EA200901481A1 - Полиглутаминовые кислоты, функционализированные катионными и гидрофобными группами, и их применения, в частности терапевтические применения - Google Patents

Полиглутаминовые кислоты, функционализированные катионными и гидрофобными группами, и их применения, в частности терапевтические применения

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Publication number
EA200901481A1
EA200901481A1 EA200901481A EA200901481A EA200901481A1 EA 200901481 A1 EA200901481 A1 EA 200901481A1 EA 200901481 A EA200901481 A EA 200901481A EA 200901481 A EA200901481 A EA 200901481A EA 200901481 A1 EA200901481 A1 EA 200901481A1
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EA
Eurasian Patent Office
Prior art keywords
modified
present
vectorization
polyglutamates
active principles
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EA200901481A
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English (en)
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EA016911B1 (ru
Inventor
Йу-Пинг Шан
Оливье Брейн
Сесиль Бонне Гонне
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Фламель Текноложи
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Publication of EA200901481A1 publication Critical patent/EA200901481A1/ru
Publication of EA016911B1 publication Critical patent/EA016911B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к новым биодеградируемым материалам на основе модифицированных полиаминокислот, используемым, в частности, для векторизации активного начала (АН). Настоящее изобретение также направлено на новые композиции, включающие фармацевтические, косметические, диетические пищевые продукты или препараты для защиты растений, основанные на этих полиаминокислотах. Целью настоящего изобретения является предоставление нового полимерного материала, который может быть использован в качестве исходного продукта для векторизации АН и который удовлетворяет всем требованиям: биосовместимости, биодеградируемости, способности легко ассоциировать или растворять многочисленные активные начала и высвобождать эти активные начала in vivo. Эта цель достигается настоящим изобретением, которое связано с новыми полиглутаматами, модифицированными катионными группами, которые, если они могут быть депротонированы, имеют pK, равное или большее 7, и гидрофобными группами, содержащими от 8 до 30 атомов углерода. Такие полиглутаматы, модифицированные катионными группами, легко и рентабельно превращают в частицы для векторизации активных начал, причём эти частицы сами способны образовывать стабильные водные коллоидные суспензии. Такие модифицированные полиглутаматы имеют то преимущество, что они являются менее вязкими, чем другие аналогичные полимеры, в то же время сохраняя способность ассоциировать с белками, например, с инсулином. Некоторые из них растворимы в воде при кислых рН и становятся нерастворимыми при физиологическом рН (7,4) и поэтому должны осаждаться при подкожном введении в месте инъекции.
EA200901481A 2007-05-03 2008-05-05 Полиглутаминовые кислоты, функционализированные катионными и гидрофобными группами, и их применения, в частности терапевтические применения EA016911B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0703185A FR2915748B1 (fr) 2007-05-03 2007-05-03 Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques
PCT/EP2008/055507 WO2008135563A1 (fr) 2007-05-03 2008-05-05 Acides polyglutamiques fonctionnalises par des groupements cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques

Publications (2)

Publication Number Publication Date
EA200901481A1 true EA200901481A1 (ru) 2010-04-30
EA016911B1 EA016911B1 (ru) 2012-08-30

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Family Applications (1)

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EA200901481A EA016911B1 (ru) 2007-05-03 2008-05-05 Полиглутаминовые кислоты, функционализированные катионными и гидрофобными группами, и их применения, в частности терапевтические применения

Country Status (15)

Country Link
US (1) US8716217B2 (ru)
EP (1) EP2152782A1 (ru)
JP (1) JP2010529214A (ru)
KR (1) KR20100016280A (ru)
CN (1) CN101663346B (ru)
AU (1) AU2008248604B2 (ru)
BR (1) BRPI0809208A2 (ru)
CA (1) CA2683741A1 (ru)
EA (1) EA016911B1 (ru)
FR (1) FR2915748B1 (ru)
IL (1) IL201017A (ru)
MX (1) MX2009011813A (ru)
NZ (1) NZ580906A (ru)
WO (1) WO2008135563A1 (ru)
ZA (1) ZA200906941B (ru)

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Also Published As

Publication number Publication date
CN101663346B (zh) 2012-03-21
CN101663346A (zh) 2010-03-03
JP2010529214A (ja) 2010-08-26
AU2008248604A1 (en) 2008-11-13
BRPI0809208A2 (pt) 2016-11-16
FR2915748B1 (fr) 2012-10-19
US20090012028A1 (en) 2009-01-08
EA016911B1 (ru) 2012-08-30
IL201017A0 (en) 2010-05-17
US8716217B2 (en) 2014-05-06
AU2008248604B2 (en) 2012-11-08
CA2683741A1 (fr) 2008-11-13
KR20100016280A (ko) 2010-02-12
MX2009011813A (es) 2009-11-13
WO2008135563A1 (fr) 2008-11-13
EP2152782A1 (fr) 2010-02-17
IL201017A (en) 2013-03-24
ZA200906941B (en) 2010-12-29
NZ580906A (en) 2011-07-29
FR2915748A1 (fr) 2008-11-07

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