EA201791916A1 - 2'-замещенные карбануклеозидные аналоги для противовирусного лечения - Google Patents
2'-замещенные карбануклеозидные аналоги для противовирусного леченияInfo
- Publication number
- EA201791916A1 EA201791916A1 EA201791916A EA201791916A EA201791916A1 EA 201791916 A1 EA201791916 A1 EA 201791916A1 EA 201791916 A EA201791916 A EA 201791916A EA 201791916 A EA201791916 A EA 201791916A EA 201791916 A1 EA201791916 A1 EA 201791916A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbaneculose
- analogues
- substituted
- virus treatment
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000009620 Orthomyxoviridae Infections Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/30—Vaccines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261610411P | 2012-03-13 | 2012-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201791916A1 true EA201791916A1 (ru) | 2018-07-31 |
Family
ID=47997868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201791916A EA201791916A1 (ru) | 2012-03-13 | 2013-03-11 | 2'-замещенные карбануклеозидные аналоги для противовирусного лечения |
| EA201491548A EA028928B9 (ru) | 2012-03-13 | 2013-03-11 | 2'-замещенные карбануклеозидные аналоги для противовирусного лечения |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201491548A EA028928B9 (ru) | 2012-03-13 | 2013-03-11 | 2'-замещенные карбануклеозидные аналоги для противовирусного лечения |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9481704B2 (https=) |
| EP (4) | EP3351552B1 (https=) |
| JP (3) | JP6242378B2 (https=) |
| KR (1) | KR102068856B1 (https=) |
| CN (2) | CN106749272B (https=) |
| AU (2) | AU2013232378B2 (https=) |
| CA (1) | CA2866381C (https=) |
| EA (2) | EA201791916A1 (https=) |
| ES (4) | ES3005115T3 (https=) |
| IL (2) | IL234586A (https=) |
| IN (1) | IN2014DN08505A (https=) |
| MD (1) | MD4496C1 (https=) |
| MX (1) | MX355267B (https=) |
| NZ (1) | NZ629996A (https=) |
| PL (1) | PL2834258T3 (https=) |
| PT (1) | PT2834258T (https=) |
| SI (1) | SI2834258T1 (https=) |
| WO (1) | WO2013138236A1 (https=) |
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| RU2572826C2 (ru) | 2008-12-02 | 2016-01-20 | Чиралджен, Лтд. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| AU2012284265B2 (en) | 2011-07-19 | 2017-08-17 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| US8633198B1 (en) | 2011-09-20 | 2014-01-21 | Nant Holdings Ip, Llc | Small molecule inhibitors of influenza A RNA-dependent RNA polymerase |
| AU2013235220C1 (en) * | 2011-12-22 | 2019-03-28 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| UA117095C2 (uk) | 2011-12-22 | 2018-06-25 | Аліос Біофарма, Інк. | Нуклеозидна сполука або її фармацевтично прийнятна сіль |
| CN106749272B (zh) | 2012-03-13 | 2019-08-30 | 吉利德科学公司 | 用于抗病毒治疗的2’-取代的卡巴-核苷类似物 |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| EP3079693B1 (en) * | 2013-12-11 | 2019-09-04 | Nant Holdings IP, LLC | Small molecule inhibitors of influenza a rna-dependent rna polymerase |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| JP6581100B2 (ja) | 2014-02-06 | 2019-09-25 | リボサイエンス・エルエルシー | インフルエンザｒｎａ複製の阻害剤としての４’−ジフルオロメチル置換ヌクレオシド誘導体 |
| WO2015143712A1 (en) * | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
| TWI678369B (zh) | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
| MX381291B (es) | 2014-09-26 | 2025-03-12 | Riboscience Llc | Derivados de nucleósidos sustituidos con 4'-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial. |
| DK3236972T3 (en) | 2014-12-26 | 2021-10-04 | Univ Emory | Antivirale N4-hydroxycytidin-derivativer |
| CN108289931B (zh) | 2015-09-23 | 2022-10-11 | 默沙东公司 | 4’-取代的核苷逆转录酶抑制剂及其制备 |
| US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
| WO2018200425A1 (en) | 2017-04-24 | 2018-11-01 | Cocrystal Pharma, Inc. | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
| JP6804790B1 (ja) | 2017-12-07 | 2020-12-23 | エモリー ユニバーシティー | Ｎ４−ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
| US11040975B2 (en) | 2017-12-08 | 2021-06-22 | Merck Sharp & Dohme Corp. | Carbocyclic nucleoside reverse transcriptase inhibitors |
| EP3829719B1 (en) | 2018-07-27 | 2025-04-02 | Cocrystal Pharma, Inc. | Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication |
| CN113286793B (zh) | 2018-09-10 | 2024-04-05 | 共结晶制药公司 | 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂 |
| EP3887355A1 (en) | 2018-11-26 | 2021-10-06 | Cocrystal Pharma, Inc. | Inhibitors of influenza virus replication |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AU2021224588B2 (en) | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TW202143949A (zh) * | 2020-03-22 | 2021-12-01 | 盈擘醫藥股份有限公司 | 用於預防或暴露後治療感染或呼吸疾病的抗病毒組成物 |
| EP4129291A4 (en) * | 2020-03-30 | 2024-04-10 | FUJIFILM Toyama Chemical Co., Ltd. | CORONAVIRUS INFECTION TREATMENT MEDICATION |
| CN111956630A (zh) * | 2020-08-20 | 2020-11-20 | 大连理工大学 | 一种瑞德西韦供雾化器用的液体制剂、制备方法及其应用 |
| EP4323362B1 (en) | 2021-04-16 | 2025-05-07 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| AU2022328698B2 (en) | 2021-08-18 | 2025-02-20 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| IL310854A (en) * | 2021-08-20 | 2024-04-01 | Shionogi & Co | Nucleoside compounds and their drug derivatives possessing viral growth inhibitory activity |
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| CN106749272B (zh) * | 2012-03-13 | 2019-08-30 | 吉利德科学公司 | 用于抗病毒治疗的2’-取代的卡巴-核苷类似物 |
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2013
- 2013-03-11 CN CN201611121597.0A patent/CN106749272B/zh active Active
- 2013-03-11 PL PL13712043T patent/PL2834258T3/pl unknown
- 2013-03-11 MD MDA20140112A patent/MD4496C1/ro active IP Right Grant
- 2013-03-11 JP JP2015500493A patent/JP6242378B2/ja active Active
- 2013-03-11 ES ES21168626T patent/ES3005115T3/es active Active
- 2013-03-11 EA EA201791916A patent/EA201791916A1/ru unknown
- 2013-03-11 KR KR1020147028523A patent/KR102068856B1/ko active Active
- 2013-03-11 CA CA2866381A patent/CA2866381C/en active Active
- 2013-03-11 PT PT137120432T patent/PT2834258T/pt unknown
- 2013-03-11 EP EP18155061.7A patent/EP3351552B1/en active Active
- 2013-03-11 CN CN201380014318.9A patent/CN104185638A/zh active Pending
- 2013-03-11 SI SI201330567A patent/SI2834258T1/sl unknown
- 2013-03-11 AU AU2013232378A patent/AU2013232378B2/en active Active
- 2013-03-11 EP EP16203290.8A patent/EP3210993B1/en active Active
- 2013-03-11 EA EA201491548A patent/EA028928B9/ru unknown
- 2013-03-11 NZ NZ629996A patent/NZ629996A/en unknown
- 2013-03-11 EP EP13712043.2A patent/EP2834258B1/en active Active
- 2013-03-11 ES ES13712043.2T patent/ES2621217T3/es active Active
- 2013-03-11 ES ES18155061T patent/ES2878087T3/es active Active
- 2013-03-11 US US13/793,557 patent/US9481704B2/en active Active
- 2013-03-11 ES ES16203290T patent/ES2709071T3/es active Active
- 2013-03-11 WO PCT/US2013/030196 patent/WO2013138236A1/en not_active Ceased
- 2013-03-11 MX MX2014011009A patent/MX355267B/es active IP Right Grant
- 2013-03-11 EP EP21168626.6A patent/EP3932931B1/en active Active
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2014
- 2014-09-11 IL IL234586A patent/IL234586A/en active IP Right Grant
- 2014-10-10 IN IN8505DEN2014 patent/IN2014DN08505A/en unknown
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2016
- 2016-09-30 US US15/282,492 patent/US20170114086A1/en not_active Abandoned
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2017
- 2017-06-21 JP JP2017121389A patent/JP6525441B2/ja active Active
- 2017-12-18 IL IL256397A patent/IL256397A/en unknown
- 2017-12-19 AU AU2017279590A patent/AU2017279590A1/en not_active Abandoned
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2018
- 2018-06-22 US US16/016,369 patent/US10941177B2/en active Active
- 2018-12-26 JP JP2018242679A patent/JP2019069986A/ja not_active Withdrawn
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2021
- 2021-01-28 US US17/161,065 patent/US11787832B2/en active Active
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