ECSP099480A - Compuestos químicos 637: piridopirimidindionas como inhibidores de la pde4 - Google Patents

Compuestos químicos 637: piridopirimidindionas como inhibidores de la pde4

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Publication number
ECSP099480A
ECSP099480A EC2009009480A ECSP099480A ECSP099480A EC SP099480 A ECSP099480 A EC SP099480A EC 2009009480 A EC2009009480 A EC 2009009480A EC SP099480 A ECSP099480 A EC SP099480A EC SP099480 A ECSP099480 A EC SP099480A
Authority
EC
Ecuador
Prior art keywords
pyridopirimidindionas
pde4
inhibitors
chemical compounds
compound
Prior art date
Application number
EC2009009480A
Other languages
English (en)
Inventor
Roger Bonnert
Mark Dickinson
Premji Meghani
Frank Burkamp
Rhona Jane Cox
Sousa Simon De
Simon Fraser Hunt
Austen Pimm
Hitesh Jayantilal Sanganee
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP099480A publication Critical patent/ECSP099480A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

La presente invención proporciona un compuesto de fórmula (I), en donde las variables están definidas aquí; un proceso para la preparación de tal compuesto; y el uso de tal compuesto en el tratamiento de un estado de enfermedad mediado por la PDE 4.
EC2009009480A 2007-01-11 2009-07-02 Compuestos químicos 637: piridopirimidindionas como inhibidores de la pde4 ECSP099480A (es)

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RU2479584C2 (ru) 2013-04-20
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SA08280783B1 (ar) 2011-04-24
KR20090101303A (ko) 2009-09-24
JP2010515712A (ja) 2010-05-13
PE20090049A1 (es) 2009-03-21
WO2008084223A2 (en) 2008-07-17
MY162022A (en) 2017-05-31
AU2008204412A1 (en) 2008-07-17
CA2674647A1 (en) 2008-07-17
RU2009123930A (ru) 2011-02-20
MX2009007231A (es) 2009-07-14
CL2008000089A1 (es) 2008-11-03
CN101636388B (zh) 2013-09-18
AU2008204412B2 (en) 2012-03-01
UY30863A1 (es) 2008-09-02
CN102532135A (zh) 2012-07-04
CN101636388A (zh) 2010-01-27
JP5369302B2 (ja) 2013-12-18
BRPI0806689A2 (pt) 2015-07-21
US20120077801A1 (en) 2012-03-29
US20090124596A1 (en) 2009-05-14
TW200836745A (en) 2008-09-16
CO6210698A2 (es) 2010-10-20
PE20121529A1 (es) 2012-12-16
AR064889A1 (es) 2009-05-06
WO2008084223A3 (en) 2008-10-02
CN104147011A (zh) 2014-11-19
US20100204203A1 (en) 2010-08-12

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