EE03444B1 - Protsess enantiomeerselt rikastatud bensimidasooli derivaatide optiliseks puhastamiseks - Google Patents

Protsess enantiomeerselt rikastatud bensimidasooli derivaatide optiliseks puhastamiseks

Info

Publication number
EE03444B1
EE03444B1 EE9700368A EE9700368A EE03444B1 EE 03444 B1 EE03444 B1 EE 03444B1 EE 9700368 A EE9700368 A EE 9700368A EE 9700368 A EE9700368 A EE 9700368A EE 03444 B1 EE03444 B1 EE 03444B1
Authority
EE
Estonia
Prior art keywords
enantiomerically enriched
benzimidazole derivatives
optical purification
enriched benzimidazole
purification
Prior art date
Application number
EE9700368A
Other languages
English (en)
Estonian (et)
Other versions
EE9700368A (et
Inventor
Oskar Sverker Von Unge Per
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20397468&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03444(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of EE9700368A publication Critical patent/EE9700368A/xx
Publication of EE03444B1 publication Critical patent/EE03444B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EE9700368A 1995-07-03 1996-06-26 Protsess enantiomeerselt rikastatud bensimidasooli derivaatide optiliseks puhastamiseks EE03444B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9500817 1995-07-03
PCT/SE1996/000841 WO1997002261A1 (en) 1995-07-03 1996-06-26 A process for the optical purification of enantiomerically enriched benzimidazole derivatives

Publications (2)

Publication Number Publication Date
EE9700368A EE9700368A (et) 1998-06-15
EE03444B1 true EE03444B1 (et) 2001-06-15

Family

ID=20397468

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700368A EE03444B1 (et) 1995-07-03 1996-06-26 Protsess enantiomeerselt rikastatud bensimidasooli derivaatide optiliseks puhastamiseks

Country Status (37)

Country Link
US (1) US5929244A (is)
EP (2) EP0836601B1 (is)
JP (1) JP4195507B2 (is)
KR (1) KR100451078B1 (is)
CN (1) CN1098261C (is)
AT (1) ATE418549T1 (is)
AU (1) AU698638B2 (is)
BR (1) BR9609450A (is)
CA (1) CA2226184C (is)
CZ (1) CZ295430B6 (is)
DE (1) DE69637788D1 (is)
DK (1) DK0836601T3 (is)
DZ (1) DZ2057A1 (is)
EE (1) EE03444B1 (is)
ES (1) ES2318850T3 (is)
HK (1) HK1010193A1 (is)
HR (1) HRP960232A2 (is)
HU (1) HUP9901717A3 (is)
IL (1) IL122811A (is)
IS (1) IS2666B (is)
MA (1) MA23921A1 (is)
MY (1) MY114018A (is)
NO (1) NO313008B1 (is)
NZ (1) NZ311842A (is)
PL (1) PL186702B1 (is)
PT (1) PT836601E (is)
RS (1) RS49826B (is)
RU (1) RU2144031C1 (is)
SA (1) SA96170103B1 (is)
SI (1) SI0836601T1 (is)
SK (1) SK284780B6 (is)
TN (1) TNSN96090A1 (is)
TR (1) TR199701754T1 (is)
TW (1) TW444010B (is)
UA (1) UA49838C2 (is)
WO (1) WO1997002261A1 (is)
ZA (1) ZA965205B (is)

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HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
EP0983263A1 (en) * 1997-05-30 2000-03-08 Dr. Reddy's Research Foundation Novel benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them
EP1056456A4 (en) * 1998-01-30 2006-10-25 Sepracor Inc R-LANSOPRAZOL COMPOSITIONS AND TREATMENTS THEREFOR
SE9900274D0 (sv) 1999-01-28 1999-01-28 Astra Ab New compound
TWI289557B (en) 1999-06-17 2007-11-11 Takeda Chemical Industries Ltd A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
ES2240113T3 (es) * 1999-06-30 2005-10-16 Takeda Pharmaceutical Company Limited Cristales de lansoprazol.
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
ES2521690T3 (es) * 2000-05-15 2014-11-13 Takeda Pharmaceutical Company Limited Procedimiento para producir un cristal de (R)-2-[[[3-metil-4-(2,2,2-trifluoroetoxi)-2-piridil]metil]sulfinil]-bencimidazol
DE60123800T2 (de) 2000-08-04 2007-10-11 Takeda Pharmaceutical Co. Ltd. Salze von benzimidazol-derivaten und deren verwendung
AU2002218506A1 (en) * 2000-12-01 2002-06-11 Takeda Chemical Industries Ltd. Process for the crystallization of (r)- or (s)-lansoprazole
KR100433735B1 (ko) * 2001-06-27 2004-06-04 주식회사 씨트리 결정형 ⅰ을 갖는 란소프라졸의 제조방법
SE0104295D0 (sv) * 2001-12-18 2001-12-18 Astrazeneca Ab New process
MXPA04007169A (es) * 2002-01-25 2004-10-29 Santarus Inc Suministro transmucosal de inhibidores de bomba de protones.
WO2004035052A1 (ja) 2002-10-16 2004-04-29 Takeda Pharmaceutical Company Limited 安定な固形製剤
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
DE10254167A1 (de) 2002-11-20 2004-06-09 Icon Genetics Ag Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen
AU2003293749B2 (en) 2002-12-06 2009-12-24 Takeda Gmbh Process for preparing (S)-pantoprazole
JP4612542B2 (ja) 2002-12-06 2011-01-12 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 光学的に純粋な有効化合物の製造方法
JP2006518751A (ja) * 2003-02-20 2006-08-17 サンタラス インコーポレイティッド 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物
US20060247277A1 (en) * 2003-02-28 2006-11-02 Yatendra Kumar Polymorphs of s-omeprazole
TWI337877B (en) * 2003-07-18 2011-03-01 Santarus Inc Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US7005732B2 (en) * 2003-10-21 2006-02-28 Honeywell International Inc. Methods and systems for providing MEMS devices with a top cap and upper sense plate
FR2863609A1 (fr) * 2003-12-15 2005-06-17 Isochem Sa Procede d'enrichissement enantiomerique d'un melange d'enantiomeres d'alpha-aminoacides
SE0400410D0 (sv) * 2004-02-20 2004-02-20 Astrazeneca Ab New compounds
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JP5563735B2 (ja) 2004-06-16 2014-07-30 タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド Ｐｐｉ多回剤形
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
US7553857B2 (en) 2005-12-23 2009-06-30 Lek Pharmaceuticals D.D. S-omeprazole magnesium
US7786309B2 (en) * 2006-06-09 2010-08-31 Apotex Pharmachem Inc. Process for the preparation of esomeprazole and salts thereof
FR2909380B1 (fr) * 2006-12-04 2009-02-20 Sidem Pharma Sa Sa Conglomerats de sels de potassium de tenatoprazole
EP1947099A1 (en) 2007-01-18 2008-07-23 LEK Pharmaceuticals D.D. Process for solvent removal from omeprazole salts
EA016297B1 (ru) * 2007-06-15 2012-03-30 Эмкьюр Фармасьютикалз Лимитед Способ сульфоксидирования биологически активных соединений
CN101323609B (zh) * 2007-06-15 2013-05-01 成都福瑞生物工程有限公司 不对称氧化硫醚成亚砜合成对映体含量高的苯并咪唑衍生物的方法
FR2920428B1 (fr) * 2007-08-29 2012-06-15 Univ Rouen Procede de dedoublement de sels de l'omeprazole
GEP20125649B (en) 2008-03-10 2012-09-25 Takeda Pharmaceutical Benzimidazole compound crystal
WO2010058409A2 (en) 2008-11-18 2010-05-27 Hetero Research Foundation Optical purification of esomeprazole
KR101001646B1 (ko) * 2008-12-12 2010-12-17 한미약품 주식회사 (ｒ)-(+)-란소프라졸의 제조방법 및 이에 사용되는 중간체
WO2011004387A2 (en) 2009-06-18 2011-01-13 Matrix Laboratories Ltd Process for the preparation of dexlansoprazole polymorphic forms
US8748619B2 (en) 2009-11-12 2014-06-10 Hetero Research Foundation Process for the resolution of omeprazole
AU2011210328A1 (en) 2010-01-29 2012-08-16 Ranbaxy Laboratories Limited Process for the preparation of crystalline forms of dexlansoprazole
KR102091211B1 (ko) * 2014-07-30 2020-03-19 가부시키가이샤 아에타스 파루마 1,4-벤조티아제핀-1-옥사이드 유도체의 광학 이성질체, 및 그것을 사용한 의약 조성물
EP3064495B1 (en) 2015-03-06 2016-12-14 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of optically pure esomeprazole

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU4640985A (en) * 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
ATE110069T1 (de) * 1989-11-29 1994-09-15 Toa Eiyo Ltd Cycloheptenopyridinderivate, verfahren zu ihrer herstellung und diese enthaltende antiulkusmitteln.
DE4035455A1 (de) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
IS4232A (is) * 1993-12-06 1995-06-07 Astra Aktiebolag Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun
HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds

Also Published As

Publication number Publication date
JPH11508590A (ja) 1999-07-27
CN1193971A (zh) 1998-09-23
CA2226184A1 (en) 1997-01-23
SK284780B6 (sk) 2005-11-03
ZA965205B (en) 1997-01-03
CN1098261C (zh) 2003-01-08
HRP960232A2 (en) 1998-02-28
DK0836601T3 (da) 2009-03-16
RU2144031C1 (ru) 2000-01-10
NZ311842A (en) 1998-12-23
IS2666B (is) 2010-08-15
DE69637788D1 (de) 2009-02-05
AU6324096A (en) 1997-02-05
DZ2057A1 (fr) 2002-10-20
ES2318850T3 (es) 2009-05-01
MX9800160A (es) 1998-03-31
IL122811A (en) 2000-11-21
PT836601E (pt) 2009-02-17
AU698638B2 (en) 1998-11-05
SI0836601T1 (sl) 2009-04-30
UA49838C2 (uk) 2002-10-15
KR100451078B1 (ko) 2004-11-16
IL122811A0 (en) 1998-08-16
YU37696A (sh) 1999-03-04
TR199701754T1 (xx) 1998-04-21
MY114018A (en) 2002-07-31
PL324394A1 (en) 1998-05-25
SK179397A3 (en) 1998-09-09
ATE418549T1 (de) 2009-01-15
EP0836601A1 (en) 1998-04-22
HUP9901717A3 (en) 2002-03-28
RS49826B (sr) 2008-08-07
EE9700368A (et) 1998-06-15
CZ421197A3 (cs) 1998-06-17
NO976030L (no) 1998-02-09
CA2226184C (en) 2008-08-05
EP1498416A1 (en) 2005-01-19
HUP9901717A2 (hu) 2000-04-28
CZ295430B6 (cs) 2005-08-17
TNSN96090A1 (fr) 2005-03-15
PL186702B1 (pl) 2004-02-27
NO313008B1 (no) 2002-07-29
HK1010193A1 (en) 1999-06-17
EP0836601B1 (en) 2008-12-24
KR19990028631A (ko) 1999-04-15
JP4195507B2 (ja) 2008-12-10
TW444010B (en) 2001-07-01
IS4638A (is) 1997-12-22
BR9609450A (pt) 1999-03-02
MA23921A1 (fr) 1996-12-31
NO976030D0 (no) 1997-12-22
US5929244A (en) 1999-07-27
SA96170103B1 (ar) 2006-07-30
WO1997002261A1 (en) 1997-01-23

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