BRPI0607130A2 - copolihidroxi-alquil-glutaminas funcionalizadas por grupamentos hidrofóbicos e as respectivas aplicações, notadamente terapêuticas - Google Patents
copolihidroxi-alquil-glutaminas funcionalizadas por grupamentos hidrofóbicos e as respectivas aplicações, notadamente terapêuticasInfo
- Publication number
- BRPI0607130A2 BRPI0607130A2 BRPI0607130-9A BRPI0607130A BRPI0607130A2 BR PI0607130 A2 BRPI0607130 A2 BR PI0607130A2 BR PI0607130 A BRPI0607130 A BR PI0607130A BR PI0607130 A2 BRPI0607130 A2 BR PI0607130A2
- Authority
- BR
- Brazil
- Prior art keywords
- novel
- hydrophobic groups
- glutamines
- vectorization
- notably
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G23/00—Compounds of titanium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
- C08L77/04—Polyamides derived from alpha-amino carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Geology (AREA)
- Inorganic Chemistry (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Environmental & Geological Engineering (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
Abstract
COPOLIHIDROXI -ALQUIL-GLUTAMINAS FUNCIONALIZADAS POR GRUPAMENTOS HIDRóFOBOS E AS RESPECTIVAS APLICAçõES, NOTADAMENTE TERAPêUTICAS. A presente invenção se refere aos novos materiais biodegradáveis à base de poliaminoácidos modificados, biodegradáveis, úteis notadamente para a vetorização de princípio(s) ativo(s) (DA) . A invenção visa também novas composições farmacêuticas, cosméticas, dietéticas ou fitossanitárias à base desses poliaminoácidos. A finalidade da invenção é fornecer uma nova matéria-prima de polímero, capaz de ser utilizada para a vetorização de DA e permitindo satisfazer de maneira ótima a todas as especificações requeridas na espécie: biocompatibilidade, biodegradabilidade, aptidão para se associar facilmente com numerosos princípios ativos ou a solubilizá-lo, e a liberar esses princípios ativos in vivo. Essa finalidade é atingida pela presente invenção que se refere a novas copolibidroxi-alquil-glutaminas, compreendendo unidades glutaminas e eventualmente unidades glutamatos e que são portadoras de grupamentos hidrófobos, comportando de 8 a 30 átomos de carbono. Essas copolihidroxi-alquil-glutamínas sao anfifílicas e estão aptas a se transformarem de modo fácil e económico em partículas de vetorização de princípios ativos, essas partículas sendo próprias para formarem suspensões coloidais aquosas estáveis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0550231A FR2881140B1 (fr) | 2005-01-27 | 2005-01-27 | Copolyhydroxyalkylglutamines fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
PCT/EP2006/050369 WO2006079614A2 (fr) | 2005-01-27 | 2006-01-23 | Copolyhydroxyalkylglutamines fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0607130A2 true BRPI0607130A2 (pt) | 2009-08-04 |
Family
ID=34955198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0607130-9A BRPI0607130A2 (pt) | 2005-01-27 | 2006-01-23 | copolihidroxi-alquil-glutaminas funcionalizadas por grupamentos hidrofóbicos e as respectivas aplicações, notadamente terapêuticas |
Country Status (13)
Country | Link |
---|---|
US (1) | US20110044930A1 (pt) |
EP (1) | EP1848411A2 (pt) |
JP (1) | JP2008528543A (pt) |
KR (1) | KR20070101337A (pt) |
CN (1) | CN101151023A (pt) |
AU (1) | AU2006208739A1 (pt) |
BR (1) | BRPI0607130A2 (pt) |
CA (1) | CA2596147A1 (pt) |
FR (1) | FR2881140B1 (pt) |
IL (1) | IL184863A0 (pt) |
MX (1) | MX2007009029A (pt) |
WO (1) | WO2006079614A2 (pt) |
ZA (1) | ZA200707079B (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2822834B1 (fr) | 2001-04-02 | 2005-02-25 | Flamel Tech Sa | Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation |
FR2840614B1 (fr) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
FR2862536B1 (fr) | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
CN100443547C (zh) * | 2007-03-15 | 2008-12-17 | 上海交通大学 | 聚(酰胺-胺)-聚(l-苄基-谷氨酸酯)纳米粒子的制备方法 |
FR2915684B1 (fr) * | 2007-05-03 | 2011-01-14 | Flamel Tech Sa | Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules |
FR2915683B1 (fr) * | 2007-05-03 | 2009-08-07 | Flamel Technologies Sa | Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif |
FR2968994B1 (fr) | 2010-12-17 | 2012-12-28 | Flamel Tech Sa | Procede de preparation de nanoparticules |
FR2968993B1 (fr) | 2010-12-17 | 2012-12-28 | Flamel Tech Sa | Nanoparticules comportant au moins un actif et au moins deux polyelectrolytes |
FR2975912B1 (fr) | 2011-05-30 | 2013-06-14 | Flamel Tech Sa | Composition a liberation controlee de buprenorphine |
EP2814461B1 (fr) * | 2012-01-09 | 2019-07-24 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide substitue |
EP3463294B1 (fr) * | 2016-06-07 | 2020-08-05 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant du glucagon humain et un co-polyaminoacide statistique |
CN108623802B (zh) * | 2018-05-08 | 2021-01-08 | 四川大学 | 一种功能性聚氨基酸衍生物及其制备方法和应用 |
CN109730081A (zh) * | 2019-02-26 | 2019-05-10 | 南京轩凯生物科技有限公司 | 一种农用杀菌剂组合物 |
CN113896236A (zh) * | 2021-09-13 | 2022-01-07 | 常州市妇幼保健院 | 一种基于谷氨酰胺修饰的二氧化钛合成方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
EP0179023B1 (fr) * | 1984-10-19 | 1991-01-23 | Battelle Memorial Institute | Polypeptide biodégradable et son utilisation pour le relargage progressif de médicaments |
CH667874A5 (fr) * | 1985-12-19 | 1988-11-15 | Battelle Memorial Institute | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. |
KR940003548U (ko) * | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
US6153193A (en) * | 1993-04-28 | 2000-11-28 | Supratek Pharma Inc. | Compositions for targeting biological agents |
FR2732218B1 (fr) * | 1995-03-28 | 1997-08-01 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation |
FR2786098B1 (fr) * | 1998-11-20 | 2003-05-30 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication |
FR2801226B1 (fr) * | 1999-11-23 | 2002-01-25 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation |
FR2814952B1 (fr) * | 2000-10-06 | 2004-01-02 | Flamel Tech Sa | Suspension colloidale de particules submicromiques de vectorisation de principes actifs et leur mode de preparation |
JP4585114B2 (ja) * | 2000-12-27 | 2010-11-24 | 三井化学株式会社 | 重合体及びその製造方法 |
JP4775985B2 (ja) * | 2000-12-27 | 2011-09-21 | 三井化学株式会社 | 重合体及びその製造方法 |
US20020169125A1 (en) * | 2001-03-21 | 2002-11-14 | Cell Therapeutics, Inc. | Recombinant production of polyanionic polymers and uses thereof |
US6676785B2 (en) * | 2001-04-06 | 2004-01-13 | Ebert Composites Corporation | Method of clinching the top and bottom ends of Z-axis fibers into the respective top and bottom surfaces of a composite laminate |
JP2003327693A (ja) * | 2002-05-15 | 2003-11-19 | Mitsuru Akashi | 親−疎水性修飾ポリ(γ−グルタミン酸) |
FR2840614B1 (fr) * | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
FR2843117B1 (fr) * | 2002-07-30 | 2004-10-15 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques |
FR2855521B1 (fr) * | 2003-05-28 | 2005-08-05 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques. |
-
2005
- 2005-01-27 FR FR0550231A patent/FR2881140B1/fr not_active Expired - Fee Related
-
2006
- 2006-01-23 MX MX2007009029A patent/MX2007009029A/es not_active Application Discontinuation
- 2006-01-23 CA CA002596147A patent/CA2596147A1/fr not_active Abandoned
- 2006-01-23 BR BRPI0607130-9A patent/BRPI0607130A2/pt not_active IP Right Cessation
- 2006-01-23 ZA ZA200707079A patent/ZA200707079B/xx unknown
- 2006-01-23 US US11/883,223 patent/US20110044930A1/en not_active Abandoned
- 2006-01-23 CN CNA2006800098643A patent/CN101151023A/zh active Pending
- 2006-01-23 KR KR1020077019053A patent/KR20070101337A/ko not_active Application Discontinuation
- 2006-01-23 EP EP06707793A patent/EP1848411A2/fr not_active Withdrawn
- 2006-01-23 WO PCT/EP2006/050369 patent/WO2006079614A2/fr active Application Filing
- 2006-01-23 JP JP2007552626A patent/JP2008528543A/ja active Pending
- 2006-01-23 AU AU2006208739A patent/AU2006208739A1/en not_active Abandoned
-
2007
- 2007-07-26 IL IL184863A patent/IL184863A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2006079614A3 (fr) | 2007-06-21 |
AU2006208739A1 (en) | 2006-08-03 |
US20110044930A1 (en) | 2011-02-24 |
EP1848411A2 (fr) | 2007-10-31 |
CN101151023A (zh) | 2008-03-26 |
JP2008528543A (ja) | 2008-07-31 |
KR20070101337A (ko) | 2007-10-16 |
WO2006079614A2 (fr) | 2006-08-03 |
IL184863A0 (en) | 2007-12-03 |
FR2881140B1 (fr) | 2007-04-06 |
ZA200707079B (en) | 2008-12-31 |
FR2881140A1 (fr) | 2006-07-28 |
MX2007009029A (es) | 2007-10-02 |
CA2596147A1 (fr) | 2006-08-03 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUI DADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2210 DE 14/05/2013. |