EA201890926A1 - ТРИАЗОЛОВЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ - Google Patents
ТРИАЗОЛОВЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯInfo
- Publication number
- EA201890926A1 EA201890926A1 EA201890926A EA201890926A EA201890926A1 EA 201890926 A1 EA201890926 A1 EA 201890926A1 EA 201890926 A EA201890926 A EA 201890926A EA 201890926 A EA201890926 A EA 201890926A EA 201890926 A1 EA201890926 A1 EA 201890926A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- acethyl
- coa
- triazole
- options
- carboxylase inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000003852 triazoles Chemical class 0.000 title abstract 2
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 abstract 2
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 abstract 2
- 108010018763 Biotin carboxylase Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562259966P | 2015-11-25 | 2015-11-25 | |
| PCT/US2016/063410 WO2017091617A1 (en) | 2015-11-25 | 2016-11-22 | Triazole acc inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201890926A1 true EA201890926A1 (ru) | 2018-12-28 |
Family
ID=57530850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890926A EA201890926A1 (ru) | 2015-11-25 | 2016-11-22 | ТРИАЗОЛОВЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20170166584A1 (enExample) |
| EP (1) | EP3380479B1 (enExample) |
| JP (1) | JP2018536661A (enExample) |
| KR (1) | KR20180082557A (enExample) |
| CN (1) | CN108349994B (enExample) |
| AR (1) | AR106806A1 (enExample) |
| AU (1) | AU2016361428A1 (enExample) |
| BR (1) | BR112018010453B1 (enExample) |
| CA (1) | CA3005900C (enExample) |
| CL (1) | CL2018001360A1 (enExample) |
| CO (1) | CO2018005369A2 (enExample) |
| EA (1) | EA201890926A1 (enExample) |
| ES (1) | ES2939977T3 (enExample) |
| MX (1) | MX2018006287A (enExample) |
| PL (1) | PL3380479T3 (enExample) |
| PT (1) | PT3380479T (enExample) |
| SI (1) | SI3380479T1 (enExample) |
| WO (1) | WO2017091617A1 (enExample) |
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| MX370976B (es) | 2011-11-11 | 2020-01-10 | Gilead Apollo Llc | Inhibidores de acetil coa carboxilasa (acc) y usos de los mismos. |
| EP3099693A4 (en) | 2014-01-31 | 2017-08-16 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| MX2016009974A (es) | 2014-01-31 | 2016-10-31 | Dana Farber Cancer Inst Inc | Derivados de diaminopirimidina bencensulfona y sus usos. |
| US11306105B2 (en) | 2015-09-11 | 2022-04-19 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
| RU2018112953A (ru) | 2015-09-11 | 2019-10-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Ацетамидтиенотриазолодиазепины и пути их применения |
| AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| US20170166582A1 (en) | 2015-11-25 | 2017-06-15 | Gilead Apollo, Llc | Pyrazole acc inhibitors and uses thereof |
| EP3380478B1 (en) | 2015-11-25 | 2020-12-23 | Gilead Apollo, LLC | Ester acc inhibitors and uses thereof |
| PL3380479T3 (pl) | 2015-11-25 | 2023-05-08 | Gilead Apollo, Llc | Triazolowe inhibitory acc i ich zastosowania |
| CN108347939B (zh) | 2015-11-25 | 2021-09-28 | 吉利德阿波罗公司 | 含有2,4-二氧代-1,4-二氢噻吩并[2,3-d]嘧啶的衍生物的杀真菌组合物 |
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| CA3155220C (en) | 2016-03-02 | 2024-01-16 | Gilead Apollo, Llc | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
| AU2018209006B2 (en) | 2017-01-22 | 2021-04-22 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
| EP3589635A1 (en) | 2017-03-03 | 2020-01-08 | Gilead Apollo, LLC | Processes for the preparation of fungicidal compounds |
| WO2018171698A1 (zh) * | 2017-03-24 | 2018-09-27 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| ES2982801T3 (es) | 2017-03-28 | 2024-10-17 | Gilead Sciences Inc | Combinaciones terapéuticas para el tratamiento de las enfermedades hepáticas |
| WO2019015583A1 (en) | 2017-07-17 | 2019-01-24 | Nanjing Ruijie Pharmatech Co., Ltd. | NOVEL COMPOUNDS AND THEIR USES AS ACC INHIBITORS |
| JP2021008403A (ja) * | 2017-09-26 | 2021-01-28 | 日本曹達株式会社 | １，３，５，６−テトラ置換チエノ［２，３−ｄ］ピリミジン−２，４（１Ｈ，３Ｈ）ジオン化合物および農園芸用殺菌剤 |
| CN110950884B (zh) * | 2018-09-27 | 2024-03-26 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
| TW202033511A (zh) | 2018-10-29 | 2020-09-16 | 美商基利阿波羅有限責任公司 | 用於製備殺真菌化合物之方法 |
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| CN111484504B (zh) * | 2019-01-25 | 2024-05-10 | 南京圣和药业股份有限公司 | Acc抑制剂的光学异构体及其应用 |
| CN113924303B (zh) * | 2019-07-02 | 2023-10-20 | 广东东阳光药业股份有限公司 | 具有立体构型的噻吩并嘧啶衍生物及其在药物中的应用 |
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| KR102698413B1 (ko) | 2020-05-05 | 2024-08-26 | 뉴베일런트, 아이엔씨. | 헤테로방향족 거대환식 에터 화학치료제 |
| CN113968871A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 苯基取代类acc抑制剂的晶型 |
| JP2024120189A (ja) * | 2021-07-20 | 2024-09-05 | 日産化学株式会社 | チエノウラシル化合物及び有害生物防除剤 |
| TW202320768A (zh) | 2021-10-01 | 2023-06-01 | 美商努法倫特公司 | 雜芳族大環醚化合物之固體形式、醫藥組成物及製備 |
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-
2016
- 2016-11-22 PL PL16809272.4T patent/PL3380479T3/pl unknown
- 2016-11-22 PT PT168092724T patent/PT3380479T/pt unknown
- 2016-11-22 MX MX2018006287A patent/MX2018006287A/es unknown
- 2016-11-22 SI SI201631672T patent/SI3380479T1/sl unknown
- 2016-11-22 EA EA201890926A patent/EA201890926A1/ru unknown
- 2016-11-22 KR KR1020187016698A patent/KR20180082557A/ko not_active Withdrawn
- 2016-11-22 JP JP2018525706A patent/JP2018536661A/ja active Pending
- 2016-11-22 ES ES16809272T patent/ES2939977T3/es active Active
- 2016-11-22 EP EP16809272.4A patent/EP3380479B1/en active Active
- 2016-11-22 AU AU2016361428A patent/AU2016361428A1/en not_active Abandoned
- 2016-11-22 CN CN201680067505.7A patent/CN108349994B/zh active Active
- 2016-11-22 US US15/359,414 patent/US20170166584A1/en not_active Abandoned
- 2016-11-22 WO PCT/US2016/063410 patent/WO2017091617A1/en not_active Ceased
- 2016-11-22 BR BR112018010453-1A patent/BR112018010453B1/pt active IP Right Grant
- 2016-11-22 CA CA3005900A patent/CA3005900C/en active Active
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- 2018-05-23 CO CONC2018/0005369A patent/CO2018005369A2/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| CA3005900A1 (en) | 2017-06-01 |
| EP3380479A1 (en) | 2018-10-03 |
| US20200017519A1 (en) | 2020-01-16 |
| CA3005900C (en) | 2023-10-31 |
| BR112018010453A8 (pt) | 2019-02-26 |
| US20170166584A1 (en) | 2017-06-15 |
| US10800791B2 (en) | 2020-10-13 |
| BR112018010453B1 (pt) | 2022-06-14 |
| CN108349994B (zh) | 2021-06-22 |
| PL3380479T3 (pl) | 2023-05-08 |
| BR112018010453A2 (pt) | 2018-11-21 |
| AU2016361428A1 (en) | 2018-05-24 |
| AR106806A1 (es) | 2018-02-21 |
| MX2018006287A (es) | 2018-09-07 |
| JP2018536661A (ja) | 2018-12-13 |
| SI3380479T1 (sl) | 2023-04-28 |
| CL2018001360A1 (es) | 2018-08-24 |
| US20190241582A1 (en) | 2019-08-08 |
| KR20180082557A (ko) | 2018-07-18 |
| CN108349994A (zh) | 2018-07-31 |
| CO2018005369A2 (es) | 2018-05-31 |
| EP3380479B1 (en) | 2022-12-07 |
| PT3380479T (pt) | 2023-03-13 |
| WO2017091617A1 (en) | 2017-06-01 |
| ES2939977T3 (es) | 2023-04-28 |
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