EP1453791B1 (en) 2010-02-10
HK1073295A1 (en) 2005-09-30
PL207877B1 (pl) 2011-02-28
CN1602294A (zh) 2005-03-30
US6673837B2 (en) 2004-01-06
ES2339432T3 (es) 2010-05-20
CY1110684T1 (el) 2015-06-10
AU2002358989A1 (en) 2003-07-09
KR20040064721A (ko) 2004-07-19
KR100860386B1 (ko) 2008-09-26
US20030119904A1 (en) 2003-06-26
CN1250521C (zh) 2006-04-12
DK1453791T3 (da) 2010-05-25
JP2005513122A (ja) 2005-05-12
DE60235318D1 (de) 2010-03-25
HU230034B1 (hu) 2015-05-28
EP1453791A1 (en) 2004-09-08
PL371130A1 (en) 2005-06-13
HUP0402545A3 (en) 2012-09-28
HUP0402545A2 (hu) 2005-04-28
ATE457300T1 (de) 2010-02-15
JP4902940B2 (ja) 2012-03-21

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