PE20121529A1 - Compuestos derivados de piridopirimidina como inhibidores de pde4 - Google Patents
Compuestos derivados de piridopirimidina como inhibidores de pde4Info
- Publication number
- PE20121529A1 PE20121529A1 PE2012001093A PE2012001093A PE20121529A1 PE 20121529 A1 PE20121529 A1 PE 20121529A1 PE 2012001093 A PE2012001093 A PE 2012001093A PE 2012001093 A PE2012001093 A PE 2012001093A PE 20121529 A1 PE20121529 A1 PE 20121529A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridopyrimidine
- optionally substituted
- compounds derived
- pde4 inhibitors
- methyl
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- Hospice & Palliative Care (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRIDOPIRIMIDINA DE FORMULA (I) DONDE: A ES CA1; E ES CE1; W ES CH2; Y ES CH2; R1 ES FENILO SUSTITUIDO CON FENILO, O HETEROCICLILO OPCIONALMENTE SUSTITUIDO; R2 ES NHC(O)R3; R3 ES ALQUILO C1-4 SUSTITUIDO CON HETEROARILO ENTRE OTROS, CICLOALQUILO C3-7 OPCIONALMENTE SUSTITUIDO, O HETEROARILO OPCIONALMENTE SUSTITUIDO CON HALO, ENTRE OTROS; A1, E1 Y G1 SON INDEPENDIENTEMENTE H O HALOGENO. ES UN COMPUESTO PREFERIDO: N-{CIS-4-[1-(4'-{[(3R,5S)-3,5-DIMETILPIPERAZIN-1-IL]METIL}BIFENIL-3-IL)-6-FLUORO-2,4-DIOXO-1,4-DIHIDROPIRIDO[2,3-d]PIRIMIDIN-3(2H)-IL]CICLOHEXIL}-2-METIL-1,3-TIAZOL-4-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE PDE4 SIENDO UTIL EN EL TRATAMIENTO DE ASMA, BRONQUITIS, OSTEOPOROSIS, ARTRITIS, PSORIASIS
Applications Claiming Priority (3)
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US88445407P | 2007-01-11 | 2007-01-11 | |
US94174907P | 2007-06-04 | 2007-06-04 | |
US95204707P | 2007-07-26 | 2007-07-26 |
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PE20121529A1 true PE20121529A1 (es) | 2012-12-16 |
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PE2012001093A PE20121529A1 (es) | 2007-01-11 | 2008-01-11 | Compuestos derivados de piridopirimidina como inhibidores de pde4 |
PE2008000127A PE20090049A1 (es) | 2007-01-11 | 2008-01-11 | Derivados de piridopirimidina como moduladores de la actividad de pde 4 |
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PE2008000127A PE20090049A1 (es) | 2007-01-11 | 2008-01-11 | Derivados de piridopirimidina como moduladores de la actividad de pde 4 |
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US (3) | US20090124596A1 (es) |
EP (1) | EP2106396B1 (es) |
JP (1) | JP5369302B2 (es) |
KR (1) | KR20090101303A (es) |
CN (3) | CN101636388B (es) |
AR (1) | AR064889A1 (es) |
AU (1) | AU2008204412B2 (es) |
BR (1) | BRPI0806689A2 (es) |
CA (1) | CA2674647A1 (es) |
CL (1) | CL2008000089A1 (es) |
CO (1) | CO6210698A2 (es) |
EC (1) | ECSP099480A (es) |
MX (1) | MX2009007231A (es) |
MY (1) | MY162022A (es) |
PE (2) | PE20121529A1 (es) |
RU (1) | RU2479584C2 (es) |
SA (1) | SA08280783B1 (es) |
TW (1) | TW200836745A (es) |
UY (1) | UY30863A1 (es) |
WO (1) | WO2008084223A2 (es) |
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- 2008-01-10 CN CN2008800080545A patent/CN101636388B/zh not_active Expired - Fee Related
- 2008-01-10 JP JP2009545224A patent/JP5369302B2/ja not_active Expired - Fee Related
- 2008-01-10 CN CN201410326870.8A patent/CN104147011A/zh active Pending
- 2008-01-10 AU AU2008204412A patent/AU2008204412B2/en not_active Ceased
- 2008-01-10 KR KR1020097016638A patent/KR20090101303A/ko not_active Application Discontinuation
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- 2008-01-10 RU RU2009123930/04A patent/RU2479584C2/ru not_active IP Right Cessation
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- 2008-01-10 EP EP08700158.2A patent/EP2106396B1/en active Active
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- 2008-01-10 WO PCT/GB2008/000061 patent/WO2008084223A2/en active Application Filing
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- 2008-01-10 UY UY30863A patent/UY30863A1/es not_active Application Discontinuation
- 2008-01-10 BR BRPI0806689-2A patent/BRPI0806689A2/pt not_active IP Right Cessation
- 2008-01-11 AR ARP080100155A patent/AR064889A1/es unknown
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- 2008-01-11 CL CL2008000089A patent/CL2008000089A1/es unknown
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Also Published As
Publication number | Publication date |
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CA2674647A1 (en) | 2008-07-17 |
EP2106396B1 (en) | 2014-09-24 |
BRPI0806689A2 (pt) | 2015-07-21 |
MY162022A (en) | 2017-05-31 |
ECSP099480A (es) | 2009-08-28 |
WO2008084223A2 (en) | 2008-07-17 |
CN104147011A (zh) | 2014-11-19 |
CN101636388B (zh) | 2013-09-18 |
AU2008204412B2 (en) | 2012-03-01 |
CN102532135A (zh) | 2012-07-04 |
AU2008204412A1 (en) | 2008-07-17 |
CO6210698A2 (es) | 2010-10-20 |
US20100204203A1 (en) | 2010-08-12 |
MX2009007231A (es) | 2009-07-14 |
EP2106396A2 (en) | 2009-10-07 |
JP2010515712A (ja) | 2010-05-13 |
RU2009123930A (ru) | 2011-02-20 |
KR20090101303A (ko) | 2009-09-24 |
SA08280783B1 (ar) | 2011-04-24 |
TW200836745A (en) | 2008-09-16 |
US20090124596A1 (en) | 2009-05-14 |
US20120077801A1 (en) | 2012-03-29 |
CN101636388A (zh) | 2010-01-27 |
AR064889A1 (es) | 2009-05-06 |
RU2479584C2 (ru) | 2013-04-20 |
WO2008084223A3 (en) | 2008-10-02 |
PE20090049A1 (es) | 2009-03-21 |
UY30863A1 (es) | 2008-09-02 |
CL2008000089A1 (es) | 2008-11-03 |
JP5369302B2 (ja) | 2013-12-18 |
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